HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

Graphical Abstract

Lack of effect of metofluthrin and sodium phenobarbital on replicative DNA synthesis and Ki-67 mRNA expression in cultured human hepatocytes
Tomoya Yamada, Hiroko Kikumoto, Brian G. Lake and Satoshi Kawamura
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00217B

An Introduction to Systems Toxicology
Nick J. Plant
Toxicol. Res., 2015, 4, 9-22
DOI: 10.1039/C4TX00058G

Reproducibility in Experimentation – the implications for regulatory toxicology.
Sir Colin Berry
Toxicol. Res., 2014, 3, 411-417
DOI: 10.1039/C4TX00069B

Graphical Abstract

Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol.
Parodi Daniela A, Sjarif Jasmine, Chen Yichang and Allard Patrick
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C4TX00141A

Cerium dioxide nanoparticles protect against oxidative stress induced injury through modulation of TGF-ß signalling
Chang Guo, Rachel Smith, Timothy W. Gant and Martin O. Leonard
Toxicol. Res., 2015,4, 464-475
DOI: 10.1039/C4TX00210E

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Top 10 most accessed Toxicology Research articles from October – December 2014

From October – December 2014, our most downloaded Toxicology Research articles were:

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014, 3, 418-432
DOI
: 10.1039/C4TX00047A

Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013, 2, 40-59
DOI: 10.1039/C2TX20031G

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012, 1, 62-68
DOI: 10.1039/C2TX20006F

The ex vivo neurotoxic, myotoxic and cardiotoxic activity of cucurbituril-based macrocyclic drug delivery vehicles
Rabbab Oun, Rafael S. Floriano, Lyle Isaacs, Edward G. Rowan and Nial J. Wheate
Toxicol. Res., 2014, 3, 447-455
DOI: 10.1039/C4TX00082J

In vitro models for liver toxicity testing
Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn
Toxicol. Res., 2013, 2, 23-39
DOI: 10.1039/C2TX20051A

Surfactant-dispersed nanodiamond: biocompatibility evaluation and drug delivery applications
Xiaoyong Zhang, ShiQi Wang, Meiying Liu, Junfeng Hui, Bin Yang, Lei Tao and Yen Wei
Toxicol. Res., 2013, 2, 335-342
DOI: 10.1039/C3TX50021G

Translation of off-target effects: prediction of ADRs by integrated experimental and computational approach
Laszlo Urban, Mateusz Maciejewski, Eugen Lounkine, Steven Whitebread, Jeremy L. Jenkins, Jacques Hamon, Alexander Fekete and Patrick Y. Muller
Toxicol. Res., 2014, 3, 433-444
DOI: 10.1039/C4TX00077C

The toxicological assessment of two anti-obesity drugs in C. elegans
Layla Aitlhadj and Stephen R. Stürzenbaum
Toxicol. Res., 2013, 2, 145-150
DOI: 10.1039/C2TX20096A

A comparative cytotoxicity study of TiO2 nanoparticles under light and dark conditions at low exposure concentrations
Swayamprava Dalai, Sunandan Pakrashi, R. S. Suresh Kumar, N. Chandrasekaran and Amitava Mukherjee
Toxicol. Res., 2012, 1, 116-130
DOI: 10.1039/C2TX00012A

Evidence based housekeeping gene selection for microRNA-sequencing (miRNA-seq) studies
D. P. Tonge and T. W. Gant
Toxicol. Res., 2013, 2, 328-334
DOI: 10.1039/C3TX50034A

Interesting read? Let us know your thoughts below.

And remember, you can submit direct to Toxicology Research here

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Issue 2 now online!

Graphical Abstract

The front cover of issue 2 feautures artwork by P. Sreenivasula Reddy from Sri Venkateswara University. With his colleagues, P. Sreenivasula Reddy evaluates reproductive toxic effects of benzo(a)pyrene (BaP) in adult male Wistar rats.

Interested to know more? Read the full article below – its free to access for the next 6 weeks:

Reproductive and paternal mediated developmental toxicity of benzo(a)pyrene in adult male Wistar rats
K. Pratap Reddy, B. P. Girish and P. Sreenivasula Reddy
Toxicol. Res., 2015, 4, 223-232
DOI: 10.1039/C4TX00121D


Keep up-to-date with the latest content in Toxicology Research by registering for our free table of contents alerts.

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Toxicology Research at SOT 2015

Members of the Toxicology Research Editorial team will be attending the SOT meeting in San Diego from March 22–26th. We’d be delighted to meet with you there to discuss your research, so please do drop by our booth (#2143) to meet our Editors Jen Griffiths and Rowan Frame (Toxicology Series books). Or email us to schedule a meeting. We would be very pleased to hear from you.

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Ahead of the meeting, we have collated some of our hottest papers here. These papers are free to access until 31st March – we do hope that you enjoy reading them.


Reproducibility in experimentation – the implications for regulatory toxicologyToxicology Research
Sir Colin Berry
Toxicol. Res., 2014, 3, 411–417, DOI: 10.1039/C4TX00069B, Review


An introduction to systems toxicology
Nick J. Plant
Toxicol. Res., 2015, 4, 9–22, DOI: 10.1039/C4TX00058G Review


An emerging platform from renewable resources: selection guidelines for human exposure of furfural-related compounds
R. F. M. Frade, J. A. S. Coelho, S. P. Simeonov and C. A. M. Afonso
Toxicol. Res., 2014, 3, 311–314, DOI: 10.1039/C4TX00019F, Communication


Genes involved in the induction of liver growth by peroxisome proliferators
Abeer H. A. Amer, Richard J. Wall, Sunir Malla, Fei Sang, Aziz Aboobaker, Simon V. Avery, Ian R. Mellor, Martin D. Rose, J. Craig Rowlands, Timothy W. Gant and David R. Bell
Toxicol. Res., 2014, 3, 315–323, DOI: 10.1039/C3TX50110H, Paper


AhR is negatively regulated by miR-203 in response to TCDD or BaP treatment
Daochuan Li, Caixia Liu, Haohui Yu, Xiaowen Zeng, Xiumei Xing, Liping Chen, Chen Gao, Zhengbao Zhang, Yongmei Xiao, Huawei Duan, Yuxin Zheng, Qing Wang and Wen Chen
Toxicol. Res., 2014, 3, 142–151, DOI: 10.1039/C3TX50083G, Paper


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Recently published books in the Issues in Toxicology Series:

You can read the first chapter for free through your Personal RSC Publishing Account


Manganese in Health and Disease: Editor(s): Lucio Costa, Michael Aschner

Manganese in Health and Disease

Lucio Costa (Editor), Michael Aschner (Editor)

ISBN: 978-1-84973-943-6

The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases.

Metabolic Profiling : Disease and Xenobiotics. Editor: Martin Grootveld

Metabolic Profiling: Disease and Xenobiotics

Martin Grootveld (Editor)

ISBN: 978-1-84973-163-8

Multivariate analysis of the multi-component analytical profiles of carefully collected biofluid and/or tissue biopsy specimens can provide a ‘fingerprint’ of their biomolecular/metabolic status. This exemplary new book highlights applications of these techniques in the areas of drug therapy and toxicology, cancer, obesity and diabetes, as well as outlining applications to cardiovascular, infectious, inflammatory and oral diseases in detail.

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EUROTOX 2014 conference

Professors Heather Wallace and Arstidis Tsatsakis at the Closing Ceremony of EUROTOX 2014

Professors Heather Wallace and Aristidis Tsatsakis at the Closing Ceremony of EUROTOX 2014

The 50th Congress of the European Societies of Toxicology (EUROTOX 2014) was held in Edinburgh this September. The Conference was presided by Professor Heather Wallace (Toxicology Research Editorial Board member) had an exciting programme with keynote lectures from Professor Roland Wolf and Professor Allister Vale, plenary lectures, symposia and workshops. In addition, there were state-of-the-art interactive poster sessions on large screens which were very popular with the delegates.

Katharina Dach (right) is presented with a Toxicology Research Poster Prize at Eurotox, Presented by Professor Nigel Gooderham (left) and Professor Aristidis Tsatsakis (centre)

Katharina Dach (right) wins the Toxicology Research Poster Prize at Eurotox and is presented with the prize by Toxicology Research Editor-in-Chief Professor Nigel Gooderham (left) and Professor Aristidis Tsatsakis (centre)

Toxicology Research was delighted to sponsor a poster prize at the event which was awarded to Katharina Dach (pictured right) from IUF Leibniz Institute for Environmental Medicine, Dusseldorf, Germany for her poster entitled ”Of mice and men: Mechanistic studies on the developmental neurotoxicity of polybrominated diphenyl ethers (PDBEs) in a 3D in vitro model”. Many congratulations to Katharina on receiving this prize.

Preparations for the 2015 event in Porto, Portugal, are already well underway. More details can be found on the website: http://eurotox2015.com/

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Recent HOT Toxicology Research articles

The following are HOT articles, as recommened by the reviewers of the articles. These have all been made free to access until 24th October:

Evaluation of changes in monoamine levels and apoptosis induced by cyfluthrin in rats
Dilek Guvenc, Abdurrahman Aksoy, Ayhan Gacar, Enes Atmaca, Kursad Y. Das and Tolga Guvenc
Toxicol. Res., DOI: 10.1039/C4TX00041B, Paper


MicroRNA-34c-3p is an early predictive biomarker for doxorubicin-induced glomerular injury progression in male Sprague-Dawley rats
Rachel J. Church, J. Eric McDuffie, Manisha Sonee, Monicah Otieno, Jing Ying Ma, Xuejun Liu, Paul B. Watkins and Alison H. Harrill
Toxicol. Res., 2014, 3, 384-394
DOI: 10.1039/C4TX00051J, Paper


Elevation of the intracellular Zn2+ level by 2-n-octyl-4-isothiazolin-3-one in rat thymocytes: an involvement of a temperature-sensitive Zn2+ pathway
Eri Fukunaga, Tomohiro M. Oyama and Yasuo Oyama
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00060A, Paper


An introduction to systems toxicology
Nick J. Plant
Toxicol. Res., 2014, Advance Article
DOI: 10.1039/C4TX00058G, Review Article

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Q2 Top Ten most accessed Toxicology Research articles

During the months April – June 2014, the most downloaded Toxicology Research articles were:

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012, 1, 62-68
DOI: 10.1039/C2TX20006F

In vitro models for liver toxicity testing
Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn
Toxicol. Res., 2013, 2, 23-39
DOI: 10.1039/C2TX20051A

Bicontinuous cubic phase nanoparticle lipid chemistry affects toxicity in cultured cells
Tracey M. Hinton, Felix Grusche, Durga Acharya, Ravi Shukla, Vipul Bansal, Lynne J. Waddington, Paul Monaghan and Benjamin W. Muir
Toxicol. Res., 2014, 3, 11-22
DOI: 10.1039/C3TX50075F

Cellular responses of aniline oligomers: a preliminary study
Xiaoyong Zhang, Hongxu Qi, Shiqi Wang, Lin Feng, Yan Ji, Lei Tao, Shuxi Li and Yen Wei
Toxicol. Res., 2012, 1, 201-205
DOI: 10.1039/C2TX20035J

Functional assessments in repeat-dose toxicity studies: the art of the possible
Will S. Redfern, Lorna C. Ewart, Pierre Lainée, Mark Pinches, Sally Robinson and Jean-Pierre Valentin
Toxicol. Res., 2013, 2, 209-234
DOI: 10.1039/C3TX20093K

Safety biomarkers for drug-induced liver injury – current status and future perspectives
Daniel J. Antoine, Alison H. Harrill, Paul B. Watkins and B. Kevin Park
Toxicol. Res., 2014, 3, 75-85
DOI: 10.1039/C3TX50077B

Evidence based housekeeping gene selection for microRNA-sequencing (miRNA-seq) studies
D. P. Tonge and T. W. Gant
Toxicol. Res., 2013, 2, 328-334
DOI: 10.1039/C3TX50034A

High throughput glutathione and Nrf2 assays to assess chemical and biological reactivity of cysteine-reactive compounds
Russell T. Naven, Sheila Kantesaria, Sashi Nadanaciva, Thomas Schroeter and Karen L. Leach
Toxicol. Res., 2013, 2, 235-244
DOI: 10.1039/C3TX50027F

After trypsinisation, 3D spheroids of C3A hepatocytes need 18 days to re-establish similar levels of key physiological functions to those seen in the liver
Krzysztof Wrzesinski and Stephen J. Fey
Toxicol. Res., 2013, 2, 123-135
DOI: 10.1039/C2TX20060K

Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013, 2, 40-59
DOI: 10.1039/C2TX20031G

Interesting read? Please share your thoughts below!

And remember, you can submit direct to Toxicology Research here

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Alan Boobis delivers Royal Society of Chemistry Toxicology Award Lecture

Toxicology Research Advisory Board member Professor Alan Boobis received the Royal Society of Chemistry’s Toxicology Award earlier this year, giving his lecture at the Toxicology Award Symposium in May in London. Professor Boobis received the award for his work on the human metabolism of carcinogens and his extensive involvement in scientific committees for the UK Government, the European Commission and internationally. You can view his full lecture below.





Other lectures from the day can be viewed on the Royal Society of Chemistry’s Toxicology Group Symposium page (note that you can also view Professor Boobis’s lecture there if the above video does not play in your browser), and you can find out more about the group’s work and activities on their pages.

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And of course you can always come back to this blog to find out about our journal news.

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Q1 Top Ten most accessed Toxicology Research articles

During January, February and March this year, the following articles were the Top Ten most accessed:

Safety biomarkers for drug-induced liver injury – current status and future perspectives
Daniel J. Antoine, Alison H. Harrill, Paul B. Watkins and B. Kevin Park  
Toxicol. Res., 2014,3, 75-85
DOI: 10.1039/c3tx50077b

In vitro models for liver toxicity testing
Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn
Toxicol. Res., 2013,2, 23-39
DOI: 10.1039/c2tx20051a

The role of chemistry in developing understanding of adverse outcome pathways and their application in risk assessment
Steve Gutsell and Paul Russell  
Toxicol. Res., 2013,2, 299-307
DOI: 10.1039/c3tx50024a

Evaluation of copper iodide and copper phosphate nanoparticles for their potential cytotoxic effect
Dipranjan Laha, Debalina Bhattacharya, Arindam Pramanik, Chitta Ranjan Santra, Panchanan Pramanik and Parimal Karmakar  
Toxicol. Res., 2012,1, 131-136
DOI: 10.1039/c2tx00009a

Functional assessments in repeat-dose toxicity studies: the art of the possible
Will S. Redfern, Lorna C. Ewart, Pierre Lainée, Mark Pinches, Sally Robinson and Jean-Pierre Valentin  
Toxicol. Res., 2013,2, 209-234
DOI: 10.1039/c3tx20093k

High throughput glutathione and Nrf2 assays to assess chemical and biological reactivity of cysteine-reactive compounds
Russell T. Naven, Sheila Kantesaria, Sashi Nadanaciva, Thomas Schroeter and Karen L. Leach  
Toxicol. Res., 2013,2, 235-244
DOI: 10.1039/c3tx50027f

Bicontinuous cubic phase nanoparticle lipid chemistry affects toxicity in cultured cells
Tracey M. Hinton, Felix Grusche, Durga Acharya, Ravi Shukla, Vipul Bansal, Lynne J. Waddington, Paul Monaghan and Benjamin W. Muir  
Toxicol. Res., 2014,3, 11-22
DOI: 10.1039/c3tx50075f

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei  
Toxicol. Res., 2012,1, 62-68
DOI: 10.1039/c2tx20006f

Evidence based housekeeping gene selection for microRNA-sequencing (miRNA-seq) studies
D. P. Tonge and T. W. Gant  
Toxicol. Res., 2013,2, 328-334
DOI: 10.1039/c3tx50034a

Comparative cytotoxicity of cadmium forms (CdCl2, CdO, CdS micro- and nanoparticles) in renal cells
Béatrice L’Azou, Isabelle Passagne, Sandra Mounicou, Mona Tréguer-Delapierre, Igor Puljalté, Joanna Szpunar, Ryszard Lobinski and Céline Ohayon-Courtès  
Toxicol. Res., 2014,3, 32-41
DOI: 10.1039/c3tx50063b

If you have any comments on any of these articles we’d love to hear them, so please leave these in the comment box below!

Do you have any article which is ready to submit to Toxicology Research? Why not submit to us here today!

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