New themed collection on ‘Molecular Glues’


We’re pleased to announce that a new themed collection from RSC Chemical Biology has now been published online.




This themed collection, guest edited by Michelle Arkin (University of California San Francisco, USA), Luc Brunsveld (TU Eindhoven, Netherlands), and Eric Fischer (Dana-Farber Cancer Institute and Harvard Medical School, USA), encompasses the wide scope of molecular glues. Topics include protein degradation glues, protein binders and stabilizers, bi-functional molecules for protein degradation and beyond with a particular interest on molecular recognition.

The articles in this collection are listed below. All articles in RSC Chemical Biology are open access and free to read.



Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction

Huan Rui, Kate S. Ashton, Jaeki Min, Connie Wang and Patrick Ryan Potts

RSC. Chem. Biol., 2023, 4, 192–215, DOI: 10.1039/D2CB00207H


Bringing enzymes to the proximity party

Gabrielle S. Tender and Carolyn R. Bertozzi

RSC. Chem. Biol., 2023, 4, 986–1002, DOI: 10.1039/D3CB00084B



Accessing three-branched high-affinity cereblon ligands for molecular glue and protein degrader design

Robert Kuchta, Christopher Heim, Alexander Herrmann, Samuel Maiwald, Yuen Lam Dora Ng, Izidor Sosič, Tim Keuler, Jan Krönke, Michael Gütschow, Marcus D. Hartmann and Christian Steinebach

RSC. Chem. Biol., 2023, 4, 229–234, DOI: 10.1039/D2CB00223J


Straightforward model construction and analysis of multicomponent biomolecular systems in equilibrium

Nick H. J. Geertjens, Pim J. de Vink, Tim Wezeman, Albert J. Markvoort and Luc Brunsveld

RSC. Chem. Biol., 2023, 4, 252–260, DOI: 10.1039/D2CB00211F


A model-informed method to retrieve intrinsic from apparent cooperativity and project cellular target occupancy for ternary complex-forming compounds

Richard R. Stein, Marianne Fouché, Jeffrey D. Kearns and Hans-Joerg Roth

RSC. Chem. Biol., 2023, 4, 512–523, DOI: 10.1039/D2CB00216G


Bind&Bite: covalently stabilized heterodimeric coiled-coil peptides for the site-selective, cysteine-free chemical modification of proteins

Jannis Beutel, Pierre Tannig, Riccardo Di Vincenzo, Thomas Schumacher, Klaus Überla and Jutta Eichler

RSC. Chem. Biol., 2023, 4, 794–803, DOI: 10.1039/D3CB00122A


We hope you enjoy this new themed collection from RSC Chemical Biology.