Archive for October, 2010

Sex hormone in cancer warfare

Inactive platinum complexes can be transformed into exciting anticancer compounds by coupling them with testosterone using a quick and simple method, claim UK scientists. This could pave the way for new target specific anticancer drugs. 

Platinum compounds cisplatin, carboplatin and oxaliplatin are commonly used to treat cancer. But these drugs can only treat a limited number of tumours and some types of cancer are now showing resistance. The drugs are also highly toxic and cause unwanted side effects. Drugs that target the site of disease without harming healthy tissue are better and have been explored by using the sex hormone oestrogen attached to a Pt compound. These target oestrogen receptors which are over-expressed in most breast cancer tumours. 

Read more of Carl Saxton’s story on these exciting papers here.

Or read the Dalton Transactions articles for FREE!

An androgenic steroid delivery vector that imparts activity to a non-conventional platinum(II) metallo-drug
Martin Huxley, Carlos Sanchez-Cano, Michael J. Browning, Carmen Navarro-Ranninger, Adoracion G. Quiroga, Alison Rodger and Michael J. Hannon
Dalton Trans., 2010 DOI:
10.1039/c0dt00838a

Conjugation of testosterone modifies the interaction of mono-functional cationic platinum(II) complexes with DNA, causing significant alterations to the DNA helix
Carlos Sanchez-Cano, Martin Huxley, Cosimo Ducani, Amal E. Hamad, Michael J. Browning, Carmen Navarro-Ranninger, Adoracion G. Quiroga, Alison Rodger and Michael J. Hannon
Dalton Trans., 2010 DOI:
10.1039/c0dt00839g

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Dalton Transactions Poster Prize winner

Congratulations to Koji Yamamoto from the Osaka University in Japan– recent winner of the Dalton Transactions Poster Prize at the 60th JSCC Symposium and the 60th Anniversary Conference on Coordination Chemistry which both took place as parallel sessions in Osaka from the 27th-30th September!

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Top Ten most-read Dalton Transactions articles in September

Read the most-read Dalton Transactions articles of September 2010, listed below:

C. N. R. Rao, S. R. C. Vivekchand, Kanishka Biswas and A. Govindaraj, Dalton Trans., 2007, 3728-3749
DOI: 10.1039/B708342D

Michael F. Lappert and John N. Murrell, Dalton Trans., 2003, 3811-3820
DOI: 10.1039/B307622A
 
Nial J. Wheate, Shonagh Walker, Gemma E. Craig and Rabbab Oun, Dalton Trans., 2010, 39, 8113-8127
DOI: 10.1039/C0DT00292E
 
P. P. Edwards, A. Porch, M. O. Jones, D. V. Morgan and R. M. Perks, Dalton Trans., 2004, 2995-3002
DOI: 10.1039/B408864F
 
Himanshu Arora, Christian Philouze, Olivier Jarjayes and Fabrice Thomas, Dalton Trans., 2010, 39, 10088-10098
DOI: 10.1039/C0DT00342E
 
Bart M. J. M. Suijkerbuijk, Bas N. H. Aerts, Harm P. Dijkstra, Martin Lutz, Anthony L. Spek, Gerard van Koten and Robertus J. M. Klein Gebbink, Dalton Trans., 2007, 1273-1276
DOI: 10.1039/B701978P
 
Christoph Janiak, Dalton Trans., 2003, 2781-2804
DOI: 10.1039/B305705B
 
Maria Vallet-Regí, J. Chem. Soc., Dalton Trans., 2001, 97-108
DOI: 10.1039/B007852M
 
Etienne Baranoff, Henk J. Bolink, Filippo De Angelis, Simona Fantacci, Davide Di Censo, Karim Djellab, Michael Grätzel and Md. Khaja Nazeeruddin, Dalton Trans., 2010, 39, 8914-8918
DOI: 10.1039/C0DT00414F
 
Constantinos G. Efthymiou, Anastasia N. Georgopoulou, Constantina Papatriantafyllopoulou, Aris Terzis, Catherine P. Raptopoulou, Albert Escuer and Spyros P. Perlepes, Dalton Trans., 2010, 39, 8603-8605
DOI: 10.1039/C0DT00493F
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2nd Dalton Transactions International Symposium

I am delighted to announce details of the 2nd Dalton Transactions International Symposium to be held in Shanghai and Hong Kong in November 2010.  This 2010 Symposium follows the very successful Symposium held in China in October 2009.  9 world class presentations (6 at each venue) will be given.

The 2nd Dalton Transactions International Symposium will take place in two venues.  16th November will see the Symposium hosted in Shanghai, as part of the 11th Conference on Solid State Chemistry and Inorganic Synthesis. The Symposium will then move to Hong Kong on 18th November.

Speaker details of both days of the Symposium are:

16th November 2010, in Shanghai:

  • Lee Cronin - University of Glasgow, UK 
  • Song Gao - Peking University, China    
  • Maochun Hong - Fujian Institute of the Research on the Structure of Matter, China
  • Lei Jiang - Chinese Academy of Sciences, Beijing, China
  • Hiroki Oshio - University of Tsukuba, Japan
  • Annie Powell - Karlsruhe Institute of Technology, Germany            

18th November 2010, in Hong Kong:

  • Lee Cronin - University of Glasgow, UK
  • Hiroki Oshio - University of Tsukuba, Japan
  • Annie Powell - Karlsruhe Institute of Technology, Germany 
  • Wai Yeung Wong - Hong Kong Baptist University, China  
  • Zuowei Xie - Chinese University of Hong Kong, China
  • Vivian Yam - University of Hong Kong, China  

More information about the two days of the Symposium can be found here.

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IUPAC define hydrogen bond

An IUPAC task group has recently published their recommendations for the definition for the hydrogen bond.

“The hydrogen bond is an attractive interaction between a hydrogen atom from a molecule or a molecular fragment X–H in which X is more electronegative than H, and an atom or a group of atoms in the same or a different molecule, in which there is evidence of bond formation.”

The recommendations continue with a list of experimental and theoretical criteria that can be used as evidence for the presence of the hydrogen bond, and finish with characteristics that are typical of hydrogen bonded systems.

For more information on the task group and to view the provisional recommendation see the IUPAC report.

Follow the links below to read two Dalton Transactions articles with a focus on bonding:

and
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Hot Article: Regioselective C-H functionalisation of 2-pyrones

A new synthetic methodology for the catalytic C–H functionalisation of 2-pyrones is described in this Dalton Transactions ‘Hot Article’.  Insight into the reaction mechanism which provides rapid and efficient entry into fused furanopyrone products, regioselectively, is given by the team from the University of York in the UK.

Pd-catalysed regioselective C–H functionalisation of 2-pyronesREAD FOR FREE! Until November 19th.

Pd-catalysed regioselective C–H functionalisation of 2-pyrones 
Michael J. Burns, Robert J. Thatcher, Richard J. K. Taylor and Ian J. S. Fairlamb
Dalton Trans., 2010, Advance Article

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Hot Article: Hexanuclear ruthenium carbonyl carbides

Octahedral, trigonal prismatic, and capped square pyramidal structures have been optimized for the Ru6C(CO)n clusters (15 ≤ n ≤ 20) using density functional theory, by a team from Dalian, China and Georgia, USA. They have shown that the very stable Ru6C(CO)17 is predicted to have an octahedral structure in accord with experiment as well as the Wade–Mingos rules. In addition, the maximum number of external CO groups around an Ru6 octahedron in a stable compound appears to be 17.  To find out more read the full text of this ‘Hot Article’ here.

The maximum number of carbonyl groups around an Ru6C polyhedral cluster: hexanuclear ruthenium carbonyl carbidesThe maximum number of carbonyl groups around an Ru6C polyhedral cluster: hexanuclear ruthenium carbonyl carbides
Chunjiao Li, Jingchen Xu, Jijun Zhao, Dongxu Tian and R. Bruce King
Dalton Trans., 2010, Advance Article
DOI: 10.1039/C0DT00670J, Paper

READ FOR FREE! Until November 17th.

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Hot Article: Explaining the intramolecular acetate-mediated formation of ruthenium vinylidene complexes

In this Dalton Transactions ‘Hot Article’ Jason  Lynam, John Slattery and colleagues from the University of York provide insight, through experimental and theoretical investigation, to the intramolecular acetate-mediated formation of ruthenium vinylidene complexes.  They show that acetate is able to lower the energy of hydrogen migration in the formation of vinylidene complexes from their alkyne tautomers. This is an example of a Ligand-Assisted Proton Shuttle (LAPS) mechanism.  Read more in this Hot Article.

Insights into the intramolecular acetate-mediated formation of ruthenium vinylidene complexes: a ligand-assisted proton shuttle (LAPS) mechanism 
Graphical abstract: Insights into the intramolecular acetate-mediated formation of ruthenium vinylidene complexes: a ligand-assisted proton shuttle (LAPS) mechanismDavid G. Johnson, Jason M. Lynam, John M. Slattery and Christine E. Welby
Dalton Trans., 2010, Advance Article
DOI: 10.1039/C0DT00431F, Paper

READ FOR FREE! Until November 15th.

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New RSC Book Series: Metallobiology

The RSC have just announced an exciting new book series on metallobiology, to provide an insightful perspective on the role of metals in biology.   As Editor-in-Chief, Professor David Garner (University of Nottingham, UK) will lead the Editorial Board of this Book Series, working with Professor Hongzhe Sun (University of Hong Kong, China), Professor Ann Walker (University of Arizona, USA) and Professor Anthony Wedd (University of Melbourne, Australia).

The Series will include the following topics:

  • Binding, transport and storage of metal ions
  • Interactions of metal ions with biomolecules, including proteins, DNA, RNA and nucleotides
  • Metal-based pharmaceuticals, including delivery and function
  • Bioorganometallic chemistry
  • Metalloporphyrins
  • Biominerals, biomineralization, biomaterials and bionanomaterials
  • Metal-based disease states, infection and immunology
  • Metal toxicology
  • Environmental bioinorganic chemistry
  • Metalloproteins
  • Metalloenzymes, including DNAzymes and ribozymes
  • Metallomes of biological systems
  • Metallothioneins
  • Bioimaging and biosensing of metals
  • Speciation of metals in biological systems
  • Spectroscopic investigations of metals in biological systems
  • Structural studies of metalloenzymes, metalloproteins and other metal-containing biomolecules 

More information can be found on the RSC Books website  here.

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Hot Article: Platinum anti-cancer complexes

Pt(IV) complexes are accepted as a class of potential anticancer compounds with better oral activity than their Pt(II) analogues.  Adoración G. Quiroga and colleagues have synthesised two novel Pt(IV) complexes based on Pt(II) analogues previously shown by them to have potential as anticancer compounds. The team from Spain, Australia and Germany describe in this paper the synthesis, characterization, and unusually high cytotoxicity against three human cancer cell lines of these novel Pt(IV) complexes.

The preparation and characterization of trans-platinum(iv) complexes with unusually high cytotoxicityThe preparation and characterization of trans-platinum(IV) complexes with unusually high cytotoxicity
Leticia Cubo, Trevor W. Hambley, Pablo J. Sanz Miguel, Amancio Carnero, Carmen Navarro-Ranninger and Adoración G. Quiroga
Dalton Trans., 2011, Advance Article
DOI: 10.1039/C0DT00565G, Paper

 READ FOR FREE! Until the 12th November.

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