Archive for July, 2012

Interview with Nissim Garti: Function is Everything

Nissim Garti, Editorial Board Member of Food & Function, talks to Anna Simpson about links between industry and academia, liquid delivery systems, what the term food and function means to him and about an interesting hobby.

Nissim Garti Nissim Garti is full professor of Chemistry at The Hebrew University of Jerusalem and is incumbent of the Ratner Chair of Chemistry. He has published over 400 peer-reviewed manuscripts, written 80 review chapters, edited 6 books, and holds 90 patents. Professor Garti has received national and international awards, including the AOCS Chang Award, the Rockefeller Award, the IFT Award (2008), and Life Time Achievement Award (2009). Recently Professor Garti’s second (modified LLCs) invention was included in the Hall of Fame of The Hebrew University. The Food Society of Israel awarded him a Lifetime Achievement Award. 

How did you become interested in food science research?

My father owned a wholesale foods outlet.  When I went to university I started at medical school but after a few weeks I decided I did not want to be a medical doctor so I changed to chemistry.  I followed my degree with a Masters in food and the rest is history; although I don’t only do food, these days a third of my work is pharmaceuticals.

You have strong links with industry; what are your views on how industry and academia can work together?

I think they must work together.  My department is called the school of applied product-oriented research so applications are always a focus of work.  My Masters students do the applied research while PhD students perform fundamental research.  I only publish the fundamental research, the rest goes into patents.  I have over 90 patents and have been involved in a few start-ups.

Could you tell us more about the Nano-sized Self-assembled Structured Liquids (NSSL) technology that is behind your start-up company NutraLease?

NSSLs are a form of modified microemulsion.  They have been known for a long time, since the fifties, but the problem was that when they were diluted they broke apart.  Our development allowed them to be diluted so when they are taken into the body and diluted during digestion they stay in-tact; they are also adsorbed onto the lumen and release their contents.

What is the main focus of your research at the moment?

I am interested in all new liquid delivery systems.  I always focus on new ways of entrapment and am interested in developing novel systems.  I am currently very interested in lyotropic liquid crystals as solubilisation vehicles.

What does the term Food & Function mean to you?

Well, function is everything.  Functionality is all about what something does, and to me, this has to be about new functions or unexpected functions; it is not interesting to present a function that would be expected.  For example, if combining protein and vitamin A resulted in a new function, such as increased bioavailability, this would be a new functionality.  So, to me, what is interesting is discovering an unexpected function, or designing a new structure which provides a new functionality, or altering the function of a known substance; these are more interesting than understanding how something works.

Could you tell us a bit about your interests outside of science

My hobby is photography.  I travel to very remote places and meet with isolated tribes that are dying from existence, known as ‘disappearing tribes’.  I am not just interested in photos as a visual record; I go with a small group and get to know the people.  I am interested in their culture and customs, the way they do things, live and have fun.  We spend time with them and build trust and only then will I take photographs, when they know me and trust me.

Also of Interest

Read Professor Garti’s recently published review in Food & Function:

Lipid polymorphism in lyotropic liquid crystals for triggered release of bioactives
Nissim Garti,  Dima Libster and Abraham Aserin, Food Funct., 2012,3, 700-713

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Food & Function issue 8 – now online

The latest issue of Food & Function is now available online!

The front cover of this issue features work by Gregory Monteith and colleagues from The University of Queensland, Australia, who have found that chemicals in the peel of some mango varieties, but not the flesh, contain certain chemicals which prevent the formation of fat cells (adipogenesis).  The authors suggest that the pathways involved in this inhibition of adipogenesis may be similar to those of resveratrol.  These results show that phytochemical differences in composition and/or quantity across cultivars can have a big impact on adipogenesis.

Read the full article here – free to access for 6 weeks

You can keep up to date with the latest developments from Food & Function by signing up for free table of contents alerts and monthly e-newsletters.

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The OCC world congress – ‘Oxidants and Antioxidants in Biology’

The world congress “Oxidants and Antioxidants in Biology” was held in Alba, Italy, 20th-23rd June 2012. It was a joint meeting of the Oxygen Club of California (OCC) and the University of Turin, Italy, co-sponsored by the Linus Pauling Institute, Oregon State University, U.S.A. This congress is part of a serial of congresses organized every other year by the OCC that gather highly recognized scientists in areas that convey basic and applied medical research.

Guliz Armagan receiving her certificate from Food & Function Associate Editor, Professor Cesaer Fraga

This year, the subject of the meeting was “Cell signaling and nutrient-gene interactions,” having sessions on NRF2-driven regulation of antioxidant defenses, nutrient-gene interactions and epigenetics, novel roles of micronutrients, lipid oxidation and signaling, and epigenetics, metabolism, and aging. The Congress had an attendance of 220 delegates from all over the world, including speakers and chairpersons, general attendants, and young scientists.

Selected from about one hundred presentations 4 Young Investigator prizes were given. The selection was done based on the quality of the work and the proficiency of the presenter by a committee of 6 senior scientists (including: John Maguire, Berkeley; Emily Ho, Corvalis; Josiane Cillard, Rennes; and Nesrin Ozer, Istambul).

Food & Function and the Royal Society of Chemistry awarded a prize for the best work in the area of Nutrition to Guliz Armagan from the Department of Biochemistry, School of Pharmacy, Ege University, Izmir, Turkey. The work, “Induction of oxidative stress, apoptosis and inflammation in rat brain regions by D-serine” was co-authored by Lutfiye Kanit, and Ayfer Yalcin from the same University.  Many congratulations to Guliz on winning this prize.

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Top ten most accessed articles in June

This month sees the following articles in Food & Function that are in the top ten most accessed:-

Nuts, especially walnuts, have both antioxidant quantity and efficacy and exhibit significant potential health benefits
Joe A. Vinson and Yuxing Cai
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO10152A

Anti-inflammatory activity of natural dietary flavonoids
Min-Hsiung Pan, Ching-Shu Lai and Chi-Tang Ho
Food Funct., 2010,1, 15-31, DOI: 10.1039/C0FO00103A, Review Article

Effects of tea and coffee on cardiovascular disease risk
Siv K Bøhn, Natalie C Ward, Jonathan M Hodgson and Kevin D Croft
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO10288A

Mango fruit peel and flesh extracts affect adipogenesis in 3T3-L1 cells
Meng-Wong Taing, Jean-Thomas Pierson, Van L. T. Hoang, Paul N. Shaw, Ralf G. Dietzgen, Michael J. Gidley, Sarah J. Roberts-Thomson and Gregory R. Monteith
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO30073G, Paper

Review of in vitro digestion models for rapid screening of emulsion-based systems
David Julian McClements and Yan Li
Food Funct., 2010,1, 32-59, DOI: 10.1039/C0FO00111B, Review Article

Recent developments on polyphenol-protein interactions: effects on tea and coffee taste, antioxidant properties and the digestive system
Prasun Bandyopadhyay, Amit K. Ghosh and Chandrasekhar Ghosh
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO00006G

Transcription profiles of LPS-stimulated THP-1 monocytes and macrophages: a tool to study inflammation modulating effects of food-derived compounds
Wasaporn Chanput, Jurriaan Mes, Robert A. M. Vreeburg, Huub F. J. Savelkoul and Harry J. Wichers
Food Funct., 2010,1, 254-261, DOI: 10.1039/C0FO00113A

Development of oral food-grade delivery systems: Current knowledge and future challenges
Revital Cohen Benshitrit, Carmit Shani Levi, Sharon Levi Tal, Eyal Shimoni and Uri Lesmes
Food Funct., 2012,3, 10-21, DOI: 10.1039/C1FO10068H, Review Article

Insights into the metabolism and microbial biotransformation of dietary flavan-3-ols and the bioactivity of their metabolites
Maria Monagas, Mireia Urpi-Sarda, Fernando Sánchez-Patán, Rafael Llorach, Ignacio Garrido, Carmen Gómez-Cordovés, Cristina Andres-Lacueva and Begoña Bartolomé
Food Funct., 2010,1, 233-253, DOI: 10.1039/C0FO00132E, Review Article

Prenylated isoflavonoids from plants as selective estrogen receptor modulators (phytoSERMs)
Rudy Simons, Harry Gruppen, Toine F. H. Bovee, Marian A. Verbruggen and Jean-Paul Vincken
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO10290K, Review Article

Why not take a look at the articles today and blog your thoughts and comments below.

Fancy submitting an article to Food & Function? Then why not submit to us today or alternatively email us your suggestions.

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Bittersweet result for dark chocolate

 

Studies show that polyphenol-rich dark chocolate has health benefits for overweight females

Studies show that polyphenol-rich dark chocolate has health benefits for overweight females

UK scientists have clinically proven that consuming polyphenol-rich dark chocolate has health benefits for overweight and obese females, whilst showing adverse effects for polyphenol-deficient chocolate.

Evidence already shows that polyphenol-rich dark chocolate can benefit blood pressure and glucose levels in healthy people, thanks to dark chocolate’s antioxidant properties. Fewer studies have examined the involvement of the endocrine system – glands that secrete hormones – in mediating the cardiometabolic health-effects of polyphenols, until now.

Suzana Almoosawi from Medical Research Council Human Nutrition Research, Cambridge, and the Queen Margaret University, Edinburgh and her colleagues, applied these findings to a group of healthy women with a range of body mass indexes (BMIs). Obesity is often linked to numerous chronic diseases, such as hypertension and type 2 diabetes, so the team were keen to study the metabolic effects observed for different concentrations of polyphenols in dark chocolate, across a range of BMIs.

Read the full article in Chemistry World

Link to journal article
Differential effect of polyphenol-rich dark chocolate on biomarkers of glucose metabolism and cardiovascular risk factors in healthy, overweight and obese subjects: a randomized clinical trial
S Almoosawi et al
Food Funct., 2012, DOI: 10.1039/c2fo30060e

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Mechanism explaining neuroprotective effects of citrus flavonoids revealed

C2FO30100HThe mechanism of pro-cellular survival and neuroprotective actions of hesperetin in PC12 cells has been elucidated by Gow-Chin Yen and co-workers in Taiwan.

Hesperidin is one of the most abundant flavonoids found in citrus fruits, in particular oranges, tangerines and lemons.  Although only a moderate anti-oxidant, studies have demonstrated that hesperetin protects neural cells against oxidative damage. Previous work by the Taiwanese team has demonstrated that hesperetin acts more as a signalling modulator than an antioxidant and protects against oxidative stress via  estrogen recptor (ER) and tyrosine kinase receptor A (TrkA) mediated actions.

In this study the team investigate the more detailed hesperetin-triggered signalling pathways revealing that the parallel pathways collaborate to induce proteins regulated by different transcriptional factors.  The elucidation of this novel mechanism explains why hesperetin, although possessing relatively low antioxidant and estrogen activities, can exhibit multiple neuroprotective effects.

Interested in knowing more details? Read the article in full for free until 10th August.

Pro-cellular survival and neuroprotection of citrus flavonoid: the actions of hesperetin in PC12 cells
Sam-Long Hwang, Jer-An Lin, Ping-Hsiao Shih, Chi-Tai Yeh and Gow-Chin Yen
Food Funct., 2012, Advance Article, DOI: 10.1039/C2FO30100H

You may also be interested in this review which is also free to access

Anti-inflammatory activity of natural dietary flavonoids, Min-Hsiung Pan, Ching-Shu Lai and Chi-Tang Ho
Food Funct., 2010,1, 15-31, DOI: 10.1039/C0FO00103A

You can keep up to date with the latest developments from Food & Function by signing up for free table of contents alerts and monthly e-newsletters.

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Food & Function receives its first partial impact factor

<em>Food & Function</em> Volume 1 Issue 1

Volume 1 Issue 1

For every new journal there are several important stages in its early life and development.  Initially there is the journal announcement and the appointment of an Editor-in-Chief, Associate Editors and Editorial Board members.  Then the first Advance Articles appear online followed by the publication of the first issue of the journal. 

The first issue of Food & Function was published in October 2010, with two more issues in November and December completing the first volume, a total of 28 articles. The next big step was the news, in 2011, that Food & Function had been accepted for indexing in both ISI and MEDLINE raising the visibility of research published in the Journal.

The next big event in the development of a journal comes after about two years; the first impact factor.  Thomson Reuters announced the 2011 impact factors at the end of June 2012 and Food & Function received an impressive first partial impact factor of 1.179. 

Why is it a partial impact factor?  To explain, the impact factor provides an indication of the average number of citations per paper, calculated by dividing the number of citations in a year by the number of citeable articles published in the preceding two years.  The number of citeable articles that the Food & Function 2011 impact factor is based on is only 28, from the three issues of Volume 1 published in October – December 2010.

Additionally, unlike the calculation of a full impact factor where articles have up to 3 years to be read and cited, these articles were published at the end of 2010 so had a much shorter time to be read by researchers and referenced in future work.

With increased visibility of the articles published in Food & Function the number of citations to the Journal is growing rapidly every week, a reflection of the high quality research being published in the Journal.

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Black soy proteins help reduce body fat in overweight and obese subjects

Diets rich in soy protein and soy peptides are reported to be beneficial for weight loss, improved insulin resistance and endothelial function, and reduced blood pressure and blood lipid levels. This artice, recently published in Food & Function from a team in Korea is the first to show the beneficial effects of black soy protein in people maintaining a normal lifestyle.

In this double-blind human trial, participants in the test group were given 4.5 g of black soy protein a day for 12 weeks. It was found that after 12 weeks of supplementation the test group had significant reductions in weight, BMI and body fat mass compared to the placebo group which presented no change. Even after only 6 weeks, the test group showed significant reduction in both BMI and body weight. Additionally, it was revealed that leptin levels were significantly reduced in the test group. This association between leptin and black soy intake could help explain the observed weight-loss activity, as leptin is a vital hormone linked to obesity which regulates energy intake, expenditure, appetite and metabolism.

To read the full paper for free, please click on the link below:

Weight reduction effects of a black soy peptide supplement in overweight and obese subjects: double blind, randomized, controlled study, Jung Hyun Kwak, Chang-Won Ahn, Soo-Hyun Park, Sung-Ug Jung, Byung-Jung Min, Oh Yoen Kim and Jong Ho Lee, Food Funct., 2012, DOI: 10.1039/c2fo10244g

You may also be interested in this Food & Function article which is free to access:

A comparison of satiety, glycemic index, and insulinemic index of wheat-derived soft pretzels with or without soy, Amber L. Simmons, Carla K. Miller, Steven K. Clinton and Yael Vodovotz, Food Funct., 2011,2, 678-683

You can keep up to date with the latest developments from Food & Function by signing up for free table of contents alerts and monthly e-newsletters.

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