Photomicrograph of a nifedipine particle and photermal spectra
Duncan Craig from the University College London and collaborators from the Universities of Cambridge and East Anglia have applied Photothermal Infrared Microscopy (PTMS) to study drug degradation.
A combination of Fourier Transform Infrared Spectroscopy (FT-IR) and a modification of atomic force microscopy, PTMS, was used to pick up microparticles of a drug known for its photo-instability and analyse its degradation by changes in the FT-IR spectrum after exposure to light. In this HOT new Analyst paper the researchers not only show the application of this new technique but discuss some limitations and areas for future development.
To know more about the study, please access the link below. This paper will be free to read until April 4th.
Analysis of single particle photodegradation using photothermal infrared microspectroscopy
Jonathan G. Moffat , Mark D. Eddleston , Peter S. Belton , William Jones and Duncan Q. M. Craig
Analyst, 2013, Advance Article
DOI: 10.1039/C3AN36686C
