Scientists from the Indian Institute of Technology have investigated the effect of visible light on the Hantzsch reaction – a method by which to produce dihydropyridines which have found merit for cardiovascular disease treatment. By doing so, they were able to develop a photocatalytic-based methodology for producing 2-arylpyridines. Whilst such compounds are popular in medicinal chemistry and supramolecular coordination chemistry fields, their synthesis can be troublesome.
Armed with a catalytic amount of [Ru(bpy)3]2+ and a household compact fluorescent lamp, the team synthesised the 2-arylpyridine compound through photocatalytic oxidation of the 1,2-dihydropyridine Hantzsch product.
For further details on the reaction conditions and mechanism, read the the Full Paper:
[Ru(bpy)3]2+ Aided Photocatalytic Synthesis of 2-Arylpyridines via Hantzsch Reaction under the Visible Irradiation and Oxygen Atmosphere
Rajakumar Ananthakrishnan and Sarifuddin Gazi
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