Finding alternatives to animal testing is currently a large area of investigation. However, once an alternative method has been developed it must undergo a validation process where it is evaluated for such things as its quality, transferability and predictivity. This means that there can be long delays before the method can be implemented. As such different ways to evaluate a method’s suitability and quality have been proposed.
This review by Marcel Leist, Nina Hasiwa, Mardas Daneshian and Thomas Hartung, discusses the principles of model development and quality control as well as giving an overview on alternative methods to animal testing that have under gone validation. Leist et al. go on to discuss the strengths and weaknesses of current traditional approaches for validation and outline new developments and challenges in the area.
Validation and quality control of replacement alternatives – current status and future challenges
Marcel Leist, Nina Hasiwa, Mardas Daneshian and Thomas Hartung
Toxicol. Res., 2012, Advance Article
DOI: 10.1039/C2TX20011B
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If you want to read more from Thomas Hartung, check out his opinion piece in Chemistry World: http://www.rsc.org/chemistryworld/2012/05/21st-century-toxicology
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