While PROteolysis Targeting Chimeras (PROTACs) were first discovered over two decades ago, targeted protein degradation remains an exciting and valuable strategy in drug development. From macrocyclic peptides to nanoparticle-based delivery systems, there continues to be a wealth and diversity of PROTACs research published in RSC Chemical Biology each year. This selection of papers highlights research into innovative targeted protein degradation strategies from 2025.
Research Spotlight
Macrocyclic peptides as a new class of targeted protein degraders
Xuefei Jing, Joel P. Mackay and Toby Passioura
Maho Miyamoto, Kosuke Saito, Hidetomo Yokoo and Yosuke Demizu
Kohei Tsuji, Xueyuan Huang, Maho Miyamoto, Sayaka Sukegawa, Hidetomo Yokoo, Hiroaki Takeuchi, Yosuke Demizu and Hirokazu Tamamura
Identification of ligands for E3 ligases with restricted expression using fragment-based methods
Alex G. Waterson, Brian D. Lehmann, Zhenwei Lu, John L. Sensintaffar, Edward T. Olejniczak, Bin Zhao, Tyson Rietz, William G. Payne, Jason Phan and Stephen W. Fesik
Muyu Xu, Jinying Qiu, Lin Tan, Jiayu Xu, Yi Wang, Wenyue Kong, Hongda Liao, Anran Chen, Xiaolan Chen, Jiying Zhang, Cookson K. C. Chiu, Meiying Zhang, Yingying Tian, Caohui Li, Biao Ma, Leiming Wang, Jingpeng Fu, Seung H. Choi, Jeffrey Hill and Weijun Shen
This selection highlights only the most recent RSC Chemical Biology papers on this topic – for much more, read the journal at RSC Chemical Biology - Home.
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