Archive for the ‘Education’ Category

Celebrating Our Books and Their Authors


This month, the Royal Society of Chemistry is celebrating its Golden Anniversary of Books, marking 50 years since the publication of the first book in our Specialist Periodical Reports series. With titles spanning the breadth of the chemical sciences for a variety of audiences, from popular science books to textbooks to professional reference books, the books program continues to thrive thanks to contributions from our international community. The RSC’s portfolio of textbooks provide an approachable and engaging suite of books for all students of the chemical sciences, from the fundamentals of organic, inorganic and physical chemistry to the frontiers of knowledge in pharmaceutical development and forensic science. The high-quality content of our books enables us to fully support learners and contribute to the development of the next generation of professional chemists. We are keen to understand how you find, access and read electronic (digital) non-fiction books in a professional or academic context, and would appreciate your insights through this short survey that will be available through December 15th, 2018.  Please join us in celebrating 50 years of books, made possible by our outstanding authors, and read on to learn more about two who recently finished their second book with us.

Meet the Authors of Our Newest Book

We recently published a brand new textbook from two California-based co-authors and leading educators, Professor Christopher Walsh, from Stanford University and Professor Yi Tang  from the University of California, Los Angeles. Their new textbook, Chemical Biology of Human Vitamins, is now the second that they have authored together with the RSC. Professor Walsh and Professor Tang are happy to share their new book with the world, and gave us some insights into their motivations and strategies for writing it, and explain what makes this such a fascinating and timely topic. Christopher Walsh’s research has focused on enzymes and enzyme inhibitors, and specifically on antibiotics and biosynthesis of biologically and medicinally active natural products. He has extensive academic leadership and biotechnology industry experience and is a member of the National Academy of Sciences, National Academy of Medicine, the American Academy of Arts and Sciences, and the American Philosophical Society. In 2010, he received the Welch Award in Chemistry for his pioneering work in biological chemistry along with co-recipient JoAnne Stubbe. Yi Tang holds joint appointments in the Department of Chemistry and Biochemistry and the Department of Bioengineering at UCLA. He has received numerous accolades, including the Arthur C. Cope Scholar Award and the Eli Lilly Award in Biological Chemistry.  

Over many decades, scientists discovered thirteen essential molecules that humans lost the capacity to make as they evolved from primordial organisms. These thirteen vitamins are crucial for metabolism, and this book chemocentrically analyzes the mode of action of each one of them to tell a compelling tale of the challenges that every human cell faces. It provides a thorough view on the key small molecules of life, the human vitamins and their active coenzyme forms. Detailing how their unique chemistries control the interconversion and the flux of hundreds of central human metabolites, Chemical Biology of Human Vitamins  examines the parallel and convergent tracks of the vitamins and their coenzyme forms. 

With these two leading educators bringing their talents and expertise to the table,  Chemical Biology of Human Vitamins aims to serve as an ideal guide and reference point for chemists in both academia and industry, graduates and advanced undergraduate students in biochemistry, chemical biology, metabolism and metabolomics, with beautifully crafted artwork to complement the cogent and engaging explanations. Professor Walsh explains, “Since the artwork is so much of the communicated message, we work hard to get that right, with clarity and as much elegance as we can.”

Highly Efficient Teamwork

The two professors first met while Tang was a postdoc with Chaitan Khosla. “We had our PKS/NRPS (polyketide synthetase/non-ribosomal peptide synthetase) super group meetings every year,” says Tang. “Chris was very friendly and open to everyone, including me. I started collaborating with Chris as an independent PI in 2010.  We worked on the biosynthesis of fungal indole alkaloids and nonribosomal peptides.”  In 2016, they started collaborating on their first book, Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery, which was published the following year; that same year, in 2017, they also started working on their newest book,  Chemical Biology of Human Vitamins, which was published earlier this fall. Now with two full textbooks completed in only two years, it is evident that these authors work very well together. They explained that balancing the workload was key to making such speedy progress. “We collaborated on different aspects of the book; Chris was mainly the writer for the text, while I worked on the figures, proofread the documents and prepared the references,” says Professor Tang. Professor Walsh explained why this system is most effective during the process: “I focus on writing a chapter at a time coincident with the artwork so that the text follows the information to be displayed in the figures,” he says. “Otherwise we have to go back and rewrite the text to match how any given figure turns out, and that is tedious with over 200 pieces of ChemDraw artwork in a book.”

A book often requires a great deal of dedication, and Professor Walsh explained how he works through the writing process to assemble the final product. “I tend to write straight through a project, starting before breakfast to capture early morning ideas. I pause when a major section or chapter is finished and only when I know how to start the next topic. I write to the exclusion of almost every other activity and can write a chapter a week with embedded artwork in first draft.  The first draft goes to my coauthor Prof Tang for additions, omissions, corrections, deletions, and most importantly setting the tone and aesthetics of each chapter.” The editorial staff at the RSC were impressed with how quickly these authors were able to work, often beating target deadlines and finishing ahead of schedule. “It was an efficient arrangement and we were able to get through each book in about eight months,” says Professor Tang.

Planning for an Effective Textbook

Once committed and with clear intentions in mind, they were able to finish with impressive haste, but it took a bit more time and a great deal of thought to get to the point where they could really take off. Both authors have previous experience with writing books, which helped make it easier to develop an idea and a plan. “This is the sixth book that I have written, the last two with co-author Professor Tang of UCLA,” says Walsh. “For about a year and a half I had a one page summary of the structures of the vitamins sitting on my office desk with the vague intent that the topic might be worth examining.” He explained what motivated him as an author and what he aims to accomplish with this work. “The prime motivation in each case, and this one in particular,” says Walsh, “is first to explain the topic to myself/ourselves, and then to others with some clarity about the chemical logic that underpins the role of key molecules in nature. Given the “vitamania” that  has turned the global vitamins and dietary supplements market into tens of billions of dollars in sales each year, we thought it would be useful to remind readers what is actually known about the molecular and chemical roles of the 13 human vitamins and why they are essential micronutrients.”

The two co-authors formulated their ideas and decided what they wanted to cover and how to approach it. “I felt that exploration of the chemistry enabled by these thirteen human vitamins, how they had been discovered, would give insight into the connectivity of the network of human metabolism and how those pathways may have evolved. The current interest in metabolomics -the simultaneous measurement of changes in metabolites in different physiologic/cellular states – would benefit from a reminder of what chemistry was actually possible in human cells. For this book, Professor Tang and I had several discussions about the scope and approach of such a work before committing our energies. Once I have committed to writing on a book project, I have outlined the number of chapters and the topics in those chapters.”

Learning by Teaching

One of the benefits of writing a book to teach others is that the authors can dive deeply into a topic and come out with a greater appreciation of different facets of a topic. Professor Tang was surprised to learn how societal focus on different vitamins change, as we understand more about human physiology and cell biology.  “Vitamin C started the wave, followed by vitamin A,” he says. “Nowadays it’s all about vitamin D, because we now understand it regulates many more cellular processes than just strengthening our bones.”

Professor Walsh says that writing this book helped him better appreciate structural features of human vitamins that he hadn’t fully considered before. “What I have learned that I had not thought deeply about the fact that nine of the thirteen vitamins have heterocyclic rings, from monocyclic to tetracyclic frameworks. Each of these nine distinct heterocycles brings particular chemistry to bear in metabolic steps: so one could say that the bulk of the chemical biology of vitamins is the chemistry of the heterocycles which are likely ancient molecules during the evolution of organisms,” Professor Walsh explains. “The eight B vitamins are classified under the letter B because they all have co-enzymatic roles. In a real sense understanding the metabolic nodes where the active coenzyme forms of the B vitamins act explains the logic of essentially all of the intersecting pathways of  energy metabolism in cell, tissues, and the whole human organism. Thus, the topic offers thirteen snapshots of the underlying logic and an alternative title would be: Human Vitamins: Thirteen Insights Into Human Metabolic Logic

Working with the Royal Society of Chemistry

While writing a book can seem like a long and daunting process,  now with fifty years of experience publishing high-quality books, the RSC aims to make it a pleasant and rewarding experience for authors. We are happy that these authors were pleased to write another book with us. “RSC has been wonderful in our writing projects.  Natural Product Biosynthesis: Chemical Logic and Enzymatic Machinery was my first experience as a book author,” says Prof. Tang. “There are many more aspects in assembling a book than just writing, including preparing the graphics to the required resolution, obtaining permissions, and thoroughly checking every detail.  RSC made the process straightforward with instructions and checklists.  The staff at RSC are not only responsive, but incredibly informative and patient with our questions and requests.  The vitamin book was much smoother in terms of assembly and submission, using our prior experience as a guide.  Overall, working with RSC has been fantastic and we will certainly choose RSC again if we write one more.”

To request an inspection copy of Profs Walsh and Tang’s latest textbook, Chemical Biology of Human Vitamins, use our online form. For more about our textbook and professional book publishing, or to propose an idea for a book please see our guidance for authors and readers. 

 

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Outstanding Student Profile: Caroline Rouget-Virbel

We introduced the Certificate of Excellence in 2017 and continued it in 2018 as a way for institutions to recognize students who have shown outstanding achievement in the chemical sciences; this year we want to showcase one of the recipients who embodies the spirit of the award and who inspires those around her to pursue their dreams while making a difference not only in their own communities but also those around the world. We are pleased to introduce you to Caroline Alice Rouget-Virbel, who will be starting her graduate studies at the University of California, Berkeley this fall.

At Princeton’s Class Day ceremony for Chemistry seniors in the Class of 2018, Caroline was recognized for her academic performance and her contributions to the department. She earned Highest Honors in Chemistry, was elected to Sigma Xi: The Scientific Research Society, and was awarded The Royal Society of Chemistry’s Certificate of Excellence. But Caroline was not the typical Princeton University undergraduate. She grew up in Pélissanne, a small town in the south of France, in what most would describe as a rural area. She attended a public school and then applied to an international boarding school, Ecole Internationale de Manosque (EIM) in the French Alps, for her high school education. There she obtained a British OIB (International Optional Baccalaureate) diploma, a joint educational degree between the French Department of Education and the University of Cambridge.

While in high school, Caroline developed interests in both science and foreign languages, which in turn got her excited about applying to foreign universities in the U.S. and England. To put this in context, Caroline grew up in a comprehensively working class environment and it was not typical and expected in her family to apply to college. To then take the step of applying outside of France for higher education was quite remarkable. She took a major leap of faith and applied to Princeton University. When she was offered admission along with a generous grant for financial aid, she simply could not turn down the opportunity. Needless to say, her acceptance of Princeton’s offer not only provided a highly constructive four-year experience for Caroline, but her contributions to the department and to the campus as a whole proved to be a plus for the University community.

During her first week on the Princeton campus, Caroline quickly identified a way to produce a steady income. Always determined to pay her own bills and add to her personal savings as much as possible, she held down a paid position as a Dining Services Student Manager, training new incoming workers and overseeing meal services for her dining hall and for special catered events. In fact, she continued to hold that job during all four years at Princeton. The summer after freshman year, she added another country to her growing list of travel experiences by serving as a volunteer at the Mahatma Gandhi Orphanage in Jaipur, India. While there, she assisted with childcare, global health initiatives, and infectious disease prevention efforts. And, of course, she explored the area and soaked in the culture.

Caroline hails from Pélissanne, a small town in rural France and is the first person in her family to apply for college, but by following her passion for science, foreign language, and community service, she has managed to expand her horizons and travel the globe.

During Caroline’s freshman and sophomore years, she began work with the campus mental health initiative. In addition, knowing how it felt to be an international student, she became involved with the University’s David International Center, taking on the responsibility of planning and leading events for incoming undergraduate and graduate students, as well as year-long community-building activities. This particular type of involvement helped not only others adjust, but also helped her as she took steps to find her place within the University, so much so that she continued to contribute to this program until she graduated. During the spring of her sophomore year, Caroline gathered information about the various science departments at the University and, after much deliberation, elected to major in chemistry. With that plan in place, she lost no time laying out her “What Next?” The summer of 2016 offered her yet another opportunity to live abroad. Caroline traveled to Dublin, Ireland, to pursue research at the National Children’s Research Center. She studied the underlying patho-mechanisms of the dysregulation of the NOX-1 and -4 genes in Hirschsprung’s-Associated Enterocolitis. Her work gave her the opportunity to add skills in protein expression and PCR analysis, gel electrophoresis, and immunofluorescence microscopy to her research “toolbox.”

As a first semester junior, Caroline decided to join a research lab a full term earlier than her peers. That plan led to a round of investigations to identify a lab that would be the right fit with her interests and her style of learning. By the second month of the term, she was hard at work in the lab of Professor David W. MacMillan, the James S. McDonnell Distinguished University Professor of Chemistry. While 12 to 14 hours of original research per week is the expectation for young chemists, Caroline spent as much time on her project as the demands of her coursework and extracurricular commitments permitted. That dedication spoke volumes since the junior year for chemistry majors is extremely demanding with regard to reading assignments, papers to write, problem sets to complete, discussion groups to attend, and the time commitment need to complete the required experimental laboratory course. She also took on the role of undergraduate preceptor in our newly restructured organic chemistry sequence. Preceptors assist instructors of auxiliary class sessions that work on learning material and practicing skills outside of the lecture period. Caroline was one of the preceptors instrumental in developing and running review sessions prior to exams. She also spent many hours tutoring students one-on-one, providing not only academic guidance, but also a “Can Do” attitude for her students who were concerned about doing well in mastering a difficult subject.

During that same period, Caroline elected to plan for a semester of study abroad with the goal of completing her Spring 2017 term in Australia. The opportunity to explore another country and live in yet another culture proved irresistible. Within no time at all, plans were put in place for her to study at the University of Melbourne. Adjusting to a program with courses that involved no periodic evaluation until the final exam, blending into a different culture, completing an original research project in a new chemistry laboratory, and pursuing opportunities to explore Australia formed the perfect combination for this intellectually curious student. And, as luck would have it, her sister was pursuing a program in Southeast Asia, so they were able to meet up and travel together, exploring the beautiful landscape of New Zealand, spending two full weeks road-tripping and camping around the South island. Caroline’s world was expanding rapidly from the rural area of France into a global viewpoint.

The summer prior to the start of her senior year was spent on the Princeton campus in order to focus on her senior thesis research. During those months, she was the senior class catalyst, bringing all of the summer researchers together for meals and other activities to create a sense of community. In her senior year, the craving for travel led her to plan a trip to the Caribbean for yet another cultural experience, which she hopes will be her next voyage into unfamiliar lands. In September of senior year, Caroline was off and running, returning to her role as a preceptor and tutor for undergraduate organic chemistry courses. Her dedication has yet to be matched. She developed a reputation for patience and careful instruction. As side projects, she designed a senior class t-shirt that included a structure from each of the senior chemistry theses and organized various get-togethers for her classmates. She also served as a Peer Academic Advisor, shepherding first and second year undergraduates as they settled into University life. All the while, Caroline was tackling her own demanding academic schedule, which included graduate level coursework, and was spending innumerable hours on her laboratory research project. The culmination of Caroline’s research was the submission of her senior thesis entitled “Application of Dual Nickel-Photoredox Catalysis to the Synthesis of Unnatural Amino Acids.”

To quote her faculty mentor, Professor MacMillan, “Caroline is one of the best undergraduates that I have ever worked with in 20 years of being an independent academic. She is smart, driven, funny, creative, and a team player. She is beloved by my research group and she can hold her own with any current graduate student in terms of her research drive.” Caroline has been accepted into the chemistry PhD program at the University of California, Berkeley. We have no doubts whatsoever that Caroline will continue to be an outstanding student and researcher as she works towards her graduate degree.

Special thank you to Kirsten M. Arentzen, Undergraduate Administrator for the Department of Chemistry at Princeton University, for contributing the majority of the content for this article, for continuously supporting the student body, and encouraging the recognition of outstanding undergraduates. 

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Chemistry Education: All Fun and Games

Besides publishing high-quality research from around the globe, the RSC’s activities support chemistry education and lifelong learning. During Teacher Appreciation Week (May 7-11) we celebrated the launch of Professional Development of Chemistry Teachers: Theory and Practice, the first book in the RSC Advances in Chemistry Education series. We reflected on all the educators who are making a difference for those studying chemical sciences and wanted to showcase one of the outstanding young educators we’ve met who are making an impact in the North America chemistry community.  At the 3rd annual University of California Chemical Symposium, Zachary Thammavongsy from the Yang Group at UC Irvine (UCI) won the coveted “Social Media Prize” for generating the most buzz around the meeting, but what really made Zach stand out was his game company, d-Orbital Games. Attendees like Chemical Science Deputy Editor, Jeremy Allen, had so much fun playing that they may not have even realized they were learning. Since many graduate students with a passion for teaching are often torn between their roles as a researcher and an educator, we caught up with Zach during Teacher Appreciation Week (May 7-11) to learn more about his accomplishments while in graduate school, what he has in store for the future, and what advice he would give to others who are inspired to teach. Zach, who won the 2017-2018 UCI Most Promising Future Faculty Award, has found a unique way to manage both research and teaching and even start his own business. Read on to learn more about Zach’s story and how teaching and learning really can can be fun and games.

Chemical Science Deputy Editor Jeremy Allen plays SeArCH with UC grad students and postdocs at the 3rd annual UCCS

“A game can be many things, but, at its core, a game is a defined set of parameters that allow a player or players to compete. This is a very structured answer, but these predefined parameters make games fun to play (either alone or against other players). A game should be fun, challenging, thought-provoking, foster a sense of competition, and ultimately provide a tangible way to accomplish one’s goals (winning). These concepts are easy to translate into simplified science topics. When playing a new game one must become familiar with the rules; I just make those rules simple to understand while teaching players about science!

“Growing up, I had amazing teachers. My source of inspiration for how to teach effectively has always been my high school teachers. They put maximum effort into their curriculum and I felt that they genuinely loved interacting with students. Now as a teaching assistant (TA), I take the same approach to teaching my lab sections and discussion courses. I don’t think I have a skill that others don’t possess in teaching, but I do believe I have the desire and the drive to pursue teaching as a career that I admire in other teachers. This is why I improve my teaching ability by taking advantage of the education classes offered at UC-Irvine and I attend teaching conferences. I am fascinated by the teaching techniques and learning strategies utilized in the subject of chemistry, and I hope to pursue conceptual learning as a research topic in the near future.

“I am a pedagogical fellow at UCI through the Division of Teaching Excellence and Innovation (DTEI). The fellowship is highly competitive as it is open to every graduate student at UCI. I learned of the fellowship through a former pedagogical fellow in the chemistry department. I submitted a sixty minute video of my teaching, collected student evaluations and underwent a formal interview process. The fellowship provided invaluable opportunities, like taking a year-long seminar on teaching techniques with pedagogical fellows from other departments and leading a two-day teaching workshop to prepare incoming graduate students in  chemistry for teaching responsibilities. Preparation for the workshop was rigorous; I now fully appreciate the time commitment instructors invest into preparing lecture notes.

“Initially, I was apprehensive about revealing my  games to my advisor. I didn’t know how she would receive the news since research is a graduate student’s top priority.”

Zach’s company d-Orbital Games uses simple but clever games to teach chemistry concepts while making education fun.

“As a pedagogical fellow, I crafted a few chemistry flash cards with some paper, pen and scissors to make a simple game to play with my colleagues. The game was so popular with those who did not have a chemistry background, that I used it as the basis of the first d-Orbital game, SeArCH! I launched a Kickstarter soon after, where I converted the seed money from the funded campaign to make more science-based card games and built a brand! The name d-Orbital Games (dOG) was brainstormed one late night in lab with an undergraduate researcher, Wyeth Gibson. It was only fitting that as an inorganic chemist, the chemistry card game company would be named after the transition metal electron orbitals (d-orbitals). I also love the acronym “dOG” since I love dogs and my parents have a shiba inu – which is the company mascot featured in our logo wearing a lab coat and goggles.

Initially, I was apprehensive about revealing my games to my advisor. I didn’t know how she would receive the news since research is a graduate student’s top priority. I finally told my PI four months after launching the d-Orbital game website and she was absolutely supportive and encouraging. I am not quite sure why I initially felt that my PI would not be receptive to the idea, as she is a very supportive mentor to her students and their scientific goals, even if it isn’t strictly research. My PI has even retweeted things posted on d-Orbital game’s Twitter. If she is reading this, Jenny, you are the best!

“I wandered often while navigating my way into starting a company. I gathered the courage to approach all types of people, not just academics. I asked business owners who started their own companies and shared my business platform at entrepreneurial meet-ups sponsored through UCI. One of my biggest challenges was approaching domestic or international manufacturers to make my games for the lowest price. The best advice I received thus far is from Catherine Croft, Ph.D., the CEO of Catlilli Games, who advised me to submit my games to award shows and attend conferences to showcase d-Orbital Games. It is amazing how many doors open by starting a conversation with people you barely know. I was happy to receive such a warm welcome at UCCS. I went to the symposium unsure how chemistry graduate students from other UCs would react to d-Orbital Games. I had one of the best moments this year watching other graduate students take interest in the education games my team developed. Specifically, I enjoy seeing the smiles and laughter that “Slap Count” brought to the table when a collective group of graduate students were competing to show off their skills in counting d-electrons! The UCCS Chair, Andrea Coleman from UC-Davis, was the star player that night, by bringing the energy to the game table.

“It is amazing how many doors open by starting a conversation with people you barely know.”

My current team is made up of lab members and childhood friends who possess skills that are unique and vital to the success of d-Orbital Games. They provide critical feedback on every detail, allowing us to provide the most accurate and fun chemistry games. Also, it is nice working with your friends! They don’t hold back on their opinions and I appreciate that a lot. The game designers can be anyone on the team, but usually Bianca and Wyeth help come up with initial concepts and game mechanics. The two editors Kim and Brian are extremely critical of spelling and grammatical errors. Ali and Mike are hometown friends that have helped me get through some of the computing and business side of the company. They are a big help from far away. Fortunately, the game designers are my lab mates. I see them every day. Since we are all busy researching, we don’t normally set a schedule for designing games. The game design happens over at the pub or during our group bonding time. We choose a chemistry topic to tackle and share how certain game mechanics can be incorporated into highlighting a difficult chemistry concept. We try to simplify our games as much as possible, so that students can quickly pick up the game in a one-hour classroom setting. From there, I talk to my editing team about the overall look of the game. I make a lot of grammatical errors, and I am so lucky to have editors that can spot all of my mistakes. The most exciting game that my team is currently working on is a proton NMR game. We try to focus primarily on games that can be implemented in the college level classroom. The proton NMR game will be our first game with a gameboard! I even had students from my organic chemistry course play test the game several times. I am exciting to be presenting the results from the proton NMR game at this summer’s ACS Biennial Conference on Chemical Education! Please come check it out if you are attending the conference!

“I had one of the best moments this year watching other graduate students take interest in the education games my team developed.”

Zach Thammavongsy (right), founder of d-Orbital Games with Connor Easley (left), Chair of the next UCCS where Zach’s games will be featured during the 2019 meeting.

“I envision some universities giving d-Orbital Games a try, if not in their classroom then hopefully in their office hours. We hope our games will assist students in their chemistry learning. Eventually, we hope to tackle every topic in general, organic, inorganic and physical chemistry. We want teachers to be able to pull one of our games off the shelf and seamlessly incorporate them into their lesson plan. We can provide the tools and detail all the new techniques for an educator to be great, but if we don’t get educators to buy in to how teaching can be beneficial to them as much as it will be for the students then that is when students suffer. From my experience, the skills I think graduate students gain from teaching are improved communication skills and professionalism. Every day is a chance for graduate teaching assistants (TA) to practice these skills so that they can be perfected for job interviews or handling difficult workplace situations in the future. Not everyone has to have the passion for teaching, but if everyone knows the benefits from getting the opportunity to teach then perhaps we can start to improve the teaching mindset of our graduate TAs and many other educators.”

We were impressed by Zach’s story and hope it will inspire other young people who are passionate about teaching and the 2019 UCCS is planning to incorporate some of Zach’s games into the program for attendees to play. The biggest lesson that Zach has learned through this experience:

Continue through the tough times. Even when your ideas don’t work out the first, or second or third time – very similar to research – talk to as many people that are willing to listen and play your game and do what makes you happy.”

We appreciate Zach sharing his story with us and hope you join us in thanking all the teachers who are making a difference;  follow Zach & d-Orbital Games and the Yang Group on Twitter to keep up with the latest happenings in both teaching and research. Educators looking for additional teaching tools can explore Learn Chemistry, the RSCs educational resource and teacher support publishing program. In addition to the magazine Education in Chemistry which covers all areas of chemistry education, our peer-reviewed journal Chemical Education Research and Practice is free to access for all, thanks to sponsorship by the RSC’s Chemistry Education Division.

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