Vibhuti Patel, Deputy Editor – Page 9

Author Archive

Ribonuclease protection assay on microchip electrophoresis

26 Apr 2011

The potential of microchip electrophoresis for the rapid and highly sensitive analysis of mRNA expression in cells by using a Cy5-labeled antisense riboprobe in the RNA protection assay has been shown by researchers from Japan.

Shouki Yatsushiro and colleagues from National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, show that results can be obtained in 120 seconds, using the same amount of riboprobe as used in the conventional method, with eight-times more sensitive detection of mRNA.

Read the article for free using the link below:

Ribonuclease protection assay on microchip electrophoresis
Yuka Yamaguchi, Shouki Yatsushiro, Shohei Yamamura, Hiroko Abe, Kaori Abe, Masahiro Watanabe, Kazuaki Kajimoto, Yasuo Shinohara, Yoshinobu Baba and Masatoshi Kataoka
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN01044H

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Most-read Analyst articles in March

26 Apr 2011

The most popular Analyst articles in March

Five of our most-read papers in March 2011 – access them FOR FREE:

Melamine sensing through riboflavin stabilized gold nanoparticles
Bappaditya Roy, Abhijit Saha and Arun K. Nandi, Analyst, 2011, 136, 67-70
DOI: 10.1039/C0AN00599A

Colorimetric detection of melamine in complex matrices based on cysteamine-modified gold nanoparticles

Xiaosheng Liang, Hongping Wei, Zongqiang Cui, Jiaoyu Deng, Zhiping Zhang, Xiangyu You and Xian-En Zhang, Analyst, 2011, 136, 179-183
DOI: 10.1039/C0AN00432D

Liquid-phase broadband cavity enhanced absorption spectroscopy (BBCEAS) studies in a 20 cm cell

L. Nitin Seetohul, Zulfiqur Ali and Meez Islam, Analyst, 2009, 134, 1887-1895
DOI: 10.1039/B907316G

Gold nanoparticle probes for the detection of mercury, lead and copper ions

Yang-Wei Lin, Chih-Ching Huang and Huan-Tsung Chang, Analyst, 2011, 136, 863-871
DOI: 10.1039/C0AN00652A

Protease sensing with nanoparticle based platforms

Katharina Welser, Rosemary Adsley, Bernadette M. Moore, Weng C. Chan and Jonathan W. Aylott, Analyst, 2011, 136, 29-41
DOI: 10.1039/C0AN00429D

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RNA analysis raises hopes of early cancer diagnosis

21 Apr 2011

An improved method for diagnosing colorectal cancer without using invasive techniques has been developed by scientists in China. A team led by Guohua Zhou at Nanjing University used a bead-based assay in conjunction with PCR to detect the RNA produced by cancer cells.

Read David Barden’s news piece in Chemistry World or access the full article for free using the link below. What impact do you think this methodology will have for diagnostics in the future? Leave your comments below.

Digital analysis of the expression levels of multiple colorectal cancer-related genes by multiplexed digital-PCR coupled with hydrogel bead-array
Zongtai Qi, Yinjiao Ma, Lili Deng, Haiping Wu, Guohua Zhou, Tomoharu Kajiyama and Hideki Kambara
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00976H

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Issue 9 now published

14 Apr 2011

Analyst, 136(9): 1769-1996

Issue 9 is now online! (apologies for the poetry, it’s just the best way to say it…)

Highlighted on this issue’s cover is work by Tony Killard and colleagues on the development of a fluorescent method for detecting the onset of coagulation in human plasma on microstructured lateral flow platforms. They’ve found that the change in the distribution of the fluorescence within the sample over time was an excellent predictor of the onset of coagulation, which could be used to determine the clotting time.

Read the article for free by clicking below:

Development of a fluorescent method for detecting the onset of coagulation in human plasma on microstructured lateral flow platforms
Magdalena M. Dudek, Nigel J. Kent, Pan Gu, Z. Hugh Fan and Anthony J. Killard
Analyst, 2011, 136, 1816-1825
DOI: 10.1039/C0AN00907E

Also in this issue are a handful of Communications, describing urgent work on topics such as detection of dopamine using fast scan cyclic voltammetry and the preparation of gold nanoparticle-decorated microparticles for hydrogen peroxide detection – do take a look and let us know your thoughts.

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Issue 8 online

29 Mar 2011

Analyst, 136(8): 1525-1768

On the cover this issue:

Highlighted on the front cover, work by Hyun Gyu Park and co-workers on an electrochemical real-time PCR system, based on intercalative binding of methylene blue with dsDNA.

Investigation of the signaling mechanism and verification of the performance of an electrochemical real-time PCR system based on the interaction of methylene blue with DNA
Byoung Yeon Won, Sujeong Shin, Songyi Baek, Ye Lim Jung, Taihua Li, Sung Chul Shin, Dae-Yeon Cho, Sang Bok Lee and Hyun Gyu Park
Analyst, 2011, 136, 1573-1579
DOI: 10.1039/C0AN00695E

The inside front cover features work by Matthew A. Cooper and co-workers on the detection of Herpes Simplex Virus DNA using a sandwich-like magnetic nanoparticle pull-down assay.

Amplification free detection of Herpes Simplex Virus DNA
David A. C. Thomson, Krassen Dimitrov and Matthew A. Cooper
Analyst, 2011, 136, 1599-1607
DOI: 10.1039/C0AN01021A

Both articles will be free to access for six weeks.

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Most-read Analyst articles in February

29 Mar 2011

The most popular Analyst articles in February

Five of our most-read papers in February 2011 – access them FOR FREE:

Gold nanoparticle probes for the detection of mercury, lead and copper ions

Yang-Wei Lin, Chih-Ching Huang and Huan-Tsung Chang, Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00652A

Nanoparticle-based strategies for detection and remediation of environmental pollutants

Yanyan Liu, Gaoxing Su, Bin Zhang, Guibin Jiang and Bing Yan, Analyst, 2011, 136, 872-877
DOI: 10.1039/C0AN00905A

Selection of DNA aptamers recognizing small cell lung cancer using living cell-SELEX

Takao Kunii, Shun-ichiro Ogura, Masayasu Mie and Eiry Kobatake, Analyst, 2011, 136, 1310-1312
DOI: 10.1039/C0AN00962H

Graphene electrochemistry: an overview of potential applications
Dale A. C. Brownson and Craig E. Banks, Analyst, 135, 2768-2778
DOI: 10.1039/C0AN00590H

Graphene versus carbon nanotubes for chemical sensor and fuel cell applications
Douglas R. Kauffman and Alexander Star, Analyst, 135, 2790-2797
DOI: 10.1039/C0AN00262C

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Pain-free uterine disease detection

22 Mar 2011

Endometriosis affects around 10% of young women resulting in a wide range of symptoms. Currently diagnosis can only be performed by laparoscopic surgery.

A potential non-invasive method to detect endometriosis by acquiring a spectral signature of the uterus has been developed by Francis Martin and colleagues from Lancaster University. They used infrared spectroscopy together with computational analysis to analyse the difference between uterine tissue affected by endometriosis and normal tissue in the uterus.

Read Elinor Richards’ news story in Chemistry World, and access the full article for free below:

Fourier-transform infrared spectroscopy discriminates a spectral signature of endometriosis independent of inter-individual variation
Karen T. Cheung, Júlio Trevisan, Jemma G. Kelly, Katherine M. Ashton, Helen F. Stringfellow, Siân E. Taylor, Maneesh N. Singh, Pierre L. Martin-Hirsch and Francis L. Martin
Analyst, 2011, Advance Article, DOI: 10.1039/c0an00972e

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Issue 7 now online

16 Mar 2011

Analyst, 136(7): 1265-1524

Analyst 2011, Issue 7 is now online.

On the front cover, Juyoung Yoon and colleagues describe new rhodamine hydrazone derivatives bearing thiol and carboxylic acid groups as selective fluorescent and colorimetric chemosensors for Hg²⁺

Rhodamine hydrazone derivatives as Hg²⁺ selective fluorescent and colorimetric chemosensors and their applications to bioimaging and microfluidic system
Ha Na Kim, Seong-Won Nam, K. M. K. Swamy, Yan Jin, Xiaoqiang Chen, Yonugmee Kim, Sung-Jin Kim, Sungsu Park and Juyoung Yoon
Analyst, 2011, 136, 1339-1343
DOI: 10.1039/C0AN00804D

The inside front cover features work by Osvaldo N. Oliveira Jr. and co-workers on the use of software tools to analyze electrical impedance spectroscopy data in electronic tongues and related sensors.

Information visualization techniques for sensing and biosensing
Fernando V. Paulovich, Marli L. Moraes, Rafael Mitsuo Maki, Marystela Ferreira, Osvaldo N. Oliveira Jr. and Maria Cristina F. de Oliveira
Analyst, 2011, 136, 1344-1350
DOI: 10.1039/C0AN00822B

Both articles will be free to access for six weeks.

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Most popular articles of 2010

15 Mar 2011

We’re proud of all the content published in Analyst but we did some number crunching and have identified some of the most popular articles of 2010. They include papers on amperometric sensors, profiling banknotes using ambient MS, and detection of melamine, as well as reviews on optical imaging in live cells and upconversion nanoparticles.

These papers will be free until the end of April – please do take a look. Or if you are one of the many who have enjoyed them already, pass on the information to any colleagues who may be interested.

Why do you think these particular papers were so well-received? We’d love to hear your thoughts via the comment thread below.

Minireview: Optical imaging of non-fluorescent nanoparticle probes in live cells
Gufeng Wang, Anthony S. Stender, Wei Sun and Ning Fang
Analyst, 2010, 135, 215-221
DOI: 10.1039/B916395F

Visual detection of melamine in infant formula at 0.1 ppm level based on silver nanoparticles
Cuiping Han and Haibing Li
Analyst, 2010, 135, 583-588
DOI: 10.1039/B923424A

Thick-film textile-based amperometric sensors and biosensors
Yang-Li Yang, Min-Chieh Chuang, Shyh-Liang Lou and Joseph Wang
Analyst, 2010, 135, 1230-1234
DOI: 10.1039/B926339J

Critical Review: Upconversion nanoparticles in biological labeling, imaging, and therapy
Feng Wang, Debapriya Banerjee, Yongsheng Liu, Xueyuan Chen and Xiaogang Liu
Analyst, 2010, 135, 1839-1854
DOI: 10.1039/C0AN00144A

Instantaneous chemical profiles of banknotes by ambient mass spectrometry
Livia S. Eberlin, Renato Haddad, Ramon C. Sarabia Neto, Ricardo G. Cosso, Denison R. J. Maia, Adriano O. Maldaner, Jorge Jardim Zacca, Gustavo B. Sanvido, Wanderson Romão, Boniek G. Vaz, Demian R. Ifa, Allison Dill, R. Graham Cooks and Marcos N. Eberlin
Analyst, 2010, 135, 2533-2539
DOI: 10.1039/C0AN00243G

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Making baby food safer

14 Mar 2011

Scientists from Spain have used a lab on a chip device to quickly analyse levels of zearalenone, a contaminant, in infant foods with a detection limit below legislative requirements.

Alberto Escarpa and his team from Alcala University, in Madrid, have made a microfluidic device that can detect zearalenone levels to well below the maximum legal amount.

Read Elinor Richards’ full news story in Chemistry World, and access the full paper for free below:

Integrated electrokinetic magnetic bead-based electrochemical immunoassay on microfluidic chips for reliable control of permitted levels of zearalenone in infant foods
Mirian Hervás, Miguel A. López and Alberto Escarpa
Analyst, 2011, Advance Article
DOI: 10.1039/C1AN15081B

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