Archive for the ‘News’ Category

Meet the winners of the Sensors & Diagnostics Outstanding Early Career Researcher Award 2023

We are thrilled to announce the launch of our prestigious Outstanding Early Career Research Award, aimed at recognising, and celebrating outstanding contributions in the realm of Sensors & Diagnostics. This initiative seeks to honour the dedication, innovation, and impactful research endeavours of promising early career researchers.

In a world where metabolic diseases like obesity and diabetes are on the rise, the need for convenient tools to measure body fat burn rates and guide lifestyle changes is paramount. In their work Handheld device quantifies breath acetone for real-life metabolic health monitoring, Dr Ines Weber and her team address this need head-on and have developed a ground-breaking handheld device. By analysing acetone content in breath, this device provides accurate measurements of fat burn rates, offering personalized insights into metabolic health. Its compact size, simplicity of use, long-term reliability, and remarkable accuracy set it apart. With specialized filtering units that selectively allow only acetone to pass through, the device accurately tracks the impact of stimuli such as diet and exercise, making it a promising tool for personalized health monitoring.

Meet the team

Grégoire Bastide, Anna Remund, Dina N. Oosthuizen, Nina Derron, Philipp Gerber and Ines Weber

 

  • Dr Grégoire Bastide: With a background in mechanical engineering from ETH Zurich and Stanford University, Grégoire Bastide’s research focuses on breath analysis and medical technology, particularly devices for disease diagnostics.
  • Dr Anna Laura Remund: Currently completing her master’s degree in mechanical engineering at ETH Zurich, Anna’s research interests lie in developing medical devices for disease diagnostics, with experience gained from research stints at Stanford University.
  • Dr Dina N. Oosthuizen: A research associate at Northeastern University, Dr. Oosthuizen specializes in designing sensor platforms for extreme environments, including space. Her expertise in chemical gas sensors and nanomaterial functionalization contributes to real-world solutions.
  • Dr Nina Derron: With a background in Health Sciences, Biomedical Engineering, and a recent PhD in Clinical Science, Dr. Derron’s research focuses on nutritional interventions, particularly intermittent fasting, and applying novel mobile technologies to enhance disease understanding and treatment.
  • Prof Gerber: A senior physician and group leader at the University Hospital Zurich, Prof. Gerber’s research interests encompass clinical studies in nutrition, focusing on the impact of nutrition on metabolic diseases. His work has been recognized with numerous grants and awards.
  • Dr Ines Weber: Dr Weber’s research centres on nanoscale engineering of sensors for healthcare applications, emphasizing personalized medicine. With experience from ETH Zurich and Stanford University, her work has garnered recognition through awards like the ETH medal and GAeF PhD award.

About being awarded by the Editorial Board of Sensors & Diagnostics the winners commented: “We are honoured to receive the Outstanding Early Career Research Award from Sensors & Diagnostics! This recognition validates the significance of our research and the development of personalized health monitors. We are grateful to Sensors & Diagnostics for selecting our publication and excited to continue pushing boundaries in sensor technologies.”

Join us in LinkedIn to celebrate Dr weber et al in their achievement!

Sensors & Diagnostics is an international gold open-access journal. All cost are waived until mid-2024.

Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.

Call for papers – Paper-Based Point-Of-Care Diagnostics

Sensors & Diagnostics is delighted to welcome papers for its latest themed collection on ‘Paper-Based Point-Of-Care Diagnostics, guest edited by Thiago Paixão (Universidade de São Paulo, Brazil), Daniel Citterio (Keio University, Japan) and William Reis de Araujo (Universidade Estadual de Campinas, Brazil).

 

 

This themed collection welcomes original research articles, reviews, communications, and perspectives that contribute to the body of knowledge on paper-based point-of-care diagnostic platforms, intending to foster innovation and improve healthcare outcomes worldwide. It highlights innovative designs, materials and technologies that enhance the functionality, sensitivity and specificity of these platforms. Additionally, it will cover integration of paper-based systems with digital health technologies for data analysis and remote health monitoring, contributing to the advancement of telemedicine and decentralized healthcare.

The deadline for submissions is 15 November 2024. Submit your work to this collection now!

Promotion of the collection is scheduled for late-2025, with articles published online as soon as they’re accepted.

Articles can be submitted via our website: www.rsc.li/sensors.  When submitting your manuscript, please mention that it is intended for this themed collection in the ‘notes to the editor’ box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.

Article processing charges will be automatically waived for all articles submitted to this themed collection until the end of 2024. Articles submitted to this collection after 2024 will not be automatically offered a waiver but authors can apply for a waiver separately. All waiver applications will be considered on a case-by-case basis.

Explore all open calls for papers from RSC journals!

About Sensors & Diagnostics

Sensors & Diagnostics publishes focused on high-impact, innovative sensing work.

The journal welcomes high-quality studies reporting innovative materials, novel detection principles, and/or significant development of known devices. All work must be of significant interest to the community, and, where relevant, must show in situ or real-life sample testing.

Sensors & Diagnostics welcomes contributions from across the breadth of related fields, including biomedical research, drug discovery, environment, food, medicine, and security and defence. Find out more.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2024, so the journal is currently completely free to publish in.

Introducing Dr Ali Yetisen: Leading Expert in Biochemical Sensors Joins Sensors & Diagnostics

Dr Ali Yetisen biochemicla sensors expert and new associate editor of Sensors and Diagnostics

Dr Ali Yetisen, an Associate Professor and Senior Lecturer at Imperial College London, is a prominent figure in the field of chemical engineering and biochemical sensors. Dr Yetisen has established himself as a leader in academia with a strong focus on people-centric research and equal opportunities.

His academic journey began with a Tosteson Fellowship at Harvard University and Massachusetts General Hospital, where he gained expertise in biochemical sensors. Now, as the director of the Centre for Biochemical Sensors at Imperial College London, Dr Yetisen leads a diverse team of researchers in pioneering advancements with real-world applications.

In addition to his scholarly pursuits, Dr Yetisen is a passionate advocate for inclusive research practices. As a Fellow of the Royal Society of Chemistry, he actively promotes networking opportunities and support mechanisms for researchers from underrepresented backgrounds.

Dr Yetisen’s impact extends beyond academia, with over 200 peer-reviewed articles and 80 international talks to his credit. He has also served as a content expert on implant safety for regulatory bodies such as the FDA.

In summary, Dr. Ali Yetisen’s journey exemplifies resilience, intellect, and a commitment to excellence. Through his ground-breaking research and advocacy efforts, he continues to shape the future of biochemical sensing and inspire positive change within the scientific community.

Join us in welcoming Dr Ali Yetisen to the Sensors & Diagnostics Editorial Board! We are thrilled and honoured to have his expertise onboard.

Sensors & Diagnostics is an international gold open-access journal. All cost are waived until mid-2024.

Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.

RSC Desktop Seminar: Omar Azzaroni, Sensors & Diagnostics Outstanding Paper Award winner

We are pleased to announce a new desktop seminar to recognise the Sensors & Diagnostics Outstanding Paper Award winners for 2022, Professor Omar Azzaroni, Waldemar A. Marmisollé, Gonzalo E. Fenoy, and Wolfgang Knoll.

Join Professor Omar Azzaroni and Sensors & Diagnostics Associate Editor Professor Carlos D. Garcia as they present their latest research. This 60-minute seminar will allow researchers of all professional levels to connect and share ideas and ask questions.

If you’re interested in the seminar but can’t make the date, register your interest and we’ll send you a link to the recording afterwards.

Tuesday 14 November 2023, 1200 GMT

 

 

Professor Omar Azzaroni

Universidad Nacional de La Plata, Argentina

Title: “Highly sensitive urine glucose detection with graphene field-effect transistors functionalized with electropolymerized nanofilms”

 

 

 

 

 

 

 

 

 

 

 

Professor Carlos D. Garcia

Clemson University, United States

Title: “Out of the furnace: transforming paper into electrochemical sensors”

 

 

 

 

 

 

 

 

 

 

Further information

Register

More about the Outstanding Paper Award Winners

Celebrating Excellence in Sensing Technology: Sensors & Diagnostics Outstanding Paper Award 2022

In the fast-paced world of scientific research, it’s not often that we get to pause and celebrate outstanding contributions. But today, we are thrilled to shine a spotlight on some remarkable work and the brilliant minds behind it. We’re pleased to announce the first-ever Sensors & Diagnostics Outstanding Paper 2022 Award!

This award was established to recognize exceptional research published in Sensors & Diagnostics.  The winning paper was selected by our esteemed Editorial Board, who considered not only the scientific quality of the research but also its potential future impact.

 

Highly Sensitive Urine Glucose Detection with Graphene Field-Effect Transistors Functionalized with Electropolymerized Nanofilms

 

Authors: Gonzalo E. Fenoy, Waldemar A. Marmisollé, Wolfgang Knoll, and Omar Azzaroni

Sens. Diagn., 2022,1, 139-148

DOI 10.1039/D1SD00007A

 

Published in Sensors & Diagnostics in 2021, the work presented in this paper not only pushes the boundaries of scientific discovery but also holds immense promise for the future of biosensing technology.

When asked about their achievement, the winning team shared their thoughts, saying, “It is a great honour to receive this award from Sensors & Diagnostics, as this is a journal distinguished for publishing innovative works in the field of sensing devices and systems.” Their dedication to advancing the field of sensing technology is evident in their remarkable contributions.

Meet the Winning Team

Now, let’s take a moment to get to know the talented individuals who brought this outstanding research to life:

 

 

  • Gonzalo E. Fenoy: Dr. Gonzalo E. Fenoy earned his Ph.D. degree in Chemistry in 2021 from the University of San Martín, Argentina. Currently serving as a Post-Doctoral research fellow at the Soft Matter Laboratory at the Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA, UNLP-CONICET), his research focuses on the development of organic electronic platforms for applications in energy and biosensing.
  • Waldemar A. Marmisollé: Dr. Waldemar A. Marmisollé, born in Junín, Argentina, in 1984, pursued his Bachelor’s degree in Chemistry at the University of La Plata (UNLP). He earned his Ph.D. in Chemistry from the same university in 2011 and has since held the position of a researcher at CONICET at INIFTA (La Plata), while also serving as a Chemistry professor at UNLP. His research revolves around the physical chemistry of electroactive materials.
  • Wolfgang Knoll: Dr. Wolfgang Knoll, a seasoned scientist with a Ph.D. in Biophysics from the University of Konstanz, has a remarkable career spanning several countries. He has contributed significantly to the field of nanomaterials and served in various prestigious research positions. Currently, he is a Regular Member of the Austrian Academy of Sciences and continues to make impactful contributions to science.
  • Omar Azzaroni: Dr. Omar Azzaroni’s journey in chemistry took him from the Universidad Nacional de La Plata (UNLP) in Argentina to postdoctoral studies at renowned institutions worldwide. His research interests encompass the design and construction of soft materials and devices with optimized properties and functions. He is a fellow of CONICET and a Professor of Physical Chemistry at UNLP.

 

Join Us in Congratulations

We invite you to join us in congratulating Gonzalo E. Fenoy, Waldemar A. Marmisollé, Wolfgang Knoll, and Omar Azzaroni on their well-deserved Sensors & Diagnostics Outstanding Paper 2022 Award. Their dedication to advancing the field of sensing devices and systems is an inspiration to all of us in the scientific community. We look forward to their future contributions and the impact they will undoubtedly have on the world of sensing technology.

In recognition of their outstanding achievement, the winning team will be presenting their research in a webinar series scheduled for November (date to be defined). This is a unique opportunity to gain insight into their ground-breaking work and its potential implications for the future of biosensing technology.

 

Sensors & Diagnostics is an international gold open-access journal. All cost are waived until mid-2024.

Sign up now to get updates on all articles as they are published on Twitter and in our e-alerts.

Meet the new Advisory Board members of Sensors & Diagnostics

We’re thrilled to announce the latest additions to the Advisory Board of Sensors & Diagnostics.

These remarkable individuals bring a wealth of experience, groundbreaking research, and a commitment to advancing knowledge in their respective areas of expertise: Professor Vipul Bansal, Dr Deah Ho Prof, Dr Jwa-Min Nam, and  Professor Lauro Tatsuo Kubota.

Professor Lauro Tatsuo Kubota is a true luminary in the field of chemistry. As a Full Professor at the Institute of Chemistry at Unicamp, Prof Kubota’s accomplishments extend far and wide. Having served as the Director of the Institute of Chemistry at Unicamp from 2014 to 2018, his leadership has left an indelible mark. His role as the Coordinator of the National Institute on Science and Technology of Bioanalytics (INCTBio) since 2008 highlights his commitment to advancing scientific exploration.

Prof Kubota’s contributions have garnered well-deserved recognition, including membership in the São Paulo State Academy of Science, the Brazilian Academy of Science, and a Fellowship with the Royal Society of Chemistry. His innovative spirit shines through his extensive research, which revolves around pioneering new sensors, novel materials, and revolutionary point-of-care devices, particularly in the realm of electrochemical transducers. With a remarkable track record of publications, patents, and awards, Prof Kubota brings a wealth of experience to the Advisory Board.

 

Dr Jwa-Min Nam, whose expertise in chemistry has made waves in the world of nanotechnology. As a full professor at Seoul National University, his journey from Northwestern University to various prestigious institutions showcases his dedication to pushing the boundaries of scientific knowledge. Dr. Nam’s extensive list of publications in high-impact journals speaks volumes about his commitment to cutting-edge research.

His remarkable work in metal nanoparticle synthesis, nanoplasmonics, biosensing, and more has not only been recognized with numerous awards but has also resulted in several patents for commercialization. His role as an Associate Editor and his presence on various editorial advisory boards underscore his influence in the scientific community.

Dr Nam’s trailblazing work in the intersection of chemistry and nanotechnology adds a new dimension to the Advisory Board.

 

Dr Dean Ho brings a unique perspective to the Advisory Board as a leader in digital medicine. As the Head of the Department of Biomedical Engineering at the National University of Singapore, his remarkable achievements include the development of over 10 technology platforms in human clinical trials, revolutionizing patient care. His contributions have led to life-saving outcomes, positioning him as a driving force in the field.

Dr Ho’s recognition by esteemed institutions like the National Academy of Inventors, the American Association for the Advancement of Science, and the American Institute for Medical and Biological Engineering is a testament to his exceptional contributions. His forthcoming book, “Medicine Without Meds,” promises to be a game-changer in accelerating innovation to benefit patients and caregivers. Dr Ho’s expertise in digital medicine and his global influence in major forums make him an invaluable addition to the Advisory Board.

 

Professor Vipul Bansal, Director of the Sir Ian Potter NanoBioSensing Facility at RMIT University Australia, brings a wealth of experience and passion to our Advisory Board. His commitment to mentoring the next generation of research leaders and translating nanotechnologies from bench to bedside is truly inspiring.

With over 200 highly cited publications and a track record of mentoring successful PhD candidates, Prof Bansal’s journey from India to Australia showcases his dedication to nanobiotechnology and materials chemistry. His establishment of the Sir Ian Potter NanoBioSensing Facility exemplifies his focus on clinical and commercial translation. His team’s work on sensors, diagnostics, biomedical imaging, and cellular immunotherapies holds the promise of transforming healthcare. Prof Bansal’s presence on our Advisory Board will undoubtedly drive new advancements in the field.

 

 

 

Dr Jeff W.M. Bulte is a Professor of Radiology, Oncology, Biomedical Engineering, and Chemical & Biomolecular Engineering at the Johns Hopkins University School of Medicine. He is the inaugural Radiology Director of Scientific Communications and serves as Director of Cellular Imaging in the Johns Hopkins Institute for Cell Engineering. He is a Fellow and Gold Medal awardee of the ISMRM, a Fellow of WMIS, AIMBE, and IAMBE, and a Distinguished Investigator of the Academy of Radiology Research. He has published over 350 papers and book chapters, which have been cited over 35,000 times. His research interest is the development of new contrast agents and theranostics as applied to molecular and cellular imaging, with particular emphasis on in vivo cell tracking and regenerative medicine.

 

 

As Sensors & Diagnostics continues to be a beacon of cutting-edge research, the addition of these distinguished experts to our Advisory Board amplifies our commitment to innovation, collaboration, and the advancement of scientific knowledge. We eagerly anticipate the fresh perspectives, insights, and directions that Prof Kubota, Dr Nam, Dr Ho, and Prof Bansal will bring to our journal’s mission.

Join us to welcome our new Advisory Board members on Twitter!

Sensors and Diagnostics, a new open access journal where we highlight emerging research on physical, chemical and bio sensors, as well as sensor devices and systems.

Sensors and Diagnostics  is open for submissions. Find out more on the journal webpagesign up for email alerts

Call for Papers-Supramolecular Sensors: From Molecules to Materials

 

 

 

 

Sensors & Diagnostics is delighted to welcome papers for its latest themed collection on ‘Supramolecular Sensors: From Molecules to Materials’, guest edited by Sankarasekaran Shanmugaraju (Indian Institute of Technology Palakkad, India), Robert Elmes (Maynooth University, Ireland) and Valeria Amendola (University of Pavia, Italy.

 

This collection aims to cover this broad field and will be accepting primary research articles, reviews, and communications related to supramolecular chemosensors for sensing and monitoring analytes such as anions, cations, small molecules, toxic chemicals, hazardous materials, and biomolecules, among others. The collection is intended to showcase recent developments in this important area of supramolecular chemistry research to inspire and attract the next generation of researchers into the field.

 

The deadline for submissions is 03 November 2023. Submit your work to this collection now!

 

Promotion of the collection is scheduled for late-2023, with articles published online as soon as they’re accepted.

 

Articles can be submitted via our website: www.rsc.li/sensors.  When submitting your manuscript, please mention that it is intended for this themed collection in the ‘notes to the editor’ box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.

 

Explore all open calls for papers from RSC journals!

About Sensors & Diagnostics

Sensors & Diagnostics publishes focused on high-impact, innovative sensing work.

The journal welcomes high-quality studies reporting innovative materials, novel detection principles, and/or significant development of known devices. All work must be of significant interest to the community, and, where relevant, must show in situ or real-life sample testing.

Sensors & Diagnostics welcomes contributions from across the breadth of related fields, including biomedical research, drug discovery, environment, food, medicine, and security and defence. Find out more.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2024, so the journal is currently completely free to publish in.

Call for Papers-Wearable Sensors for Healthcare Applications

 

Sensors & Diagnostics is delighted to welcome papers for its latest themed collection on ‘Wearable Sensors for Healthcare Applications’, guest edited by Wei Gao (California Institute of Technology, United States); Parameswar K. Iyer (Indian Institute of Technology Guwahati, India); Shyam S. Pandey (Kyushu Institute of Technology, Japan); Prashant Sonar (Queensland University of Technology, Australia); and Yeon-Ho Im (Jeonbuk National University, South Korea).

 

The research area of sensors is progressing rapidly with notable developments in allied areas that have allowed sensors to be incorporated into fabrics or used as wearable gadgets and implants. Stretchable and flexible components are indispensable for wearable sensors. These components must be created or selected to have high mechanical strength and conform to human body motion. Additionally, a crucial requirement is biocompatibility, as the placement of the sensor on the skin should not trigger any allergies or discomfort. Although wearable biosensors are improving, more advancements in terms of selectivity, accuracy, and calibration are needed.

 

The objective of this themed collection is to publish high-quality research on the development and applications of different wearable sensors. We welcome primary research articles, reviews, and communications in this area of research.

 

The deadline for submissions is 27 October 2023. Submit your work to this collection now!

 

Promotion of the collection is scheduled for late-2023, with articles published online as soon as they’re accepted.

 

Articles can be submitted via our website: www.rsc.li/sensors.  When submitting your manuscript, please mention that it is intended for this themed collection in the ‘notes to the editor’ box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.

 

Explore all open calls for papers from RSC journals!

About Sensors & Diagnostics

Sensors & Diagnostics publishes focused on high-impact, innovative sensing work.

The journal welcomes high-quality studies reporting innovative materials, novel detection principles, and/or significant development of known devices. All work must be of significant interest to the community, and, where relevant, must show in situ or real-life sample testing.

Sensors & Diagnostics welcomes contributions from across the breadth of related fields, including biomedical research, drug discovery, environment, food, medicine, and security and defence. Find out more.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2024, so the journal is currently completely free to publish in.

 

Call for papers – Functional Nanomaterials for Sensing and Diagnostics Applications

Sensors & Diagnostics is delighted to welcome papers for its latest themed collection on ‘Functional Nanomaterials for Sensing and Diagnostics Applications’, guest edited by Suresh Kumar Kailasa (Sardar Vallabhbhai National Institute of Technology, India); Tae Jung Park (Chung-Ang University, South Korea); and Tsuyoshi Minami (The University of Tokyo, Japan).

We welcome primary research articles, reviews and communications on the following topics:

  • Functional 0D nanostructured materials for molecular sensing
  • Plasmonic fluorescent sensors for point of care diagnostics
  • Nanostructure-based paper strips for biomarker detection
  • Functional nanomaterials in diagnostics and therapeutics
  • Nanomaterials for molecular imaging and therapeutics

The deadline for submissions is 31 October 2023. Submit your work to this collection now!

Promotion of the collection is scheduled for late-2023, with articles published online as soon as they’re accepted.

Articles can be submitted via our website: www.rsc.li/sensors-diagnostics. When submitting your manuscript, please mention that it is intended for this themed collection in the ‘notes to the editor’ box. The Editorial Office reserves the right to check suitability of submissions for both the journal and the scope of the collection, and inclusion of accepted articles in the final themed collection is not guaranteed.

Explore all open calls for papers from RSC journals!

About Sensors & Diagnostics

Sensors & Diagnostics publishes focused on high-impact, innovative sensing work.

The journal welcomes high-quality studies reporting innovative materials, novel detection principles, and/or significant development of known devices. All work must be of significant interest to the community, and, where relevant, must show in situ or real-life sample testing.

Sensors & Diagnostics welcomes contributions from across the breadth of related fields, including biomedical research, drug discovery, environment, food, medicine, and security and defence. Find out more.

As a gold open access journal, there are no barriers to accessing content and your research article will reach an international audience. Please note that the article processing charges are waived until mid-2024, so the journal is currently completely free to publish in.

Welcome Sahika Inal to our Editorial Board

Welcome to Sensors & Diagnostics!

Our Editors in Chief Sabine Szunerits and Xueji Zhang are delighted to announce and introduce Sahika Inal as an Editorial board member!

Sahika Inal is an Associate Professor of Bioengineering with affiliations in Electrical Engineering and Materials Science and Engineering at King Abdullah University of Science and Technology (KAUST). She has a B.Sc. degree in Textile Engineering from Istanbul Technical University (Turkey), an M.Sc. in Polymer Science, and a Ph.D. in Experimental Physics, both from the University of Potsdam (Germany). She completed her postdoctoral training at the Center of Microelectronics of Provence of the Ecole Nationale Supérieure des Mines de Saint-Étienne (France). Her expertise is in polymer science and bioelectronic devices, particularly in the photophysics of conjugated polymers, characterization of polymer films and the design of biosensors and actuators. Since 2016, Inal lab at KAUST exploits the functionalities of organic electronic materials, investigates ionic/electronic charge transport, and designs electronic devices that record/stimulate biological signals. Sahika is a Fellow of the Royal Society of Chemistry and has received recognitions including ACS PMSE Young Investigator Award 2022, Beilby Medal and Prize 2022, 2022 WCC Rising Star (ACS), and shortlisted for the Nature Research Awards for Inspiring Women in Science in 2021. She is the author of 97+ publications and her work has been cited more than 7800 times.

Please join us in extending a warm welcome to Professor Sahika Inal as a member of the Sensors and Diagnostics Editorial Board!

Sensors and Diagnostics, a new open access journal where we highlight emerging research on physical, chemical and bio sensors, as well as sensor devices and systems.

Sensors and Diagnostics  is open for submissions. Find out more on the journal webpage, sign up for email alerts or submit your manuscript now.