Author Archive

Top 10 most downloaded articles: July – September 2016

We are delighted to share with you the top 10 most downloaded articles in Toxicology Research from July–September 2016. These papers are free to access for the next two weeks with a free publishing personal account – register here.

Toxicology Research, led by Editor-in-Chief Professor Nigel Gooderham (Imperial College, London), is a multidisciplinary journal covering high impact research in fundamental, translational and applied areas of toxicology. The Journal is published by the Royal Society of Chemistry and is the official journal of the British Toxicology Society and the Chinese Society of Toxicology. More details about the journal, the scope and our author guidelines are available on our website.

We hope you enjoy reading these highly accessed articles, and we welcome your future submissions to the Journal.

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014, 3, 418-432
DOI: 10.1039/C4TX00047A

Characterization of a functional C3A liver spheroid model
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams and Steven D.Webb
Toxicol. Res., 2016, 5, 1053-1065
DOI: 10.1039/C6TX00101G

Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013, 2, 40-59
DOI: 10.1039/C2TX20031G

Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids
Katarzyna Wojdyla, Krzysztof Wrzesinski, James Williamson, Stephen J. Fey and Adelina Rogowska-Wrzesinska
Toxicol. Res., 2016, 5, 905-920
DOI: 10.1039/C5TX00469A

Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980–2013
Jen-Yin Goh, Richard J. Weaver, Libby Dixon, Nicola J. Platt and Ruth A. Roberts
Toxicol. Res., 2015, 4, 1297-1307
DOI: 10.1039/C5TX00123D

Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data
Chad H. G. Allen, Alexios Koutsoukas, Isidro Cortés-Ciriano, Daniel S. Murrell, Thérèse E. Malliavin, Robert C. Glen and Andreas Bender
Toxicol. Res., 2016, 5, 883-894
DOI: 10.1039/C5TX00406C

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012, 1, 62-68
DOI: 10.1039/C2TX20006F

Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
Emma Wincent, Florane Le Bihanic and Kristian Dreij
Toxicol. Res., 2016, 5, 788-799
DOI: 10.1039/C6TX00004E

In vitro models for liver toxicity testing
Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn
Toxicol. Res., 2013, 2, 23-39
DOI: 10.1039/C2TX20051A

Effects of monoolein-based cubosome formulations on lipid droplets and mitochondria of HeLa cells
Angela Maria Falchi, Antonella Rosa, Angela Atzeri, Alessandra Incani, Sandrina Lampis, Valeria Meli, Claudia Caltagirone and Sergio Murgia
Toxicol. Res., 2015, 4, 1025-1036
DOI: 10.1039/C5TX00078E

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Q2 Top 10 for Toxicology Research

Functional assessments in repeat-dose toxicity studies: the art of the possible 
Will S. Redfern, Lorna C. Ewart, Pierre Lainée, Mark Pinches, Sally Robinson and Jean-Pierre Valentin  
Toxicol. Res., 2013, 2, 209-234  
DOI: 10.1039/C3TX20093K 

In vitro models for liver toxicity testing  
Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn    
Toxicol. Res., 2013, 2, 23-39  
DOI: 10.1039/C2TX20051A 

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond  
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei 
Toxicol. Res., 2012, 1, 62-68  
DOI: 10.1039/C2TX20006F 

High throughput glutathione and Nrf2 assays to assess chemical and biological reactivity of cysteine-reactive compounds  
Russell T. Naven, Sheila Kantesaria, Sashi Nadanaciva, Thomas Schroeter and Karen L. Leach  
Toxicol. Res., 2013, 2, 235-244  
DOI: 10.1039/C3TX50027F 

Novel in vitro and mathematical models for the prediction of chemical toxicity 
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton  
Toxicol. Res., 2013, 2, 40-59  
DOI: 10.1039/C2TX20031G 

Corona protein composition and cytotoxicity evaluation of ultra-small zeolites synthesized from template free precursor suspensions 
S. Laurent, E.-P. Ng, C. Thirifays, L. Lakiss, G.-M. Goupil, S. Mintova, C. Burtea, E. Oveisi, C. Hébert, M. de Vries, M. M. Motazacker, F. Rezaee and M. Mahmoudi  
Toxicol. Res., 2013, 2, 270-279  
DOI: 10.1039/C3TX50023C 

Role of NF-κB in the oxidative stress-induced lung inflammatory response to iron and selenium at ambient levels  
Pushya A. Potnis, Robert Mitkus, Ahmed Elnabawi, Katherine Squibb and Jan L. Powell 
Toxicol. Res., 2013, 2, 259-269  
DOI: 10.1039/C3TX50012H 

Mechanisms of lead and manganese neurotoxicity  
April P. Neal and Tomas R. Guilarte  
Toxicol. Res., 2013, 2, 99-114  
DOI: 10.1039/C2TX20064C 

A comparative cytotoxicity study of TiO2 nanoparticles under light and dark conditions at low exposure concentrations  
Swayamprava Dalai, Sunandan Pakrashi, R. S. Suresh Kumar, N. Chandrasekaran and Amitava Mukherjee   
Toxicol. Res., 2012, 1, 116-130  
DOI: 10.1039/C2TX00012A 

Chronic ethanol and high glucose inducible CYP2E1 mediated oxidative stress leads to greater cellular injury in VL-17A cells: a potential mechanism for liver injury due to chronic alcohol consumption and hyperglycemia  
Kavitha Swaminathan, S. Mathan Kumar, Dahn L. Clemens and Aparajita Dey   
Toxicol. Res., 2013, 2, 245-258  
DOI: 10.1039/C3TX50016K

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Potential mechanism for liver injury due to chronic alcohol consumption and hyperglycemia

Scientists from India have examined the roles of alcohol and high glucose levels on ethanol metabolizing enzymes and how such conditions can promote oxidative stress and cellular damage. Diabetes, characterized by the presence of inherent oxidative stress, may be further complicated by the additional oxidative stress generated due to the metabolism of alcohol.

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Chronic ethanol and high glucose inducible CYP2E1 mediated oxidative stress leads to greater cellular injury in VL-17A cells: a potential mechanism for liver injury due to chronic alcohol consumption and hyperglycemia
Kavitha Swaminathan, S. Mathan Kumar, Dahn L. Clemens and Aparajita Dey
Toxicol. Res., 2013, Advance Article, 2013 
DOI: 10.1039/C3TX50016K

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