Archive for the ‘Hot articles’ Category

HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

Shanshan Zhu, Xiaolong Xu, Rui Rong, Bing Li and Xue Wang
Toxicol. Res., 2016, 5, 97-106

DOI: 10.1039/C5TX00292C, Paper

Graphical Abstract

Ke-Wei Tian, Hong Jiang, Bei-Bei Wang, Fan Zhang and Shu Han
Toxicol. Res., 2016, 5, 79-96

DOI: 10.1039/C5TX00272A, Paper

Graphical Abstract
Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

Wenchao Xu, Fei Luo, Baofei Sun, Hua Ye, Jun Li, Le Shi, Yi Liu, Xiaolin Lu, Bairu Wang, Qingling Wang, Qizhan Liu and Aihua Zhang
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00225G, Paper

Graphical Abstract


Qian Ba, Chao Huang, Yijing Fu, Junyang Li, Jingquan Li, Ruiai Chu, Xudong Jia and Hui Wang
Toxicol. Res., 2016, Advance Article
DOI: 10.1039/C5TX00378D, Paper

Graphical Abstract
Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

Isabel Costa, Félix Carvalho, Teresa Magalhães, Paula Guedes de Pinho, Ricardo Silvestre and Ricardo Jorge Dinis-Oliveira
Toxicol. Res., 2015, 4, 1443-1452
DOI: 10.1039/C5TX00209E, Paper

Graphical Abstract

Paul N. Sanderson, Wendy Simpson, Richard Cubberley, Maja Aleksic, Stephen Gutsell and Paul J. Russell
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00246J, Paper

Graphical Abstract

Carla Nunes, Natércia Teixeira, Diana Serra, Víctor Freitas, Leonor Almeida and João Laranjinha
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00214A, Paper

Graphical Abstract

Lizhen Jiang, Yanbo Li, Yang Li, Caixia Guo, Yongbo Yu, Yang Zou, Yumei Yang, Yang Yu, Junchao Duan, Weijia Geng, Qiuling Li and Zhiwei Sun
Toxicol. Res., 2015, 4, 1453-1464
DOI: 10.1039/C5TX00118H, Paper

Graphical Abstract

Muthuraman Pandurangan, Gansukh Enkhtaivan and Doo Hwan Kim
Toxicol. Res., 2015, Advance Article

DOI: 10.1039/C5TX00269A, Paper

Graphical abstract

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

Viktoria Vágány and Andrew G. Smith
Toxicol. Res., 2015, 4, 1128-1142
DOI: 10.1039/C5TX00011D, Review Article

Graphical Abstract


Ugir Hossain Sk, Vikram Patial and Supriya Sharma
Toxicol. Res., 2015, 4, 1204-1213
DOI: 10.1039/C5TX00112A, Paper

Graphical Abstract


Jun Yan, Zhiqing Lin, Bencheng Lin, Honglian Yang, Wei Zhang, Lei Tian, Huanliang Liu, Huashan Zhang, Xiaohua Liu and Zhuge Xi
Toxicol. Res., 2015, 4, 1225-1237
DOI: 10.1039/C5TX00039D, Paper

Graphical Abstract


Ifigeneia V. Mavragani, Danae A. Laskaratou, Benjamin Frey, Serge M. Candéias, Udo S. Gaipl, Katalin Lumniczky and Alexandros G. Georgakilas
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00222B, Review Article

Graphical Abstract

Nigel Greene and William Pennie
Toxicol. Res., 2015, 4, 1159-1172
DOI: 10.1039/C5TX00055F, Review Article

Graphical Abstract


Nuan P. Cheah, Jeroen L.A. Pennings, Jolanda P. Vermeulen, Roger W.L. Godschalk, Frederik J. van Schooten and Antoon Opperhuizen
Toxicol. Res., 2015, 4, 1250-1259
DOI: 10.1039/C4TX00213J, Paper

Graphical Abstract


Jen-Yin Goh, Richard J. Weaver, Libby Dixon, Nicola J. Platt and Ruth A. Roberts
Toxicol. Res., 2015, 4, 1297-1307
DOI: 10.1039/C5TX00123D, Paper

Graphical Abstract

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

AsFAs: a lesser known class of arsenolipids, are they toxic as well?

Seafood is a major source of heavy metal toxicity worldwide. In mid 20th century, Japan witnessed two most dramatic and emotionally moving cases of industrial pollution in history, Minimata disease and Itai itai disease caused by Mercury and  Cadmium contamination respectively. Arsenic is yet another example of toxic heavy metal found in marine food. Arsenic content in marine food is up to 100-fold higher than in terrestrial food and arsenic is mostly present as organic species as arsenobetaine, arsenosugars and arsenolipids.

The classes of arsenolipids include arsenic containing hydrocarbons (AsHCs), arsenosugars-phospholipids (AsPLs), cationic trimethylarsonio fatty alcohols as well as  arsenic-containing fatty acids (AsFAs). AsFAs consist of a polar dimethylarsinoyl group and a carboxylic acid with a long hydrocarbon chain (saturated or unsaturated) in the middle. AsFAs were identified in several cod liver oil samples, in edible fish like herring or red mullet and in brown algae.

AsFAs and metabolites

In a recent article published in Toxicology Research by Schwerdtle et al. from University of Münster, the thorough assessment conducted for in vitro toxicological profiling of AsFAs and their three metabolites ( DMAV, DMAPr and thio-DMAPr) is illustrated. The study involved cytotoxicity , bioavailability and genotoxicity analysis of a satutared and an unsaturated arsenic-containing fatty acid for the first time in human liver cells (HepG2). Also, the toxicity of the three metabolites was characterised in human liver cells and urothelial (UROtsa) cells.

‘ Saturated and unsaturated AsFAs exert cytotoxicity in human liver cells, although they are less toxic than iAsIII and do not show any genotoxic effects’, conclude Schwerdtle et al.

To find out more about the in vitro toxicological analysis of AsFAs, read the the full article for free* by following the link.

In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites

S. Meyer, G. Raber, F. Ebert, L. Leffers, S. M. Müller, M. S. Taleshi, K. A. Francesconi and T. Schwerdtle

Toxicol. Res., 2015, Advance Article

DOI: 10.1039/C5TX00122F

About the webwriter
Sushil Benke is a graduate student under the supervision of Dr. H. N. Gopi in the Department of Chemistry at Indian Institute of Science Education and Research (IISER), Pune. His research focuses on the development of novel antimicrobial peptidomimetics.

*Access is free through a registered RSC account.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

Graphical Abstract

Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes
Tomoya Yamada, Hiroko Kikumoto, Brian G. Lake and Satoshi Kawamura
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00217B

An Introduction to Systems Toxicology
Nick J. Plant
Toxicol. Res., 2015, 4, 9-22
DOI: 10.1039/C4TX00058G

Reproducibility in Experimentation – the implications for regulatory toxicology.
Sir Colin Berry
Toxicol. Res., 2014, 3, 411-417
DOI: 10.1039/C4TX00069B

Graphical Abstract

Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol.
Parodi Daniela A, Sjarif Jasmine, Chen Yichang and Allard Patrick
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00141A

Cerium dioxide nanoparticles protect against oxidative stress induced injury through modulation of TGF-ß signalling
Chang Guo, Rachel Smith, Timothy W. Gant and Martin O. Leonard
Toxicol. Res., 2015,4, 464-475
DOI: 10.1039/C4TX00210E

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Recent HOT Toxicology Research articles

The following are HOT articles, as recommened by the reviewers of the articles. These have all been made free to access until 24th October:

Evaluation of changes in monoamine levels and apoptosis induced by cyfluthrin in rats
Dilek Guvenc, Abdurrahman Aksoy, Ayhan Gacar, Enes Atmaca, Kursad Y. Das and Tolga Guvenc
Toxicol. Res., DOI: 10.1039/C4TX00041B, Paper


MicroRNA-34c-3p is an early predictive biomarker for doxorubicin-induced glomerular injury progression in male Sprague-Dawley rats
Rachel J. Church, J. Eric McDuffie, Manisha Sonee, Monicah Otieno, Jing Ying Ma, Xuejun Liu, Paul B. Watkins and Alison H. Harrill
Toxicol. Res., 2014, 3, 384-394
DOI: 10.1039/C4TX00051J, Paper


Elevation of the intracellular Zn2+ level by 2-n-octyl-4-isothiazolin-3-one in rat thymocytes: an involvement of a temperature-sensitive Zn2+ pathway
Eri Fukunaga, Tomohiro M. Oyama and Yasuo Oyama
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00060A, Paper


An introduction to systems toxicology
Nick J. Plant
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00058G, Review Article

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Congratulations to Stephen Fey et al. whose Toxicology Research article is featuring in Medical News Today

The latest article by Stephen J. Fey  et al. in Toxicology Research is gathering media attention… Illustrated with another eye-catching cover, the work by this collaboration from Denmark and Switzerland looks at the HepG2/C3A cells stability following their recovery after trypsinization.  

The work has been press-released by the University of Southern Denmark: New cutting-edge cell research will lead to safer medical experiments on humans

and picked up by Medical News Today.

Read both articles by Stephen Fey et al. on the topic:

HepG2/C3A 3D spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation
Krzysztof Wrzesinski, Maria Chiara Magnone, Line Visby Hansen, Marianne Ehrhorn Kruse, Tobias Bergauer, Maria Bobadilla, Marcel Gubler, Jacques Mizrahi, Kelan Zhang, Christina M. Andreasen, Kira Eyð Joensen, Signe Marie Andersen, Jacob Bastholm Olesen, Ove B. Schaffalitzky de Muckadell and Stephen J. Fey
Toxicol. Res., 2013, Advance Article
DOI: 10.1039/C3TX20086H, Paper

After trypsinisation, 3D spheroids of C3A hepatocytes need 18 days to re-establish similar levels of key physiological functions to those seen in the liver
Krzysztof Wrzesinski and Stephen J. Fey
Toxicol. Res., 2013, 2, 123-135
DOI: 10.1039/C2TX20060K

Remember, all Toxicology Research articles are Free to access until the end of 2013!

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Accepted Manuscript: Methylmercury-Induced Neurotoxicity

In this latest accepted manuscript from Michael Aschner and colleagues from Vanderbilt University Medical Center, USA,  cellular processes affected by MeHg, including oxidative stress, cellular signaling and gene expression are reviewed and genetic, environmental and nutritional factors capable of modifying MeHg toxicity are discussed.

Read it here – its free to access!

Mechanisms and modifiers of methylmercury-induced neurotoxicity 
Stephanie J. B. Fretham, Samuel Caito, Ebany J. Martinez-Finley and Michael Aschner
Toxicol. Res., 2012, DOI:10.1039/C2TX20010D, Review 

Our Accepted Manuscript service now allows online publication of the submitted version upon acceptance making your research available in citable form even more rapidly.

Do you want to get involved in Toxicology Research?

  • Submit your latest research – there’s still time to be considered for one of the first issues
  • Sign up for the contents alerts and newsletter – keep up to date with the latest research published in the journal
  • All articles published in 2012 and 2013 are free to access. Arrange for your free access by simply filling in this short online registration form
Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)