Researchers in the US have developed a new photocatalysed coupling reaction that could provide a pathway to a huge number of biologically active compounds.
The coupling mechanism uses chloroheteroarenes in the direct α-arylation of amines
Heterocycles and heteroaromatic compounds are of great interest to medicinal chemists, due to their widespread use in pharmaceuticals. They are able to increase the aqueous solubility and decrease the lipophilicity of drugs, as well as improving their potency and biocompatibility.
Read the full article in Chemistry World»
Read the original journal article in Chemical Science – it’s free to access until 24th September:
Amine α-Heteroarylation via Photoredox Catalysis: A Homolytic Aromatic Substitution Pathway
David W. C. MacMillan and Christopher K Prier
Chem. Sci., 2014, Accepted Manuscript, DOI: 10.1039/C4SC02155J, Edge Article
