Toxicology Research blog

We are very pleased to announce the publication of a themed collection titled Advances in Experimental and Regulatory Toxicology.

This is a collection of papers consisting of invited contributions to honour the contributions made to toxicology by Professor Iain Purchase and Dr Cliff Elcombe. The British Toxicology Society (BTS) readily agreed with the guest editorial team that it would be appropriate to publish a special collection in their journal as a mark of respect and appreciation of the contribution of Iain Purchase and Cliff Elcombe made to the science of toxicology, primarily but not exclusively through their involvement with the Central Toxicology Laboratory (CTL).

The contributors represent a range of scientific excellence, some having worked at CTL or had collaborated with scientists in CTL. Others are scientists whose success in solving toxicological problems represent the ambitions of Iain Purchase and Cliff Elcombe in their approach to addressing toxicological problems. Guest Edited by Brian Lake, Lewis Smith and Sam Cohen.

You can see the entire collection here.

We are delighted to share with you the top 30 most downloaded articles in Toxicology Research from January-December 2016. All of these papers are free to access for the next two weeks with a free publishing personal account – register here.

Comment on “Promising blood-derived biomarkers for estimation of the postmortem interval” by I. Costa, F. Carvalho, T. Magalhães, P. G. de Pinho, R. Silvestre & R. J. Dinis-Oliveira. (Toxicol. Res., 2015, 4, 1443–1452)
Joris Meurs and Katarzyna M. Szykuła
Toxicol. Res., 2016,5, 714-715
DOI: 10.1039/C5TX00397K

Mycotoxins: cytotoxicity and biotransformation in animal cells
Jikai Wen, Peiqiang Mu and Yiqun Deng
Toxicol. Res., 2016,5, 377-387
DOI: 10.1039/C5TX00293A

Key mechanisms involved in ionizing radiation-induced systemic effects. A current review
Ifigeneia V. Mavragani, Danae A. Laskaratou, Benjamin Frey, Serge M. Candéias, Udo S. Gaipl, Katalin Lumniczky and Alexandros G. Georgakilas
Toxicol. Res., 2016,5, 12-33
DOI: 10.1039/C5TX00222B

Characterization of a functional C3A liver spheroid model
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams and Steven D. Webb
Toxicol. Res., 2016,5, 1053-1065
DOI: 10.1039/C6TX00101G

Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
Emma Wincent, Florane Le Bihanic and Kristian Dreij
Toxicol. Res., 2016,5, 788-799
DOI: 10.1039/C6TX00004E

Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data
Chad H. G. Allen, Alexios Koutsoukas, Isidro Cortés-Ciriano, Daniel S. Murrell, Thérèse E. Malliavin, Robert C. Glen and Andreas Bender
Toxicol. Res., 2016,5, 883-894
DOI: 10.1039/C5TX00406C

Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids
Katarzyna Wojdyla, Krzysztof Wrzesinski, James Williamson, Stephen J. Fey and Adelina Rogowska-Wrzesinska
Toxicol. Res., 2016,5, 905-920
DOI: 10.1039/C5TX00469A

1H NMR-based urine metabolomics for the evaluation of kidney injury in Wistar rats by 3-MCPD
Jian Ji, Lijuan Zhang, Hongxia Zhang, Chao Sun, Jiadi Sun, Hui Jiang, Mandour H. Abdalhai, YinZhi Zhang and Xiulan Sun
Toxicol. Res., 2016,5, 689-696
DOI: 10.1039/C5TX00399G

Epigenetic toxicity of trichloroethylene: a single-molecule perspective
Yi Cui, Samrat Roy Choudhury and Joseph Irudayaraj
Toxicol. Res., 2016,5, 641-650
DOI: 10.1039/C5TX00454C

Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos
Hejing Hu, Qiuling Li, Lizhen Jiang, Yang Zou, Junchao Duan and Zhiwei Sun
Toxicol. Res., 2016,5, 609-620
DOI: 10.1039/C5TX00383K

Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration
Rui Chen, Lin Zhao, Ru Bai, Ying Liu, Liping Han, Zhifang Xu, Feng Chen, Herman Autrup, Dingxin Long and Chunying Chen
Toxicol. Res., 2016,5, 602-608
DOI: 10.1039/C5TX00464K

In silico prediction of hERG potassium channel blockage by chemical category approaches
Chen Zhang, Yuan Zhou, Shikai Gu, Zengrui Wu, Wenjie Wu, Changming Liu, Kaidong Wang, Guixia Liu, Weihua Li, Philip W. Lee and Yun Tang
Toxicol. Res., 2016,5, 570-582
DOI: 10.1039/C5TX00294J

Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies
Iness R. Benmessaoud, Anne-Laure Mahul-Mellier, Endre Horváth, Bohumil Maco, Massimo Spina, Hilal A. Lashuel and Làszló Forró
Toxicol. Res., 2016,5, 407-419
DOI: 10.1039/C5TX00303B

Modeling the toxicity of chemical pesticides in multiple test species using local and global QSTR approaches
Nikita Basant, Shikha Gupta and Kunwar P. Singh
Toxicol. Res., 2016,5, 340-353
DOI: 10.1039/C5TX00321K

Cytotoxic and sublethal effects of silver nanoparticles on tendon-derived stem cells – implications for tendon engineering
Tik Shing Cheung, Pui Man Lau, Haifei Lu, Ho Pui Ho, Pauline Po Yee Lui and Siu Kai Kong
Toxicol. Res., 2016,5, 318-330
DOI: 10.1039/C5TX00349K

Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells
Qian Ba, Chao Huang, Yijing Fu, Junyang Li, Jingquan Li, Ruiai Chu, Xudong Jia and Hui Wang
Toxicol. Res., 2016,5, 107-115
DOI: 10.1039/C5TX00378D

Evaluation of zinc-doped magnetite nanoparticle toxicity in the liver and kidney of mice after sub-chronic intragastric administration
Shanshan Zhu, Xiaolong Xu, Rui Rong, Bing Li and Xue Wang
Toxicol. Res., 2016,5, 97-106
DOI: 10.1039/C5TX00292C

Evaluation of the intracellular uptake and cytotoxicity effect of TiO2 nanostructures for various human oral and lung cells under dark conditions
Chieh-Wei Chen, Jing-Hong Huang, Tsung-Ching Lai, Yi-Hua Jan, Michael Hsiao, Chung-Hsuan Chen, Yeu-Kuang Hwu and Ru-Shi Liu
Toxicol. Res., 2016,5, 303-311
DOI: 10.1039/C5TX00312A

Intravenous injection of L-BMAA induces a rat model with comprehensive characteristics of amyotrophic lateral sclerosis/Parkinson–dementia complex
Ke-Wei Tian, Hong Jiang, Bei-Bei Wang, Fan Zhang and Shu Han
Toxicol. Res., 2016,5, 79-96
DOI: 10.1039/C5TX00272A

Screening and validation for plasma biomarkers of nephrotoxicity based on metabolomics in male rats
Yubo Li, Haoyue Deng, Liang Ju, Xiuxiu Zhang, Zhenzhu Zhang, Zhen Yang, Lei Wang, Zhiguo Hou and Yanjun Zhang
Toxicol. Res., 2016,5, 259-267
DOI: 10.1039/C5TX00171D

Toxicity mechanism in fetal lung fibroblast cells for multi-walled carbon nanotubes defined by chemical impurities and dispersibility
Aparna Shinde and Candace S. J. Tsai
Toxicol. Res., 2016,5, 248-258
DOI: 10.1039/C5TX00211G

Grape seed proanthocyanidin extract protects against perfluorooctanoic acid-induced hepatotoxicity by attenuating inflammatory response, oxidative stress and apoptosis in mice
Wenwen Liu, Changshui Xu, Xi Sun, Haibin Kuang, Xiaodong Kuang, Weiying Zou, Bei Yang, Lei Wu, Fangming Liu, Ting Zou and Dalei Zhang
Toxicol. Res., 2016,5, 224-234
DOI: 10.1039/C5TX00260E

Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway
Yu-Sang Li, Chang-Long Leng, Man-Tang Chen, Wei Kevin Zhang, Xiao-Jun Li, He-Bin Tang, Hong-Cai Shang and Li-Hua Zhu
Toxicol. Res., 2016,5, 210-223
DOI: 10.1039/C5TX00317B

In vitro toxicity evaluation of silica-coated iron oxide nanoparticles in human SHSY5Y neuronal cells
Gözde Kiliç, Carla Costa, Natalia Fernández-Bertólez, Eduardo Pásaro, João Paulo Teixeira, Blanca Laffon and Vanessa Valdiglesias
Toxicol. Res., 2016,5, 235-247
DOI: 10.1039/C5TX00206K

miR-122 plays an important role in ochratoxin A-induced hepatocyte apoptosis in vitro and in vivo
Liye Zhu, Tao Yu, Xiaozhe Qi, Bo Yang, Lei Shi, Haoshu Luo, Xiaoyun He, Kunlun Huang and Wentao Xu
Toxicol. Res., 2016,5, 160-167
DOI: 10.1039/C5TX00104H

Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways
Carla Nunes, Natércia Teixeira, Diana Serra, Víctor Freitas, Leonor Almeida and João Laranjinha
Toxicol. Res., 2016,5, 53-65
DOI: 10.1039/C5TX00214A

Cytotoxic effects of aspartame on human cervical carcinoma cells
Muthuraman Pandurangan, Gansukh Enkhtaivan and Doo Hwan Kim
Toxicol. Res., 2016,5, 45-52
DOI: 10.1039/C5TX00269A

Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo
Ashley J. Broom, Jeffrey Ambroso, Gino Brunori, Angie K. Burns, James R. Armitage, Ian Francis, Mitul Gandhi, Richard A. Peterson, Timothy W. Gant, Alan R. Boobis and Jonathan J. Lyon
Toxicol. Res., 2016,5, 136-150
DOI: 10.1039/C5TX00197H

Mechanistic understanding of molecular initiating events (MIEs) using NMR spectroscopy
Paul N. Sanderson, Wendy Simpson, Richard Cubberley, Maja Aleksic, Stephen Gutsell and Paul J. Russell
Toxicol. Res., 2016,5, 34-44
DOI: 10.1039/C5TX00246J

Evaluation of CdTe/CdS/ZnS core/shell/shell quantum dot toxicity on three-dimensional spheroid cultures
Mehriban Ulusoy, Antonina Lavrentieva, Johanna-Gabriela Walter, Franziska Sambale, Mark Green, Frank Stahl and Thomas Scheper
Toxicol. Res., 2016,5, 126-135
DOI: 10.1039/C5TX00236B

We hope you enjoy reading the top 30 most accessed articles of 2016 and wish you all the best for 2017.

For up to date journal information, why not follow Toxicology Research @ToxRes on Twitter.