Top 10 most downloaded articles: January – March 2017

We are delighted to share with you the top 10 most downloaded articles in Toxicology Research  from January – March 2017. These papers are free to access for the next two weeks with a free publishing personal account – register here.

We hope you enjoy reading these highly accessed articles, and we welcome your future submissions to the journal.

Prediction of the effect of formulation on the toxicity of chemicals
Pritesh Mistry, Daniel Neagu, Antonio Sanchez-Ruiz, Paul R. Trundle, Jonathan D. Vessey and John Paul Gosling
Toxicol. Res., 2017, 6, 42-53
DOI: 10.1039/C6TX00303F

Pyrazinamide-induced hepatotoxicity and gender differences in rats as revealed by a 1H NMR based metabolomics approach
He Zhao, Zhi-Hong Si, Ming-Hui Li, Lei Jiang, Yong-Hong Fu, Yue-Xiao Xing, Wei Hong, Ling-Yu Ruan, Pu-Ming Li and Jun-Song Wang
Toxicol. Res., 2017, 6, 17-29
DOI: 10.1039/C6TX00245E

Synergistic effects of particulate matter (PM2.5) and sulfur dioxide (SO2) on neurodegeneration via the microRNA-mediated regulation of tau phosphorylation
Tingting Ku, Minjun Chen, Ben Li, Yang Yun, Guangke Li and Nan Sang
Toxicol. Res., 2017, 6, 7-16
DOI: 10.1039/C6TX00314A

Modelling compound cytotoxicity using conformal prediction and PubChem HTS data
Fredrik Svensson, Ulf Norinder and Andreas Bender
Toxicol. Res., 2017, 6, 73-80
DOI: 10.1039/C6TX00252H

Tris(2-chloroethyl) phosphate (TCEP) and tris(2-chloropropyl) phosphate (TCPP) induce locomotor deficits and dopaminergic degeneration in Caenorhabditis elegans
Tiantian Xu, Ping Li, Siyu Wu, Lili Lei and Defu He
Toxicol. Res., 2017, 6, 63-72
DOI: 10.1039/C6TX00306K

A DEHP plasticizer alters synaptic proteins via peroxidation
Shaohui Wang, Pengyan Zhang, Ruifang Liu, Yuan Li, Chao Liu and Xiaomei Liao
Toxicol. Res., 2017, 6, 89-97
DOI: 10.1039/C6TX00361C

Lipid droplets alleviate cadmium induced cytotoxicity in Saccharomyces cerevisiae
Selvaraj Rajakumar and Vasanthi Nachiappan
Toxicol. Res., 2017, 6, 30-41
DOI: 10.1039/C6TX00187D

Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid
James A. Akingbasote, Alison J. Foster, Huw B. Jones, Rhiannon David, Nigel J. Gooderham, Ian D. Wilson and J. Gerry Kenna
Toxicol. Res., 2017, 6, 81-88
DOI: 10.1039/C6TX00376A

Progress of in vivo studies on the systemic toxicities induced by titanium dioxide nanoparticles
Fashui Hong, Xiaohong Yu, Nan Wu and Yu-Qing Zhang
Toxicol. Res., 2017, 6, 115-133
DOI: 10.1039/C6TX00338A

Circulating miRNAs and their target genes associated with arsenism caused by coal-burning
Baofei Sun, Junchao Xue, Jun Li, Fei Luo, Xiong Chen, Yonglian Liu, Qingling Wang, Caihua Qi, Zhonglan Zou, Aihua Zhang and Qizhan Liu
Toxicol. Res., 2017, 6, 162-172
DOI: 10.1039/C6TX00428H

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Outstanding Reviewers for Toxicology Research in 2016

Following the success of Peer Review Week in September 2016 (dedicated to reviewer recognition) during which we published a list of our top reviewers, we are delighted to announce that we will continue to recognise the contribution that our reviewers make to the journal by announcing our Outstanding Reviewers each year.

We would like to highlight the Outstanding Reviewers for Toxicology Research in 2016, as selected by the editorial team, for their significant contribution to the journal. The reviewers have been chosen based on the number, timeliness and quality of the reports completed over the last 12 months.

We would like to say a big thank you to those individuals listed here as well as to all of the reviewers that have supported the journal. Each Outstanding Reviewer will receive a certificate to give recognition for their significant contribution.

Dr Manuel Alvarez-Guerra, Universidad de Cantabria

Dr Aleksandra Buha, University of Belgrade

Professor Wen Chen, Sun Yat-sen University

Dr Maofa Ge, Chinese Academy of Sciences

Professor Xinbiao Guo, Peking University

Dr Thomas Harrop, Bio21 Molecular Science and Biotechnology Institute

Dr Sumedha Roy, University of Burdwan

Dr Hanna Stevens, University of Iowa

Dr Dayong Wang, Southeast University

Professor Xu Yang, Central China Normal University

We would also like to thank the Toxicology Research board and the toxicology community for their continued support of the journal, as authors, reviewers and readers.


If you would like to become a reviewer for our journal, just email us with details of your research interests and an up-to-date CV or résumé.  You can find more details in our author and reviewer resource centre

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Top 10 most downloaded articles: October – December 2016

We are delighted to share with you the top 10 most downloaded articles in Toxicology Research  from October–December 2016. These papers are free to access for the next two weeks with a free publishing personal account – register here.

We hope you enjoy reading these highly accessed articles, and we welcome your future submissions to the journal.

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014,3, 418-432
DOI: 10.1039/C4TX00047A

Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013,2, 40-59
DOI: 10.1039/C2TX20031G

Characterization of a functional C3A liver spheroid model
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams and Steven D. Webb
Toxicol. Res., 2016,5, 1053-1065
DOI: 10.1039/C6TX00101

Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980–2013
Jen-Yin Goh, Richard J. Weaver, Libby Dixon, Nicola J. Platt and Ruth A. Roberts
Toxicol. Res., 2015,4, 1297-1307
DOI: 10.1039/C5TX00123D

Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi
Vilmos Csizmadia, Paul Hales, Christopher Tsu, Jingya Ma, Jiejin Chen, Pooja Shah, Paul Fleming, Joseph J. Senn, Vivek J. Kadambi, Larry Dick and Francis S. Wolenski
Toxicol. Res., 2016,5, 1619-1628
DOI: 10.1039/C6TX00220J

Effects of monoolein-based cubosome formulations on lipid droplets and mitochondria of HeLa cells
Angela Maria Falchi, Antonella Rosa, Angela Atzeri, Alessandra Incani, Sandrina Lampis, Valeria Meli, Claudia Caltagirone and Sergio Murgia
Toxicol. Res., 2015,4, 1025-1036
DOI: 10.1039/C5TX00078E

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012,1, 62-68
DOI: 10.1039/C2TX20006F

Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
Emma Wincent, Florane Le Bihanic and Kristian Dreij
Toxicol. Res., 2016,5, 788-799
DOI: 10.1039/C6TX00004E

Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data
Chad H. G. Allen, Alexios Koutsoukas, Isidro Cortés-Ciriano, Daniel S. Murrell, Thérèse E. Malliavin, Robert C. Glen and Andreas Bender
Toxicol. Res., 2016,5, 883-894
DOI: 10.1039/C5TX00406C

Gender specific differences in the liver proteome of rats exposed to short term and low-concentration hexabromocyclododecane (HBCD)
I. Miller, C. Diepenbroek, E. Rijntjes, J. Renaut, K. J. Teerds, C. Kwadijk, S. Cambier, A. J. Murk, A. C. Gutleb and T. Serchi
Toxicol. Res., 2016,5, 1273-1283
DOI: 10.1039/C6TX00166A

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Top 30 Most Accessed Toxicology Research Articles of 2016

We are delighted to share with you the top 30 most downloaded articles in Toxicology Research from January-December 2016. All of these papers are free to access for the next two weeks with a free publishing personal account – register here.

Comment on “Promising blood-derived biomarkers for estimation of the postmortem interval” by I. Costa, F. Carvalho, T. Magalhães, P. G. de Pinho, R. Silvestre & R. J. Dinis-Oliveira. (Toxicol. Res., 2015, 4, 1443–1452)
Joris Meurs and Katarzyna M. Szykuła
Toxicol. Res., 2016,5, 714-715
DOI: 10.1039/C5TX00397K

Mycotoxins: cytotoxicity and biotransformation in animal cells
Jikai Wen, Peiqiang Mu and Yiqun Deng
Toxicol. Res., 2016,5, 377-387
DOI: 10.1039/C5TX00293A

Key mechanisms involved in ionizing radiation-induced systemic effects. A current review
Ifigeneia V. Mavragani, Danae A. Laskaratou, Benjamin Frey, Serge M. Candéias, Udo S. Gaipl, Katalin Lumniczky and Alexandros G. Georgakilas
Toxicol. Res., 2016,5, 12-33
DOI: 10.1039/C5TX00222B

Characterization of a functional C3A liver spheroid model
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams and Steven D. Webb
Toxicol. Res., 2016,5, 1053-1065
DOI: 10.1039/C6TX00101G

Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
Emma Wincent, Florane Le Bihanic and Kristian Dreij
Toxicol. Res., 2016,5, 788-799
DOI: 10.1039/C6TX00004E

Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data
Chad H. G. Allen, Alexios Koutsoukas, Isidro Cortés-Ciriano, Daniel S. Murrell, Thérèse E. Malliavin, Robert C. Glen and Andreas Bender
Toxicol. Res., 2016,5, 883-894
DOI: 10.1039/C5TX00406C

Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids
Katarzyna Wojdyla, Krzysztof Wrzesinski, James Williamson, Stephen J. Fey and Adelina Rogowska-Wrzesinska
Toxicol. Res., 2016,5, 905-920
DOI: 10.1039/C5TX00469A

1H NMR-based urine metabolomics for the evaluation of kidney injury in Wistar rats by 3-MCPD
Jian Ji, Lijuan Zhang, Hongxia Zhang, Chao Sun, Jiadi Sun, Hui Jiang, Mandour H. Abdalhai, YinZhi Zhang and Xiulan Sun
Toxicol. Res., 2016,5, 689-696
DOI: 10.1039/C5TX00399G

Epigenetic toxicity of trichloroethylene: a single-molecule perspective
Yi Cui, Samrat Roy Choudhury and Joseph Irudayaraj
Toxicol. Res., 2016,5, 641-650
DOI: 10.1039/C5TX00454C

Genome-wide transcriptional analysis of silica nanoparticle-induced toxicity in zebrafish embryos
Hejing Hu, Qiuling Li, Lizhen Jiang, Yang Zou, Junchao Duan and Zhiwei Sun
Toxicol. Res., 2016,5, 609-620
DOI: 10.1039/C5TX00383K

Silver nanoparticles induced oxidative and endoplasmic reticulum stresses in mouse tissues: implications for the development of acute toxicity after intravenous administration
Rui Chen, Lin Zhao, Ru Bai, Ying Liu, Liping Han, Zhifang Xu, Feng Chen, Herman Autrup, Dingxin Long and Chunying Chen
Toxicol. Res., 2016,5, 602-608
DOI: 10.1039/C5TX00464K

In silico prediction of hERG potassium channel blockage by chemical category approaches
Chen Zhang, Yuan Zhou, Shikai Gu, Zengrui Wu, Wenjie Wu, Changming Liu, Kaidong Wang, Guixia Liu, Weihua Li, Philip W. Lee and Yun Tang
Toxicol. Res., 2016,5, 570-582
DOI: 10.1039/C5TX00294J

Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies
Iness R. Benmessaoud, Anne-Laure Mahul-Mellier, Endre Horváth, Bohumil Maco, Massimo Spina, Hilal A. Lashuel and Làszló Forró
Toxicol. Res., 2016,5, 407-419
DOI: 10.1039/C5TX00303B

Modeling the toxicity of chemical pesticides in multiple test species using local and global QSTR approaches
Nikita Basant, Shikha Gupta and Kunwar P. Singh
Toxicol. Res., 2016,5, 340-353
DOI: 10.1039/C5TX00321K

Cytotoxic and sublethal effects of silver nanoparticles on tendon-derived stem cells – implications for tendon engineering
Tik Shing Cheung, Pui Man Lau, Haifei Lu, Ho Pui Ho, Pauline Po Yee Lui and Siu Kai Kong
Toxicol. Res., 2016,5, 318-330
DOI: 10.1039/C5TX00349K

Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells
Qian Ba, Chao Huang, Yijing Fu, Junyang Li, Jingquan Li, Ruiai Chu, Xudong Jia and Hui Wang
Toxicol. Res., 2016,5, 107-115
DOI: 10.1039/C5TX00378D

Evaluation of zinc-doped magnetite nanoparticle toxicity in the liver and kidney of mice after sub-chronic intragastric administration
Shanshan Zhu, Xiaolong Xu, Rui Rong, Bing Li and Xue Wang
Toxicol. Res., 2016,5, 97-106
DOI: 10.1039/C5TX00292C

Evaluation of the intracellular uptake and cytotoxicity effect of TiO2 nanostructures for various human oral and lung cells under dark conditions
Chieh-Wei Chen, Jing-Hong Huang, Tsung-Ching Lai, Yi-Hua Jan, Michael Hsiao, Chung-Hsuan Chen, Yeu-Kuang Hwu and Ru-Shi Liu
Toxicol. Res., 2016,5, 303-311
DOI: 10.1039/C5TX00312A

Intravenous injection of L-BMAA induces a rat model with comprehensive characteristics of amyotrophic lateral sclerosis/Parkinson–dementia complex
Ke-Wei Tian, Hong Jiang, Bei-Bei Wang, Fan Zhang and Shu Han
Toxicol. Res., 2016,5, 79-96
DOI: 10.1039/C5TX00272A

Screening and validation for plasma biomarkers of nephrotoxicity based on metabolomics in male rats
Yubo Li, Haoyue Deng, Liang Ju, Xiuxiu Zhang, Zhenzhu Zhang, Zhen Yang, Lei Wang, Zhiguo Hou and Yanjun Zhang
Toxicol. Res., 2016,5, 259-267
DOI: 10.1039/C5TX00171D

Toxicity mechanism in fetal lung fibroblast cells for multi-walled carbon nanotubes defined by chemical impurities and dispersibility
Aparna Shinde and Candace S. J. Tsai
Toxicol. Res., 2016,5, 248-258
DOI: 10.1039/C5TX00211G

Grape seed proanthocyanidin extract protects against perfluorooctanoic acid-induced hepatotoxicity by attenuating inflammatory response, oxidative stress and apoptosis in mice
Wenwen Liu, Changshui Xu, Xi Sun, Haibin Kuang, Xiaodong Kuang, Weiying Zou, Bei Yang, Lei Wu, Fangming Liu, Ting Zou and Dalei Zhang
Toxicol. Res., 2016,5, 224-234
DOI: 10.1039/C5TX00260E

Mouse hepatic neoplasm formation induced by trace level and low frequency exposure to diethylnitrosamine through β-catenin signaling pathway
Yu-Sang Li, Chang-Long Leng, Man-Tang Chen, Wei Kevin Zhang, Xiao-Jun Li, He-Bin Tang, Hong-Cai Shang and Li-Hua Zhu
Toxicol. Res., 2016,5, 210-223
DOI: 10.1039/C5TX00317B

In vitro toxicity evaluation of silica-coated iron oxide nanoparticles in human SHSY5Y neuronal cells
Gözde Kiliç, Carla Costa, Natalia Fernández-Bertólez, Eduardo Pásaro, João Paulo Teixeira, Blanca Laffon and Vanessa Valdiglesias
Toxicol. Res., 2016,5, 235-247
DOI: 10.1039/C5TX00206K

miR-122 plays an important role in ochratoxin A-induced hepatocyte apoptosis in vitro and in vivo
Liye Zhu, Tao Yu, Xiaozhe Qi, Bo Yang, Lei Shi, Haoshu Luo, Xiaoyun He, Kunlun Huang and Wentao Xu
Toxicol. Res., 2016,5, 160-167
DOI: 10.1039/C5TX00104H

Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways
Carla Nunes, Natércia Teixeira, Diana Serra, Víctor Freitas, Leonor Almeida and João Laranjinha
Toxicol. Res., 2016,5, 53-65
DOI: 10.1039/C5TX00214A

Cytotoxic effects of aspartame on human cervical carcinoma cells
Muthuraman Pandurangan, Gansukh Enkhtaivan and Doo Hwan Kim
Toxicol. Res., 2016,5, 45-52
DOI: 10.1039/C5TX00269A

Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo
Ashley J. Broom, Jeffrey Ambroso, Gino Brunori, Angie K. Burns, James R. Armitage, Ian Francis, Mitul Gandhi, Richard A. Peterson, Timothy W. Gant, Alan R. Boobis and Jonathan J. Lyon
Toxicol. Res., 2016,5, 136-150
DOI: 10.1039/C5TX00197H

Mechanistic understanding of molecular initiating events (MIEs) using NMR spectroscopy
Paul N. Sanderson, Wendy Simpson, Richard Cubberley, Maja Aleksic, Stephen Gutsell and Paul J. Russell
Toxicol. Res., 2016,5, 34-44
DOI: 10.1039/C5TX00246J

Evaluation of CdTe/CdS/ZnS core/shell/shell quantum dot toxicity on three-dimensional spheroid cultures
Mehriban Ulusoy, Antonina Lavrentieva, Johanna-Gabriela Walter, Franziska Sambale, Mark Green, Frank Stahl and Thomas Scheper
Toxicol. Res., 2016,5, 126-135
DOI: 10.1039/C5TX00236B

 

We hope you enjoy reading the top 30 most accessed articles of 2016 and wish you all the best for 2017.

For up to date journal information, why not follow Toxicology Research @ToxRes on Twitter.

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Top 10 most downloaded articles: July – September 2016

We are delighted to share with you the top 10 most downloaded articles in Toxicology Research from July–September 2016. These papers are free to access for the next two weeks with a free publishing personal account – register here.

Toxicology Research, led by Editor-in-Chief Professor Nigel Gooderham (Imperial College, London), is a multidisciplinary journal covering high impact research in fundamental, translational and applied areas of toxicology. The Journal is published by the Royal Society of Chemistry and is the official journal of the British Toxicology Society and the Chinese Society of Toxicology. More details about the journal, the scope and our author guidelines are available on our website.

We hope you enjoy reading these highly accessed articles, and we welcome your future submissions to the Journal.

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014, 3, 418-432
DOI: 10.1039/C4TX00047A

Characterization of a functional C3A liver spheroid model
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams and Steven D.Webb
Toxicol. Res., 2016, 5, 1053-1065
DOI: 10.1039/C6TX00101G

Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013, 2, 40-59
DOI: 10.1039/C2TX20031G

Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids
Katarzyna Wojdyla, Krzysztof Wrzesinski, James Williamson, Stephen J. Fey and Adelina Rogowska-Wrzesinska
Toxicol. Res., 2016, 5, 905-920
DOI: 10.1039/C5TX00469A

Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980–2013
Jen-Yin Goh, Richard J. Weaver, Libby Dixon, Nicola J. Platt and Ruth A. Roberts
Toxicol. Res., 2015, 4, 1297-1307
DOI: 10.1039/C5TX00123D

Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data
Chad H. G. Allen, Alexios Koutsoukas, Isidro Cortés-Ciriano, Daniel S. Murrell, Thérèse E. Malliavin, Robert C. Glen and Andreas Bender
Toxicol. Res., 2016, 5, 883-894
DOI: 10.1039/C5TX00406C

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012, 1, 62-68
DOI: 10.1039/C2TX20006F

Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
Emma Wincent, Florane Le Bihanic and Kristian Dreij
Toxicol. Res., 2016, 5, 788-799
DOI: 10.1039/C6TX00004E

In vitro models for liver toxicity testing
Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn
Toxicol. Res., 2013, 2, 23-39
DOI: 10.1039/C2TX20051A

Effects of monoolein-based cubosome formulations on lipid droplets and mitochondria of HeLa cells
Angela Maria Falchi, Antonella Rosa, Angela Atzeri, Alessandra Incani, Sandrina Lampis, Valeria Meli, Claudia Caltagirone and Sergio Murgia
Toxicol. Res., 2015, 4, 1025-1036
DOI: 10.1039/C5TX00078E

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Top 10 Reviewers for Toxicology Research

In celebration of Peer Review Week, with the theme of Recognition for Review – we would like to highlight the top 10 reviewers for Toxicology Research in 2016, as selected by the editorial team for their significant contribution to the journal.

We would like to say a massive thank you to these reviewers as well as the Toxicology Research board and all of the toxicology community for their continued support of the journal, as authors, reviewers and readers.

Name

Institution

Dayong Wang

Southeast University

Hanna Stevens

University of Iowa

Manuel Alvarez-Guerra

Universidad de Cantabria

Wen Chen

Sun Yat-sen University

Sumedha Roy

University of Burdwan

Zhiyong Tang

National Center for Nanoscience and Technology

Xinbiao Guo

Peking University

Samera H Hamad

University of Wisconsin-Madison

Dongye Li

Xuzhou Medical College

Y M Zhou

Nanjing Agricultural University

As a little added bonus to celebrate Peer Review Week, for the next four weeks our reviewers will be in with a chance of winning a fantastic prize! Simply submit a review for any of our journals between 19 September and 16 October 2016 and you will be automatically eligible for a chance to win one of our fantastic prizes.

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Open Access content in Toxicology Research

We are very pleased to share with you below some of the latest Open Access papers published in Toxicology Research. These research papers and high-impact reviews are free to access for all – we hope you enjoy reading them.

Comment on “Promising blood-derived biomarkers for estimation of the postmortem interval”
I. Costa, F. Carvalho, T. Magalhães, P. G. de Pinho, R. Silvestre & R. J. Dinis-Oliveira
Joris Meurs and Katarzyna M. Szykuła
Toxicol
. Res., 2016, 5, 714-715
DOI: 10.1039/C5TX00397K

Improving the prediction of organism-level toxicity through integration of chemical, protein target and cytotoxicity qHTS data
Chad H. G. Allen, Alexios Koutsoukas, Isidro Cortés-Ciriano, Daniel S. Murrell, Thérèse E. Malliavin, Robert C. Glen and Andreas Bender
Toxicol. Res., 2016, 5, 883-894
DOI: 10.1039/C5TX00406C

Characterization of a functional C3A liver spheroid model
Harriet Gaskell, Parveen Sharma, Helen E. Colley, Craig Murdoch, Dominic P. Williams and Steven D. Webb
Toxicol. Res., 2016, 5, 1053-1065
DOI: 10.1039/C6TX00101G

Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
Emma Wincent, Florane Le Bihanic and Kristian Dreij
Toxicol. Res., 2016, 5, 788-799
DOI: 10.1039/C6TX00004E

Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids
Katarzyna Wojdyla, Krzysztof Wrzesinski, James Williamson, Stephen J. Fey and Adelina Rogowska-Wrzesinska
Toxicol
. Res., 2016, 5, 905-920
DOI: 10.1039/C5TX00469A

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Most downloaded articles in Toxicology Research – see what your peers have been reading

We are delighted to share with you the top 10 most downloaded articles in Toxicology Research from 1st April 2016 – 30th June 2016. These papers are free to access for the next two weeks with a free publishing personal account – register here.

Toxicology Research, led by Editor-in-Chief Professor Nigel Gooderham (Imperial College, London), is a multidisciplinary journal covering high impact research in fundamental, translational and applied areas of toxicology. The Journal is published by the Royal Society of Chemistry and is the official journal of the British Toxicology Society and the Chinese Society of Toxicology. More details about the journal, the scope and our author guidelines are available on our website.

We hope you enjoy reading these highly accessed articles, and we welcome your future submissions to the Journal.

Statistical evaluation of toxicological bioassays – a review
Ludwig A. Hothorn
Toxicol. Res., 2014,3, 418-432
DOI: 10.1039/C4TX00047A

Novel in vitro and mathematical models for the prediction of chemical toxicity
Dominic P. Williams, Rebecca Shipley, Marianne J. Ellis, Steve Webb, John Ward, Iain Gardner and Stuart Creton
Toxicol. Res., 2013,2, 40-59
DOI: 10.1039/C2TX20031G

A comparative study of cellular uptake and cytotoxicity of multi-walled carbon nanotubes, graphene oxide, and nanodiamond
Xiaoyong Zhang, Wenbing Hu, Jing Li, Lei Tao and Yen Wei
Toxicol. Res., 2012,1, 62-68
DOI: 10.1039/C2TX20006F

Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980–2013
Jen-Yin Goh, Richard J. Weaver, Libby Dixon, Nicola J. Platt and Ruth A. Roberts
Toxicol. Res., 2015,4, 1297-1307
DOI: 10.1039/C5TX00123D

Dibutyl phthalate induced oxidative stress does not lead to a significant adjuvant effect on a mouse asthma model
Shaohui Chen, Huihui You, Lin Mao and Xu Yang
Toxicol. Res., 2015,4, 260-269
DOI: 10.1039/C4TX00096J

Effects of monoolein-based cubosome formulations on lipid droplets and mitochondria of HeLa cells
Angela Maria Falchi, Antonella Rosa, Angela Atzeri, Alessandra Incani, Sandrina Lampis, Valeria Meli, Claudia Caltagirone and Sergio Murgia
Toxicol. Res., 2015,4, 1025-1036
DOI: 10.1039/C5TX00078E

Synergistic interaction between lipid-loading and doxorubicin exposure in Huh7 hepatoma cells results in enhanced cytotoxicity and cellular oxidative stress: implications for acute and chronic care of obese cancer patients
S. AlGhamdi, V. Leoncikas, K. E. Plant and N. J. Plant
Toxicol. Res., 2015,4, 1479-1487
DOI: 10.1039/C5TX00173K

In vitro models for neurotoxicology research
Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos and Félix Carvalho
Toxicol. Res., 2015,4, 801-842
DOI: 10.1039/C4TX00043A

Health hazards of methylammonium lead iodide based perovskites: cytotoxicity studies
Iness R. Benmessaoud, Anne-Laure Mahul-Mellier, Endre Horváth, Bohumil Maco, Massimo Spina, Hilal A. Lashuel and Làszló Forró
Toxicol. Res., 2016,5, 407-419
DOI: 10.1039/C5TX00303B

In vitro models for liver toxicity testing
Valerie Y. Soldatow, Edward L. LeCluyse, Linda G. Griffith and Ivan Rusyn
Toxicol. Res., 2013,2, 23-39
DOI: 10.1039/C2TX20051A

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Call for papers: Systems Toxicology

You are invited to contribute to the upcoming Toxicology Research themed issue on Systems Toxicology.

Guest Edited by Professor Ian Wilson (Imperial College London, UK) this upcoming themed issue will cover a wide span of topics, from mathematical in silico models, more descriptive “omics”-based approaches (genomics, transcriptomics, proteomics, metabonomics, etc.), to developing a systems view of toxicity.

Systems toxicology, which forms a subdivision of systems biology and was pioneered by Leroy Hood, has many definitions, but as a framework for hypothesis generation and testing may represent an important new way of explaining, modelling and predicting the consequences of the exposure of organisms to toxins. It is clear from even a cursory examination of the literature that systems toxicology has now reached a sufficient state of maturity that a themed issue dedicated to this field is overdue.

For your article to be considered for this themed issue we must receive your manuscript by 3 February 2017.

Communications, Full Papers and Review articles are welcomed. If you are interested in submitting please contact us to let us know.

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Nanotoxicology: RSC Toxicology Award Seminar

The RSC Toxicology Award Seminar is due to take place at Burlington House in London on 19th April 2016 between 12pm- 6pm.

The Seminar will celebrate the 2015 Toxicology Award, which will be presented to Professor Vicki Stone (Heriot-Watt University) for pioneering transdisciplinary approaches to assessing the safety of nanomaterials.

Graphical AbstractVicki Stone (BSc PhD FIBiol FRSE) is Director of the Nano Safety Research Group at Heriot-Watt University, Edinburgh, and an Honorary Principal Scientist at the Institute of Occupational Medicine.   She has acted as the Editor-in-chief of the journal Nanotoxicology for 6 years (2006-2011). Vicki has also published over 130 publications pertaining to particle toxicology over the last 16 years and was recently recognised by Thomson Reuters as one of the top 1% of all researchers in the world for the most cited publications in the field of Pharmacology and Toxicology.


Registration is open until 18th April
To book your place click here

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