Ionic liquid research could help understand Alzheimer’s disease

HOT PCCP Communication

The self assembly of proteins into fibrils has been implicated in conditions including Alzheimer’s disease.

Scientists in Australia have shown that the amyloid fibrilization of the peptide Aβ16-22 – an important fragment used to model full length Aβ – is promoted in protic ionic liquids (pILs) containing phosphate or sulphate ions and suppressed in pILs contain mesylate ions.

Read the full PCCP communication at:

The impact of ionic liquids on amyloid fibrilization of Aβ16-22: tuning the rate of fibrilization using a reverse Hofmeister strategy
Natalie Debeljuh, Colin J. Barrow and Nolene Byrne
Phys. Chem. Chem. Phys., 2011
DOI: 10.1039/C1CP22256B

Changes in amyloid fibrilization over time

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