Author Archive

C-H activation: an article collection

C-H ActivationOne of the simplest and most utilised chemical reactions is the burning of hydrocarbons and while combustion is an excellent way to exploit the energy content of this naturally occurring resource, there is a lot more we can do with the ‘inert’ C-H bond.

C-H activation allows us to convert cheaper hydrocarbon starting materials into more valuable and versatile products; leading to the development of a wide range of reagents and catalysts that activate C-H bonds. To keep you up to date with the latest developments in the field we have created this article collection, where all articles are free to download until 15th December.

Click here for the full list of free articles

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Physical organic chemistry: An article collection

Model of a polycyclic aromatic hydrocarbonPhysical organic chemistry, the study of the underlying principles and rationale of organic reactions which looks at the interrelationships between the structure and reactivity of organic molecules, now encompasses a wider range of contexts than ever before

Making use of tools such as chemical kinetics, quantum chemistry, thermochemistry, chemical equilibrium and computational chemistry, to name but a few, researchers are investigating topics such as:

  • Supramolecular interactions, aggregation and reactivity
  • The computation of transition states and mechanisms
  • Molecular recognition, reactions and catalysis in biology
  • Materials where molecular structure controls function
  • Structure activity correlations
  • Mechanisms in synthesis and catalysis

To highlight some of the cutting edge research that ChemComm, Chemical Science and Organic & Biomolecular Chemistry publish we have collected a selection of articles for you to enjoy. These will be free to access until 25th September!

Click here for the full list of free articles

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Investigating protein interactions with anticancer drugs

You can have too much of a good thing, in a manner of speaking. Cisplatin, a platinum-based anticancer drug, has been hugely successful in treating a range of cancers but severe side-effects require its administration to be dose-limited.  Analogues, such as carboplatin and nedaplatin have been developed to overcome these problems; carboplatin can be administered at 20 times the dosage of cisplatin.  These drugs, however, have their own problems and exhibit inherent and acquired toxicity.

Investigation into the uptake of platinum anticancer drugs has highlighted that the regulation of transport using carriers/ channel-mediated systems may be one of the key factors for drug resistance.  In particular, copper transporters and chaperones have been identified as participating in the uptake, transport and efflux of these drugs.

mechanism of in vivo activation of platinum anticancer compounds

The interactions of the N-terminus of hCTR1 with carboplatin

Hongzhe Sun and co-workers have advanced on previous work in which they employed NMR to  study metallodrug-biomolecule interactions. They identified that the methionine residues in the N-terminus of human CTR1 (hCTR1_N), a copper transporter, were essential to allow binding to cisplatin, potentially activating the drug.

Looking at carboplatin and nedaplatin as well as cisplatin’s clinically ineffective isomer, transplatin, the research team extended their studies to further understand the interaction between platinum compounds with hCTR1_N and compare their findings with cisplatin.

The NMR studies revealed that carboplatin and nedaplatin both bound to the methionine residues of the transporter, although when compared to cisplatin, less was activated. Interestingly, they are more stable than cisplatin, potentially due to shielding effects of their ligands. Transplatin was also found to bind to methionine residues at a much higher rate than its isomer.  This sophisticated investigation into the kinetics and speciation of platinum-based drugs gives greater understanding into drug-binding and insights into their distinct biological roles.

Read more about this research in Sun’s Chemical Science Edge article, free to access for a limited period.

Posted on behalf of Sarah Brown, Chemical Science web writer.

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Molecular recognition and modern physical organic chemistry – free articles!

Chemical Science and ChemComm are sponsoring the symposium on Playing Ball: Molecular Recognition and Modern Physical Organic Chemistry in honour of Professor Julius Rebek Jr at the spring ACS meeting. To celebrate, we’re giving free access to some recent articles from Professor Rebek and the symposium speakers until 1st April.

Why don’t you have a read and let us know what you think?

Encapsulation of the uranyl dication
Stephan Beer, Orion B. Berryman, Dariush Ajami and Julius Rebek Jr., Chem. Sci., 2010, 1, 43-47

Shape-shifting in contorted dibenzotetrathienocoronenes
Chien-Yang Chiu, Bumjung Kim, Alon A. Gorodetsky, Wesley Sattler, Sujun Wei, Aaron Sattler, Michael Steigerwald and Colin Nuckolls, Chem. Sci., 2011, 2, 1480-1486

Gas-phase H/D-exchange reactions on resorcinarene and pyrogallarene capsules: Proton transport through a one-dimensional Grotthuss mechanism
Henrik D. F. Winkler, Egor V. Dzyuba, Julian A. W. Sklorz, N. Kodiah Beyeh, Kari Rissanen and Christoph A. Schalley, Chem. Sci., 2011, 2, 615-624

A dissymmetric molecular capsule with polar interior and two mechanically locked hemispheres
Marcos Chas and Pablo Ballester, Chem. Sci., 2012, 3, 186-191

A benzocrown-6-calix[4]arene methacrylate copolymer: Selective extraction of caesium ions from a multi-component system
Brett M. Rambo, Sung Kuk Kim, Jong Seung Kim, Christopher W. Bielawski and Jonathan L. Sessler, Chem. Sci., 2010, 1, 716-722

Cell surface-based differentiation of cell types and cancer states using a gold nanoparticle-GFP based sensing array
Avinash Bajaj, Subinoy Rana, Oscar R. Miranda, Joseph C. Yawe, D. Joseph Jerry, Uwe H. F. Bunz and Vincent M. Rotello, Chem. Sci., 2010, 1, 134-138

Donor-substituted octacyano[4]dendralenes: a new class of cyano-rich non-planar organic acceptors
Benjamin Breiten, Yi-Lin Wu, Peter D. Jarowski, Jean-Paul Gisselbrecht, Corinne Boudon, Markus Griesser, Christine Onitsch, Georg Gescheidt, W. Bernd Schweizer, Nicolle Langer, Christian Lennartz and François Diederich, Chem. Sci., 2011, 2, 88-93

A transparent photo-responsive organogel based on a glycoluril supergelator
Konrad Tiefenbacher, Henry Dube, Dariush Ajami and Julius Rebek, Chem. Commun., 2011, 47, 7341-7343

Recent advances in hydrogen-bonded hexameric encapsulation complexes
Liat Avram, Yoram Cohen and Julius Rebek Jr., Chem. Commun., 2011, 47, 5368-5375

A light controlled cavitand wall regulates guest binding
Orion B. Berryman, Aaron C. Sather and Julius Rebek Jr., Chem. Commun., 2011, 47, 656-658

Thermodynamically controlled self-sorting of hetero-bimetallic metallo-supramolecular macrocycles: what a difference a methylene group makes!
Boris Brusilowskij, Egor V. Dzyuba, Ralf W. Troff and Christoph A. Schalley, Chem. Commun., 2011, 47, 1830-1832

Anion-dependent fluorescence in bis(anilinoethynyl)pyridine derivatives: switchable ON–OFF and OFF–ON responses
Calden N. Carroll, Brian A. Coombs, Sean P. McClintock, Charles A. Johnson II, Orion B. Berryman, Darren W. Johnson and Michael M. Haley, Chem. Commun., 2011, 47, 5539-5541

Sodium and pH responsive hydrogel formation by the supramolecular system calix[4]pyrrole derivative/tetramethylammonium cation
Begoña Verdejo, Francisco Rodríguez-Llansola, Beatriu Escuder, Juan F. Miravet and Pablo Ballester, Chem. Commun., 2011, 47, 2017-2019

Conformational and spectroscopic properties of π-extended, bipyrrole-fused rubyrin and sapphyrin derivatives
Se-Young Kee, Jong Min Lim, Soo-Jin Kim, Jaeduk Yoo, Jung-Su Park, Tridib Sarma, Vincent M. Lynch, Pradeepta K. Panda, Jonathan L. Sessler, Dongho Kim and Chang-Hee Lee, Chem. Commun., 2011, 47, 6813-6815

Just add tetrazole: 5-(2-Pyrrolo)tetrazoles are simple, highly potent anion recognition elements
Rebecca J. M. Courtemanche, Thomas Pinter and Fraser Hof, Chem. Commun., 2011, 47, 12688-12690

Synthesis of cationic quantum dots via a two-step ligand exchange process
Yi-Cheun Yeh, Debabrata Patra, Bo Yan, Krishnendu Saha, Oscar R. Miranda, Chae Kyu Kim and Vincent M. Rotello, Chem. Commun., 2011, 47, 3069-3071

Expanding the chemical space for push-pull chromophores by non-concerted [2+2] and [4+2] cycloadditions: access to a highly functionalised 6,6-dicyanopentafulvene with an intense, low-energy charge-transfer band
Govindasamy Jayamurugan, Jean-Paul Gisselbrecht, Corinne Boudon, Franziska Schoenebeck, W. Bernd Schweizer, Bruno Bernet and François Diederich, Chem. Commun., 2011, 47, 4520-4522

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Stimuli-Responsive Supramolecular Assemblies – free content for a limited period

Chemical Science and ChemComm are delighted to be sponsoring the New Frontiers in Stimuli-Responsive Supramolecular Assemblies symposium at the ACS spring meeting in San Diego.

To celebrate this fantastic symposium, Chemical Science is giving free access to some recent articles from a selection of the symposium’s guest speakers. Why not check out why they choose to publish with Chemical Science?

Cell surface-based differentiation of cell types and cancer states using a gold nanoparticle-GFP based sensing array
Avinash Bajaj, Subinoy Rana, Oscar R. Miranda, Joseph C. Yawe, D. Joseph Jerry, Uwe H. F. Bunz and Vincent M. Rotello, Chem. Sci., 2010, 1, 134-138

Cylindrical micelles from the living crystallization-driven self-assembly of poly(lactide)-containing block copolymers
Nikos Petzetakis, Andrew P. Dove and Rachel K. O’Reilly, Chem. Sci., 2011, 2, 955-960

A programmable transducer self-assembled from DNA
Banani Chakraborty, Natasha Jonoska and Nadrian C. Seeman, Chem. Sci., 2012, 3, 168-176

A mechanistic study of Lewis acid-catalyzed covalent organic framework formation
Eric L. Spitler, Marissa R. Giovino, Sarah L. White and William R. Dichtel, Chem. Sci., 2011, 2, 1588-1593

Cell-compatible, integrin-targeted cryptophane-129Xe NMR biosensors
Garry K. Seward, Yubin Bai, Najat S. Khan and Ivan J. Dmochowski, Chem. Sci., 2011, 2, 1103-1110

This content will be free to access until 1st April.

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