Co-crystallisation of nevirapine with maleic acid lead to around a fivefold increase in the aqueous solubility of the drug.
Mino Caira and colleagues have created co-crystals of nevirapine (an antiretroviral drug) with maleic acid that could improve the aqueous solubility of the drug. Their success was a result of exploiting several hydrogen-bonding functionalities in nevirapine, in particular (but not exclusively) its rigid amide group.
Read their paper to find out more – its currently free.
Co-crystals of the antiretroviral nevirapine: crystal structures, thermal analysis and dissolution behaviour
Mino R. Caira, Susan A. Bourne, Halima Samsodien, Emile Engel, Wilna Liebenberg, Nicole Stieger and Marique Aucamp
CrystEngComm, 2012
DOI: 10.1039/C2CE06507J
