HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

Viktoria Vágány and Andrew G. Smith
Toxicol. Res., 2015, 4, 1128-1142
DOI: 10.1039/C5TX00011D, Review Article

Graphical Abstract


Ugir Hossain Sk, Vikram Patial and Supriya Sharma
Toxicol. Res., 2015, 4, 1204-1213
DOI: 10.1039/C5TX00112A, Paper

Graphical Abstract


Jun Yan, Zhiqing Lin, Bencheng Lin, Honglian Yang, Wei Zhang, Lei Tian, Huanliang Liu, Huashan Zhang, Xiaohua Liu and Zhuge Xi
Toxicol. Res., 2015, 4, 1225-1237
DOI: 10.1039/C5TX00039D, Paper

Graphical Abstract


Ifigeneia V. Mavragani, Danae A. Laskaratou, Benjamin Frey, Serge M. Candéias, Udo S. Gaipl, Katalin Lumniczky and Alexandros G. Georgakilas
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00222B, Review Article

Graphical Abstract

Nigel Greene and William Pennie
Toxicol. Res., 2015, 4, 1159-1172
DOI: 10.1039/C5TX00055F, Review Article

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Nuan P. Cheah, Jeroen L.A. Pennings, Jolanda P. Vermeulen, Roger W.L. Godschalk, Frederik J. van Schooten and Antoon Opperhuizen
Toxicol. Res., 2015, 4, 1250-1259
DOI: 10.1039/C4TX00213J, Paper

Graphical Abstract


Jen-Yin Goh, Richard J. Weaver, Libby Dixon, Nicola J. Platt and Ruth A. Roberts
Toxicol. Res., 2015, 4, 1297-1307
DOI: 10.1039/C5TX00123D, Paper

Graphical Abstract

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Issue 5 now online!

Graphical AbstractThe front cover of issue 5 features artwork by  Shao-Chen Sun from Nanjing Agricultural University. With his colleagues, Shao-Chen explored possible mechanisms for the toxic effects of ZEN on pig oocytes. They cultured porcine oocytes to maturation in media with different ZEN concentrations (5–30 μM), after which they analyzed oocyte oxidative stress status, autophagy, early apoptosis, and epigenetic modifications by immunofluorescence, quantitative real-time PCR analysis and western blot approaches.

Want to know more? Read the full article below – its free to access for the next 6 weeks!

Jun Han, Ting Wang, Le Fu, Liang-Yu Shi, Cheng-Cheng Zhu, Jun Liu, Yu Zhang, Xiang-Shun Cui, Nam-Hyung Kim and Shao-Chen Sun
Toxicol. Res., 2015, 4, 1184-1194
DOI: 10.1039/C5TX00070J

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AsFAs: a lesser known class of arsenolipids, are they toxic as well?

Seafood is a major source of heavy metal toxicity worldwide. In mid 20th century, Japan witnessed two most dramatic and emotionally moving cases of industrial pollution in history, Minimata disease and Itai itai disease caused by Mercury and  Cadmium contamination respectively. Arsenic is yet another example of toxic heavy metal found in marine food. Arsenic content in marine food is up to 100-fold higher than in terrestrial food and arsenic is mostly present as organic species as arsenobetaine, arsenosugars and arsenolipids.

The classes of arsenolipids include arsenic containing hydrocarbons (AsHCs), arsenosugars-phospholipids (AsPLs), cationic trimethylarsonio fatty alcohols as well as  arsenic-containing fatty acids (AsFAs). AsFAs consist of a polar dimethylarsinoyl group and a carboxylic acid with a long hydrocarbon chain (saturated or unsaturated) in the middle. AsFAs were identified in several cod liver oil samples, in edible fish like herring or red mullet and in brown algae.

AsFAs and metabolites

In a recent article published in Toxicology Research by Schwerdtle et al. from University of Münster, the thorough assessment conducted for in vitro toxicological profiling of AsFAs and their three metabolites ( DMAV, DMAPr and thio-DMAPr) is illustrated. The study involved cytotoxicity , bioavailability and genotoxicity analysis of a satutared and an unsaturated arsenic-containing fatty acid for the first time in human liver cells (HepG2). Also, the toxicity of the three metabolites was characterised in human liver cells and urothelial (UROtsa) cells.

‘ Saturated and unsaturated AsFAs exert cytotoxicity in human liver cells, although they are less toxic than iAsIII and do not show any genotoxic effects’, conclude Schwerdtle et al.

To find out more about the in vitro toxicological analysis of AsFAs, read the the full article for free* by following the link.

In vitro toxicological characterisation of arsenic-containing fatty acids and three of their metabolites

S. Meyer, G. Raber, F. Ebert, L. Leffers, S. M. Müller, M. S. Taleshi, K. A. Francesconi and T. Schwerdtle

Toxicol. Res., 2015, Advance Article

DOI: 10.1039/C5TX00122F

About the webwriter
Sushil Benke is a graduate student under the supervision of Dr. H. N. Gopi in the Department of Chemistry at Indian Institute of Science Education and Research (IISER), Pune. His research focuses on the development of novel antimicrobial peptidomimetics.

*Access is free through a registered RSC account.

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Top 10 most accessed Toxicology Research articles from April – June 2015

From April – June 2015, our most downloaded Toxicology Research articles were:

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014, 3, 418-432
DOI: 10.1039/C4TX00047A

Novel in vitro and mathematical models for the prediction of chemical toxicity

Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013, 2, 40-59
DOI: 10.1039/C2TX20031G

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012, 1, 62-68
DOI: 10.1039/C2TX20006F

Quantum dot induced cellular perturbations involving varying toxicity pathways
Abdullah Al-Ali, Neenu Singh, Bella Manshian, Tom Wilkinson, John Wills, Gareth J. S. Jenkins and Shareen H. Doak
Toxicol. Res., 2015, 4, 623-633
DOI: 10.1039/C4TX00175C

An introduction to systems toxicology
Nick J. Plant
Toxicol. Res., 2015, 4, 9-22
DOI: 10.1039/C4TX00058G

Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol
Parodi Daniela A, Sjarif Jasmine, Chen Yichang and Allard Patrick
Toxicol. Res., 2015, 4, 645-654
DOI: 10.1039/C4TX00141A

Contributors to the New Talents issue

Toxicol. Res., 2015, 4, 541-544
DOI: 10.1039/C5TX90009C
From themed collection New Talents

Uptake of gold nanoparticles in primary human endothelial cells
Henrik Klingberg, Lene B. Oddershede, Katrin Loeschner, Erik H. Larsen, Steffen Loft and Peter Møller
Toxicol. Res., 2015, 4, 655-666
DOI: 10.1039/C4TX00061G

Manganese-induced neurotoxicity: from C. elegans to humans

Pan Chen, Sudipta Chakraborty, Tanara V. Peres, Aaron B. Bowman and Michael Aschner
Toxicol. Res., 2015, 4, 191-202
DOI: 10.1039/C4TX00127C

Interaction of tannic acid with carbon nanotubes: enhancement of dispersibility and biocompatibility
Xiaoyong Zhang, Meiying Liu, Xiqi Zhang, Fengjie Deng, Cuiying Zhou, Junfeng Hui, Wanyun Liu and Yen Wei
Toxicol. Res., 2015, 4, 160-168
DOI: 10.1039/C4TX00066H

Interesting read? Let us know your thoughts below.

And remember, you can submit direct to Toxicology Research here

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Issue 4 now online!

Graphical Abstract

The front cover of issue 4 features artwork by Arthur Grollman (Stony Brook University, USA)  and Robert Turesky (University of Minnesota, USA). With their colleagues, Grollman and Turesky highlight novel approaches to quantify exposure to AA, by analysis of aristolactam (AL) DNA adducts, employing ultraperformance liquid chromatography–electrospray ionization/multistage mass spectrometry (UPLC-ESI/MSn).

Intesrested to know more? Read the full article below – its free to access for the next 6 weeks:

New approaches for biomonitoring exposure to the human carcinogen aristolochic acid
Byeong Hwa Yun, Viktoriya S. Sidorenko, Thomas A. Rosenquist, Kathleen G. Dickman, Arthur P. Grollman and Robert J. Turesky
Toxicol. Res., 2015, 4, 763-776
DOI: 10.1039/C5TX00052A


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Toxicology Research 2014 Impact Factor

Toxicology Research 2014 Impact Factor is 3.98We are pleased to announce that the latest Impact Factor* for Toxicology Research is 3.98, according to the 2014 Journal Citation Reports ® (JCR). This is the first full Impact Factor for the Journal, placing us in the Top Ten of the JCR “toxicology” subject category.

We would like to thank all of our authors, referees, Editorial Board and Advisory Board for their contributions to the success of the Journal.

Click here to find out how other Royal Society of Chemistry journals performed in the latest Impact Factor release.

*The Impact Factor provides an indication of the average number of citations per paper. Produced annually, Impact Factors are calculated by dividing the number of citations in a year by the number of citeable articles published in the preceding two years.

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HOT articles in Toxicology Research

Take a look at our recent HOT Toxicology Research articles, these are now free to access for the next few weeks!

CpG site-specific RASSF1a hypermethylation is associated with occupational PAH exposure and genomic instability
Zhini He, Huawei Duan, Biao Zhang, Miao Li, Liping Chen, Bo Zhang, Xiaonian Zhu, Chen Gao, Jie Li, Xiao Zhang, Jingmaio Zhang, Shan Wang, Xiaowen Zeng, Daochuan Li, Xiumei Xing, Zhengbao Zhang, Lu Ma, Qing Bai, Caixia Liu, Yongmei Xiao, Yuxin Zheng and Wen Chen
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00013K

Graphical Abstract


Molecular modeling and spectroscopic study of quinone–protein adducts: insight into toxicity, selectivity, and reversibility
Mohamed Saleh Elgawish, Naoya Kishikawa, Mohamed A. Helal, Kaname Ohyama and Naotaka Kuroda
Toxicol. Res., 2015, Advance Article
DOI: 10.1039/C5TX00098J

Graphical Abstract


p, p’- Dichlorodiphenyltrichloroethane inhibits the apoptosis of colorectal adenocarcinoma DLD1 cells through PI3K/AKT and Hedgehog/Gli1 signaling pathways
Li Song, meirong zhao, Jianxin Liu, Zhuoyu Li, Hong Xiao and Weiping Liu
Toxicol. Res., 2015, Accepted Manuscript
DOI: 10.1039/C5TX00006H

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Poster prize winner at the 2nd Eco-toxicology conference 2015

Toxicology Research were delighted to sponsor a poster prize at the 2nd Eco-toxicology conference, which took place from the 25th – 28th April 2015 in Xiamen, China. Many congratulations to Liang-ying He (Guangzhou Institute of Geochemistry, Chinese Academy of Sciences) for winning this prize with their poster entitiled: “Dissemination of Antibiotic Resistance Genes in Representative Broiler Feedlots Environments: Identification of Indicator ARGs and Correlations with Environmental Variables“.

“Broiler feedlots may represent an important source of antibiotic resistance genes (ARGs) in the environment. However, the prevalence and dissemination mechanisms of various types of ARGs in the environment of broiler feedlots have not previously been identified. We examined the occurrence, abundance and variation of ARGs conferring resistance to chloramphenicols, sulfonamides and tetracyclines in the environments of two representative types of broiler feedlots (free range and indoor) and assessed their dissemination mechanisms. Horizontal gene transfer and co-selection were found to play important roles in ARG dissemination in the environment. fexA, sul1 and tetW could be reliable indicator genes to surrogate anthropogenic sources of ARGs in boiler feedlots. The distribution and transportation of ARGs from the boiler feedlots to the receiving environments were correlated with environmental variables. The findings highlight the contribution of some chemicals such as antibiotics and metals to the development of ARGs in broiler feedlots environments; and the observed ARG dissemination mechanism in the broiler feedlots facilitates the development of effective mitigation measures.”

Many congratulations to Liang-ying on receiving your prize

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Poster prize winner at BTS congress 2015

Toxicology Research were delighted to sponsor a poster prize at the British Toxicology Society Annual Congress, which took place from the 20th to 22th April 2015 at St. John’s Hotel, Solihull. Many congratulations to Gareth Miles (MRC Toxicology Unit, University of Leicester) for winning this prize with his poster entitiled: “Aerobically-poised leukeamic cells identify the BH3 mimetic ABT-737 as a potential mitochondrial toxin“.

“There is growing need for a more stringent system to identify drug induced mitochondrial toxicity” explains Gareth. “The aim of our work is to set up a real time drug screening system using high through put methodologies to identify drug induced mitochondrial dysfunction. To identify drug induced mitochondrial liabilities, cells are forced to rely on mitochondrial oxidative phosphorylation by culturing cells on a glucose free – galactose based media. Any perturbations in mitochondrial function or increase in cell death represents a potential mitochondrial toxic insult. The methods include mitochondrial respiratory chain complex activity assessment using a seahorse bioscience analyser and flow cytometry analysis of both early and late stage cell death. In addition to this we are currently mapping the mitochondrial proteome using label free quantitative proteomics, with the aim being able to identify proteomic changes that may be causative to the identified toxicity. This screening platform, followed by in depth proteomic analysis aims to provide a means to (i) identify mitochondrial toxins (ii) identify the proteins involved in these toxicological responses.”

Many congratulations to Gareth on receiving this prize.

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Cellular and Molecular Mechanisms of Toxicity Conference – EUROTOX travel fellowships for early career researchers

The Gordon Research Conference on Cellular and Molecular Mechanisms of Toxicity will be taking place in New Hampshire, USA, August 8-14, 2015. The conference is a premier forum for showcasing the latest, most innovative advances in mechanistic toxicological research. Emerging technologies in mechanistic toxicology and computational, 3D, and in vivo modeling as well as systems biology approaches to assessing risk to human disease will be highlighted.

Session Topics include:
- Keynote Session: Mechanistic and Personalized Approaches to Evaluating Toxicity and the Microbiome
- What’s in Your Toolbox: Emerging Technologies for Mechanistic Toxicology / Late Breaking Talks
- Computational Models in Toxicology
- Incorporating the Inflammasome into Mechanistic Toxicology Research / Late Breaking Talks
- What’s in Your Toolbox: Novel In Vivo Model Systems in Mechanistic Toxicology
- Systems Pharmacology Approaches to Mechanisms of Drug Efficacy and Toxicity / Late Breaking Talks
- Generational Considerations in Toxicological Sciences
- Microphysiological Systems or Animals? The Present and Future of Safety and Efficacy Testing / Late Breaking Talks
- Keynote Session: Genetic and Epigenetic Mechanisms of Toxicology / Communicating Science and Risk

***Furthermore, applicants are sought for travel fellowships to attend this conference. These fellowships are intended to enhance the career progression of early career scientists and are open to all applicants based in Europe who are either working towards or up to 10 years post PhD. Advanced undergraduate students with current research related to molecular toxicology will also be considered for this fellowship. Successful applicants will receive up to 850EU travel support from EUROTOX and assistance with registration/accommodation from the GRC Conference. Winners will be selected on the scientific quality and relevance of the proposed abstract together with the likely benefit of the award to the individual’s career development as a European Toxicologist. Some abstracts may be selected for oral presentation.

To apply for a travel fellowship, please contact the conference chair, Dr Dana Dolinoy, by clicking here. More details about the conference can be found on the website.

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