The front cover of issue 5 features artwork by Shao-Chen Sun from Nanjing Agricultural University. With his colleagues, Shao-Chen explored possible mechanisms for the toxic effects of ZEN on pig oocytes. They cultured porcine oocytes to maturation in media with different ZEN concentrations (5–30 μM), after which they analyzed oocyte oxidative stress status, autophagy, early apoptosis, and epigenetic modifications by immunofluorescence, quantitative real-time PCR analysis and western blot approaches.
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