Archive for the ‘Uncategorized’ Category

New Ceria Nanoparticles to Fight Antibiotic-Resistant Bacteria

New Ceria Nanoparticles to Fight Antibiotic-Resistant Bacteria

An infographic highlighting ceria-based nanoparticles as intracellular antibacterial agents

We would like to share an infographic highlighting the excellent work by Inge K. Herrmann et al. on ceria/bioglass nanohybrids that significantly reduce bacterial survival inside human cells without harming the human cells, overcoming the major shortcomings of conventional antibiotics! Check out the infographic below to learn more or get the full story from their Nanoscale article.

Inorganic nanohybrids combat antibiotic-resistant bacteria hiding within human macrophages
Martin T. Matter, Meagan Doppegieter, Alexander Gogos, Kerda Keevend, Qun Ren and Inge K. Herrmann
Nanoscale, 2021, DOI: 10.1039/D0NR08285F

An infographic summarising the content of the article “Inorganic nanohybrids combat antibiotic-resistant bacteria hiding within human macrophages"

 

Meet the authors

Dr Martin T Matter

Martin T. Matter

Dr Martin T. Matter completed his BSc and MSc studies in Nanosciences at the University of Basel and pursued his doctoral studies in nanostructured surgical materials at ETH Zurich and Empa St. Gallen. Since 2020, he is working on translating a nanoparticle-based wound care platform technology from the lab to clinics. He has been awarded the ETH medal and MaP award for his outstanding doctoral thesis, the Empa Innovation Award, and the Swiss Nanotech Startup Award.

Professor Inge K Herrmann Inge K. Herrmann

Inge K. Herrmann is a chemical engineer with additional training in (pre)clinical research. After graduating with a PhD from ETH Zurich, she underwent further training at the University Hospital Zurich (USZ), the University of Illinois (US) and the Imperial College London (UK). Since 2015, she is heading a research group at the Swiss Federal Laboratories for Materials Science and Technology (Empa) specialized on nanoscale materials and devices for healthcare. In 2019, she joined the Department of Mechanical and Process Engineering as an assistant professor at ETH Zurich where she is heading the Nanoparticle Systems Engineering Lab. She has spearheaded several translational nanomedicine projects, and serves as a scientific advisor of the spin-offs hemotune, anavo and veltist commercializing technologies emerging from her lab. Inge has won various prestigious awards, including the Bayer Healthcare Award and the Johnson & Johnson Award, the Swiss National Science Foundation Eccellenza Fellowship, the Empa Innovation Award 2020 and the ETH Zurich Dandelion Award 2021 for interdisciplinary collaboration and entrepreneurship.

 

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Microchip-Based Toolkit to Complement Protein Analysis Using Cryo-Electron Microscopy

Microchip-Based Toolkit to Complement Protein Analysis Using Cryo-Electron Microscopy

An infographic highlighting the structure determination of proteins including the first antibody binding site on the SARS-CoV-2 nucleocapsid (N) protein

We would like to share an infographic highlighting the excellent work by Deborah F. Kelly et al. on a microchip-based toolkit that performs complementary structural and biochemical analysis on low-molecular weight proteins alongside cryo-EM! Check out the infographic below to learn more or get the full story from their Nanoscale article.

Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy
Michael A. Casasanta, G. M. Jonaid, Liam Kaylor, William Y. Luqiu, Maria J. Solares, Mariah L. Schroen, William J. Dearnaley, Jarad Wilson, Madeline J. Dukes and Deborah F. Kelly
Nanoscale, 2021, DOI: 10.1039/D1NR00388G

An infographic summarising the content of the article “Microchip-based structure determination of low-molecular weight proteins using cryo-electron microscopy"

Meet the authors

Dr Michael Casasanta

Michael Casasanta
Dr Michael Casasanta completed his PhD in Biochemistry at Virginia Tech and his post-doctoral training in Biomedical Engineering at Penn State University. Dr. Casasanta is currently a Senior Scientific Consultant working in the Boston area.
Professor Deb Kelly Deb Kelly
Dr Deb Kelly is a professor of Biomedical Engineering at Penn State University and the president-elect of the Microscopy Society of America. She directs the Center for Structural Oncology at the Huck Institutes of the Life Sciences where she holds the Lloyd and Dottie Foehr Huck Chair in Molecular Biophysics. Dr. Kelly co-leads the Next-Generation Therapies research program at the Penn State Cancer Institute and also holds an appointment in the Materials Research Institute.

 

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Dr Dong Qin joins the Associate Editor team

Dr Dong Qin joins the Associate Editor team

Welcome to Nanoscale and Nanoscale Advances!

 

 

We are delighted to welcome Dr Dong Qin, Georgia Institute of Technology, USA, as a new Associate Editor working across Nanoscale and Nanoscale Advances.

 

 

 

 

What attracted you to pursue a career in nanoscience and how did you get to where you are now?

After my PhD study on the fundamental work of gas phase spectroscopy, I was very fortunate to have an opportunity to work on soft lithography as a postdoctoral fellow with Professor George M. Whitesides at Harvard University back in 1997. I am in debt to George who brought me to this fascinating world of nanoscale science where I enjoyed the research in the field of nanostructures and nanomaterials with a solid training as a physical chemist. I had been doing independent work in building the research infrastructure for nanoscale science and engineering from 1997-2011, during which I witness the progress of the field. When I finally returned back to academia in 2012, I decided to start my own research in the field of nanoscale nanomaterials, metal nanocrystals, with my keen focus on the optical properties for the development of in situ methodology to characterize the catalytically significant interface by fingerprinting spectroscopy. It has been a rewarding journey at Georgia Tech as I renowned my passion in both nanoscale science and spectroscopy.

 

What is the most exciting research paper that you have read recently?

Single atom catalysis! Questions remain on the ability to probe single atom and we are part of the efforts to address this challenge at the moment.

 

What is your biggest passion outside of science?

Free-lance writing!

 

What career would you have chosen if you had not taken this career path?

 An educator – I have enormous passion in teaching! Students in my classes will not only learn knowledge but also my positive attitude toward life in broad.

 

Why should young people study chemistry?

Chemistry introduces the smallest building blocks, atoms, which are essential in building structure-property relationship of materials in our daily life!

 

Please join us in welcoming Dr Qin to Nanoscale and Nanoscale Advances!

Best wishes,

Dr Charlotte Marshall                          Dr Ania Rulka

Managing Editor, Nanoscale                  Executive Editor, Nanoscale Advances

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Outstanding Reviewers for Nanoscale Advances in 2019

We would like to highlight the Outstanding Reviewers for Nanoscale Advances in 2019, as selected by the editorial team, for their significant contribution to the journal. The reviewers have been chosen based on the number, timeliness and quality of the reports completed over the last 12 months.

We would like to say a big thank you to those individuals listed here as well as to all of the reviewers that have supported the journal. Each Outstanding Reviewer will receive a certificate to give recognition for their significant contribution.

Dr He Chen, Miami University, ORCID:0000-0001-5426-769X

Professor Yi-Jun Xu, Fuzhou University, ORCID:0000-0002-2195-1695

Dr Xuping Sun, University of Electronic Science and Technology of China, ORCID:0000-0001-5034-1135

Dr Yupeng Li, University of Delaware

Prof. Han Zhang, Shenzhen University, ORCID:0000-0002-0166-1973

Dr Ke Xu, Hubei University of Arts and Science

Prof. Junwei Zheng, Soochow University, ORCID:0000-0002-6937-062X

Professor Katsuhiko Ariga, National Institute for Materials Science, ORCID:0000-0002-2445-2955

Dr Christopher Abram, Otto von Guericke University, ORCID:0000-0003-3645-6977

Prof. Sanat Kumar, Columbia University, ORCID:0000-0002-6690-2221

We would also like to thank the Nanoscale and Nanoscale Advances board and the Nano chemistry community for their continued support of the journal, as authors, reviewers and readers.

 

If you would like to become a reviewer for our journal, just email us with details of your research interests and an up-to-date CV or résumé.  You can find more details in our author and reviewer resource centre

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2019 KJF International Conference on Organic Materials for Electronics and Photonics (KJF-ICOMEP 2019)

Nanoscale and Nanoscale Advances are delighted to provide student poster prizes at 2019 KJF International Conference on Organic Materials or Electronics and Photonics (KJF-ICOMEP 2019).

The conference will be held on August 27 to 30, 2019 in Jeju island, Korea.

Conference Scope

  • Organic Transistors, Memories, and Photovoltaics
  • Molecular Photonics
  • OLED Materials and Devices
  • Nonlinear Optical Materials and Devices
  • Electrochromic Materials and Devices
  • Molecular Recognition
  • Sensors and Bioelectronics
  • Other Related Topics

Key dates

Early Registration due 31st Jul 2019
Abstract submission due 25th Jul 2019
More information available on the conference website: http://www.kjf-icomep2019.org/

 

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Prize Winner: Professor Xiao Cheng Zen

Congratulations to our Associate Editor, Professor Xiao Cheng Zen, who has been awarded the Royal Society of Chemistry Surfaces and Interfaces Award for 2017 for his development of a unified theory to understand the relationship between structure and properties of nanoscale materials at surfaces and interfaces.

 

Xiao Cheng Zeng is currently at the University of Nebraska-Lincoln, where his main research interests cover the physical chemistry of confined water, ice, and ice hydrate in nanoscale; ions and radicals at air/water interfaces; heterogeneous catalysis on supported gold clusters; and computer-aided design of low-dimensional materials including liganded gold clusters and perovskite solar-cell materials.

He is the recipient of many awards, and is a fellow of the American Association for the Advancement of Science (AAAS), the American Physical Society (APS), and the Royal Society of Chemistry (FRSC). He has published 475+ articles in refereed journals (Google Scholar h-index: 70; citations 17000+). Four articles were featured in Chemistry World (RSC) and ten papers were featured in Chemical & Engineering News (ACS).

 

 

Professor Xiao Cheng Zen has been an Associate Editor for Nanoscale since 2012, and we congratulate him for his success!

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Ready. Set. GO!

Graphene oxide (GO) is a versatile material with applications ranging from electronics to energy storage and biosensors. As a biosensing substrate, GO has many favorable attributes such as low cost, high signal-to-noise ratio, and the ability to efficiently quench fluorescence.

Scheme for the GO-aptamer based sensor for detection of thrombin.

This ability to quench fluorescence has inspired a range of biosensors using GO and Förster resonance energy transfer (FRET) for the sensitive detection of proteins using labelled probes, such as aptamers. However, the target proteins in such assays can non-specifically adsorb onto the surface of GO, thereby reducing the sensitivity.

To address this, Gao and co-workers implemented the use of polyethylene glycol (PEG) to prevent the non-specific adsorption of thrombin onto GO while implementing an aptamer-binding assay.  The authors report that the detection limit could be improved by optimizing the GO:PEG concentration. This manuscript helps to establish GO as promising tool in the biomedical and biotechnology fields.

Highly sensitive detection for proteins using graphene oxide-aptamer based sensors
Li Gao, Qin Li, Raoqi Li, Lirong Yan, Yang Zhou, Keping Chen and Haixia Shi
Nanoscale, 2015, Advance Article. DOI: 10.1039/C5NR01187F

Dr Lee Barrett is a guest web writer for the Nanoscale blog. Lee is currently a postdoctoral researcher in the Centre for Molecular Nanometrology at the University of Strathclyde. His research is currently focused on the development of nanoparticle-based sensors and surface enhanced Raman scattering (SERS). Follow him on Twitter @L_Bargie.

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In situ synthesis of luminescent carbon nanoparticles toward target bioimaging

In situ synthesis of luminescent carbon nanoparticles toward target bioimaging

An in-situ synthesis of biocompatible fluorescent carbon nanoparticles (FCNs) is reported for targeted bioimaging. The nanoparticles were formed via dehydration of hyalurinic acid (HA), and through careful alteration of the carbonisation times, the total content of HA and fluorescence in the carbon nanoparticles could be controlled. Sharker et al. then compared two colloidally stable FCN samples; one partially carbonised sample that still contained some HA (HA-FCN), against a “non-specific” fully carbonised sample containing no HA (FCN).

Before in vivo testing, both sets of particles were tested on different cell lines at dosages up to 1.0 mg/ml and were found to not affect cell viability. Interestingly, HA-FCNs showed more uptake than the non-specific FCNs, and were internalised more various cell lines; including cancer cells. This is speculated to be due to the over expression of the CD-44 receptor which can facilitate uptake of particles containing targeting molecules such as HA-FCNs. In vivo bio-distribution studies showed more accumulation of HA-FCNs in tumours pre-implanted into mice compared to FCNs, when particles were injected into the tail vein. This is expected to be of enormous potential in not only bioimaging, but also drug delivery and diagnostics.

In situ synthesis of luminescent carbon nanoparticles toward target bioimaging
Shazid Md. Sharker, Sung Min Kim, Jung Eun Lee, Ji Hoon Jeong, Insik In, Kang Dea Lee, Haeshin Lee and Sung Young Park
Nanoscale, 2015, 7, 5468-5475. DOI: 10.1039/C4NR07422J

Dr Mike Barrow is a guest web writer for the Nanoscale blog. He currently works as a Postdoctoral Researcher at the University of Liverpool.

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Nanoscale Issue 4 of 2014 out now!

Graphical abstract: Front coverNanoscale is delighted to present its current issue.

Towards biocompatible nano/microscale machines: self-propelled catalytic nanomotors not exhibiting acute toxicity is the article highlighted on the outside front cover by Elaine Lay Khim Chng, Guanjia Zhao and Martin Pumera.

The inside front cover features an article on Design of advanced porous graphene materials: from graphene nanomesh to 3D architectures by Lili Jiang and Zhuangjun Fan.

Issue 3 contains the following Review, Feature and Mini-review articles:

Highly reactive {001} facets of TiO2-based composites: synthesis, formation mechanism and characterization
Wee-Jun Ong, Lling-Lling Tan, Siang-Piao Chai, Siek-Ting Yong and Abdul Rahman Mohamed Graphical abstract: Inside front cover

Engineering BiOX (X = Cl, Br, I) nanostructures for highly efficient photocatalytic applications
Hefeng Cheng, Baibiao Huang and Ying Dai

Metallic glass nanostructures: fabrication, properties, and applications
Lianci Liu, Molla Hasan and Golden Kumar

Inorganic nanostructured materials for high performance electrochemical supercapacitors
Sheng Liu, Shouheng Sun and Xiao-Zeng You

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This week’s HOT article

Take a look at this week’s selection! This article is available free for a limited time: Graphical abstract: Emerging advances in nanomedicine with engineered gold nanostructures

Emerging advances in nanomedicine with engineered gold nanostructures
Joseph A. Webb and Rizia Bardhan
DOI: 10.1039/C3NR05112A, Review Article

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