New microfluidic device: putting pen to paper

Pressing the buttons allows the device to be programmed for specific tests

George Whitesides and colleagues at Harvard University have developed a paper-based microfluidic device that can be programmed to carry out any test the user wants.

Read the article via the Lab on a Chip homepage.

Devices made from simple materials such as paper have great potential in developing countries, as they are cheap and easy to use.  The paper is soaked in a polymer solution and cured using light to create a network of channels.

Whitesides’ new programmable 3D device can be activated using the humble ballpoint pen.

To find out how, and also why it ‘brings another layer of sophistication to microfluidic devices’, read David Barden’s full story at Highlights in Chemical Technology.

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Analytical Research Forum 2010

The Analytical Research Forum was held at Loughborough University this year. We were in excellent company, as we were sharing the campus with many young teams from numerous sports on training camps, and in particular the World Rope-Skipping Championships! 

The keynote speakers included Gary Eiceman from New Mexico State University, US who gave a fascinating talk on the possibilites of ion-mobilty mass spectrometry, and some thoughts on what the future holds for this technique. Read one of recent articles in Analyst.

Ion mobility mass spectrometry (IM-MS) became a bit of theme with further discussion from Perdita Barran on the use of nano-electrospray ionisation mass spectrometry and IM-MS for examining biological systems in the gas phase.

Perdita was also presented with the 2009 Joseph Black award for her developments in the field of mass spectrometry, especially ion-mobility techniques, and the application of these techniques to biological macromolecules and their gas phase interactions.

Look out for the Emerging Investigators Issue in Analyst early next year, which Perdita is co-Guest Editing with Christy Haynes.

Fingerprinting and forensics was another popular theme of the conference, with a very impressive keynote from David Russell from the University of East Anglia. He updated delegates on the methods his group have developed to detect drugs and metabolites on fingerprints. The  method of combining magnetic microparticles or gold nanoparticles with antibodies is so powerful, you can expect to see this approach in use in the near future – drug-drivers beware! Read his article on these methods in Analyst.

Brett Paull, Analytical Methods Editor-in-ChiefAnalytical Methods Editor-in-Chief, Brett Paull gave the final keynote talk on the Wednesday morning, on the topic of monolithic materials for separation science. 

Other talks which were also impressive included “Ion mobility-mass spectrometry of 3-D supramolecular architectures” by Martin De Cecco from the University of Edinburgh and “Spatially standardized cell biology” by Jonathan West from ISAS, Dortmund, Germany.

The social and networking side of ARF is however just as important as the science, and there were plenty of opportunities for this too. The quiz held in the bar on the Monday night required a combination of largely musical knowledge with a small amount of chemistry! This was most abely won by Perdita Barran’s group from the University of Edinburgh. The conference dinner was also traditionally held on the Tuesday evening.

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Interview with Justin Gooding

Analyst Editorial Board Member Justin Gooding talks to Bibiana Campos-Seijo about dinosaurs, science funding in Australia and his desire to be a professional sportsman.

Read the interview in full on the Highlights in Chemical Technology website.

Justin Gooding is a chemistry professor at the University of New South Wales, Australia. His current research interests focus on surface modification of nanoparticles and nanoporous photonic crystals with self-assembled monolayers for the development of biointerfaces, biosensors and molecular electronics of application in sensing and cell biology.

Read some of Justin’s recent research published in RSC Journals:

Wet chemical routes to the assembly of organic monolayers on silicon surfaces via the formation of Si–C bonds: surface preparation, passivation and functionalization
Simone Ciampi, Jason B. Harper and J. Justin Gooding
Chem. Soc. Rev., 2010, 39, 2158 – 2183, http://dx.doi.org/10.1039/b923890p

The importance of surface chemistry in mesoporous materials: lessons from porous silicon biosensors
Kristopher A. Kilian, Till Böcking and J. Justin Gooding
Chem. Commun., 2009, 630 – 640, http://dx.doi.org/10.1039/b815449j

Multi-analyte sensing: a chemometrics approach to understanding the merits of electrode arrays versus single electrodes
Diako Ebrahimi, Edith Chow, Justin J. Gooding and David B. Hibbert
Analyst, 2008, 133, 1090 – 1096, http://dx.doi.org/b804811h

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Faraday 149: Analysis for Healthcare Diagnostics and Theranostics

The need in healthcare to detect biomolecular species such as proteins, oligonucleotides (DNA and RNA) and cells for diagnostics is driving the current development of physical techniques.

Themes of this meeting include:
Systems/Devices to Inform Therapy (SDIT) 
Physical Techniques for Diagnostics (PTD)
High-Throughput Measurement and Analysis (HTMA)
Towards Real-time Clinical Measurement (TRCM)

This meeting is being held at the University of Edinburgh from 6-8 September, 2010.

Registration deadline 6th August

For further information about about this meeting and to register, please visit the website.

Faraday Discussion 149 is organised by the Faraday Division in association with the Analytical Division.

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Colorimetric sensor detects pesticide toxins

Inhibiting acetylcholinesterase alters the growth of nanoparticles causing a colour change

A paper-based colorimetric dipstick bioassay that can detect low levels of pesticides has been developed by John Brennan and colleagues at McMaster University in Hamilton, Canada.

You can access the paper via the Analyst homepage.

Organophosphate pesticides can be toxic to both humans and animals as they inhibit important enzymes such as acetylcholinesterase (AChE) in the nervous system.  They are still in widespread use so there is a need for a simple method to detect their residues.  Now, Brennan’s team has created a gold nanoparticle-based dipstick test to identify inhibitors of the acetylcholinesterase enzyme that would be easy to use for in-field applications.

Brennan says he hopes to develop this system by ‘integrating the various reagents involved in the assay into a single lateral flow device, which should avoid the need for adding external reagents’.  His group are also ‘investigating other enzymes that are known to support catalytic growth of gold nanoparticles to further evaluate this sensor platform’.

To read the full story, head to Highlights in Chemical Technology.

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GRC Bioanalytical Sensors

The 2010 GRC on Bioanalytical Sensors took place 20-25 June in the green setting of Colby-Sawyer College, New Hampshire, USA.  Talks by leading researchers set the tone for five days of high-quality, cutting edge and interdisciplinary science presented in a format that drove discussion in a hugely positive way.  You can see the latest work in this field via the Analyst homepage.

Co-Chairs Antje Baeumner and Weihong Tan

Co-Chairs Anjte Baeumner of Cornell University and Weihong Tan of the University of Florida had put together a packed programme which covered topics such as nanotechnology, point-of-care applications, commercialisation and microfluidics.  The unique structure of GRC meetings gives research communities the chance to engage in person, and this opportunity was exploited to the full here.  Debate was free-flowing between the internationally diverse delegates, with conversations often continuing into break and meal times.

It wasn’t all intense work, though.  Vice-Chair of the meeting was Analyst US Associate Editor, Steve Soper, who arranged a social programme that was almost as busy as the scientific one.  From golf to hiking, volleyball to historical visits, there was plenty to do in the free afternoons.  And with Analyst sponsoring the evening refreshments, there was no excuse for an early night!

I was very impressed by my first experience of a Gordon Research Conference.  The talks and posters presented showcased some of the most exciting developments in the broad field of bioanalytical sensing, but more importantly there was a sense of community amongst those attending.  This atmosphere nurtured the sort of personal interaction that can only lead to more exciting science in the future.

– Vibhuti Patel, Deputy Editor

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