Vibhuti Patel, Deputy Editor – Page 10

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Issue 6 online

01 Mar 2011

Analyst, 2011, 136(6): 1053-1264

Issue 6 of Analyst is now online. And it’s Chinese research on both our covers this time!

Front cover: Chenxin Cai and co-workers from Nanjing Normal University have demonstrated a simple and effective sensing platform for the detection of hydrogen peroxide released from cells.

Electrochemical detection of extracellular hydrogen peroxide released from RAW 264.7 murine macrophage cells based on horseradish peroxidase–hydroxyapatite nanohybrids
Chunyun Li, Hui Zhang, Ping Wu, Zhunan Gong, Guanglin Xu and Chenxin Cai
Analyst, 2011, 136, 1116-1123
DOI: 10.1039/C0AN00825G

Inside front cover: Yang Tian and colleagues from Tongji University, Shanghai report on a new and facile assay for hydroxyl radicals in photocatalytic systems.

Communication: Fluorescence imaging of hydroxyl radicals at superhydrophobic gold flower-like surface in photocatalytic system
Yan Liu, Anwei Zhu and Yang Tian
Analyst, 2011, 136, 1106-1108
DOI: 10.1039/C0AN00821D

Both articles will be free to access until 6th April, so do take a look!

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Most-read Analyst articles in January

01 Mar 2011

The most popular Analyst articles in January

Five of our most-read papers in January 2011 – access them FOR FREE:

A simple but highly sensitive and selective colorimetric and fluorescent probe for Cu²⁺ in aqueous media

Yamin Li, Xiaoling Zhang, Baocun Zhu, Juan Xue, Zhi Zhu and Weihong Tan, Analyst, 2011, 136, 1124-1128
DOI: 10.1039/C0AN00682C

Thick-film textile-based amperometric sensors and biosensors
Yang-Li Yang, Min-Chieh Chuang, Shyh-Liang Lou and Joseph Wang, Analyst, 135, 1230
DOI: 10.1039/b926339j

Graphene electrochemistry: an overview of potential applications
Dale A. C. Brownson and Craig E. Banks, Analyst, 135, 2768-2778
DOI: 10.1039/C0AN00590H

Luminescent lanthanide complexes as analytical tools in anion sensing, pH indication and protein recognition

Satoshi Shinoda and Hiroshi Tsukube, Analyst, 2011, 136, 431-435
DOI: 10.1039/C0AN00808G

Upconversion nanoparticles in biological labeling, imaging, and therapy

Feng Wang, Debapriya Banerjee, Yongsheng Liu, Xueyuan Chen and Xiaogang Liu, Analyst, 2010, 135, 1839-1854
DOI: 10.1039/C0AN00144A

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Continuous immunosensor for disease diagnosis

25 Feb 2011

Scientists from Korea have immobilised a reactive antibody onto the surface of a microfluidic sensor to allow immunosensing with minimal steps to analyse a fluctuating analyte concentration continuously. They found that the antibody showed rapid kinetic properties in both the association and dissociation reactions, and also had a high binding affinity.

When monitoring the analyte level in the sample, the binder was able to be continuously recycled without interrupting the analytical conditions, according to the researchers. The continuous immunosensor displayed characteristics that were suitable for in vitro disease diagnosis so could be used as a novel analytical tool for a direct online clinical decision, they added.

Minimum-step immuno-analysis based on continuous recycling of the capture antibody
Hyun-Kyu Cho, Sung-Min Seo, Il-Hoon Cho, Sung-Ho Paek, Dong-Hyung Kim and Se-Hwan Paek
Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00811G

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Analytical developments on ChemSpider

18 Feb 2011

Our colleagues over at ChemSpider have been very busy working on some exciting spectral interpretation tools:

The Spectral Game goes mobile

If you’ve never seen this before, a spectrum is displayed and the student must identify the molecule that the spectrum relates to from a number of possible choices. Simple but effective, and now this interactive learning tool can be accessed via mobile devices, so get your iPhone out and take a look: www.spectralgame.com

Spectra School

Over 700 ¹H NMR, ¹³C NMR, UV, IR and MS spectra have been uploaded into the database from SpectraSchool, a project that was part-funded by the RSC. But these aren’t just a bank of spectra – they’re interactive! You can zoom in to look at sections in more detail and even download the NMR spectra so you can process them in your own software package. Take a look at the spectra for caffeine here.

We’re certainly excited by these developments, not just because we love all things analytical, but because we hope they’ll help to support education in a very practical way.

Once you’ve had a play, let us know what you think by posting below or tweeting us: @analystrsc

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Issue 5 online

17 Feb 2011

Analyst, 2011, 136(5): 849-1052

Issue 5 of 2011 is now online – and there’s an Australian takeover of our covers!

On the front cover, Stephen J. Blanksby and co-workers describe a straightforward method using DESI-MS for detecting additives in polymer-based coatings.

Desorption electrospray ionisation mass spectrometry reveals in situ modification of a hindered amine light stabiliser resulting from direct N–OR bond cleavage
Martin R. L. Paine, Philip J. Barker and Stephen J. Blanksby
Analyst, 2011, 136, 904-912
DOI: 10.1039/C0AN00656D

The inside front cover features work by Paul S. Francis and co-workers on deriving the greatest emission intensity from rapid light-producing reactions in chemiluminescence flow-cells.

Solution mixing and the emission of light in flow-cells for chemiluminescence detection
Jessica M. Terry, Elizabeth M. Zammit, Teo Slezak, Neil W. Barnett, Don C. Olson, Duane K. Wolcott, Donna L. Edwards and Paul S. Francis
Analyst, 2011, 136, 913-919
DOI: 10.1039/C0AN00591F

Both articles will be free to access for six weeks, so do take a look.

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Breath test

14 Feb 2011

The work could open up a whole new area of medical diagnostics and health research

Take a look at this Spectroscopy Now article, which highlights work from Robert Peverall and colleagues on the detection of trace species in breath using near infrared Fourier transform broadband cavity enhanced absorption spectroscopy.

The paper is in the latest issue of Analyst, and can be accessed using the link below:

Trace species detection in the near infrared using Fourier transform broadband cavity enhanced absorption spectroscopy: initial studies on potential breath analytes
W. Denzer, G. Hancock, M. Islam, C. E. Langley, R. Peverall, G. A. D. Ritchie and D. Taylor
Analyst, 2011, 136, 801-806
DOI: 10.1039/C0AN00462F

Let us know your thoughts on this exciting piece of research by posting a comment below, or tweet us @analystrsc.

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Raman imaging gives new hope for cancer diagnosis

11 Feb 2011

False colour images of the SERS nanoparticle signals.

Pop over to Chemistry World to read how combining two Raman spectroscopic imaging techniques could offer a valuable tool for future disease diagnosis.

“[The] work solves a limitation of Raman imaging by developing strategies to go from about 5 to 50mm depth penetration,” says Sanjiv Sam Gambhir, director of the Molecular Imaging Program at Stanford University.

Co-authored by Analyst Board members Duncan Graham and Pavel Matousek, the paper describes how putting SERS together with deep Raman spectroscopy can enable non-invasive analysis of multiple antibodies for different diseases tagged to nanoparticles.

The original article, published in Chemical Science, can be accessed using the link below:

Surface enhanced spatially offset Raman spectroscopic (SESORS) imaging – the next dimension
Nicholas Stone, Marleen Kerssens, Gavin Rhys Lloyd, Karen Faulds, Duncan Graham and Pavel Matousek
Chem. Sci., 2011, Advance Article
DOI: 10.1039/c0sc00570c

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Issue 4 online

07 Feb 2011

Analyst, 2011, 136(4): 621-848

Analyst Volume 136, Issue 4 is now online, with Comms on the covers:

On the front cover, work by Matt Trau and co-workers on a microparticle-based flow cytometry assay for the analysis of 5MeC-binding proteins, which may have potential in cancer detection.

Communication: Bisulfite-free analysis of 5MeC-binding proteins and locus-specific methylation density using a microparticle-based flow cytometry assay
Simon R. Corrie, Pavel Sova, Qinghua Feng, Tiffany Blair, Nancy B. Kiviat and Matt Trau
Analyst, 2011, 136, 688-691
DOI: 10.1039/C0AN00790K

The inside front cover features work by Daxiang Cui and co-workers on the use of magnetic nanoclusters for the detection of hepatitis B virus surface antibodies, showing potential for the diagnosis of infectious diseases.

Communication: The potential of magnetic nanocluster and dual-functional protein-based strategy for noninvasive detection of HBV surface antibodies
Hengyao Hu, Hao Yang, Ding Li, Kan Wang, Jing Ruan, Xueqing Zhang, Jun Chen, Chenchen Bao, Jiajia Ji, Donglu Shi and Daxiang Cui
Analyst, 2011, 136, 679-683
DOI: 10.1039/C0AN00517G

Both articles will be free to access for six weeks, so do take a look and leave your comments back here on the blog.

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ChemSpider connects chemistry and mass spec

25 Jan 2011

Find Out How ChemSpider Connects Chemistry & Mass Spectrometry Online – Register Today…

Connecting chemistry and mass spectrometry on the internet in the very first Chemistry World live webinar on 31 January, discover the powerful combination of the modern mass spectrometry and the ChemSpider database of chemical structures in metabolomics research.

Dr Antony Williams of the RSC and Dr John Shockcor from Waters will be speaking on:

Connecting Chemistry and Mass Spectrometry on the Internet – ChemSpider
Monday 31 January 2011

Join the live webinar – Register Here

Be part of the active audience at the Royal Society of Chemistry, London, UK – Register Here

This Chemistry World webinar is brought to you in partnership with ChemSpider and Waters.

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Most-read Analyst articles in December

25 Jan 2011

The most popular Analyst articles in December

Five of our most-read papers in December 2010 – access them FOR FREE:

Gold nanoparticle probes for the detection of mercury, lead and copper ions

Yang-Wei Lin, Chih-Ching Huang and Huan-Tsung Chang, Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00652A

Fluorescent gold clusters as nanosensors for copper ions in live cells

C. V. Durgadas, C. P. Sharma and K. Sreenivasan, Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00424C

A novel single-labeled fluorescent oligonucleotide probe for silver(I) ion detection based on the inherent quenching ability of deoxyguanosines

Lei Wang, Jingqi Tian, Hailong Li, Yingwei Zhang and Xuping Sun, Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00669F

SERS-based sandwich immunoassay using antibody coated magnetic nanoparticles for Escherichia coli enumeration

Burcu Guven, Nese Basaran-Akgul, Erhan Temur, Ugur Tamer and İsmail Hakkı Boyacı, Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00473A

Intact skin analysis by desorption electrospray ionization mass spectrometry

Mária Katona, Júlia Dénes, Réka Skoumal, Miklós Tóth and Zoltán Takáts, Analyst, 2011, Advance Article
DOI: 10.1039/C0AN00688B

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