Archive for the ‘Themed collections’ Category

Themed collection on Amyloids and Protein Aggregation

We are pleased to announce our themed collection on amyloids and protein aggregation in Chemical Science, guest edited by Prof. Sara Linse, Lund University (Sweden) and Prof. Tuomas Knowles, University of Cambridge (United Kingdom). This collection highlights key mechanistic findings demystifying the process of amyloid formation.

Read our  Guest Editors’ summary and insights in the accompanying editorial.

The collection features a combination of Review, Perspective and Research Articles covering the thermodynamic, mechanistic and kinetic aspects of amyloid formation. These are studied using a diverse range of techniques including (but not limited to) NMR spectroscopy, Cryo-electron tomography, single molecule detection and computational studies. Articles in this collection also describe novel characterization and quantification strategies.

Browse the collection, which includes:


Molecular mechanisms of amyloid formation in living systems
Tessa Sinnige
Chem. Sci., 2022, 13, 7080-7097, DOI: 10.1039/D2SC01278B

A perspective addressing how molecular mechanisms of amyloid formation, which have been extensively studied in test tube reactions, can apply to the complex situations in living cells and organisms.

 

Stability matters, too – the thermodynamics of amyloid fibril formation
Alexander K. Buell
Chem. Sci., 2022,13, 10177-10192, DOI: 10.1039/D1SC06782F

A review highlighting important open questions regarding the thermodynamics of amyloid formation and addressing the current state of experimental exploration.

 

Single molecule sensing of amyloid-β aggregation by confined glass nanopores
Ru-Jia Yu,  Si-Min Lu,  Su-Wen Xu,  Yuan-Jie Li, Qun Xu,  Yi-Lun Ying and  Yi-Tao Long
Chem. Sci., 2019,10, 10728-10732, DOI: 10.1039/C9SC03260F

In this research article, the authors employ a novel technique for direct sensing the amyloidosis process of Aβ1-42 peptide, of great significance in Alzheimer’s disease, using a glass nanopore.

 

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants
Georg Meisl, Xiaoting Yang, Christopher M. Dobson, Sara Linse and Tuomas P. J. Knowles
Chem. Sci., 2017,8, 4352-4362, DOI: 10.1039/C7SC00215G

Here, the authors show that changes in the ionic strength of the solution leads to significant variation in the aggregation mechanism of the Aβ42 peptide, linked to Alzheimer’s disease, and they provide a means to relating the different aggregation mechanisms response to varying electrostatic interactions.

 

Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers
Lydia M. Young, Ling-Hsien Tu, Daniel P. Raleigh, Alison E. Ashcroft and Sheena E. Radford
Chem. Sci., 2017,8, 5030-5040, DOI: 10.1039/C7SC00620A

In this research article, the authors observe that co-assembly into hetero-oligomers controls the lag time of amylin assembly. They relate the mechanism to that of prions.

 

Origin of metastable oligomers and their effects on amyloid fibril self-assembly
Filip Hasecke, Tatiana Miti, Carlos Perez, Jeremy Barton, Daniel Schölzel, Lothar Gremer, Clara S. R. Grüning, Garrett Matthews, Georg Meisl, Tuomas P. J. Knowles, Dieter Willbold, Philipp Neudecker, Henrike Heise, Ghanim Ullah, Wolfgang Hoyer and Martin Muschol
Chem. Sci., 2018,9, 5937-5948, DOI: 10.1039/C8SC01479E

This research article conveys how the inhibitory effects of metastable oligomers on amyloid fibril formation can be revealed by analysis of oligomer and fibril assembly kinetics simultaneously.

 

Identification of on- and off-pathway oligomers in amyloid fibril formation
Alexander J. Dear, Georg Meisl, Anđela Šarić, Thomas C. T. Michaels, Magnus Kjaergaard, Sara Linse and Tuomas P. J. Knowles
Chem. Sci., 2020,11, 6236-6247, DOI: 10.1039/C9SC06501F

A research article enabling the comparison of amyloid oligomers’ contribution to fibril formation by establishing a general non-binary definition for on- and off- pathway intermediates.

 

Atomic resolution map of the soluble amyloid beta assembly toxic surfaces
Rashik Ahmed, Michael Akcan, Adree Khondker, Maikel C. Rheinstädter, José C. Bozelli, Jr, Richard M. Epand, Vincent Huynh, Ryan G. Wylie, Stephen Boulton, Jinfeng Huang, Chris P. Verschoord and Giuseppe Melacini
Chem. Sci., 2019,10, 6072-6082, DOI: 10.1039/C9SC01331H

In this research article, the authors show an atomic resolution map of amyloid beta assembly “toxic surfaces” that facilitate the early pathogenic events in Alzheimer’s disease.

 

C-terminal truncation of α-synuclein promotes amyloid fibril amplification at physiological pH
Ingrid M. van der Wateren, Tuomas P. J. Knowles, Alexander K. Buell, Christopher M. Dobson and Céline Galvagnion
Chem. Sci., 2018,9, 5506-5516, DOI: 10.1039/C8SC01109E

Here, the authors show how the pH range at which α-synuclein secondary nucleation occurs can be shifted from acidic to neutral values by C-terminal truncation.


We hope you enjoy reading these articles and the rest in this themed collection published in Chemical Science!

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Most Popular 2022 Chemical Science Articles By Subject

Here at Chemical Science, we are pleased to present our readers with a series of subject-specific collections of our most popular content published last year. These specially curated collections are designed to highlight some of the exceptional research published in Chemical Science – and like all Chemical Science articles, they are free to access and read from anywhere in the world with no restrictions. We hope you will have a great time reading these collections.

Many of the articles selected in the collections below are also included in our 2022 ChemSci Pick of the Week Collections, as well as our 2022 Chemical Science HOT Article Collections.

 

Organic chemistry

This specially curated collection pulls together some of the most popular articles from 2022 in the field of organic chemistry. The collection presents some outstanding contributions to the field, ranging from photocatalytic radical generation to prediction of protein pKa.
Browse the full collection

 

Materials and energy chemistry

This specially curated collection pulls together some of the most read, cited and shared articles from 2022 in the field of materials and energy chemistry. The collection highlights some outstanding contributions ranging from reviews detailing recent advances in energy storage technologies through to new state-of-the-art research on organic ferroelectrics, methods for nanoparticle synthesis, porous materials for isomer separation and many other topics.
Browse the full collection

 

Catalysis chemistry

This specially curated collection includes some of the most popular articles from 2022 in the field of catalysis. The collection presents some outstanding contributions to the field, including contributions on photocatalysis, electrocatalytic reduction, organocatalysis, and biocatalysis.
Browse the full collection

 

Analytical chemistry

This specially curated collection pulls together some of the most popular articles from 2022 in the field of analytical chemistry. The collection presents some outstanding contributions to the field, including NIR fluorescent probes for in vivo imaging, new isotope labelling methodologies for NMR, and single-molecule reaction kinetics.
Browse the full collection

 

Chemical biology

This specially curated collection pulls together some of the most popular articles from 2022 in the field of chemical biology. The collection presents some outstanding contributions to the field, ranging from imaging to peptide catalysis.
Browse the full collection

 

Physical & theoretical chemistry

This specially curated collection pulls together some of the most popular articles from 2022 in the field of physical and theoretical chemistry. The collection presents some outstanding contributions to the field, ranging from deep learning models for predicting drug-target interactions, through to investigations into colour-tunable persistent luminescence in low-dimensional zinc-organic halide microcrystals.
Browse the full collection

 

Main group, inorganic & organometallic chemistry

This specially curated collection pulls together some of the most popular articles from 2022 in the fields of main group, inorganic and organometallic chemistry. The collection presents some outstanding contributions to the field, ranging from dysprosium single molecule magnets to air and water stable germacarbonyl compounds.
Browse the collection

 

Supramolecular chemistry

This specially curated collection pulls together some of the most popular articles from 2022 in the field of supramolecular chemistry. The collection presents some outstanding contributions to the field, ranging from the synthesis of catenane assemblies to chiral molecular nanosilicas.
Browse the collection

 

Chemical science logoSubmit to Chemical Science today! Check out our author guidelines for information on our article types and find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. Browse the articles in our latest issues by signing up to our E-Alerts.

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Malika Jeffries-EL selects her Editor’s Choice in organic electronics

Chemical Science welcomes our newest Associate Editor, Professor Malika Jeffries-EL, who brings a wealth of experience in organic electronics and functional materials to Chemical Science.

Malika recently came to the end of her time as an Associate Editor for Journal of Materials Chemistry C and Materials Advances and, in celebration of her joining the Editorial Board for Chemical Science, she has selected her Editor’s Choice from papers published in Chemical Science, Journal of Materials Chemistry C and Materials Advances. We hope you enjoy reading through this selection!

Malika Jeffries-EL

 

You can explore the full collection of papers that are in Malika’s Editor’s Choice here!

Highlighted articles include:

A cell membrane-targeting AIE photosensitizer as a necroptosis inducer for boosting cancer theranostics
Niu Niu, Ying Yu, Zhijun Zhang, Miaomiao Kang, Lei Wang, Zheng Zhao, Dong Wang and Ben Zhong Tang
Chem. Sci., 2022, 13, 5929-5937

Detection of multi-reference character imbalances enables a transfer learning approach for virtual high throughput screening with coupled cluster accuracy at DFT cost
Chenru Duan, Daniel B. K. Chu, Aditya Nandy and Heather J. Kulik
Chem. Sci., 2022, 13, 4962-4971

Acenaphthene-triphenylamine (acceptor-donor) based luminophores for organic light emitting diodes: combined experimental and theoretical study
Jairam Tagare, Aravind Babu Kajjam, Kasturi Singh, Sabita Patel and Sivakumar Vaidyanathan
Mater. Adv., 2022, 3, 399-408

Synthesis and photoswitchable amphiphilicity and self-assembly properties of photochromic spiropyran derivatives
Yiwei Zhang, Maggie Ng, Eugene Yau-Hin Hong, Alan Kwun-Wa Chan, Nathan Man-Wai Wu, Michael Ho-Yeung Chan, Lixin Wu and Vivian Wing-Wah Yam
J. Mater. Chem. C, 2020, 8, 13676-13685

Open-circuit-voltage shift of over 0.5 V in organic photovoltaic cells induced by a minor structural difference in alkyl substituents
Mitsuharu Suzuki, Kengo Terai, Cassandre Quinton, Hironobu Hayashi, Naoki Aratani and Hiroko Yamada
Chem. Sci., 2020,11, 1825-1831

 

We encourage you to submit your best work in organic electronics and functional materials to Malika and our team of Associate Editors now! Check out the Chemical Science author guidelines for more information.

 

Chemical Science, Royal Society of Chemistry

 

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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Happy Chinese New Year!

Happy Chinese New Year to all our authors, reviewers and readers from all of us at Chemical Science!

To celebrate the year of the tiger we have put together a collection highlighting our most popular articles from the past year from our Chinese authors, as well as a selection of infographics accompanying some of these papers, which you can find below.

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Celebrating the 100th Anniversary of Chemistry at Nankai University

The Department of Chemistry at Nankai University was initiated in 1921 by Professor Zongyue Qiu, just 2 years after the founding of Nankai University. Over the years the department has evolved, most recently in the founding of the College of Chemistry in 1995, which then became an entity in 2000. The College of Chemistry of Nankai University has become a leading national base for research and education in chemistry. Chemical Science and the Royal Society of Chemistry are delighted to help celebrate the 100th anniversary of chemical sciences in Nankai University with a themed collection.

This themed collection features articles published in Chemical Science by authors at Nankai University, and speakers at our joint symposium “Celebrating the 100th Anniversary of Chemistry at Nankai University  with New Frontiers in Chemistry: A Chemical Science Symposium”. The symposium is dedicated to the latest research that crosses new frontiers and boundaries within the chemical sciences and introduces new concepts, and will feature 8 leading researchers in multidisciplinary fields as the invited speakers, alongside 16 flash talks from outstanding young researchers, chaired by Chemical Science Associate Editors Professor Jinlong Gong and Professor Ning Jiao.

We hope you enjoy reading this collection and look forward to seeing you at the symposium on the 29th September.

 

Chemical Science

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Chemical Science: Celebrating a century of chemical excellence at Nanjing University

Celebrating a century of chemical excellence at Nanjing UniversityEstablished in 1920, the School of Chemistry and Chemical Engineering of Nanjing University is one of the world’s most active and recognised chemistry institutions. After a century of development and evolution, it is now a globally leading department dedicated to advancing the chemical sciences through cutting-edge research and world-renowned education. Chemical Science and the Royal Society of Chemistry are delighted to help celebrate the 100th anniversary of chemical sciences in Nanjing University with a themed collection. This collection was specially curated by the Dean and Vice Dean of the School of Chemistry and Chemical Engineering at Nanjing University, Professors Shuhua Li and Wei Wang, alongside Chemical Science Associate Editor Yi-Tao Long, Professor of Analytical Chemistry at Nanjing University.

This themed collection features 42 articles published in Chemical Science, the flagship journal of the Royal Society of Chemistry, between 2016-2020 by scientists in the School of Chemistry and Chemical Engineering of Nanjing University. The articles cover a broad spectrum of synthetic chemistry, analytical chemistry, material chemistry, chemical biology, and others.

In joint celebration with the 10th anniversary of Chemical Science, a virtual Symposium will be held on 12th October. The symposium will feature introductions from Chemical Science Executive Editor May Copsey and Royal Society of Chemistry Director of Publishing Emma Wilson alongside scientific talks from Chemical Science Editor-in-Chief Andrew Cooper, Associate Editors Yi-Tao Long and Shu-Li You, and Advisory Board Member Wonwoo Nam.

For more information and to register for this free-to-attend event now please visit: https://www.rsc.org/events/detail/45449/academic-forum-for-100-years-anniversary-of-chemistry-in-nanjing-university-and-10-years-anniversary-of-chemical-science

We hope you enjoy reading this collection and look forward to seeing you at the symposium on the 12th October.

Celebrating a century of chemical excellence at Nanjing University

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Most Popular 2018 – 2019 Chemical Science Articles By Subject

The ongoing COVID-19 pandemic has had wide reaching implications on the global research community. In addition to limitations on the ability to conduct research, many in our community are experiencing restricted or no access to institutional resources and published research articles. In-line with our continuing efforts to support the chemical sciences community, we have put together some subject-specific collections of our most popular Chemical Science content from 2018 and 2019. These specially curated collections are designed to highlight some of the exceptional research published in Chemical Science – and like all Chemical Science articles, they are free to access and read from anywhere on the globe with no restrictions. We hope you will find them useful during this time.

Many of the articles selected in the collections below are also included in our 20182019 and 2020 ChemSci Pick of the Week Collections, as well as our 20182019 and 2020 Chemical Science HOT Article Collections.

 

Organic chemistry

This collection presents some outstanding contributions to the field, ranging from dual vicinal functionalisation of heterocycles via an interrupted Pummerer coupling/[3,3]-sigmatropic rearrangement cascade to a review of C4-H indole functionalisation. Browse the full collection

 

Catalysis Chemistry

This specially curated collection pulls together some of the most popular articles from 2018 and 2019 in the field of catalysis. Articles range from Pd doped with Te for the highly selective electrocatalytic reduction of aqueous CO2 to a review of catalyst characterization in the presence of solvent through liquid phase structure-activity relationships.
Browse the full collection

 

Analytical chemistry

This collection ranges from high throughput reaction screening using desorption electrospray ionization mass spectrometry to a review of fluorescent probes for organelle-targeted bioactive species imaging.
Browse the full collection

 

Materials chemistry

This collection presents some outstanding contributions to the field, ranging from the rational design of a water-soluble NIR AIEgen to a review of the mechanical properties of metal-organic frameworks.
Browse the full collection

 

Main group, inorganic & organometallic chemistry

This collection presents articles ranging from the reactivity of diborane(4) towards pyridine and isocyanide to a review of spin states, vibrations and spin relaxation in molecular nanomagnets and spin qubits.
Browse the full collection

 

Chemical biology

This collection includes articles ranging from dual-biomarker-triggered fluorescence probes for differentiating cancer cells to a review of the biomedical applications of copper-free click chemistry.
Browse the full collection

 

Physical & theoretical chemistry

This collection presents some outstanding contributions to the field, ranging from a study that asks why are photosynthetic reaction centres dimeric to a review of polariton chemistry.
Browse the full collection

 

Supramolecular chemistry

This collection presents some outstanding contributions to the field, ranging from a halogen-bond assembled supramolecular catalyst, XBphos-Rh, to a review of electrochemically switchable rotaxanes.
Browse the full collection

 

Chemical Science, Royal Society of Chemistry

Submit to Chemical Science today! Check out our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

Keep up to date with our latest articles, reviews, collections & more by following us on Twitter. You can also keep informed by signing up to our E-Alerts.

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Fighting cancer with artificial antigen-presenting cells

Antigen-presenting cells (ACPs) are key players in the immune systems fight against cancer. On detection of tumor tissues, these ACPs pick up antigenic fragments of the tumor cell, migrate to the lymphoid organs and present the antigen to T-cells which play a central role in cell mediated immunity. Therefore, artificial ACPs (aAPCs) are often used in the development of immune-mediated anti-cancer therapies as they show great potential to mimic antigen-presentation, promoting T-cell activation.

Carl Figdor, a world-class immunologist, and colleagues from Radbound University discuss the current status of aAPC development in a Chemical Science Perspective. This review is partly focused on the developments in nanoscience which might improve future designs for immune-mediated anti-cancer therapies.

As a synthetic mimic, aAPCs must encompass the three signals that natural APCs use to encourage T-cell activation. This perspective discusses how these signals have been incorporated into aAPC designs, but also how physical properties such a size and shape are essential for targeting the aAPCs to T-cell rich areas in vivo.

Artificial antigen-presenting cells have the potential to develop into a widespread and powerful therapeutic tool. To download the full perspective, click on the link below – access is free for a limited time only!

Joep van der Weijden, Leonie Paulis, Martijn Verdoes, Jan C M van Hest and Carl Figdor
DOI: 10.1039/C4SC01112K
Looking for the best articles at the chemistry-biology interface. Check out our Chemical Biology Themed Collection showcasing some of the great research papers and reviews published in Chemical Science, in the areas of chemical biology and bioinorganic chemistry.
*Access is free through a registered RSC account – click here to register
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Editors’ Choice: Chemical Biology

Meet our Editors

Ben DavisProfessor Ben Davis (University of Oxford) handles submissions to Chemical Science in the areas of bioorganic chemistry and chemical biology and Professor Tom Muir (Princeton) welcomes papers in chemical biology.

Tom MuirRead their interviews on our blog to find out more about them. We invite you to submit your next high-quality research paper to their editorial offices.

Looking for the best articles at the chemistry-biology interface?

Ben and Tom have picked some of their favourite articles recently published in Chemical Science. You can read these articles for free for a limited period by clicking on the links below.

Chemical Science citationsChemical Science is the Royal Society of Chemistry’s flagship journal; publishing articles of exceptional significance and high-impact reviews from across the chemical sciences. The journal’s latest (2012) Impact Factor is 8.3. Research in Chemical Science is not only of the highest quality but also has excellent visibility; this is reflected in our latest citation profile.

Read our chemical biology Editor’s Choice selection for FREE today:

Chemical fidelity of an RNA polymerase ribozyme
James Attwater,   Shunsuke Tagami,   Michiko Kimoto,   Kyle Butler,  Eric T. Kool,   Jesper Wengel,   Piet Herdewijn,   Ichiro Hirao and   Philipp Holliger*
Chem. Sci., 2013,4, 2804-2814

Remodeling a β-peptide bundle
Matthew A. Molski, Jessica L. Goodman, Fang-Chieh Chou, David Baker, Rhiju Das and Alanna Schepartz  
Chem. Sci., 2013,4, 319-324

Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase
Susanna M. Saario, Michele K. McKinney, Anna E. Speers, Chu Wang and Benjamin F. Cravatt    
Chem. Sci., 2012,3, 77-83

A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells
Charles N. Birts,   Sharandip K. Nijjar,   Charlotte A. Mardle,   Franciane Hoakwie,   Patrick J. Duriez,   Jeremy P. Blaydes* and   Ali Tavassoli*  
Chem. Sci., 2013,4, 3046-3057

Chemical biology toolkit for exploring protein kinase catalyzed phosphorylation reactions
Sanela Martić and Heinz-Bernhard Kraatz  
Chem. Sci., 2013,4, 42-59

Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?
Viktor Brabec, Suzanne E. Howson, Rebecca A. Kaner, Rianne M. Lord, Jaroslav Malina, Roger M. Phillips, Qasem M. A. Abdallah, Patrick C. McGowan, Alison Rodger and Peter Scott
Chem. Sci., 2013, DOI: 10.1039/C3SC51731D

You can find many more excellent articles on chemical biology on our dedicated webpage:

Online collection: Chemical biology

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Chem Sci articles in 2013 Cancer Nanotechnology collection– free till 28 July

We are pleased to present a web collection of articles from publications across the RSC journal portfolio demonstrating the use of (nano)technology in the diagnosis, imaging and treatment of cancer.

This web collection will be free to access until the 28th July, so register for an RSC Publishing personal account and read this cutting edge research for free this week!

Read these Chemical Science Edge Articles as part of this special cancer nanotechnology collection:

A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles
Jinzhuan Wang, Xiaoyong Wang, Yajie Song, Jing Wang, Changli Zhang, Cunjie Chang, Jun Yan, Lin Qiu, Mingmin Wu and Zijian Guo
Chem. Sci., 2013,4, 2605-2612
DOI: 10.1039/C3SC50554E

Graphical abstract: A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles

Poly(ethylene oxide)-block-polyphosphester-based paclitaxel conjugates as a platform for ultra-high paclitaxel-loaded multifunctional nanoparticles
Shiyi Zhang, Jiong Zou, Mahmoud Elsabahy, Amolkumar Karwa, Ang Li, Dennis A. Moore, Richard B. Dorshow and Karen L. Wooley
Chem. Sci., 2013,4, 2122-2126
DOI: 10.1039/C3SC50252J

Graphical abstract: Poly(ethylene oxide)-block-polyphosphester-based paclitaxel conjugates as a platform for ultra-high paclitaxel-loaded multifunctional nanoparticles

Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells
Rachel C. Huxford, Kathryn E. deKrafft, William S. Boyle, Demin Liu and Wenbin Lin
Chem. Sci., 2012,3, 198-204
DOI: 10.1039/C1SC00499A

Graphical abstract: Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells

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