Role of aspartic acid in regulating the growth of common kidney stones

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Yu Huang, S. Roger Qiu and colleagues have used in situ atomic force microscopy to investigate how the growth of calcium oxalate monohydrate is inhibited by 6-residue linear aspartic acid peptides. 

Analysis of the step speed data showed that the aspartic acid enantiomers block active kink sites through step-pinning.

 
Calcium oxalate monohydrate is the main inorganic component in the most common types of kidney stones, so preventing their formation is of great clinical importance.

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Growth inhibition of calcium oxalate monohydrate crystal by linear aspartic acid enantiomers investigated by in situ atomic force microscopy
Kang R. Cho, E. Alan Salter, James J. De Yoreo, Andrzej Wierzbicki, Selim Elhadj, Yu Huang and S. Roger Qiu
CrystEngComm, 2013
DOI: 10.1039/C2CE25936B, Paper

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