In this communication recently published online as an ‘Accepted Manuscript’ Frederick Lewis and co-workers from the USA and India investigate the effect of flanking purine bases on the 3’ vs the 5’-TT dimer upon UV irradiation of DNA hairpins possessing TTT steps with flanking purine bases.
The study demonstrates moderate to high facial selectivity for the 3’-dimer over the 5’ dimer depending on the identity and location of flanking purine bases. The effects of flanking purines on facial selectivity are attributed to a combination of their ground state conformational effects and electron transfer quenching.
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Facially-Selective Thymine-Thymine Photodimerization in TTT Triads
Prakash P Neelakandan, Zhengzheng Pan, Mahesh Hariharan and Frederick D Lewis
Photochem. Photobiol. Sci., 2012, Accepted Manuscript, DOI: 10.1039/C2PP25089F
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