Archive for March, 2015

HOT articles in Analyst

Take a look at our most recent HOT Analyst articles, these are now free to access for the next few weeks!

Graphical Abstract

Rapid biodiagnostic ex vivo imaging at 1 μm pixel resolution with thermal source FTIR FPA
C. R. Findlay, R. Wiens, M. Rak, J. Sedlmair, C. J. Hirschmugl, Jason Morrison, C. J. Mundy, M. Kansiz and K. M. Gough
Analyst, 2015, 140, 2493-2503
DOI: 10.1039/C4AN01982B

Controlled growth of immunogold for amplified optical detection of aflatoxin B1
Xu Wang, Reinhard Niessner and Dietmar Knopp
Analyst, 2015, 140, 1453-1458
DOI: 10.1039/C4AN02281E

A Comparative Study of Graphene-Hydrogel Hybrid Bionanocomposites for Biosensing

S. L. Burrs, D. C. Vanegas, M. Bhargava, N. Mechulan, P. Hendershot, H. Yamaguchi, C. Gomes and E. S. McLamore
Analyst, 2015, 140, 1466-1476
DOI: 10.1039/C4AN01788A

Pre-Equlibration Kinetic Size-Exclusion Chromatography with Mass Spectrometry Detection (peKSEC-MS) for Label-Free Solution-Based
Jiayin Bao, Svetlana M. Krylova, Leonid T. Cherney, J. C. Yves Le Blanc, Patrick Pribil, Philip E. Johnson, Derek J. Wilson and Sergey N. Krylov
Analyst, 2015, 140, 990-994
DOI: 10.1039/C4AN02232G

Forensic determination of blood sample age using a bioaffinity-based assay
Juliana Agudelo, Crystal Huynh and Jan Halámek
Analyst, 2015, 140, 1411-1415
DOI: 10.1039/C4AN02269F
Graphical Abstract
Oxidative damage in DNA bases revealed by UV Resonant Raman spectroscopy

Francesco D’Amico, Francesca Cammisuli, Riccardo Addobbati, Clara Rizzardi, Alessandro Gessini, Claudio Masciovecchio, Barbara Rossi and Lorella Pascolo
Analyst, 2015, 140, 1477-1485
DOI: 10.1039/C4AN02364A

The lipid-reactive oxygen species phenotype of breast cancer. Raman spectroscopy and mapping, PCA and PLSDA for invasive ductal carcinoma and invasive lobular carcinoma. Molecular tumorigenic mechanis
Jakub Surmacki, Beata Brozek-Pluska, Radzislaw Kordek and Halina Abramczyk
Analyst, 2015, 140, 2121-2133
DOI: 10.1039/C4AN01876A

Self-cleaning properties in engineered sensors for dopamine electroanalytical detection

Guido Soliveri, Valentina Pifferi, Guido Panzarasa, Silvia Ardizzone, Giuseppe Cappelletti, Daniela Meroni, Katia Sparnacci and Luigi Falciola
Analyst, 2015, 140, 1486-1494
DOI: 10.1039/C4AN02219J

Near-infrared excited ultraviolet emitting upconverting phosphors as an internal light source in dry chemistry test strips for glucose sensing
T. Valta, V. Kale, T. Soukka and C. Horn
Analyst, 2015, Advance Article
DOI: 10.1039/C4AN02028F

Micromotors to capture and destroy anthrax simulant spores
Jahir Orozco, Guoqing Pan, Sirilak Sattayasamitsathit, Michael Galarnyk and Joseph Wang
Analyst, 2015, 140, 1421-1427
DOI: 10.1039/C4AN02169J

Compact 3D-Printed Interface for Coupling Open Digital Microchips with Venturi Easy Ambient Sonic-Spray Ionization Mass Spectrometry
Jie-Bi Hu, Ting-Ru Chen, Chia-Hsien Chang, Ji-Yen Cheng, Yu-Chie Chen and Pawel L. Urban
Analyst, 2015, 140, 1495-1501
DOI: 10.1039/C4AN02220C

Rapid Microstructure Characterization of Polymer Thin Films with 2D-Array Multifocus Raman Microspectroscopy
Ashok Zachariah Samuel, Sohshi Yabumoto, Kenichi Kawamura and Koichi Iwata
Analyst, 2015, 140, 1847-1851
DOI: 10.1039/C4AN01983K
Graphical Abstract
Real-time detection of H5N1 influenza virus through hyperbranched rolling circle amplification

Seyed Vahid Hamidi, Hedayatollah Ghourchian and Gholamreza Tavoosidana
Analyst, 2015, 140, 1502-1509
DOI: 10.1039/C4AN01954G

Nitrogen-Doped Carbon Dots from Plant Cytoplasm as Selective and Sensitive Fluorescent Probes for Detecting P-Nitroaniline in Both Aqueous and Soil Systems
Haoran Yuan, Denian Li, Yan Liu, Xizhe Xu and Chuanxi Xiong
Analyst, 2015, 140, 1428-1431
DOI: 10.1039/C4AN01869A

Simultaneous strain and temperature sensing using slightly tapered optical fiber with inner air-cavity
H. F. Chen, D. N. Wang and Y. Wang
Analyst, 2015, 140, 1859-1862
DOI: 10.1039/C4AN02230K

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Analytical Science Twitter Poster Conference Winners

Following last month’s Analytical Science Twitter Poster Conference we are delighted to introduce the poster prize winners in this blog post. The event was a great success, featuring work from across the analytical sciences, submitted from all over the world. Around 80 posters were presented during the conference, as well as a couple of videos. Around 380 people took part, asking questions and sharing ideas, with Tweets from Europe, USA, Canada, South America, Africa, Asia and Australia. The science was excellent, subjects presented included diagnosing diseases using nanotechnology, detecting 3rd hand smoke with HPLC, analysing latent fingerprints and microbial metabolomics among many others.

We’d like to say a huge thank you to everyone who took part in the event, in particular the Chair and Scientific Committee for dedicating their time and efforts and making the event such a success!

Chair and Organisers, Matt Baker, University of Strathclyde, UK @ChemistryBaker, Royal Society of Chemistry Analyst @analystrsc, Analytical Methods @MethodsRSC and JAAS @JAASNews. Scientific Committee, Carsten Engelhard, Universität Siegen @EngelhrC, Craig Banks, Manchester Metropolitan University @Act_mmu, Damien Arrigan, Curtin University @arri_aus, Jean-Francois Masson, University of Montreal @Masson_chem, Karen Faulds, University of Strathclyde @FauldsKaren, Martin Resano, University of Zaragoza @MartinResano, Nick Stone, University of Exeter @profnickstone, Perdita Barran, The University of Manchester @PerditaB, Raychelle Burks, Doane College @DrRubidium, Renee JiJi, University of Missouri @ReneeJiJi, Richard Dluhy, University of Georgia @radluhy, Roy Goodacre, The University of Manchester @RoyGoodacre

Many congratulations to the four prize winners of the Analytical Science Twitter Poster Conference!


Sarah-Jane Richards


Poster: Cholera and Sugars

My PhD research has focussed on the neutralisation and detection of bacteria and toxins. I am particularly interested in the development of rapid, label-free and inexpensive diagnostics, especially methods for low resource settings, such as in less-developed countries. We use carbohydrate functionalised gold nanoparticles as a colourimetric test for detecting bacteria and toxins and have optimised the particle design so that the method gives rapid readouts in biologically relevant (saline) conditions. We have also shown that this method is compatible with a simple mobile phone camera set up, removing the need for a spectrometer, making the system preferable for use in low resource and low expertise environments.

In the future, I aspire to develop these diagnostic methods into kit-type formats in order to facilitate their use by untrained operators. I am also interested in developing a paper based lateral flow assay for toxin detection, which will further improve the viability of the system in low resource environments by significantly reducing the cost. Having just finished by PhD studies, I am in the process of exploring my options for carrying out post-doctoral research, with a future view to starting my own research group.


Zoe Ayres


Poster: Heavy metal detection in aqueous environments using a novel diamond-based electrochemical sensor

I am really pleased to be selected as a runner up for the #rscanalyticalposter competition, which has been a great opportunity for me to get my research out to a wider audience. Work involves the development of novel diamond-based electrochemical sensors, capitalising on the material and electrochemical properties of freestanding boron doped diamond (BDD) films, including chemical and mechanical inertness, large solvent window, low background currents and the ability to be processed into any geometry electrode. Focus is currently on the development of Electrochemical-X-ray Fluorescence (EC-XRF), with an aim of ultimately detecting trace heavy metals in-situ, at a lake or riverside. Here the BDD functions as both an electrode, to preconcentrate metals from solution onto the electrode surface and X-ray window, to enable unambigious chemical identification of the metals on the surface and quantification by XRF. My research goals are to develop diamond-based sensors for use in real-world applications, whilst my career plans are to stay within analytical chemistry where I would love to be involved in the R&D of new analytical techniques.

I would like to take the opportunity to thank my supervisor Professor Julie Macpherson and Diamond colleagues in the Warwick Electrochemistry and Interfaces group, as well as Element Six for the growth of the BDD X-ray window electrodes used in this project. Thank also go to EPSRC and Element Six for funding my PhD project (EPSRC Case award EP/L505110/1).


James Hands


Poster: Illuminating the Future of Cancer Diagnosis via Serum ATR-FTIR Spectroscopy

James is a Chemistry PhD candidate who is developing rapid spectroscopic methodologies for cancer diagnosis in collaboration with clinical partners at Royal Preston NHS Foundation Trust and The Walton Centre NHS Foundation Trust supported by Brain Tumour North West and the Sydney Driscoll Neuroscience Foundation. His research work has established a robust and highly reproducible diagnostic method for the diagnosis of brain cancer with high sensitivities and specificities using patient sera and ATR-FTIR. James recently developed a stratified diagnostic approach which allows for rapid diagnosis of cancer vs. non-cancer, metastatic cancer vs. organ confined, brain cancer severity and the organ of origin for metastatic disease. This work has resulted in 4 publications and 2 journal front covers. In addition to the 2014 Federation of Analytical Chemistry and Spectroscopy Societies Student Award, he has also been awarded Best Clinical Poster at the British Neuro-oncology Society Annual Meeting 2013 and awarded 2 prizes at the National Health Service (NHS) Research & Innovation Showcase 2013/14 at Royal Preston Hospital, UK. James’ future goals include continuing research in the USA as a postdoctoral researcher in the field of biomedical spectroscopy.


Emily-Rose Billinge


Poster: Tunable Resistive Pulse Sensing for Bioassays

During my undergraduate degree in neuroscience I was fascinated by the discovery and measurement of biomarkers, especially in relation to making peripheral measurements to analyse the nervous system as, at current, it is very difficult to diagnose disorders of the brain and invasive measurements carry high risk. This led me to take up a PhD researching the development of new technologies and methodologies to be used in bioassays. To do this I anchor a capture probe, termed “aptamers”, to micro and nanoscale beads. Aptamers are sequences of DNA which can bind specific targets in solution, by attaching these to the surface of beads it is possible to have each bead capture the target protein in solution. We then follow and measure this interaction using a nanopore technology allowing us to identify and quantify proteins in solution. The system we use is rapid and is highly portable so it is hoped that one day this could lead towards point-of-care testing in the field.

Following on from this I’d really like a career which involves both scientific measurements and interaction with the public. I also thoroughly enjoy writing and want to improve scientific representation so hopefully in the future I will be able to incorporate this into my future work. For now, however, I’m fairly happy to see where the world takes me with no fixed agenda and enjoy the journey.

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Phone camera checks water for arsenic

UK scientists have developed a mobile phone-based system to help people avoid drinking water contaminated with arsenic.1 The phone’s camera measures quantum dot fluorescence in response to arsenic, achieving a limit of detection as low as 5μM.

Approximately 57 million people worldwide encounter As(III) concentrations exceeding the World Health Organization (WHO) recommended maximum of 10μg/L on a regular basis. Chronic exposure to this well known carcinogen and poison, which binds to proteins and impairs cell function, is one of the largest environmental health disasters in the world. Finding a portable, easy-to-use method to measure levels of this most toxic form of arsenic in drinking water is therefore vital.

Read the full article in Chemistry World >>>

A step towards Mobile Arsenic measurement for surface waters
Camille Ann De Villiers, Marta C Lapsley and Elizabeth A H Hall
Analyst, 2015, Accepted Manuscript
DOI: 10.1039/C4AN02368D

Do you fancy submitting an article to Analyst? Why not submit to us here today or alternatively email us with your suggestions!

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