Featuring in this issue:
– A review by Joao B. T. Rocha et al. covering the extreme sensitivity of aminolevulinate dehydratase (δ-ALA-D) to oxidation or inhibition by soft-electrophiles (Pb, Hg, etc) and pro-oxidant situations found in human pathologies, and discusses the fact that the enzyme can be considered a universal marker of oxidative stress.
Aminolevulinate dehydratase (δ-ALA-D) as marker protein of intoxication with metals and other pro-oxidant situations
Joao B. T. Rocha, Rogerio A. Saraiva, Solange C. Garcia, Fernanda S. Gravina and Cristina W. Nogueira
– A paper by Amitava Mukherjee et al. exploring the difference in toxicity mechanism of TiO2 nanoparticles at low concentrations in a freshwater bacterial isolate, Bacillus licheniformis, under light (UV-illuminated) and dark (non-illuminated) conditions.
A comparative cytotoxicity study of TiO2 nanoparticles under light and dark conditions at low exposure concentrations
Swayamprava Dalai, Sunandan Pakrashi, R. S. Suresh Kumar, N. Chandrasekaran and Amitava Mukherjee
– A paper by Heather Wallace et al. examining the influence of cyclo-oxygenase (COX) expression on the effects of naproxen on cytotoxicity and upon polyamine metabolism in human colorectal cancer cells in vitro.
Naproxen causes cytotoxicity and induces changes in polyamine metabolism independent of cyclo-oxygenase expression
Alun Hughes, Fiona R. Saunders and Heather M. Wallace
All articles published in 2012 and 2013 are free to access.