Archive for May, 2016

The role of advanced nanomaterials in tackling key global challenges

Duncan Graham, University of Strathclyde

Kian Ping Loh, National University of Singapore

As human demand on earth’s limited resources continues to grow and evolve, global challenges are emerging that require solutions to sustain the quality of life and improve communities where socio-economic disparities remain.  The chemical sciences, and in particular advanced nanomaterials, can play a leading role in providing solutions to some of these global challenges.  Top of the list in terms of the most pressing global challenges is the change in our environment.  For instance, the quality of air that we breathe is being affected by industrialization and other human activities. Can more efficient chemical processes be devised to reduce the release of pollutants into the atmosphere? Or can new materials be produced which sequester and maintain the quality of the air which we are used to breathing?

Climate change has been discussed since the 1830s and it is clear that human activities are having a highly detrimental effect on our climate.  Can nanoscience provide solutions to reduce the rising temperatures experienced globally? Can chemistry have a role in understanding some of the mechanisms that are resulting in climate change and as a result provide effective mediation measures?

Water is the major component of the surface of our planet – however an alarmingly large number of countries struggle to have access to this most basic necessity for drinking, agriculture and sanitation.  Can chemistry and advanced nanomaterials provide solutions to new desalination processes? Or be used to harness solar energy to provide sanitation in remote parts of the globe?

In addition to our environmental concerns, the human population is increasing in some parts of the world which results in a greater demand for food, energy and agricultural lands; this all contributes to increasing food prices.  Can we find chemical solutions to enhance the ability to feed our growing population and can these be effective solutions in the areas that need it most?

With a rapidly aging population in many developed countries, health is also a concern across the globe.  People are living longer – health monitoring and diagnostics create the need for wearable, portable sensors. With the boundaries between countries becoming increasingly transparent, infectious diseases, caused by rapidly mutating biological agents, are potentially worrying. Anti-microbial resistance features prominently in the national research agenda of many countries. Drug discovery is taking longer and costing more than it should.  Can chemistry, and in particular advanced nanomaterials, play a role in addressing some of these health challenges which are common to all countries across the globe?  Can we produce new materials for sensing, diagnosis of disease or produce a therapeutic effect using different mechanisms to traditional small molecule drugs?

Finally, all of the earth’s activities require energy and we have to move towards a sustainable energy future.  Can chemistry play a role in providing new materials which can harvest solar energy efficiently? Furthermore, can we safely harness the potential cleanliness of nuclear fuel? How can bioenergy be used to create a sustainable future based on renewables?  These global challenges affect everyone on the planet and unless steps are taken now, with a strong scientific basis for the solutions, the future health and wellbeing of the global civilisation is at risk.

(more…)

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iPAINT: brushing-up on super resolution microscopy

In recent years, super-resolution microscopy has enabled researchers to explore biological interfaces at the nanoscale. Single-molecule localization methods, such as point accumulation for imaging in nanoscale topography (PAINT), are fundamental techniques for studying the morphology and architecture of living matter. While super-resolution microscopy techniques like PAINT have acquired the interest of researchers in biology, it remains elusive to applications in soft matter and materials science.

In issue 16 of Nanoscale, researchers from the Netherlands have endeavoured to overcome the limitations of PAINT, such as a pre-requisite for hydrophobic domains or specific ligand/receptor pairs, by introducing interface point accumulation for imaging in nanoscale topography (iPAINT). In short, this new technique enables nanometre resolution imaging of interfaces by non-covalent, continuous labelling during imaging. This was achieved by labelling silica nanoparticles with polyethylene glycol (PEG) end-functionalized with a photoactivatable rhodamine analogue (PEG552) that is able to continuously adsorb and desorb from the interface. This method of labelling is essential for interfaces such as emulsions, foams and crystals like ice.

By employing iPAINT as a generic imaging method, the authors are able to obtain super-solution images at different interfaces in 3D. This innovation allows users to develop PAINT in other fields, such as colloid and interface science, food science, soft matter physics and nanotechnology.

iPAINT: a general approach tailored to image the topology of interfaces with nanometer resolution
A. Aloi, N. Vilanova, L. Albertazzi and I. K. Voets
Nanoscale, 2016, DOI: 10.1039/C6NR00445H

Dr Lee Barrett is a guest web writer for the Nanoscale blog. Lee is currently a postdoctoral researcher in the Centre for Molecular Nanometrology at the University of Strathclyde. His research is currently focused on the development of nanoparticle-based sensors and surface enhanced Raman scattering (SERS). Follow him on twitter @L_Bargie

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