Editor’s Choice: Takehiko Kitamori selects his top Analyst papers by Japanese authors

Analyst Associate Editor, Professor Takehiko Kitamori (University of Tokyo, Japan) has selected his Top 5 articles published by Japanese authors recently published in Analyst.

Professor Kitamori is former Vice President of the University of Tokyo and is also a Professor in the Department of Applied Chemistry. His areas of research are micro/extended-nano fluidics, integration of chemical systems on microchips, applied laser spectroscopy for ultrasensitive detection, analytical chemistry, and extended-nano space chemistry.

Below, see what Takehiko says about each of the articles he has selected- all of which are free to access for the next 4 weeks!


Temperature-responsive molecular recognition chromatography using phenylalanine and tryptophan derived polymer modified silica beads

Yuki Hiruta et al., Analyst, 2016, 141, 910-917, DOI: 10.1039/C5AN01996F

Molecular recognition characteristics were realized in temperature-responsive chromatography using a temperature-controllable stationary phase and water as the sole mobile phase, which has been continuously developed by the authors. Functionalizing poly(N-isopropylacrylamide)-modified stationary phase by aromatic amino acids dramatically increases the retention times of aromatic steroids and aromatic amino acids in the separation. The method has potential in the separation of complex and delicate peptides, proteins and antibodies, which is important in biomedical and biochemical analysis.

Nanoparticle-assisted laser desorption/ionization using sinapic acid-modified iron oxide nanoparticles for mass spectrometry analysis

Hanaka Komori et al., Analyst, 2015, 140, 8134-8137, DOI: 10.1039/C5AN02081F

Very useful iron oxide nanoparticles for matrix-assisted laser desorption/ionization mass spectrometry was reported, which greatly suppresses the background noise by self-ionization of ionization-assisting material. While conventional ionization methods and instruments have limitations by the molecular weight of the analyte, their new method allowed analysis of various molecules at wide-range molecular weights (102-104) such as pesticides, plant hormones, peptides and proteins.

DNA sensor’s selectivity enhancement and protection from contaminating nucleases due to a hydrated ionic liquid

Hisae Tateishi-Karimata et al., Analyst, 2015, 140, 4393-4398, DOI: 10.1039/C5AN00545K

The authors discovered that using the hydrated ionic liquid can enhance the selectivity of DNA sequence sensing by 10,000 times, due to stabilization of the triplex structure of DNA and inhibition of DNA degradation by contaminating nuclease. The DNA sensor using the hydrated ionic liquid greatly contributes to detection of disease-related genes in genetic diagnosis.

Affinity imaging mass spectrometry (AIMS): high-throughput screening for specific small molecule interactions with frozen tissue sections

T. Yoshimi et al., Analyst, 2015, 140, 7202-7208, DOI: 10.1039/C5AN01381J

A new imaging mass spectrometry system coupled with affinity-based imaging was applied to screening of chemical compounds with high affinity for Alzheimer’s disease brain. The method is very selective and applicable widely for organs and tissues, which will be important in medical diagnosis and cell biology.

Micro-thermography in millimeter-scale animals by using orally-dosed fluorescent nanoparticle thermosensors

Satoshi Arai et al., Analyst, 2015, 140, 7534-7539, DOI: 10.1039/C5AN01287B

The authors developed polymer nano-particles including temperature sensitive and less temperature sensitive dye, which allowed temperature sensing in millimeter tissue with self-calibration. Ratio-metric temperature mapping of fruit fly larva was successfully demonstrated with good temperature resolution (< 1 degree).

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