10 most downloaded articles: April – June 2017

We are delighted to share with you the top 10 most downloaded articles in Toxicology Research  from April – June 2017. These papers are free to access for the next two weeks with a free publishing personal account – register here.

We hope you enjoy reading these highly accessed articles, and we welcome your future submissions to the journal.

Statistical evaluation of toxicological bioassays – a review 
Ludwig A. Hothorn
Toxicol. Res., 2014, 3, 418-432
DOI: 10.1039/C4TX00047A

Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980–2013 
Jen-Yin Goh, Richard J. Weaver, Libby Dixon, Nicola J. Platt and Ruth A. Roberts
Toxicol. Res., 2015, 4, 1297-1307
DOI: 10.1039/C5TX00123D

Characterization of a functional C3A liver spheroid model 
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams and Steven D. Webb
Toxicol. Res., 2016, 5, 1053-1065
DOI: 10.1039/C6TX00101

Novel in vitro and mathematical models for the prediction of chemical toxicity 
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013, 2, 40-59
DOI: 10.1039/C2TX20031G

Quantifying the pharmaceutical industry’s contribution to published 3Rs research 2002–2012
Seth Cunningham, Nicola Partridge, Nicola Platt and Ruth A. Roberts
Toxicol. Res., 2015, 4, 311-316
DOI: 10.1039/C4TX00100A

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi 
Vilmos Csizmadia, Paul Hales, Christopher Tsu, Jingya Ma, Jiejin Chen, Pooja Shah, Paul Fleming, Joseph J. Senn, Vivek J. Kadambi, Larry Dick and Francis S. Wolenski
Toxicol. Res., 2016, 5, 1619-1628
DOI: 10.1039/C6TX00220J

Effects of monoolein-based cubosome formulations on lipid droplets and mitochondria of HeLa cells 
Angela Maria Falchi, Antonella Rosa, Angela Atzeri, Alessandra Incani, Sandrina Lampis, Valeria Meli, Claudia Caltagirone and Sergio Murgia
Toxicol. Res., 2015, 4, 1025-1036
DOI: 10.1039/C5TX00078E

Gender specific differences in the liver proteome of rats exposed to short term and low-concentration hexabromocyclododecane (HBCD) 
I. Miller, C. Diepenbroek, E. Rijntjes, J. Renaut, K. J. Teerds, C. Kwadijk, S. Cambier, A. J. Murk, A. C. Gutleb and T. Serchi
Toxicol. Res., 2016, 5, 1273-1283
DOI: 10.1039/C6TX00166A

Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
Emma Wincent, Florane Le Bihanic and Kristian Dreij
Toxicol. Res., 2016, 5, 788-799
DOI: 10.1039/C6TX00004E

Evaluating the effects of nacre on human skin and scar cells in culture
Vipul Agarwal, Edwin S. Tjandra,  K. Swaminathan Iyer, Barry Humfrey, Mark Fear, Fiona M. Wood,  Sarah Dunlop and Colin L. Raston
Toxicol. Res., 2014, 3, 223-227
DOI: 10.1039/C4TX00004H

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