We are delighted to announce that Michael Shuler (Cornell University, USA) will be acting as Thought Leader for this collection. His research focuses on “Body-on-a-Chip” devices applied to evaluate different treatments for cancer, such as multi-drug resistant cancer. Read Michael Shuler’s recent Editorial for more information.
An emerging area of interest for drug development over the last 13 years has been constructing human biomimetic systems by combining the techniques of microfabrication and tissue engineering. In this collection, we define an “Organ-on-a-Chip” as a physical microscale model (typically an order of 10−6 to 10−4 of actual size) of a particular human organ.
The questions we aim to address in this collection are whether these emerging technologies will improve both drug development and the regulation of human exposure to chemicals. What technical challenges remain? What will be the most effective way to utilize this emerging technology? Can this technology lead to cost effective, measurable improvements in human health? Our goal is to highlight the new advances in this growing field with an emphasis on the interface between the technological advancements and high impact applications of organ-, body- and disease-on-a-chip technologies.
Interested in submitting to the collection?
We have recently launched a second collection highlighting efforts to translate this concept into practice. A series of papers that address aspects of the issues involved in moving from “proof-of-principle” devices to systems that can be routinely incorporated into testing of drugs, cosmetics, food ingredients, and chemicals would be valuable to the development of the field of microphysiological systems. We seek contributions that will help us fulfill this goal. More information can be found on the updated blog.
We welcome submissions of original research articles and reviews to this collection and the collection is open for submissions.
If you are interested in submitting to the series, please get in touch with the Lab on a Chip Editorial Office at firstname.lastname@example.org.