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The latest article by Stephen J. Fey  et al. in Toxicology Research is gathering media attention… Illustrated with another eye-catching cover, the work by this collaboration from Denmark and Switzerland looks at the HepG2/C3A cells stability following their recovery after trypsinization.  

The work has been press-released by the University of Southern Denmark: New cutting-edge cell research will lead to safer medical experiments on humans

and picked up by Medical News Today.

Read both articles by Stephen Fey et al. on the topic:

HepG2/C3A 3D spheroids exhibit stable physiological functionality for at least 24 days after recovering from trypsinisation
Krzysztof Wrzesinski, Maria Chiara Magnone, Line Visby Hansen, Marianne Ehrhorn Kruse, Tobias Bergauer, Maria Bobadilla, Marcel Gubler, Jacques Mizrahi, Kelan Zhang, Christina M. Andreasen, Kira Eyð Joensen, Signe Marie Andersen, Jacob Bastholm Olesen, Ove B. Schaffalitzky de Muckadell and Stephen J. Fey
Toxicol. Res., 2013, Advance Article
DOI: 10.1039/C3TX20086H, Paper

After trypsinisation, 3D spheroids of C3A hepatocytes need 18 days to re-establish similar levels of key physiological functions to those seen in the liver
Krzysztof Wrzesinski and Stephen J. Fey
Toxicol. Res., 2013, 2, 123-135
DOI: 10.1039/C2TX20060K

Remember, all Toxicology Research articles are Free to access until the end of 2013!

In this latest accepted manuscript from Michael Aschner and colleagues from Vanderbilt University Medical Center, USA,  cellular processes affected by MeHg, including oxidative stress, cellular signaling and gene expression are reviewed and genetic, environmental and nutritional factors capable of modifying MeHg toxicity are discussed.

Read it here - its free to access!

Mechanisms and modifiers of methylmercury-induced neurotoxicity 
Stephanie J. B. Fretham, Samuel Caito, Ebany J. Martinez-Finley and Michael Aschner
Toxicol. Res., 2012, DOI:10.1039/C2TX20010D, Review 

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