Can you treat cancer this way too?! Really?!!

Writers Choice: Amphiphilic chitosan modified upconversion nanoparticles for in vivo photodynamic therapy induced by near-infrared light

Imagine a scenario where one morning, a close friend of yours calls you and painfully conveys the news of him being diagnosed with cancer and you, instead of sitting horrified and helpless, casually say “Hey don’t worry man, we have PDT!” That sounds fascinating right?! Yes, Photodynamic therapy has shown potential to do that. With the same fascination towards the idea of photodynamic therapy, inventors of PDT pursued research on this therapy and shaped an unconventional out of box method of treating cancer.  The simple mechanism of working of this technique is widely known. Drugs used in this technique are light sensitive. In response to specific light irradiated on the drug molecule, it converts surrounding molecular oxygen into form of oxygen which kills nearby cancer cells. The reasons this therapy called as out of box here are multifold. First, there are many photosensitizers easily available approved by FDA which can easily respond to specific light and produced the effect explained above. Second it makes use of naturally available oxygen molecules surrounding cancer cells. Last and importantly all the conventional drugs/ therapies for the cancer are immunosuppressive meaning they suppress our immune system after treatment unlike PDT, which is immunostimulative which stimulates immune system of the patient after treatment.

Proving very promising in its early years of research, PDT faces a major challenge.  Light sensitive drugs usually respond to visible light. Visible light’s penetration in the tissues and cells is poor because it is mostly absorbed and hence the drug does not get sufficient light to tackle cancer cells (This is the low penetration depth of visible light). This is a major bottleneck in PDT’s usage and is being addressed by researchers all over the globe.

In one very fine effort by Sisi Cui etal they try to address the problem stated above in very interesting way. The key fact they have exploited here is though visible light’s penetration in the tissue and biological matter is weak but near infer red (NIR) light can penetrate deeply in the same tissue without any problem.  So NIR light can be good alternative to visible light. Here Sisi Cui etal synthesized NaYF4(Er,Yb) nanoparticles ( upconversion nanoparticles) which can convert NIR light to visible light. A chitosan derivative (biocompatible polymer) has coated these nanoparticles with drugs deposited on their surface. So upconversion nanoparticles and light sensitive drug are in close proximity of each other. So when NIR light is irradiated, upcoversion nanoparticles convert that light in visible light( drug is essentially insensitive to NIR light) and transfers that light to the drug which in response coverts surrounding oxygen from the molecular form to the form which can kill the cancer cells. This study which is cited below has not only addressed the problems associated with the synthesis of hydrophilic NaYF4 nanoparticles brilliantly, but also shown that the scheme they have proposed works successfully which they have demonstrated actually by killing in vitro cancer cells.

Amphiphilic chitosan modified upconversion nanoparticles for in vivo photodynamic therapy induced by near-infrared light
Sisi Cui, Haiyan Chen, Hongyan Zhu, Junmei Tian, Xuemei Chi, Zhiya Qian, Samuel Achilefu and Yueqing Gu
J. Mater. Chem. C, 2012, 22, 4861-4873. DOI:10.1039/C2JM16112E

Padmanabh Joshi is a guest web writer for the Journal of Materials Chemistry blog. He currently works at the Department of Chemistry, University of Cincinnati.

To keep up-to-date with all the latest research, sign-up to our RSS feed or Table of contents alert.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

35 Responses to “Can you treat cancer this way too?! Really?!!”

  1. Padmanabh Joshi says:

    Nice blog

  2. No matter what, whatever the information on a task immediately.
    Talk to the question. Because it is worth essay
    writing spending the extra mkney paying a professional for writing.
    The essays essay witing are alsso summation transitions.

  3. Jonathan says:

    What’s up, every time i used to check web site posts
    here in the early hours in the morning, because
    i love to learn more and more.

    Feel free to visit my blog post – after effects opening sequence (Jonathan)

  4. I’ve been surfing on-line greater than 3 hours as of late, yet I never discovered any interesting article like yours.
    It’s beautiful worth enough for me. Personally, if all web owners and bloggers made excellent content material as
    you did, the web will probably be a lot more helpful
    than ever before.

  5. Way cool! Some extremely valid points! I appreciate you penning this write-up plus the rest
    of the website is also really good.

  6. Thanks designed for sharing such a good thought,
    post is nice, thats why i have read it entirely

  7. Heya i am for the first time here. I found this board and I find It truly useful & it
    helped me out a lot. I hope to give something back and aid others like you
    helped me.

  8. yahoomail says:

    If you already use a domain name registered then you’ll
    need to login for a domain registrar and move your ‘name servers’ over
    for a new web host, your free template site provider should supply instructions concerning how to do this when you sign up.
    Our clients and prospects expect us to be able to answer their questions
    and close deals irrespective of where we’re.

    Feel free to surf to my weblog … yahoomail

  9. These are genuinely enormous ideas in regarding blogging.
    You have touched some fastidious points here.

    Any way keep up wrinting.

  10. thoxuanduong says:

    Hãy tưởng tượng một kịch bản mà một buổi sáng, một người bạn thân của bạn gọi cho bạn và đau đớn truyền tải các tin tức của ông được chẩn đoán mắc bệnh ung thư và bạn, thay vì ngồi sợ hãi và bất lực, tình cờ nói “Hey không lo lắng người đàn ông, chúng tôi có PDT!” Nghe có vẻ hấp dẫn quyền?! Có, liệu pháp quang động đã cho thấy tiềm năng để làm điều đó. Với những niềm đam mê cùng một đối với ý tưởng của quang trị liệu, nhà phát minh của PDT theo đuổi nghiên cứu về trị liệu này và có hình dạng một độc đáo ra khỏi hộp phong kham dieu tri ung thu. Cơ chế đơn giản làm việc của kỹ thuật này được biết đến. Thuốc được sử dụng trong kỹ thuật này là ánh sáng nhạy cảm. Đối phó với cụ thể ánh sáng chiếu xạ trên các phân tử ma túy, nó chuyển đổi xung quanh các phân tử oxy vào hình thức của oxy mà giết chết gần đó tế bào ung thư. Lý do các liệu pháp này gọi là khi ra khỏi hộp dưới đây là việc. Trước tiên, có rất nhiều nhạy dễ dàng có sẵn, được chấp thuận bởi FDA có thể dễ dàng đối phó với ánh sáng cụ thể và sản xuất các hiệu ứng giải thích ở trên. Thứ hai nó làm cho việc sử dụng phân tử oxy đều có sẵn ở xung quanh tế bào ung thư. Cuối cùng và quan trọng tất cả các loại thuốc thông thường / phương pháp điều trị cho bệnh ung thư là immunosuppressive có nghĩa là họ ngăn chặn hệ thống miễn dịch của chúng tôi sau khi điều trị không giống như PDT, mà là immunostimulative kích thích hệ thống miễn dịch của bệnh nhân sau khi điều trị.

  11. Cheap Replica Michael Kors Huge Discounts Save More. If You Really Are A
    Lover Of Fashionable Michael Kors Bags and Purses, You Certainly Understand That Owning
    It. Get 2015 Sales MK Satchels to Follow The Step
    Of Fashion World! from site: http://www.wordmetro.com/outlet-michael-kors-store-locator

  12. Excellent way of describing, and good article to take
    information on the topic of my presentation topic, which
    i am going to present in school.

  13. If you are reading for somebody, inform them what you think, say exactly what you are aware of as
    well as let the other person make the details.

    Here is my web site … http://cps.umk.edu.my

  14. A viewer гecently questioned tɦe Savings Mom Һow to Ье aⅼwaʏs
    a mystery shopper, аѕ weⅼⅼ as іn thе column of thіs month, she telⅼѕ ʏοu
    how.

    my website … Dokumentenbewertung

  15. En cualquier caso Twitter ofrece mucho más que la posibilidad de envío de
    mensajes y es la red con mayor número de aplicaciones. http://scysj.net/comment/html/index.php?page=1&id=37929

  16. Christina says:

    El proyecto CODICE es la solución técnica que ha dado la Dirección de Patrimonio del
    Estado, para permitir la interoperabilidad de la Contratación electrónica a nivel nacional, europeo y mundial. http://issuu.com/dynamicbliss1928/docs/buenavista_-232

  17. Joe Stone says:

    Good post with clear visualisation

  18. Sasi Kumar says:

    Really nice article. Thanks for the post

  19. Walton says:

    Interesting article. Thanks. https://essayelites.com/ is the top rated essay writing service, which offers all types of writing assistance to the students.

  20. The blog article is pretty good. The article explores cancer treatment methods. One of the deadly diseases that people fear a lot is cancer. There are a few ways that you can manage to combat with cancer if you can diagnose the disease as early as possible. The blog article talks about those cancer treatment methods. If you are looking for effective cancer treatment methods, you should go through the article and gain the knowledge that you require to fight the deadly disease.

  21. Thanks designed for sharing such a good thought,
    post is nice, thats why i have read it entirely
    Great

  22. The post is good. The article asks can you treat cancer this way too. According to the article, Light sensitive drugs generally react to visible light. Visible light’s incursion in the tissues and cells is poor for the reason that it is mostly absorbed and therefore, the drug does not get adequate light to deal with cancer cells.

  23. cams says:

    Very good article, especially very hopeful for people who have cancer

  24. カルティエ タンクソロ 革ベルト

    Can you treat cancer this way too?! Really?!!

  25. happy wheels says:

    Just how do you come up with these brilliant ideas.

  26. You calendar says:

    Thanx for sharing. It is perfectly designed with such good thoughts. Great and very informative.

  27. Robbyn says:

    Thanx for sharing such a nice post. I have read it many times and it is overall a great post.

  28. Thank you so much for sharing these amazing tips. I must say you are an incredible writer, I love the way that you describe the things. Please keep sharing.

  29. Great Post. I was surfing the Internet for information and came across your blog. I am impressed by the information you have on this blog. Thanks a lot for sharing this! Please visit our website you get more information regarding Skin issues

  30. writing help says:

    Thank you for sharing such a lovely piece. It was a real delight to read the blog. The downsides raised in this piece are extremely close to me and I made my actionable points out of it. thanks for the article looking for more updates.

  31. That is really very interesting point of view, I have never thought about it, thanks for posting

  32. CustomThesis says:

    Such an impressive share! It is well-written and contains all the info, your Post is very unique and all information is reliable for new readers. I`m working as an academic consultant in USA and offers affordable Assignment Help services to college students.

  33. Quite an informative piece. Thank you for enlightening us on the various effects and scenarios of cancer. Early detection of cancer is important to help combat its effects. https://thesuperioressays-us.com

  34. Nayra Sharma says:

    Good article. Really useful tool

Leave a Reply

*