Review: Gd(III) chelates for MRI contrast agents

Kai-Hsiang Chuang and Chang-Tong Yang from the Singapore Bioimaging Consortium, A*STAR provide a timely review on the major developments of Gd(III) chelates as MRI contrast agents, from high relaxivity to ‘‘smart’’, from blood pool to blood–brain barrier.


The review covers:

  • Relaxivity of Gd(III) based MRI contrast agents
  • Smart contrast agents (pH-, metal ion-, enzyme- ; small biomolecule-activated)
  • Blood pool contrast agents (non-covalent binding to plasma proteins, polymeric and dendrimeric contrast agents)
  • Blood–brain barrier permeable contrast agents

Should your interests lie in coordination chemistry, polymer and supramolecular chemistry, medicinal chemistry, spectroscopy, biology or radiology, this review is for you!

Gd(III) chelates for MRI contrast agents: from high relaxivity to “smart”, from blood pool to blood–brain barrier permeable
Chang-Tong Yang and Kai-Hsiang Chuang
Med. Chem. Commun., 2012, Advance Article
DOI: 10.1039/C2MD00279E, Review Article

Why not also view our 2011 collection of topical review articles, across the full range of the journal scope, here.

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