Archive for the ‘Collections’ Category

A mechanistic study on the cellular uptake, intracellular trafficking, and antisense gene regulation of bottlebrush polymer-conjugated oligonucleotides

A research infographic summarising the linked article.

Read the full article here.

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

Photoreactive bioorthogonal lipid probes and their applications in mammalian biology

Infographic Bioorthogonal lipid probes: unlocking a world of possibilities by Dr Kamat

 

Read the full article here.

 

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

Methyltetrazine as a small live-cell compatible biorthogonal handle for imaging enzyme activities in situ

Infographic about Methyltetrazine as a small live-cell compatible biorthogonal handle for imaging enzyme activities in situ

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RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues

infographic of efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues

Read the full article by Phillip Holliger & Alexander Taylor here

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

Photo-induced telomeric DNA damage in human cancer cells

 

Read the full article by Dr Benjamin Elias & Dr Anabell Decottignies here

 

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index.  Find out more about the journal and submit your work at rsc.li/rsc-chembio

RSC Chemical Biology

Royal Society of Chemistry

www.rsc.org

 

Call for papers – Medicinal Chemistry Small Molecule Probes

A banner with photographs of the Guest Editors and a summary of the information in this post

RSC Chemical Biology is delighted to welcome papers for its latest online themed collection on ‘Medicinal Chemistry Small Molecule Probes’, guest edited by John Spencer (University of Sussex, UK), Gemma Nixon (University of Liverpool, UK), and Miraz Rahman (King’s College London, UK).

Contributions are welcome which investigate general medicinal chemistry, chemical probes for imaging, proteomics, protacs, fragment-based drug discovery, covalent binders, chemical tools for protein profiling and activity modulation, and natural product inspired medicinal chemistry and chemical biology.

The deadline for submissions is 1 June 2023. Submit your work to the collection now!

Promotion of the collection is scheduled for late 2023, with articles published online as soon as they’re accepted.

Authors are welcome to submit original research in the form of a Communication or Full Paper. Articles can be submitted via our website: rsc.li/rsc-chembio. When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.

Explore all open calls for papers from RSC journals!

About RSC Chemical Biology:

Led by Hiroaki Suga (University of Tokyo), RSC Chemical Biology is dedicated to publishing and disseminating the most exceptionally significant, breakthrough findings of interest to the chemical biology community. All submissions are handled by our experienced and internationally recognised Associate Editors. For more information on the journal, please visit the journal homepage.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Articles accepted for publication in this themed collection will have their article processing charges waived.

RSC Chemical Biology is now indexed in the Directory of Open Access Journals (DOAJ), PubMed Central, Scopus and Web of Science: Emerging Sources Citation Index. Find out more about the journal and submit your work at rsc.li/rsc-chembio.

New themed collection on ‘Development of bio-orthogonal tools’

A banner advertising the themed collection described in this post

We’re pleased to announce that a new themed collection from RSC Chemical Biology has now been published online.

Read the collection

Guest-edited by Chengqi Yi (Peking University, China) and Yan Zhang (Nanjing University, China), this collection highlights work on bio-orthogonal chemistry, reactions and probes in labeling, manipulating, imaging and sequencing of protein, DNA, RNA and bioactive metabolites.

The article line-up is provided below. All articles in RSC Chemical Biology are open access and free to read.

Editorial

Introduction to ‘Development of bio-orthogonal tools’
Yan Zhang and Chengqi Yi
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB90045A

Reviews

Labeling and sequencing nucleic acid modifications using bio-orthogonal tools
Hui Liu, Yafen Wang and Xiang Zhou
RSC. Chem. Biol., 2022, 3, 994–1007, DOI: 10.1039/D2CB00087C

Imitate to illuminate: labeling of bacterial peptidoglycan with fluorescent and bio-orthogonal stem peptide-mimicking probes
Huibin Lin, Chaoyong Yang and Wei Wang
RSC. Chem. Biol., 2022, 3, 1198–1208, DOI: 10.1039/D2CB00086E

Papers

A library of Rhodamine6G-based pH-sensitive fluorescent probes with versatile in vivo and in vitro applications
Benton Swanson, Margaret Durdan, Miranda Eberle, Seth Woodbury, Ava Mauser, Jason Gregory, Boya Zhang, David Niemann, Jacob Herremans, Peter X. Ma, Joerg Lahann, Megan Weivoda, Yuji Mishina and Colin F. Greineder
RSC. Chem. Biol., 2022, 3, 748–764, DOI: 10.1039/D2CB00030J

Methyltetrazine as a small live-cell compatible bioorthogonal handle for imaging enzyme activities in situ
Diana Torres-García, Merel A. T. van de Plassche, Emma van Boven, Tyrza van Leeuwen, Mirjam G. J. Groenewold, Alexi J. C. Sarris, Luuk Klein, Herman S. Overkleeft and Sander I. van Kasteren
RSC. Chem. Biol., 2022, 3, 1325–1330, DOI: 10.1039/D2CB00120A

We hope you enjoy this new themed collection from RSC Chemical Biology.

Call for papers – Molecular and nanotheranostics

 

A slide summarising the information in this blog post.

RSC Chemical Biology and RSC Medicinal Chemistry are delighted to welcome papers for an online themed collection on ‘Molecular and nanotheranostics’, guest edited by Prof. Thimmaiah Govindaraju (Jawaharlal Nehru Centre for Advanced Scientific Research, India).

 Over a decade of intense research has positioned theranostics as a promising and integrated approach to advance biomedical research and medicine. The term theranostics essentially conveys the idea of combining therapeutic and diagnostic modalities to provide a holistic solution for disease management. Theranostics is also referred to as diagnostic therapy, wherein molecular and/or material tools for non-invasive treatment and diagnostic imaging are strategically embedded into a single system. For instance, multifunctional diagnostic platforms carrying therapeutic and target tracking agents offer remedial effects and imaging of markers in tissue or organs, which is used to assess disease staging, treatment planning and therapeutic efficacy.

Theranostics has the potential to revolutionize the practice and adaptation of personalized medicine to tackle chronic disease conditions like cancer and neuronal disorders. Generally, radiopharmaceutical, nano and macromolecular systems armed with tools to detect, treat, track, and image biomolecular targets in real-time have been employed as theranostics to effectively manage disease progression and cure.

In recent years, the field has witnessed the emergence of small molecules or small molecular conjugates as theranostic tools. This special collection in RSC Chemical Biology and RSC Medicinal Chemistry intends to cover and highlight advancements in molecular theranostics with particular emphasis on chemical biology of molecular design of theranostic tools and their selective interaction with the biomolecular targets to image and ameliorate the pathological conditions. This themed collection is anticipated to catalyze the development of precision theranostics as advanced and personalizable tools in chemical biology and modern medicine.

 The deadline for submissions has been extended to 30 June 2023.

 Articles can be submitted via  the appropriate journal’s website, where you can find details on their scopes and focus. RSC Chemical Biology accepts exceptionally significant and breakthrough findings of interest to the chemical biology community, while RSC Medicinal Chemistry publishes significant research in medicinal chemistry and related drug discovery science.

RSC Chemical Biology: rsc.li/rsc-chembio
RSC Medicinal Chemistry: rsc.li/rsc-medchem

Authors are welcome to submit original research in the form of a Communication or Full Paper. Note that RSC Chemical Biology is a gold open access, journal, however submissions for this collection will have their article processing charges (APCs) waived.

When submitting your manuscript, please mention that it is intended for this themed collection in the “notes to the editor” box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed. Promotion of the collection is scheduled for late-2023, with articles published online as soon as they’re accepted.

Explore all open calls for papers from RSC journals!

New themed collection on Xenonucleic acids (XNA)

We’re pleased to announce that a new themed collection from RSC Chemical Biology has now been published online.

Read the Collection

Guest-edited by Dennis Bong (Ohio State University), Philipp Holliger (MRC Laboratory of Molecular Biology), and Chaoyong Yang (Xiamen University), this themed collection covers all aspects of modified nucleic acids in chemical and synthetic biology including both in vitro as well as in vivo applications, and new chemistries. Taken together, the papers collected in this themed collection represent the state of the art on XNAs and highlights work at the interface of chemistry and biology.

A selection of the articles has been provided below. All articles in RSC Chemical Biology are open access and free to read.

Editorial

Introduction to the themed collection on XNA xenonucleic acids
Dennis Bong, Philipp Holliger and Chaoyong Yang
RSC. Chem. Biol., 2022, 3, DOI: 10.1039/D2CB90036J

Reviews

From polymerase engineering to semi-synthetic life: artificial expansion of the central dogma
Leping Sun, Xingyun Ma, Binliang Zhang, Yanjia Qin, Jiezhao Ma, Yuhui Du and Tingjian Chen
RSC Chem. Biol., 2022, 3, 1173-1197, DOI: 10.1039/D2CB00116K

Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications
Chaturong Suparpprom and Tirayut Vilaivan
RSC Chem. Biol., 2022, 3, 648-697, DOI: 10.1039/D2CB00017B

Communications

Efficient synthesis and replication of diverse sequence libraries composed of biostable nucleic acid analogues
John R. D. Hervey, Niklas Freund, Gillian Houlihan, Gurpreet Dhaliwal, Philipp Holliger and Alexander I. Taylor
RSC Chem. Biol., 2022, 3, 1209-1215, DOI: 10.1039/D2CB00035K

Dependence of click-SELEX performance on the nature and average number of modified nucleotides
Julia Siegl, Olga Plückthun and Günter Mayer
RSC Chem. Biol., 2022, 3, 288-294, DOI: 10.1039/D2CB00012A

Papers

Synthesis and structure–activity relationship of peptide nucleic acid probes with improved interstrand-crosslinking abilities: application to biotin-mediated RNA-pulldown
Enrico Cadoni, Francesca Pennati, Penthip Muangkaew, Joke Elskens, Annemieke Madder and Alex Manicardi
RSC Chem. Biol., 2022, 3, 1129-1143, DOI: 10.1039/D2CB00095D

Stimuli-responsive assembly of bilingual peptide nucleic acids
Hector S. Argueta-Gonzalez, Colin S. Swenson, George Song and Jennifer M. Heemstra
RSC Chem. Biol., 2022, 3, 1035-1043, DOI: 10.1039/D2CB00020B

Mutant polymerases capable of 2′ fluoro-modified nucleic acid synthesis and amplification with improved accuracy
Trevor A. Christensen, Kristi Y. Lee, Simone Z. P. Gottlieb, Mikayla B. Carrier and Aaron M. Leconte
RSC Chem. Biol., 2022, 3, 1044-1051, DOI: 10.1039/D2CB00064D

Covalently attached intercalators restore duplex stability and splice-switching activity to triazole-modified oligonucleotides
Anna Dysko, Ysobel R. Baker, Graham McClorey, Matthew J. A. Wood, Sabine Fenner, Glynn Williams, Afaf El-Sagheer and Tom Brown
RSC Chem. Biol., 2022, 3, 765-772, DOI: 10.1039/D2CB00100D

Conjugation of oligonucleotides with activated carbamate reagents prepared by the Ugi reaction for oligonucleotide library synthesis
Ryosuke Kita, Takashi Osawa and Satoshi Obika
RSC Chem. Biol., 2022, 3, 728-738, DOI: 10.1039/D1CB00240F

A ruthenium–oligonucleotide bioconjugated photosensitizing aptamer for cancer cell specific photodynamic therapy
Luke K. McKenzie, Marie Flamme, Patrick S. Felder, Johannes Karges, Frederic Bonhomme, Albert Gandioso, Christian Malosse, Gilles Gasser and Marcel Hollenstein
RSC Chem. Biol., 2022, 3, 85-95, DOI: 10.1039/D1CB00146A

Targeting a conserved structural element from the SARS-CoV-2 genome using L-DNA aptamers
Jing Li and Jonathan T. Sczepanski
RSC Chem. Biol., 2022, 3, 79-84, DOI: 10.1039/D1CB00172H

 

We hope you enjoy this new themed collection from RSC Chemical Biology.

The first RSC Chemical Biology Emerging Investigators collection

Photographs of the six corresponding authors on the articles in this collection

We’re pleased to announce that our first Emerging Investigators collection has now been published online!

Read the collection

RSC Chemical Biology is committed to supporting and recognizing the excellent work of early career researchers. We are thus proud to present our first annual Emerging Investigators collection. The collection showcases research carried out by internationally recognised, up-and-coming scientists in the early stage of their independent careers who are making outstanding contributions to their respective fields. Each contributor was recommended by an expert in their field for carrying out work with the potential to influence future directions. The collection encompasses the entire scope of the journal.

Looking forward, we will soon be inviting for an Emerging Investigators Collection that will be published in 2023, and you are encouraged to recommend a colleague at the beginning of their career by contacting the Editorial Office. To be considered, a scientist must be a research group leader with less than 10 years of independent research (although the timescale is flexible in cases of career breaks and personal circumstances).

Congratulations to all the featured researchers on their work. Join us in celebrating their contributions!

Editorial

RSC Chemical Biology Emerging Investigators Collection and Outstanding Paper Award 
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB90027K

Profile

Contributors to the RSC Chemical Biology Emerging Investigators Collection 2022 
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB90028A

Communications

The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides 
Truc Lam Pham, Jennifer Zilke, Christine Charlotte Müller and Franziska Thomas
RSC. Chem. Biol., 2022, 3, 426–430, DOI: 10.1039/D1CB00252J

A light-initiated chemical reporter strategy for spatiotemporal labeling of biomolecules 
Feifei Wang, Hao Kong, Xiangfeng Meng, Xiao Tian, Changjiang Wang, Lei Xu, Xiang Zhang, Lei Wang and Ran Xie
RSC. Chem. Biol., 2022, 3, 539–545, DOI: 10.1039/D2CB00072E

A dual-responsive doxorubicin–indoximod conjugate for programmed chemoimmunotherapy 
Zhaoxuan Yang, Jiaqi Huang, Yaying Lin, Xiangjie Luo, Haojin Lin, Hongyu Lin and Jinhao Gao
RSC. Chem. Biol., 2022, 3, 853–858, DOI: 10.1039/D1CB00257K

Fluorescent metabolic labeling-based quick antibiotic susceptibility test for anaerobic bacteria
Juan Gao, Juanxiu Qin, Chenling Ding, Yuan Gao, Junnan Guo, Min Li, Chaoyong Yang and Wei Wang
RSC Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB00163B

Papers

Proteomic characterization of phagocytic primary human monocyte-derived macrophages
Regan F. Volk, José L. Montaño, Sara E. Warrington, Katherine L. Hofmann and Balyn W. Zaro
RSC. Chem. Biol., 2022, 3, 783–793, DOI: 10.1039/D2CB00076H

Improved ClickTags enable live-cell barcoding for highly multiplexed single cell sequencing
Xinlu Zhao, Shiming Sun, Wenhao Yu, Wenqi Zhu, Zihan Zhao, Yiqi Zhou, Xiuheng Ding, Nan Fang, Rong Yang and Jie P. Li
RSC. Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB00046F

Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines 
Samantha M. Horwitz, Tamra C. Blue, Joseph A. Ambarian, Shotaro Hoshino, Mohammad R. Seyedsayamdost and Katherine M. Davis
RSC. Chem. Biol., 2022, 3, 420–425, DOI: 10.1039/D1CB00255D

One-step asparaginyl endopeptidase (OaAEP1)-based protein immobilization for single-molecule force spectroscopy
Xuan Ding, Ziyi Wang, Bin Zheng, Shengchao Shi, Yibing Deng, Hanyang Yu and Peng Zheng
RSC Chem. Biol., 2022, Advance Article, DOI: 10.1039/D2CB00135G