Archive for the ‘Uncategorized’ Category

Top 10 most downloaded articles: July – September

We are delighted to share with you the top 10 most downloaded articles in Toxicology Research  from July – September 2017. These papers are free to access for the next two weeks with a free publishing personal account – register here.

We hope you enjoy reading these highly accessed articles, and we welcome your future submissions to the journal.

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014, 3, 418-432
DOI: 10.1039/C4TX00047A

Characterization of a functional C3A liver spheroid model
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams and Steven D. Webb
Toxicol. Res., 2016, 5, 1053-1065
DOI: 10.1039/C6TX00101

Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980–2013
Jen-Yin Goh, Richard J. Weaver, Libby Dixon, Nicola J. Platt and Ruth A. Roberts
Toxicol. Res., 2015, 4, 1297-1307
DOI: 10.1039/C5TX00123D

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi
Vilmos Csizmadia, Paul Hales, Christopher Tsu, Jingya Ma, Jiejin Chen, Pooja Shah, Paul Fleming, Joseph J. Senn, Vivek J. Kadambi, Larry Dick and Francis S. Wolenski
Toxicol. Res., 2016, 5, 1619-1628
DOI: 10.1039/C6TX00220J

A. R. Iskandar, B. Titz, A. Sewer, P. Leroy, T. Schneider, F. Zanetti, C. Mathis, A. Elamin, S. Frentzel, W. K. Schlage, F. Martin, N. V. Ivanov, M. C. Peitscha and J. Hoeng
Toxicol. Res., 2017,6, 631-653
DOI: 10.1039/C7TX00047B

Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn
Toxicol. Res., 2013, 2, 23-29
DOI: 10.1039/C2TX20051A

Patricia Erebi Tawari, Zhipeng Wang, Mohammad Najlah, Chi Wai Tsang, Vinodh Kannappan, Peng Liu, Christopher McConville, Bin He, Angel L. Armesillaa and Weiguang Wang
Toxicol. Res., 2015, 4, 1439-1442
DOI: 10.1039/C5TX00210A

Effects of monoolein-based cubosome formulations on lipid droplets and mitochondria of HeLa cells
Angela Maria Falchi, Antonella Rosa, Angela Atzeri, Alessandra Incani, Sandrina Lampis, Valeria Meli, Claudia Caltagirone and Sergio Murgia
Toxicol. Res., 2015, 4, 1025-1036
DOI: 10.1039/C5TX00078E

Toxic mechanisms of microcystins in mammals
Nicole L. McLellana and Richard A. Manderville
Toxicol. Res., 2017, 6, 391-405
DOI: 10.1039/C7TX00043J

Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013, 2, 40-59
DOI: 10.1039/C2TX20031G

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HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

Wenchao Xu, Fei Luo, Baofei Sun, Hua Ye, Jun Li, Le Shi, Yi Liu, Xiaolin Lu, Bairu Wang, Qingling Wang, Qizhan Liu and Aihua Zhang
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00225G, Paper

Graphical Abstract


Qian Ba, Chao Huang, Yijing Fu, Junyang Li, Jingquan Li, Ruiai Chu, Xudong Jia and Hui Wang
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00378D, Paper

Graphical Abstract
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Issue 6 now online

Graphical AbstractThe front cover of issue 6 features artwork by Charbel Gebraël and Catherine Jumarie from Université du Québec à Montréal. Gebraël and Jumarie determine how the Cd-induced hormesis-like effect on MTT activity in the Caco-2 cells is a differentiation stage-specific phenomenon that is not observed with xenobiotics acting as AhR ligands

Want to know more? Read the full article below – its free to access for the next 6 weeks!

C. Gebraël and C. Jumarie
Toxicol. Res., 2015, 4, 1488-1497
DOI: 10.1039/C5TX00284B

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Issue 5 now online!

Graphical AbstractThe front cover of issue 5 features artwork by  Shao-Chen Sun from Nanjing Agricultural University. With his colleagues, Shao-Chen explored possible mechanisms for the toxic effects of ZEN on pig oocytes. They cultured porcine oocytes to maturation in media with different ZEN concentrations (5–30 μM), after which they analyzed oocyte oxidative stress status, autophagy, early apoptosis, and epigenetic modifications by immunofluorescence, quantitative real-time PCR analysis and western blot approaches.

Want to know more? Read the full article below – its free to access for the next 6 weeks!

Jun Han, Ting Wang, Le Fu, Liang-Yu Shi, Cheng-Cheng Zhu, Jun Liu, Yu Zhang, Xiang-Shun Cui, Nam-Hyung Kim and Shao-Chen Sun
Toxicol. Res., 2015, 4, 1184-1194
DOI: 10.1039/C5TX00070J

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Issue 4 now online!

Graphical Abstract

The front cover of issue 4 features artwork by Arthur Grollman (Stony Brook University, USA)  and Robert Turesky (University of Minnesota, USA). With their colleagues, Grollman and Turesky highlight novel approaches to quantify exposure to AA, by analysis of aristolactam (AL) DNA adducts, employing ultraperformance liquid chromatography–electrospray ionization/multistage mass spectrometry (UPLC-ESI/MSn).

Intesrested to know more? Read the full article below – its free to access for the next 6 weeks:

New approaches for biomonitoring exposure to the human carcinogen aristolochic acid
Byeong Hwa Yun, Viktoriya S. Sidorenko, Thomas A. Rosenquist, Kathleen G. Dickman, Arthur P. Grollman and Robert J. Turesky
Toxicol. Res., 2015, 4, 763-776
DOI: 10.1039/C5TX00052A


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Top 10 most accessed Toxicology Research articles from January – March 2015

From January – March 2015, our most downloaded Toxicology Research articles were:

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014,3, 418-432
DOI: 10.1039/C4TX00047A

Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013,2, 40-59
DOI: 10.1039/C2TX20031G

An introduction to systems toxicology
Nick J. Plant
Toxicol. Res., 2015,4, 9-22
DOI: 10.1039/C4TX00058G

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond

Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012,1, 62-68
DOI: 10.1039/C2TX20006F

DNA damage by oxo- and peroxo-chromium(v) complexes: insight into the mutation and carcinogenesis mechanisms
Lamis Judah, Roberto Marin, Diane Stroup, Chrys Wesdemiotis and Rathindra N. Bose
Toxicol. Res., 2014,3, 56-66
DOI: 10.1039/C3TX50061F

A comparative cytotoxicity study of TiO2 nanoparticles under light and dark conditions at low exposure concentrations

Swayamprava Dalai, Sunandan Pakrashi, R. S. Suresh Kumar, N. Chandrasekaran and Amitava Mukherjee
Toxicol. Res., 2012,1, 116-130
DOI: 10.1039/C2TX00012A

Interaction of tannic acid with carbon nanotubes: enhancement of dispersibility and biocompatibility

Xiaoyong Zhang, Meiying Liu, Xiqi Zhang, Fengjie Deng, Cuiying Zhou, Junfeng Hui, Wanyun Liu and Yen Wei
Toxicol. Res., 2015,4, 160-168
DOI: 10.1039/C4TX00066H

An unexpected increase of toxicity of amino acid-containing ionic liquids
Ksenia S. Egorova, Marina M. Seitkalieva, Alexandra V. Posvyatenko and Valentine P. Ananikov
Toxicol. Res., 2015,4, 152-159
DOI: 10.1039/C4TX00079J

Bicontinuous cubic phase nanoparticle lipid chemistry affects toxicity in cultured cells
Tracey M. Hinton, Felix Grusche, Durga Acharya, Ravi Shukla, Vipul Bansal, Lynne J. Waddington, Paul Monaghan and Benjamin W. Muir
Toxicol. Res., 2014,3, 11-22
DOI: 10.1039/C3TX50075F

New structural alerts for Ames mutagenicity discovered using emerging pattern mining techniques
Laurence Coquin, Steven J. Canipa, William C. Drewe, Lilia Fisk, Valerie J. Gillet, Mukesh Patel, Jeffrey Plante, Richard J. Sherhod and Jonathan D. Vessey
Toxicol. Res., 2015,4, 46-56
DOI: 10.1039/C4TX00071D

Interesting read? Let us know your thoughts below.

And remember, you can submit direct to Toxicology Research here

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Issue 3 now online!

Graphical Abstract

The front cover of issue 3 features artwork by Shareen H. Doak from Swansea University. With her colleagues Shareen asseses the impact of varying QD surface chemistry on cellular uptake and a range of indicators for cell perturbation following exposure.

Interested to know more? Read the full article below – its free to access for the next 6 weeks:

Quantum dot induced cellular perturbations involving varying toxicity pathways
Abdullah Al-Ali, Neenu Singh, Bella Manshian, Tom Wilkinson, John Wills, Gareth J. S. Jenkins and Shareen H. Doak
Toxicol. Res., 2015, 4, 623-633
DOI: 10.1039/C4TX00175C


This issue is a part-themed issue on the topic of New Talents. Click here to read the editorial by Professor Nigel Gooderham.

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HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

Graphical Abstract

Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes
Tomoya Yamada, Hiroko Kikumoto, Brian G. Lake and Satoshi Kawamura
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00217B

An Introduction to Systems Toxicology
Nick J. Plant
Toxicol. Res., 2015, 4, 9-22
DOI: 10.1039/C4TX00058G

Reproducibility in Experimentation – the implications for regulatory toxicology.
Sir Colin Berry
Toxicol. Res., 2014, 3, 411-417
DOI: 10.1039/C4TX00069B

Graphical Abstract

Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol.
Parodi Daniela A, Sjarif Jasmine, Chen Yichang and Allard Patrick
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00141A

Cerium dioxide nanoparticles protect against oxidative stress induced injury through modulation of TGF-ß signalling
Chang Guo, Rachel Smith, Timothy W. Gant and Martin O. Leonard
Toxicol. Res., 2015,4, 464-475
DOI: 10.1039/C4TX00210E

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Top 10 most accessed Toxicology Research articles from October – December 2014

From October – December 2014, our most downloaded Toxicology Research articles were:

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014, 3, 418-432
DOI
: 10.1039/C4TX00047A

Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013, 2, 40-59
DOI: 10.1039/C2TX20031G

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012, 1, 62-68
DOI: 10.1039/C2TX20006F

The ex vivo neurotoxic, myotoxic and cardiotoxic activity of cucurbituril-based macrocyclic drug delivery vehicles
Rabbab Oun, Rafael S. Floriano, Lyle Isaacs, Edward G. Rowan and Nial J. Wheate
Toxicol. Res., 2014, 3, 447-455
DOI: 10.1039/C4TX00082J

In vitro models for liver toxicity testing
Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn
Toxicol. Res., 2013, 2, 23-39
DOI: 10.1039/C2TX20051A

Surfactant-dispersed nanodiamond: biocompatibility evaluation and drug delivery applications
Xiaoyong Zhang, ShiQi Wang, Meiying Liu, Junfeng Hui, Bin Yang, Lei Tao and Yen Wei
Toxicol. Res., 2013, 2, 335-342
DOI: 10.1039/C3TX50021G

Translation of off-target effects: prediction of ADRs by integrated experimental and computational approach
Laszlo Urban, Mateusz Maciejewski, Eugen Lounkine, Steven Whitebread, Jeremy L. Jenkins, Jacques Hamon, Alexander Fekete and Patrick Y. Muller
Toxicol. Res., 2014, 3, 433-444
DOI: 10.1039/C4TX00077C

The toxicological assessment of two anti-obesity drugs in C. elegans
Layla Aitlhadj and Stephen R. Stürzenbaum
Toxicol. Res., 2013, 2, 145-150
DOI: 10.1039/C2TX20096A

A comparative cytotoxicity study of TiO2 nanoparticles under light and dark conditions at low exposure concentrations
Swayamprava Dalai, Sunandan Pakrashi, R. S. Suresh Kumar, N. Chandrasekaran and Amitava Mukherjee
Toxicol. Res., 2012, 1, 116-130
DOI: 10.1039/C2TX00012A

Evidence based housekeeping gene selection for microRNA-sequencing (miRNA-seq) studies
D. P. Tonge and T. W. Gant
Toxicol. Res., 2013, 2, 328-334
DOI: 10.1039/C3TX50034A

Interesting read? Let us know your thoughts below.

And remember, you can submit direct to Toxicology Research here

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Issue 2 now online!

Graphical Abstract

The front cover of issue 2 feautures artwork by P. Sreenivasula Reddy from Sri Venkateswara University. With his colleagues, P. Sreenivasula Reddy evaluates reproductive toxic effects of benzo(a)pyrene (BaP) in adult male Wistar rats.

Interested to know more? Read the full article below – its free to access for the next 6 weeks:

Reproductive and paternal mediated developmental toxicity of benzo(a)pyrene in adult male Wistar rats
K. Pratap Reddy, B. P. Girish and P. Sreenivasula Reddy
Toxicol. Res., 2015, 4, 223-232
DOI: 10.1039/C4TX00121D


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