Archive for the ‘Biocatalysis’ Category

Reviews in Catalysis

Are you new to the field of catalysis and searching for a good starting point in the literature?
Are you an experienced researcher on the hunt for a comprehensive overview on recent advances in catalysis?

Then look no further.

Over the past year we have published a number of Perspectives and Mini Reviews authored by world-leading scientists and covering all areas of catalysis.  

Scroll down to begin browsing our reviews in:

Asymmetric organocatalysis
Metal-mediated asymmetric catalysis
Fuel synthesis
Nanocatalysis
Biomimetic and biocatalysis
Zeolitic catalysis
Photocatalysis

(more…)

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Green ionic liquids for sugar fatty acid ester biosynthesis

sugar fatty acid synthesisIn this Perspective, the use of ionic liquids as alternative reaction media to traditional organic solvents for the biosynthesis of sugar fatty acids esters is explored.  Sugar fatty acids are extremely important industrially as non-ionic surfactants in a wide range of applications in food, cosmetics and pharmaceuticals.

Read more for FREE at:

Enzymatic synthesis of sugar fatty acid esters in ionic liquids
Zhen Yang and Ze-Lin Huang
Catal. Sci. Technol., 2012, Advance Article
DOI: 10.1039/C2CY20109G

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Biodegradation pathway for α,β-unsaturated haloesters

Kurt Faber and colleagues from the Unviersity of Graz report the reductive dehalogenation of  β-haloacrylic ester derivatives using members of the ‘Old Yellow Enzyme’ family of flavoproteins in this HOT Catalysis Science & Technology communication.  They have combined the ‘reductive activity of ene-reductases with the spontaneous β-elimination of hydohalous acid from the unstable (saturated) intermediates’ in this biodegradation pathway.  Such work is important for its application to the disposal of organic halogenated materials that have negative effects on the environment.

This is another fantastic article that is due to be included in our upcoming Biocatalysis themed issue.  Download the communication today – it’s free

Reductive dehalogenation of β-haloacrylic ester derivatives mediated by ene-reductases
Gábor Tasnádi,  Christoph K. Winkler,  Dorina Clay,  Mélanie Hall and Kurt Faber
Catal. Sci. Technol., 2012
DOI: 10.1039/C2CY20079A

You might also find the group’s previous Dalton Transactions paper interesting:

Bioreduction of α-methylcinnamaldehyde derivatives: chemo-enzymatic asymmetric synthesis of Lilial™ and Helional™
Clemens Stueckler, Nicole J. Mueller, Christoph K. Winkler, Silvia M. Glueck, Karl Gruber, Georg Steinkellner and Kurt Faber
Dalton Trans., 2010, 39, 8472-8476
DOI: 10.1039/C002971H
From themed issue Bridging the gap in catalysis via multidisciplinary approaches

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Biocatalysis for isotopic labelling

Isotopic labelling is an important tool to investigate chemical processes, from discrete reactions to pharmacodynamics and biological metabolism. Replacing atoms with isotopes is an interesting area of chemistry and this Hot Communication by Matthew Truppo et al. from Merck is no exception.

Transaminase reaction

The team use transaminases to create chiral amines. The method allows efficient generation of both deuterium and tritium labelled amines and is effective on several ketone substrates, potentially providing a general route to D and T labelled chiral amines for a range of applications.

Asymmetric, biocatalytic labeled compound synthesis using transaminases
Matthew Truppo, Jacob M. Janey, Brendan Grau, Krista Morley, Scott Pollack, Greg Hughes and Ian Davies

This article is due to be published in our upcoming themed issue focusing on biocatalysis, other articles to be included in this special issue include,

Mutational analysis of phenolic acid decarboxylase from Bacillus subtilis (BsPAD), which converts bio-derived phenolic acids to styrene derivatives
Annika Frank, William Eborall, Ralph Hyde, Sam Hart, Johan P. Turkenburg and Gideon Grogan

Stereoselective synthesis of bulky 1,2-diols with alcohol dehydrogenases
Justyna Kulig, Robert Christian Simon, Christopher Rose, Masood Husain, Matthias Häckh, Steffen Lüdeke, Kirsten Zeitler, Wolfgang Kroutil, M Pohl and Dörte Rother

Asymmetric reduction of a key intermediate of eslicarbazepine acetate using whole cell biotransformation in a biphasic medium
Manpreet Singh, Sawraj Singh, Sateesh Deshaboina, Hare Krishnen, Richard Lloyd, Karen Holt-Tiffin, Apurba Bhattacharya and Rakeshwar Bandichhor
C2CY00537A

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