Archive for the ‘Chemistry World’ Category

3D printing outclasses glass

Reactionware revolution continues with nanoparticle flow reactor

A UK team has demonstrated the power of 3D printing in producing complex labware for about the same cost as a paperback book.

The inaugural study to come from Victor Sans’ group at the University of Nottingham, UK, is a proof of concept. In it they designed, manufactured and optimised a cheap yet complex flow reactor for a model system – silver nanoparticle synthesis.

Check out the full story by Reaction Chemistry & Engineering’s Development Editor Hugh Cowley in Chemistry World!


This article is free to access when you register:

O. Okafor et al, React. Chem. Eng., 2017, DOI: 10.1039/c6re00210b

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Automated fluorine radiolabelling moves closer to the clinic

New technique could improve tumour diagnosis and treatment

A new automated fluorine-18 radiolabelling procedure could allow better tumour diagnosis and treatment in the clinic.

Graham Smith and coworkers at the Institute of Cancer Research have used two different radiolabelling platforms to successfully label three small biological molecules with fluorine-18, which could allow the batch production of these radiopharmaceuticals to satellite PET centres around the country.

“We showed how the process could be automated, and reported some indicative trends for the radiolabelling efficiency so that radiochemists with an interest in this type of radiolabelling can quickly adapt and optimise to suit a chosen peptide of interest,” comments Smith.

Check out the full story in Chemistry World.

 


This article is free to access until March 14th.

L Allott et al, React. Chem. Eng., 2017, DOI: 10.1039/c6re00204h

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‘Robo-chemist’ optimises reactions in one day

Reaction Chemistry & Engineering Chair Klavs Jensen and colleague Steve Buchwald have developed an intelligent automated reactor that drastically cuts the time it takes to optimise cross-coupling reactions.

Their automated flow reactor that can respond to the results of experiments and determine the optimum conditions for catalytic reactions within a single day.

suzuki miyaura optimisation

RCE Advisory Board member Ryan Hartman highly praises the research as a ‘vital contribution that advances both synthetic chemistry and chemical engineering’ in Chemistry World.

Check out the full story by Jamie Durrani here.


This article is open access

B J Reizman et al, React. Chem. Eng., 2016, DOI: 10.1039/C6RE00153J

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Batch and flow: united at last

Batch and flow chemistry can finally be carried out together on the same system!

Reaction Chemistry & Engineering Editorial Board member Steve Ley and colleague Daniel Fitzpatrick at the University of Cambridge have developed an automated reactor that can carry out both batch and flow processes, allowing for greater automation of multi-step synthesis.

Read the full story in Chemistry World.

This article is free to access until 25 November 2016

D E Fitzpatrick and S V Ley, React. Chem. Eng., 2016, DOI: 10.1039/C6RE00160B

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Flow chemistry for on-demand chlorine

No one wants to stock cylinders of toxic and corrosive chlorine in the lab. Now, researchers working with the gas can generate small amounts when and where they need it.

Read the full story by Abigail Hallowes in Chemistry World.

This article is free to access until 05 October 2016

F J Strauss et alReact. Chem. Eng., 2016, DOI: 10.1039/C6RE00135A

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A colour is worth a thousand spectra

Scientists from Germany have developed a quick and low-cost screening method for photocatalytic reactions based on a simple change of colour.

In a recent study in Reaction Chemistry & Engineering, Burkhard König and a colleague from the University of Regensburg have developed a simple colorimetric method to analyse the outcome of photocatalytic reactions. An organic dye changes colour if a reaction works and can even indicate how much of the starting materials has been consumed.

Read the full story by Michaela Mühlberg in Chemistry World.

This article is free to access until 19 September 2016:

Michal Poznik and Burkhard Konig, React. Chem. Eng, 2016, DOI: 10.1039/C6RE00117C

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Connections in flow

Chemistry World has spoken to Reaction Chemistry & Engineering Editorial Board Chair Professor Klavs Jensen about his work in the field of flow chemistry and continuous processing, culminating in the recent construction of an on-demand continuous flow pharmaceutical production platform with colleagues from MIT.

This achievement was made possible because of close collaboration between chemists and chemical engineers. As a journal, Reaction Chemistry & Engineering seeks to foster clear communication and knowledge sharing between the two disciplines that may lead to future endeavours such as this.

‘It makes sense to form a journal that allows the community from both sides to interact. So we want chemical engineers to publish papers that are interesting to the chemists and chemists to publish papers that have some engineering content and so will also be interesting to the engineers’, explains Professor Jensen, discussing his hopes for the journal. ‘We’d like to have something in between, that actually highlights from both sides what is the contribution in terms of understanding and developing new reactions, being able to optimize those, and understanding the kinetics. But also what does it take to run those – and so we bring together the two disciplines.’

Professor Jensen is convinced that a new journal is needed to do this: ‘Existing journals have reviewers that determine what is published, and they’ve developed their own communities. So it’s much harder to take an existing journal and change the course than it is to redefine, to really set a new goal and create a journal that satisfies the needs from both sides.’

To keep up with the latest research at the interface of chemistry and chemical engineering sign up to the Reaction Chemistry & Engineering TOC alerts or RSS feed, and follow us on Twitter.

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Carbon monoxide where you want it, when you want it

Synthetic chemists have invented two new room temperature methods for generating carbon monoxide from cheap precursors and using it straight away, so that deadly amounts of the gas never build up.

Carbon monoxide is toxic, flammable and disperses fast in air. It also happens to be one of the most useful C1 building blocks for organic synthesis. Important industrial processes use bulk quantities. But concerns over safety, especially in cylinder storage and transportation, are hampering research. Carbon monoxide surrogates do exist, but involve costly components, high temperatures or harsh conditions.

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To generate carbon monoxide at the point of use, Wim De Borggraeve and coworkers at KU Leuven, Belgium, have devised a triple system of cheap and common mesyl chloride, triethylamine and formic acid. Alternatively, collaborative work between the groups of Steven Ley at the University of Cambridge, UK, and Trond Ulven at the University of Southern Denmark, brings together chemistry developed in Denmark with flow chemistry technology from Cambridge.

Read the full story in Chemistry World.

Both articles are free to access:

Low-cost instant CO generation at room temperature using formic acid, mesyl chloride and triethylamine, Cedrick Veryser, Seger Van Mileghem, Brecht Egle, Philippe Gilles and Wim M. De Borggraeve, React. Chem. Eng., 2016, DOI: 10.1039/c6re00006a

Controlled generation and use of CO in flow, Steffen V. F. Hansen, Zoe E. Wilson, Trond Ulven and Steven V. Ley, React. Chem. Eng., 2016, DOI: 10.1039/c6re00020g

If you are unable to read Reaction Chemistry & Engineering content through automatic free institutional access, you can fill in this form to gain free individual access to the first two volumes.

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