Archive for the ‘Themed collections’ Category

Fighting cancer with artificial antigen-presenting cells

Antigen-presenting cells (ACPs) are key players in the immune systems fight against cancer. On detection of tumor tissues, these ACPs pick up antigenic fragments of the tumor cell, migrate to the lymphoid organs and present the antigen to T-cells which play a central role in cell mediated immunity. Therefore, artificial ACPs (aAPCs) are often used in the development of immune-mediated anti-cancer therapies as they show great potential to mimic antigen-presentation, promoting T-cell activation.

Carl Figdor, a world-class immunologist, and colleagues from Radbound University discuss the current status of aAPC development in a Chemical Science Perspective. This review is partly focused on the developments in nanoscience which might improve future designs for immune-mediated anti-cancer therapies.

As a synthetic mimic, aAPCs must encompass the three signals that natural APCs use to encourage T-cell activation. This perspective discusses how these signals have been incorporated into aAPC designs, but also how physical properties such a size and shape are essential for targeting the aAPCs to T-cell rich areas in vivo.

Artificial antigen-presenting cells have the potential to develop into a widespread and powerful therapeutic tool. To download the full perspective, click on the link below – access is free for a limited time only!

Joep van der Weijden, Leonie Paulis, Martijn Verdoes, Jan C M van Hest and Carl Figdor
DOI: 10.1039/C4SC01112K
Looking for the best articles at the chemistry-biology interface. Check out our Chemical Biology Themed Collection showcasing some of the great research papers and reviews published in Chemical Science, in the areas of chemical biology and bioinorganic chemistry.
*Access is free through a registered RSC account – click here to register
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Editors’ Choice: Chemical Biology

Meet our Editors

Ben DavisProfessor Ben Davis (University of Oxford) handles submissions to Chemical Science in the areas of bioorganic chemistry and chemical biology and Professor Tom Muir (Princeton) welcomes papers in chemical biology.

Tom MuirRead their interviews on our blog to find out more about them. We invite you to submit your next high-quality research paper to their editorial offices.

Looking for the best articles at the chemistry-biology interface?

Ben and Tom have picked some of their favourite articles recently published in Chemical Science. You can read these articles for free for a limited period by clicking on the links below.

Chemical Science citationsChemical Science is the Royal Society of Chemistry’s flagship journal; publishing articles of exceptional significance and high-impact reviews from across the chemical sciences. The journal’s latest (2012) Impact Factor is 8.3. Research in Chemical Science is not only of the highest quality but also has excellent visibility; this is reflected in our latest citation profile.

Read our chemical biology Editor’s Choice selection for FREE today:

Chemical fidelity of an RNA polymerase ribozyme
James Attwater,   Shunsuke Tagami,   Michiko Kimoto,   Kyle Butler,  Eric T. Kool,   Jesper Wengel,   Piet Herdewijn,   Ichiro Hirao and   Philipp Holliger*
Chem. Sci., 2013,4, 2804-2814

Remodeling a β-peptide bundle
Matthew A. Molski, Jessica L. Goodman, Fang-Chieh Chou, David Baker, Rhiju Das and Alanna Schepartz  
Chem. Sci., 2013,4, 319-324

Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase
Susanna M. Saario, Michele K. McKinney, Anna E. Speers, Chu Wang and Benjamin F. Cravatt    
Chem. Sci., 2012,3, 77-83

A cyclic peptide inhibitor of C-terminal binding protein dimerization links metabolism with mitotic fidelity in breast cancer cells
Charles N. Birts,   Sharandip K. Nijjar,   Charlotte A. Mardle,   Franciane Hoakwie,   Patrick J. Duriez,   Jeremy P. Blaydes* and   Ali Tavassoli*  
Chem. Sci., 2013,4, 3046-3057

Chemical biology toolkit for exploring protein kinase catalyzed phosphorylation reactions
Sanela Martić and Heinz-Bernhard Kraatz  
Chem. Sci., 2013,4, 42-59

Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding?
Viktor Brabec, Suzanne E. Howson, Rebecca A. Kaner, Rianne M. Lord, Jaroslav Malina, Roger M. Phillips, Qasem M. A. Abdallah, Patrick C. McGowan, Alison Rodger and Peter Scott
Chem. Sci., 2013, DOI: 10.1039/C3SC51731D

You can find many more excellent articles on chemical biology on our dedicated webpage:

Online collection: Chemical biology

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Chem Sci articles in 2013 Cancer Nanotechnology collection– free till 28 July

We are pleased to present a web collection of articles from publications across the RSC journal portfolio demonstrating the use of (nano)technology in the diagnosis, imaging and treatment of cancer.

This web collection will be free to access until the 28th July, so register for an RSC Publishing personal account and read this cutting edge research for free this week!

Read these Chemical Science Edge Articles as part of this special cancer nanotechnology collection:

A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles
Jinzhuan Wang, Xiaoyong Wang, Yajie Song, Jing Wang, Changli Zhang, Cunjie Chang, Jun Yan, Lin Qiu, Mingmin Wu and Zijian Guo
Chem. Sci., 2013,4, 2605-2612
DOI: 10.1039/C3SC50554E

Graphical abstract: A platinum anticancer theranostic agent with magnetic targeting potential derived from maghemite nanoparticles

Poly(ethylene oxide)-block-polyphosphester-based paclitaxel conjugates as a platform for ultra-high paclitaxel-loaded multifunctional nanoparticles
Shiyi Zhang, Jiong Zou, Mahmoud Elsabahy, Amolkumar Karwa, Ang Li, Dennis A. Moore, Richard B. Dorshow and Karen L. Wooley
Chem. Sci., 2013,4, 2122-2126
DOI: 10.1039/C3SC50252J

Graphical abstract: Poly(ethylene oxide)-block-polyphosphester-based paclitaxel conjugates as a platform for ultra-high paclitaxel-loaded multifunctional nanoparticles

Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells
Rachel C. Huxford, Kathryn E. deKrafft, William S. Boyle, Demin Liu and Wenbin Lin
Chem. Sci., 2012,3, 198-204
DOI: 10.1039/C1SC00499A

Graphical abstract: Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cells

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