In this review Tomas R. Guilarte and April P. Neal summarise the toxicokinetics of lead and manganese; describing their neurotoxic mechanisms and discussing the commonalities in their neurotoxicity.
Mechanisms of lead and manganese neurotoxicity
April P. Neal and Tomas R. Guilarte
DOI: 10.1039/C2TX20064C
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In addition to high quality research papers Toxicology Research features topical review articles across the full range of the journal scope. Since the journal launch and Issue 1 published in July last year, we have aimed at providing readers with strong reviews designed to give an interesting insight into the topic, focussing on the key developments, trends and future directions.
Epigenetics – relevance to drug safety science
Catherine C. Priestley, Mark Anderton, Ann T. Doherty, Paul Duffy, Howard R. Mellor, Helen Powell and Ruth Roberts
Toxicol. Res., 2012, 1, 23-31
Mechanisms and modifiers of methylmercury-induced neurotoxicity
Stephanie J. B. Fretham, Samuel Caito, Ebany J. Martinez-Finley and Michael Aschner
Toxicol. Res., 2012, 1, 32-38
Mitochondrial glutathione in toxicology and disease of the kidneys
Lawrence H. Lash
Toxicol. Res., 2012, 1, 39-46
Aminolevulinate dehydratase (δ-ALA-D) as marker protein of intoxication with metals and other pro-oxidant situations
Joao B. T. Rocha, Rogerio A. Saraiva, Solange C. Garcia, Fernanda S. Gravina and Cristina W. Nogueira
Toxicol. Res., 2012, 1, 85-102
Perfluorooctane sulfonate (PFOS) and calcium channel downstream signaling molecules
Yu Wang and Yihe Jin
Toxicol. Res., 2012, 1, 103-107
Role of innate and adaptive immunity during drug-induced liver injury
C. David Williams and Hartmut Jaeschke
Toxicol. Res., 2012, 1, 161-170
S-Methyl-L-cysteine sulphoxide: the Cinderella phytochemical? William M. B. Edmands, Nigel J. Gooderham, Elaine Holmes and Stephen C. Mitchell
Toxicol. Res., 2013, 2, 11-22
In vitro models for liver toxicity testing Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn
Toxicol. Res., 2013, 2, 23-39
Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013, 2, 40-59
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Rusyn et al. discuss the benefits and disadvantages associated with using traditional in vitro systems whilst also examining the usefulness of the novel in vitro liver models for toxicity testing.
Want to know more? Read the entire review for free….
In vitro models for liver toxicity testing
Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn
DOI: 10.1039/C2TX20051A
| Interested in liver toxicology? You may also be interested in these related articles:
Role of innate and adaptive immunity during drug-induced liver injury Novel in vitro and mathematical models for the prediction of chemical toxicity |
In this review C. David Williams and Hartmut Jaeschke, University of Kansas Medical Center:
– Compare the existing hypotheses for potential causes of IDILI and discuss the potential roles of immune involvement in DILI;
– Compare and contrast what is known about the mechanisms of APAP-induced liver injury and IDILI;
– Describe the strategies and methods currently being used to study APAP-induced liver injury.
Read the full review for free or have a browse around the Toxicology Research website to see the latest accepted articles.
Role of innate and adaptive immunity during drug-induced liver injury
C. David Williams and Hartmut Jaeschke
DOI: 10.1039/C2TX20032E
(1) Physiological differences between cells currently used and human hepatocytes in their natural state
(2) Lack of physiological integration with other cells/systems within organs, required to amplify the initial toxicological lesion into overt toxicity
(3) An inability to assess how low level cell damage may develop into overt organ toxicity in some people
(4) Failure to consider systemic effects.
This review by Dominic P. Williams and colleagues presents an in-depth look at how combining technology, such as bioartificial livers (BALs), and mathematical models can allow the design of in vitro systems that can mimic the in vivo systems more accurately. This would allow the testing of theoretical hypothesis testing and a reduction of in vivo animal testing.
For the complete, detailed discussion read this review for free by following the link below….
Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
DOI: 10.1039/C2TX20031G
Included in the discussion:
Mitchell et al. hope that this review will act as a catalyst to stimulate greater scrutiny of this important amino acid derivative, which they say has surprisingly not received as much as it should have considering its abundance and wide distribution.
Read the full review today for free….. HERE
S-Methyl-L-cysteine sulphoxide: the Cinderella phytochemical?
William M. B. Edmands, Nigel J. Gooderham, Elaine Holmes and Stephen C. Mitchell
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However, in view of the presence of these vicinal thiol groups in its active centre, δ-ALA-D can also be very sensitive towards being oxidized by different soft electrophiles and by metals that compete with Zn(II) at its active centre.
In this review Joao B. T. Rocha, Cristina W. Nogueira and colleagues from Universidade Federal de Santa Maria, discuss the in vitro and in vivo inhibition of δ-ALA-D by soft electrophiles, such as Hg(II), Cd(II), Sn(II), As(III), Bi(III), In(III), Tl(III), Se(IV) and Te(IV) as well as how δ-ALA-D can be a marker of oxidative stress in human pathologies, such as diabetes and hyperglycemia.
Find out more about how δ-ALA-D is more than a biomarker of Pb(II) but rather a universal marker of oxidative stress by reading the review today… it is free to access after all!
Aminolevulinate dehydratase (δ-ALA-D) as marker protein of intoxication with metals and other pro-oxidant situations
Joao B. T. Rocha, Rogerio A. Saraiva, Solange C. Garcia, Fernanda S. Gravina and Cristina W. Nogueira
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Finding alternatives to animal testing is currently a large area of investigation. However, once an alternative method has been developed it must undergo a validation process where it is evaluated for such things as its quality, transferability and predictivity. This means that there can be long delays before the method can be implemented. As such different ways to evaluate a method’s suitability and quality have been proposed.
This review by Marcel Leist, Nina Hasiwa, Mardas Daneshian and Thomas Hartung, discusses the principles of model development and quality control as well as giving an overview on alternative methods to animal testing that have under gone validation. Leist et al. go on to discuss the strengths and weaknesses of current traditional approaches for validation and outline new developments and challenges in the area.
Validation and quality control of replacement alternatives – current status and future challenges
Marcel Leist, Nina Hasiwa, Mardas Daneshian and Thomas Hartung
Toxicol. Res., 2012, Advance Article
DOI: 10.1039/C2TX20011B
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This review from Lawrence H. Lash, Wayne State University, summarises the pathways of mitochondrial glutathione transport and discusses studies on its manipulation in toxicological and pathological states. This includes:
Read the full review here, and while you are there have a look at the rest our recently published articles.
Mitochondrial glutathione in toxicology and disease of the kidneys
Lawrence H. Lash
Toxicol. Res., 2012, DOI: 10.1039/C2TX20021J
| Get involved in Toxicology Research!
• Submit your latest research – there’s still time to be considered for one of the first issues • Sign-up for the contents alerts and newsletter – keep up to date with the latest research published in the journal • All articles published in 2012 and 2013 are free to access. Arrange for your free access by simply filling in this short online registration form |
