Shearing, bending or brittle?
C. Malla Reddy and colleagues study polymorphic forms of 6-chloro-2,4-dinitroaniline to demonstrate a direct relationship between mechanical properties, crystal structure and tableting behaviour in this HOT CrystEngComm communication. Understanding the structure-property relationships ocurring in pharmaceuticals and using this knowledge to eliminate inferior active pharmaceutical ingredient properties could play an important role in reducing formulation and manufacturing costs in the industry.
Why not take a look, they will be free to read for 4 weeks.
Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound
Partha Pratim Bag, Miles Chen, Changquan Calvin Sun and C. Malla Reddy
CrystEngComm, 2012
DOI: 10.1039/C2CE25100K
CrystEngComm, 2012, 14, 2335-2596
You may also be interested in taking a look at our recent themed issue on Crystal engineering and crystallography in the pharmaceutical industry.
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