OBC issue 3 online now, featuring: cylindrical peptides, tubulin inhibitors, aliphatic C–H functionalization & much more

On the front cover (right) of this week’s issue is a paper on cylindrical peptide assemblies from Andrew D. Abell and colleagues from The University of Adelaide. Abell et al. present a new template-based approach to peptide based nanotubes using a ‘smart’ scaffold designed to be constrained into a β-strand geometry.

New cylindrical peptide assemblies defined by extended parallel β-sheets
Ashok D. Pehere, ChRistopher J. Sumby and Andrew D. Abell
DOI: 10.1039/C2OB26637G

Featuring on the inside cover (left) is a paper from Mouad Alami, Abdallah Hamze and co-workers reporting the synthesis and antiproliferative activity of tri- and tetrasubstituted 1,1-diarylolefins related to isocombretastatin A-4.

Synthesis, biological evaluation, and structure–activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors
Abdallah Hamze and Mouad Alami et al.
DOI: 10.1039/C2OB26253C

Both cover articles are free to access for 6 weeks.

Also in this issue and free to access:

HOT – Sulfoxide-TFAA and nucleophile combination as new reagent for aliphatic C–H functionalization at indole 2α-position

HOT – Integrin and matrix metalloprotease dual-targeting with an MMP substrate–RGD conjugate

HOT – Organocatalytic conjugate addition promoted by multi-hydrogen-bond cooperation: access to chiral 2-amino-3-nitrile-chromenes

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