Author Archive

Issue 6 now online

Graphical AbstractThe front cover of issue 6 features artwork by Charbel Gebraël and Catherine Jumarie from Université du Québec à Montréal. Gebraël and Jumarie determine how the Cd-induced hormesis-like effect on MTT activity in the Caco-2 cells is a differentiation stage-specific phenomenon that is not observed with xenobiotics acting as AhR ligands

Want to know more? Read the full article below – its free to access for the next 6 weeks!

C. Gebraël and C. Jumarie
Toxicol. Res., 2015, 4, 1488-1497
DOI: 10.1039/C5TX00284B

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And the time of death was?

Graphical AbstractScientists in Portugal have developed a tool to calculate the post-mortem interval (PMI) or ‘time of death’ of a cadaver from a blood sample.

Monitoring changes in body temperature, as well as the stages of rigor mortis are among the traditional methods currently used to estimate the PMI. But environmental fluctuations, such as temperature, can impact the rate at which these changes occur, reducing their reliability.

Read the full article in Chemistry World >>>


Promising blood-derived biomarkers for estimation of the postmortem interval
Isabel Costa, Félix Carvalho, Teresa Magalhães, Paula Guedes de Pinho, Ricardo Silvestre and Ricardo Jorge Dinis-Oliveira
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00209E, Paper

Do you fancy submitting an article to Toxicology Research? Why not submit to us here today or alternatively email us with your suggestions!

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HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

Viktoria Vágány and Andrew G. Smith
Toxicol. Res., 2015, 4, 1128-1142
DOI: 10.1039/C5TX00011D, Review Article

Graphical Abstract


Ugir Hossain Sk, Vikram Patial and Supriya Sharma
Toxicol. Res., 2015, 4, 1204-1213
DOI: 10.1039/C5TX00112A, Paper

Graphical Abstract


Jun Yan, Zhiqing Lin, Bencheng Lin, Honglian Yang, Wei Zhang, Lei Tian, Huanliang Liu, Huashan Zhang, Xiaohua Liu and Zhuge Xi
Toxicol. Res., 2015, 4, 1225-1237
DOI: 10.1039/C5TX00039D, Paper

Graphical Abstract


Ifigeneia V. Mavragani, Danae A. Laskaratou, Benjamin Frey, Serge M. Candéias, Udo S. Gaipl, Katalin Lumniczky and Alexandros G. Georgakilas
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00222B, Review Article

Graphical Abstract

Nigel Greene and William Pennie
Toxicol. Res., 2015, 4, 1159-1172
DOI: 10.1039/C5TX00055F, Review Article

Graphical Abstract


Nuan P. Cheah, Jeroen L.A. Pennings, Jolanda P. Vermeulen, Roger W.L. Godschalk, Frederik J. van Schooten and Antoon Opperhuizen
Toxicol. Res., 2015, 4, 1250-1259
DOI: 10.1039/C4TX00213J, Paper

Graphical Abstract


Jen-Yin Goh, Richard J. Weaver, Libby Dixon, Nicola J. Platt and Ruth A. Roberts
Toxicol. Res., 2015, 4, 1297-1307
DOI: 10.1039/C5TX00123D, Paper

Graphical Abstract

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Issue 5 now online!

Graphical AbstractThe front cover of issue 5 features artwork by  Shao-Chen Sun from Nanjing Agricultural University. With his colleagues, Shao-Chen explored possible mechanisms for the toxic effects of ZEN on pig oocytes. They cultured porcine oocytes to maturation in media with different ZEN concentrations (5–30 μM), after which they analyzed oocyte oxidative stress status, autophagy, early apoptosis, and epigenetic modifications by immunofluorescence, quantitative real-time PCR analysis and western blot approaches.

Want to know more? Read the full article below – its free to access for the next 6 weeks!

Jun Han, Ting Wang, Le Fu, Liang-Yu Shi, Cheng-Cheng Zhu, Jun Liu, Yu Zhang, Xiang-Shun Cui, Nam-Hyung Kim and Shao-Chen Sun
Toxicol. Res., 2015, 4, 1184-1194
DOI: 10.1039/C5TX00070J

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Top 10 most accessed Toxicology Research articles from April – June 2015

From April – June 2015, our most downloaded Toxicology Research articles were:

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014, 3, 418-432
DOI: 10.1039/C4TX00047A

Novel in vitro and mathematical models for the prediction of chemical toxicity

Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013, 2, 40-59
DOI: 10.1039/C2TX20031G

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012, 1, 62-68
DOI: 10.1039/C2TX20006F

Quantum dot induced cellular perturbations involving varying toxicity pathways
Abdullah Al-Ali, Neenu Singh, Bella Manshian, Tom Wilkinson, John Wills, Gareth J. S. Jenkins and Shareen H. Doak
Toxicol. Res., 2015, 4, 623-633
DOI: 10.1039/C4TX00175C

An introduction to systems toxicology
Nick J. Plant
Toxicol. Res., 2015, 4, 9-22
DOI: 10.1039/C4TX00058G

Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol
Parodi Daniela A, Sjarif Jasmine, Chen Yichang and Allard Patrick
Toxicol. Res., 2015, 4, 645-654
DOI: 10.1039/C4TX00141A

Contributors to the New Talents issue

Toxicol. Res., 2015, 4, 541-544
DOI: 10.1039/C5TX90009C
From themed collection New Talents

Uptake of gold nanoparticles in primary human endothelial cells
Henrik Klingberg, Lene B. Oddershede, Katrin Loeschner, Erik H. Larsen, Steffen Loft and Peter Møller
Toxicol. Res., 2015, 4, 655-666
DOI: 10.1039/C4TX00061G

Manganese-induced neurotoxicity: from C. elegans to humans

Pan Chen, Sudipta Chakraborty, Tanara V. Peres, Aaron B. Bowman and Michael Aschner
Toxicol. Res., 2015, 4, 191-202
DOI: 10.1039/C4TX00127C

Interaction of tannic acid with carbon nanotubes: enhancement of dispersibility and biocompatibility
Xiaoyong Zhang, Meiying Liu, Xiqi Zhang, Fengjie Deng, Cuiying Zhou, Junfeng Hui, Wanyun Liu and Yen Wei
Toxicol. Res., 2015, 4, 160-168
DOI: 10.1039/C4TX00066H

Interesting read? Let us know your thoughts below.

And remember, you can submit direct to Toxicology Research here

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Issue 4 now online!

Graphical Abstract

The front cover of issue 4 features artwork by Arthur Grollman (Stony Brook University, USA)  and Robert Turesky (University of Minnesota, USA). With their colleagues, Grollman and Turesky highlight novel approaches to quantify exposure to AA, by analysis of aristolactam (AL) DNA adducts, employing ultraperformance liquid chromatography–electrospray ionization/multistage mass spectrometry (UPLC-ESI/MSn).

Intesrested to know more? Read the full article below – its free to access for the next 6 weeks:

New approaches for biomonitoring exposure to the human carcinogen aristolochic acid
Byeong Hwa Yun, Viktoriya S. Sidorenko, Thomas A. Rosenquist, Kathleen G. Dickman, Arthur P. Grollman and Robert J. Turesky
Toxicol. Res., 2015, 4, 763-776
DOI: 10.1039/C5TX00052A


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HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

CpG site-specific RASSF1a hypermethylation is associated with occupational PAH exposure and genomic instability
Zhini He, Huawei Duan, Biao Zhang, Miao Li, Liping Chen, Bo Zhang, Xiaonian Zhu, Chen Gao, Jie Li, Xiao Zhang, Jingmaio Zhang, Shan Wang, Xiaowen Zeng, Daochuan Li, Xiumei Xing, Zhengbao Zhang, Lu Ma, Qing Bai, Caixia Liu, Yongmei Xiao, Yuxin Zheng and Wen Chen
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00013K

Graphical Abstract


Molecular modeling and spectroscopic study of quinone–protein adducts: insight into toxicity, selectivity, and reversibility
Mohamed Saleh Elgawish, Naoya Kishikawa, Mohamed A. Helal, Kaname Ohyama and Naotaka Kuroda
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00098J

Graphical Abstract


p, p’- Dichlorodiphenyltrichloroethane inhibits the apoptosis of colorectal adenocarcinoma DLD1 cells through PI3K/AKT and Hedgehog/Gli1 signaling pathways
Li Song, meirong zhao, Jianxin Liu, Zhuoyu Li, Hong Xiao and Weiping Liu
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00006H

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Poster prize winner at the 2nd Eco-toxicology conference 2015

Toxicology Research were delighted to sponsor a poster prize at the 2nd Eco-toxicology conference, which took place from the 25th – 28th April 2015 in Xiamen, China. Many congratulations to Liang-ying He (Guangzhou Institute of Geochemistry, Chinese Academy of Sciences) for winning this prize with their poster entitiled: “Dissemination of Antibiotic Resistance Genes in Representative Broiler Feedlots Environments: Identification of Indicator ARGs and Correlations with Environmental Variables“.

“Broiler feedlots may represent an important source of antibiotic resistance genes (ARGs) in the environment. However, the prevalence and dissemination mechanisms of various types of ARGs in the environment of broiler feedlots have not previously been identified. We examined the occurrence, abundance and variation of ARGs conferring resistance to chloramphenicols, sulfonamides and tetracyclines in the environments of two representative types of broiler feedlots (free range and indoor) and assessed their dissemination mechanisms. Horizontal gene transfer and co-selection were found to play important roles in ARG dissemination in the environment. fexA, sul1 and tetW could be reliable indicator genes to surrogate anthropogenic sources of ARGs in boiler feedlots. The distribution and transportation of ARGs from the boiler feedlots to the receiving environments were correlated with environmental variables. The findings highlight the contribution of some chemicals such as antibiotics and metals to the development of ARGs in broiler feedlots environments; and the observed ARG dissemination mechanism in the broiler feedlots facilitates the development of effective mitigation measures.”

Many congratulations to Liang-ying on receiving your prize

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Top 10 most accessed Toxicology Research articles from January – March 2015

From January – March 2015, our most downloaded Toxicology Research articles were:

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014,3, 418-432
DOI: 10.1039/C4TX00047A

Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013,2, 40-59
DOI: 10.1039/C2TX20031G

An introduction to systems toxicology
Nick J. Plant
Toxicol. Res., 2015,4, 9-22
DOI: 10.1039/C4TX00058G

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond

Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012,1, 62-68
DOI: 10.1039/C2TX20006F

DNA damage by oxo- and peroxo-chromium(v) complexes: insight into the mutation and carcinogenesis mechanisms
Lamis Judah, Roberto Marin, Diane Stroup, Chrys Wesdemiotis and Rathindra N. Bose
Toxicol. Res., 2014,3, 56-66
DOI: 10.1039/C3TX50061F

A comparative cytotoxicity study of TiO2 nanoparticles under light and dark conditions at low exposure concentrations

Swayamprava Dalai, Sunandan Pakrashi, R. S. Suresh Kumar, N. Chandrasekaran and Amitava Mukherjee
Toxicol. Res., 2012,1, 116-130
DOI: 10.1039/C2TX00012A

Interaction of tannic acid with carbon nanotubes: enhancement of dispersibility and biocompatibility

Xiaoyong Zhang, Meiying Liu, Xiqi Zhang, Fengjie Deng, Cuiying Zhou, Junfeng Hui, Wanyun Liu and Yen Wei
Toxicol. Res., 2015,4, 160-168
DOI: 10.1039/C4TX00066H

An unexpected increase of toxicity of amino acid-containing ionic liquids
Ksenia S. Egorova, Marina M. Seitkalieva, Alexandra V. Posvyatenko and Valentine P. Ananikov
Toxicol. Res., 2015,4, 152-159
DOI: 10.1039/C4TX00079J

Bicontinuous cubic phase nanoparticle lipid chemistry affects toxicity in cultured cells
Tracey M. Hinton, Felix Grusche, Durga Acharya, Ravi Shukla, Vipul Bansal, Lynne J. Waddington, Paul Monaghan and Benjamin W. Muir
Toxicol. Res., 2014,3, 11-22
DOI: 10.1039/C3TX50075F

New structural alerts for Ames mutagenicity discovered using emerging pattern mining techniques
Laurence Coquin, Steven J. Canipa, William C. Drewe, Lilia Fisk, Valerie J. Gillet, Mukesh Patel, Jeffrey Plante, Richard J. Sherhod and Jonathan D. Vessey
Toxicol. Res., 2015,4, 46-56
DOI: 10.1039/C4TX00071D

Interesting read? Let us know your thoughts below.

And remember, you can submit direct to Toxicology Research here

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Issue 3 now online!

Graphical Abstract

The front cover of issue 3 features artwork by Shareen H. Doak from Swansea University. With her colleagues Shareen asseses the impact of varying QD surface chemistry on cellular uptake and a range of indicators for cell perturbation following exposure.

Interested to know more? Read the full article below – its free to access for the next 6 weeks:

Quantum dot induced cellular perturbations involving varying toxicity pathways
Abdullah Al-Ali, Neenu Singh, Bella Manshian, Tom Wilkinson, John Wills, Gareth J. S. Jenkins and Shareen H. Doak
Toxicol. Res., 2015, 4, 623-633
DOI: 10.1039/C4TX00175C


This issue is a part-themed issue on the topic of New Talents. Click here to read the editorial by Professor Nigel Gooderham.

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