Archive for the ‘Uncategorized’ Category

New themed collection on ‘Molecular Glues’

 

We’re pleased to announce that a new themed collection from RSC Chemical Biology has now been published online.

 

READ THE COLLECTION 

 

This themed collection, guest edited by Michelle Arkin (University of California San Francisco, USA), Luc Brunsveld (TU Eindhoven, Netherlands), and Eric Fischer (Dana-Farber Cancer Institute and Harvard Medical School, USA), encompasses the wide scope of molecular glues. Topics include protein degradation glues, protein binders and stabilizers, bi-functional molecules for protein degradation and beyond with a particular interest on molecular recognition.

The articles in this collection are listed below. All articles in RSC Chemical Biology are open access and free to read.

 

REVIEWS

Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction

Huan Rui, Kate S. Ashton, Jaeki Min, Connie Wang and Patrick Ryan Potts

RSC. Chem. Biol., 2023, 4, 192–215, DOI: 10.1039/D2CB00207H

 

Bringing enzymes to the proximity party

Gabrielle S. Tender and Carolyn R. Bertozzi

RSC. Chem. Biol., 2023, 4, 986–1002, DOI: 10.1039/D3CB00084B

 

PAPERS 

Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design

Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D. Hartmann and Christian Steinebach

RSC. Chem. Biol., 2023, 4, 229–234, DOI: 10.1039/D2CB00223J

 

Straightforward model construction and analysis of multicomponent biomolecular systems in equilibrium

Nick H. J. Geertjens, Pim J. de Vink, Tim Wezeman, Albert J. Markvoort and Luc Brunsveld

RSC. Chem. Biol., 2023, 4, 252–260, DOI: 10.1039/D2CB00211F

 

A model-informed method to retrieve intrinsic from apparent cooperativity and project cellular target occupancy for ternary complex-forming compounds

Richard R. Stein, Marianne Fouché, Jeffrey D. Kearns and Hans-Joerg Roth

RSC. Chem. Biol., 2023, 4, 512–523, DOI: 10.1039/D2CB00216G

 

Bind&Bite: covalently stabilized heterodimeric coiled-coil peptides for the site-selective, cysteine-free chemical modification of proteins

Jannis Beutel, Pierre Tannig, Riccardo Di Vincenzo, Thomas Schumacher, Klaus Überla and Jutta Eichler

RSC. Chem. Biol., 2023, 4, 794–803, DOI: 10.1039/D3CB00122A

 

We hope you enjoy this new themed collection from RSC Chemical Biology.

Collaboration with the 1st FERROPTOSIS FRANCE SYMPOSIUM on January 26, 2024

RSC Chemical Biology is pleased to partner with the 1st FERROPTOSIS FRANCE SYMPOSIUM on January 26, 2024. The symposium features renowned speakers, presenting the latest developments and future trends in the field of ferroptosis.

For full details, visit https://www.ferroptosisfrance.fr/. Registrations extended until 19/01/1024. Hurry!

Register at https://www.ferroptosisfrance.fr/tickets

Introducing Sander van Kasteren: Bridging Chemistry and Immunology as Associate Editor

Welcome to the team Sander!

Sander van Kasteren's picture

We’re excited to introduce Sander van Kasteren as our new Associate Editor. His ground-breaking work in chemistry and immunology brings a wealth of expertise and innovation to our editorial team.

Bridging Chemistry and Immunology

Sander’s research connects the dots between chemistry and immunology, focusing on understanding early immune reactions. His innovative methods for studying antigen presentation and T-cell activation are making waves in the scientific community.

Academic Journey

Starting as an organic chemistry student in Edinburgh, Sander’s journey led him to Oxford and the lab of Prof Benjamin G. Davis. There, he contributed to MRI and histological probes for detecting early brain inflammation. His expertise grew under Prof Colin Watts in Dundee, where he worked on protease inhibitors for better antigen cross-presentation.

Leadership and Recognition

In 2012, Sander founded his own group at Leiden University and later joined the Institute of Chemical Immunology, where he’s a board member. His remarkable contributions have earned him fellowships, grants, and awards, including the 2012 Early Career Investigator Award from the British Biochemical Society.

Associate Editor Role for RSC Chemical Biology

Now, Sander van Kasteren takes on a new role as our Associate Editor, bringing his expertise to our publication. We’re thrilled to welcome him and look forward to the valuable insights he’ll bring to our community.

 

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

RSC Chemical Biology Webinar: Outstanding Paper Award Winner 2022

Join us to celebrate the Outstanding Paper Award winners of 2022!

The team at RSC Chemical Biology are delighted to invite you to our upcoming webinar to celebrate the winner of our Outstanding Paper Award from 2022. The winner is Professor Craig Crews, of Yale University, for their paper “OligoTRAFTACs: A generalizable method for transcription factor degradation”.

 

 

 

The webinar, scheduled to last for one hour, will feature a presentation from the group of Professor Craig Crews discussing their work, and this will be followed by a presentation from Professor Michelle Arkin, an Editorial Board Member for RSC Chemical Biology, highlighting some ongoing work in her group at the University of California, San Francisco.

This event is being held online through Zoom and is completely free to attend. It will be held on Tuesday 21st November at 17:00 GMT. You can find more information on our Event Page and can register for the event here.

We look forward to seeing you at the webinar!

 

 

Celebrating Excellence in Chemical Biology: RSC Chemical Biology Outstanding Paper Award 2022

We are delighted to announce our annual RSC Chemical Biology Outstanding Paper 2022 Award, to recognize some of the outstanding work published in the journal, as well as the authors behind those articles. Selected by our Editorial Board, the winning paper was chosen from a shortlist based on the science presented, and also the potential future impact of the research.

We are thrilled to reveal that the award for 2022 goes to

“OligoTRAFTACs: A generalizable method for transcription factor degradation”

Authors:  Kusal T. G. Samarasinghe, Elvira An, Miriam A. Genuth, Ling Chu, Scott A. Holley, and Craig M. Crews.

RSC Chem. Biol., 2022,3, 1144-1153
DOI 10.1039/D2CB00138A

 

This paper represents a significant leap forward in the field of chemical biology. It introduces a novel method, OligoTRAFTACs, which provides an approach for targeted transcription factor degradation. We reached out to the winning team, and they shared their thoughts on receiving this prestigious award. In their words, “We are honoured and pleased to receive the 2022 RSC Chemical Biology Outstanding Paper Award. We thank the editorial board members for recognizing our work on developing oligoTRAFTACs for targeted transcription factor degradation. Targeted protein degradation has been widely explored in academia and industry, and many degraders are already found their way to the clinic. We believe that progressive innovation of proximity-inducing modalities will contribute to expanding the targeted protein degradation and beyond. This recognition highlights the importance of such developments, and it will undoubtedly impel the research community to further advance the chemical biology field.”

Furthermore, we are excited to announce that the winning team will be presenting their research in a webinar series scheduled for October, with the date to be defined. This will be a unique opportunity to delve deeper into their ground-breaking work and engage with the authors directly.

Meet the authors

 

Let’s take a moment to get to know the authors behind this exceptional paper:

  • Dr. Craig M. Crews is the John C. Malone Professor of Molecular, Cellular and Developmental Biology at Yale University. With a rich academic and biotech background, Dr. Crews has been a pioneer in using small molecules to control intracellular protein levels. His contributions have led to the development of innovative therapies, including the FDA-approved drug Kyprolis™ for the treatment of multiple myeloma. Dr. Crews’ commitment to advancing the field of chemical biology has earned him numerous awards and honors, including the Connecticut Medal of Technology in 2022.
  • Dr. Scott A. Holley, a Professor and Chair of the Department of Molecular, Cellular and Developmental Biology, specializes in systems developmental biology, biophysics, and biomechanics. His research focuses on early spinal column development in zebrafish, shedding light on the fundamental processes that shape vertebrate embryos.
  • Dr. Ling Chu, born and raised in China, has a diverse academic journey, from chemistry to chemical biology. After completing his Ph.D. at the Scripps Research Institute, he transitioned to chemical biology research at Yale School of Medicine, where he developed innovative tools for live-cell super-resolution imaging. Dr. Chu’s work has bridged the gap between chemistry and biology.
  • Miriam A. Genuth holds a BA from the University of Chicago and a Ph.D. from the University of California, San Francisco. Her research journey has led her to study chick cranial neural crest cell migration and zebrafish body elongation in the Holley lab at Yale, contributing to our understanding of developmental biology.
  • Elvira An, a graduate candidate in the Department of Pharmacology at Yale University, brings her background in mathematics and post-baccalaureate research experience to the lab of Craig Crews. Her research focuses on unraveling the mechanisms of chemically induced cell fate changes, a critical area in chemical biology.
  • Kusal T. G. Samarasinghe’s academic journey spans from Sri Lanka to the United States, culminating in his pivotal role in the development of OligoTRAFTACs. His work targets hard-to-drug transcription factors, expanding the druggable space within targeted protein degradation and pushing the boundaries of what’s possible in this field.

The RSC Chemical Biology Outstanding Paper 2022 Award not only celebrates the accomplishments of these exceptional researchers but also highlights the transformative potential of their work. We eagerly anticipate the impact of OligoTRAFTACs on the future of chemical biology and look forward to the insights that will be shared during the upcoming webinar series.

Congratulations to the winning team, and thank you for your invaluable contributions to the field of chemical biology!

 

Professor Laura Kiessling joins the Advisory Board

Welcome Prof Kiessling to RSC Chemical Biology!

 

 

We are delighted to welcome Prof Kiessling to the Advisory Board of RSC Chemical Biology.

Professor Kiessling received an Sc.B. degree in chemistry at MIT, where she performed undergraduate research in organic synthesis with Professor Bill Roush. She received a Ph.D. degree in chemistry at Yale University for her research with Stuart L. Schreiber. She was an American Cancer Society postdoctoral fellow with Peter B. Dervan at California Institute of Technology. She then joined the faculty at the University of Wisconsin–Madison, where she became the Steenbock Professor of Chemistry, the Laurens Anderson Professor of Biochemistry, and the Director of the Keck Center for Chemical Genomics. In 2017, she returned to MIT as the Novartis Professor of Chemistry.

Professor Kiessling is a member of the American Academy of Arts & Sciences, the American Academy of Microbiology, the American Philosophical Society, and National Academy of Sciences. She is the founding Editor-In-Chief of the journal ACS Chemical Biology . She is an author of over 140 peer-reviewed journal articles, and an inventor on more than 28 US patents. She has advised approximately 100 graduate students and postdoctorates. Alumni from her research group are contributing through their positions as faculty members of distinguished research universities, medical schools, and colleges and as research scientists at innovative start-up companies, leading corporations, and government laboratories.

 

About RSC Chemical Biology

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

Welcome Lingyin Li to the Editorial Board!

We are delighted to introduce Lingyin Li as an Associate Editor for RSC Chemical Biology!

 

Dr. Lingyin Li is an associate professor in the Biochemistry Department at Stanford School of Medicine. She is also a faculty fellow at the Sarafan ChEM-H Institute and a core investigator at the Arc Institute. She attended the University of Science and Technology of China, where she majored in Polymer Physics at the Chemistry and Chemical Engineering Institute, and earned a bachelor of engineering degree. Dr. Li obtained her Ph.D. in Chemistry from the University of Wisconsin-Madison under the mentorship of Dr. Laura Kiessling. She then sought her postdoctoral training in biochemistry and cancer immunology at Harvard Medical School with Dr. Tim Mitchison. Dr. Li joined the faculty at Stanford School of Medicine in 2015. Her lab has focused on the chemical biology of the cGAMP-STING pathway and harnessing it for the treatment of cancer and autoimmune diseases. Dr. Li has been honored with several prestigious awards including the C&En News Talented 12, NIH Director’s New Innovator Award, and Eli Lilly Award in Biological Chemistry.

 

About RSC Chemical Biology

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

Introducing Jin Zhang to the team!

We are delighted to introduce Jin Zhang as an Advisory board member for RSC Chemical Biology

 

Dr Jin Zhang received her PhD in Chemistry from University of Chicago in 2000.  After completing her postdoctoral work in the laboratory of Roger Tsien at UC San Diego, she joined the faculty of Johns Hopkins University School of Medicine in 2003. She was promoted to Professor of Pharmacology, Neuroscience and Chemical and Biomolecular Engineering in 2013. In 2015 she moved back to UC San Diego and is currently Professor and vice Chair in Department of Pharmacology. She is also a member of the Moores Cancer Centre and an Affiliate Professor in Departments of Bioengineering and Chemistry & Biochemistry at UC San Diego. She co-directs the Centre for Cell Signaling San Diego with Dr Alexandra Newton. Research in her lab focuses on developing enabling technologies to probe the active molecules in their native environment and characterizing how these active molecules change in diseases including cancer. Dr Zhang is a recipient of Biophysical Society Margaret Oakley Dayhoff Award (2009), NIH Director’s Pioneer Award (2009), John J. Abel Award in Pharmacology (2012), Pfizer Award in Enzyme Chemistry (2012), NCI Outstanding Investigator Award (2015 and 2022), Novartis Global Scholar Award (2021), Robert R. Ruffolo Career Achievement Award in Pharmacology (2022) and the Protein Society Christian B. Anfinsen Award (2022). She was elected as a Fellow of the American Association for the Advancement of Science (AAAS) in 2014, a Fellow of the American Institute for Medical and Biological Engineering (AIMBE) in 2019 and a Fellow of American Society for Pharmacology and Experimental Therapeutics in 2021 (FASPET). Dr Zhang also received UC San Diego Chancellor’s Award for Excellence in Postdoctoral Scholar Mentoring in 2019 and Outstanding Graduate Student Mentoring Award in UC San Diego Jacobs School of Engineering in 2022. Dr Zhang will be receiving the Carolyn Cohen Innovation Award from the Biophysical Society in 2023.

About RSC Chemical Biology

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2022, so the journal is currently free to publish in.

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

 

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

 

Upcoming conferences highlighted for RSC Chemical Biology readers! January 2023

RSC Chemical Biology is highlighting some upcoming conferences in January 2023 that we think would be of interest to our broad chemical biology readership. We’re sponsoring these conferences and attending one too! Please consider registering!

3rd PSL Chemical Biology Symposium

12-13th Jan 2023
Paris, France
Registration deadline: 31st Oct 2022
Poster abstract deadline: 30th Nov 2022
RSC Chemical Biology will be attending this conference!

RSC Chemical Biology and Bio-organic Group Forum 2023

13th Jan 2023
Belfast, United Kingdom
Oral/poster abstract deadline: 11th Nov 2022
Registration deadline: 25th Nov 2022

Advances in Chemical Biology – DECHEMA

24-25 Jan 2023
Frankfurt, Germany
Poster abstract submission deadline: 31st Oct 2022
Last minute poster deadline: 6th Jan 2022

RSC Desktop Seminar Series – The Interface of Chemistry & Biology

 

We are delighted to introduce the latest series of Desktop Seminars on the Interface of Chemistry & Biology.

This exciting Series will feature talks from authors and Board Members from across the RSC’s publishing portfolio, including RSC Chemical Biology, RSC Advances, ChemComm, Chemical Science, and Molecular Omics.

Each session will include two talks from a range of international speakers highlighting their research in relation to the interface of chemistry and biology.

 

Save the dates and join us for these free virtual events: 

RSC Desktop Seminar with ChemCommRegister Here

Join us on Wednesday 26th October 2022, at 15:00 GMT / 10:00 EST

Featuring Prof. Mingxu You, University of Massachusetts Amherst, USA, and Prof. Amanda Hargrove, Duke University, USA

 

RSC Desktop Seminar with RSC Chemical Biology – Register Here

Join us on Friday 11th November 2022, at 14:00 GMT / 15:00 CET

Featuring Prof. Jennifer Andexer, University of Freiburg, Germany, and Prof. Roderich Suessmuth, TU Berlin, Germany

 

RSC Desktop Seminar with Chemical ScienceRegister Here

Join us on Thursday 17th November 2022, at 15:00 GMT / 10:00 EST

Featuring Prof. Gonçalo Bernardes, University of Cambridge, UK, and Prof. Dorothea Fiedler, Research Institute for Molecular Pharmacology (FMP) and Humboldt University of Berlin, Germany

 

RSC Desktop Seminar with RSC AdvancesRegister Here

Join us on Thursday 24th November 2022, at 11:00 GMT / 16:30 IST

Featuring Prof. Surajit Ghosh, Indian Institute of Technology Jodhpur, India, and Dr. Christine Beemelmanns, Hans-Knoll Institute, Germany

More dates to be announced soon!