Potential mechanism for liver injury due to chronic alcohol consumption and hyperglycemia

Scientists from India have examined the roles of alcohol and high glucose levels on ethanol metabolizing enzymes and how such conditions can promote oxidative stress and cellular damage. Diabetes, characterized by the presence of inherent oxidative stress, may be further complicated by the additional oxidative stress generated due to the metabolism of alcohol.

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Chronic ethanol and high glucose inducible CYP2E1 mediated oxidative stress leads to greater cellular injury in VL-17A cells: a potential mechanism for liver injury due to chronic alcohol consumption and hyperglycemia
Kavitha Swaminathan, S. Mathan Kumar, Dahn L. Clemens and Aparajita Dey
Toxicol. Res., 2013, Advance Article, 2013 
DOI: 10.1039/C3TX50016K

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