Archive for the ‘RSC Advances’ Category

Welcome to our new Associate Editors: Angela Meireles & Amanda Garner

A warm welcome to both Professor M. Angela. A. Meireles and Professor Amanda L. Garner who start as Associate Editors for RSC Advances in June!

Angela Meireles. RSC Advances Associate Editor RSCEmployed for close to 34 years at the University of Campinas (UNICAMP) in São Paulo, Brazil, Professor Meireles completed her PhD in Chemical Engineering at Iowa State University. Starting as an Assistant Professor in the School of Food Engineering in 1983, she has since become a Professor and has supervised 50 PhD dissertations, 30 MSc theses and approximately 72 undergraduate research projects. She has also coordinated scientific exchange projects between UNICAMP and European universities in France, Germany, Holland, and Spain. Angela has served as a Head of Department, as Associate Dean for Undergraduate Studies of Food Engineering and as Associated Director at the Chemical, Biological, and Agricultural Pluridisciplinary Research Center.

Professor Meireles’ expertise helped her serve as the coordinator of Food Science for the Coordination for the Improvement of Higher Education Personnel (CAPES) between 2014 and 2018. She is a partner and innovative director of Bioativos Naturais, Ltd. and a current invited Professor at the School of Food Engineering at the University of Campinas.

Angela is excited to join the RSC Advances team, saying “I am truly grateful to belong to the Editorial team of this prestigious Open Access Journal: this is the future of scientific publications.”

 

Browse a selection of work published by Angela:

Sub-2 μm fully porous and partially porous (core–shell) stationary phases for reversed phase liquid chromatography
Endler M. Borges, Mauricio A. Rostagno and M. Angela A. Meireles
RSC Adv., 2014, 4, 22875-22887
DOI: 10.1039/ C3RA45418E, Review Article

Fast analysis of phenolic terpenes by high-performance liquid chromatography using a fused-core column
Giovani L. Zabot, Moyses N. Moraes, Maurício A. Rostagno and M. Angela A. Meireles
Anal. Methods, 2014, 6, 7457-7468
DOI: 10.1039/ C4AY01124D, Paper

Fast analysis of β-ecdysone in Brazilian ginseng (Pfaffia glomerata) extracts by high-performance liquid chromatography using a fused-core column
Mauricio A. Rostagno, Isabel C. N. Debien, Renata Vardanega, Gislaine C. Nogueira, Gerardo F. Barbero and M. Angela A. Meireles
Anal. Methods, 2014, 6, 2452-2459
DOI: 10.1039/ C3AY42276C, Paper

 

Amanda L Garner. RSC Advances Associate Editor RSCAmanda Garner received her Ph.D. in Chemistry from the University of Pittsburgh working under the supervision of Prof. Kazunori Koide and completed NIH-funded postdoctoral studies in the laboratory of Prof. Kim Janda at The Scripps Research Institute. She began her independent career in 2013 in the Department of Medicinal Chemistry at the University of Michigan.
Her laboratory uses chemical biology, medicinal chemistry and molecular and cellular biology approaches to investigate the high-risk/high-reward areas of targeting microRNAs, RNA-protein and protein-protein interactions for probe and drug discovery.

Amanda looks forward to her new role, saying “I am excited for the opportunity to help RSC Advances in promoting the high-quality and impactful chemical research being performed within the global community.”

 

 

 

 

 

Browse a selection of work published by Amanda:

cat-ELCCA: catalyzing drug discovery through click chemistry
Amanda L. Garner
Chem. Commun., 2018, 54, 6531-6539
DOI: 10.1039/C8CC02332H, Feature Article

A click chemistry-based microRNA maturation assay optimized for high-throughput screening
Daniel A. Lorenz and Amanda L. Garner
Chem. Commun., 2016, 52, 8267-8270
DOI: 10.1039/C6CC02894B, Communication

Antagonism of a zinc metalloprotease using a unique metal-chelating scaffold: tropolones as inhibitors of P. aeruginosa elastase
Jessica L. Fullagar, Amanda L. Garner, Anjali K. Struss, Joshua A. Day, David P. Martin, Jing Yu, Xiaoqing Cai, Kim D. Janda and Seth M. Cohen
Chem. Commun., 2013, 49, 3197-3199
DOI: 10.1039/C3CC41191E, Communication

Submit your research or reviews to Angela & Amanda now, they will be delighted to receive them!

See our author guidelines for information on our article types or find out more about the advantages of publishing in a Royal Society of Chemistry journal.

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Read our Editors’ Collection on Graphene by Pablo Denis

We are delighted to share with you our latest collection of recently published articles focusing on Graphene, handpicked by Associate Editor Pablo Denis.

As the world’s largest gold open access chemistry journal, all publications in RSC Advances are free to access. We hope you enjoy reading these articles.

We invite you to submit your research to this collection and give your work the global visibility it deserves.

 

Submit your research now

Featured articles:

Graphene, hexagonal boron nitride, and their heterostructures: properties and applications
Jingang Wang, Fengcai Ma and Mengtao Sun
RSC Adv., 2017, 7, 16801-16822. DOI: 10.1039/C7RA00260B

Uniform nanoporous graphene sponge from natural polysaccharides as a metal-free electrocatalyst for hydrogen generation
Jinan Niu, Antonio Domenech-Carbó, Ana Primo and Hermenegildo Garcia
RSC Adv., 2019, 9, 99-106. DOI: 10.1039/C8RA08745H

Synthesis and characterization of sulfophenyl-functionalized reduced graphene oxide sheets
Benjamin Diby Ossonon and Daniel Bélanger
RSC Adv., 2017, 7, 27224-27234. DOI: 10.1039/C6RA28311J

 

Read the full collection here

Pablo Denis, RSC Advances Associate Editor

 

 

Meet the Editor

Associate Editor Pablo A. Denis was born in 1975 in Uruguay. He received a PhD in Chemistry in 2004 before becoming a Postdoctoral Fellow at the University of California at Davis, and is now based at the Universidad de la Republica Oriental del Uruguay, Uruguay. His research interests include the investigation of 2D materials by means of first principle calculations.

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Read our Editors’ Collection on Supramolecular Chemistry by Leyong Wang

We are delighted to share with you our latest collection of recently published articles focusing on Supramolecular Chemistry, handpicked by Associate Editor Leyong Wang.

As the world’s largest gold open access chemistry journal, all publications in RSC Advances are free to access. We hope you enjoy reading these articles.

We invite you to submit your research to this collection and give your work the global visibility it deserves.

 

Submit your research now

Featured articles:

Bioinspired temporal supramolecular polymerization
Shikha Dhiman, Aritra Sarkara and Subi J. George
RSC Adv., 2018, 8, 18913-18925. DOI: 10.1039/C8RA03225D

Supramolecular control of liquid crystals by doping with halogen-bonding dyes
Jaana Vapaavuori, Antti Siiskonen, Valentina Dichiarante, Alessandra Forni, Marco Saccone, Tullio Pilati, Christian Pellerin, Atsushi Shishido, Pierangelo Metrangolo and Arri Priimagi
RSC Adv., 2017, 7, 40237-40242. DOI: 10.1039/C7RA06397K

Preparation of prolinamide with adamantane for aldol reaction catalysis in brine and separation using a poly(AN-MA-β-CD) nanofibrous film via host–guest interaction
Rui Wang, Enjie Xu, Zhenming Su, Haifeng Duan, Jinjin Wang, Longqi Xue, Yingjie Lin, Yaoxian Li, Zhonglin Wei and Qingbiao Yang
RSC Adv., 2018, 8, 28376-28385, DOI: 10.1039/C8RA04802A

 

Read the full collection here

Professor Leyong Wang, RSC Advances Associate Editor, Editor's Collection: Supramolecular Chemistry

 

 

 

Meet the Editor

Associate Editor Leyong Wang is a Professor at Nanjing University. His research focuses on supramolecular systems of molecular devices, from molecular macrocycles and cages, to topological molecules, and supramolecular dynamic materials for drug delivery and molecular sensing.

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ENQA meeting sets record for attendance

The 19th National Meeting of Analytical Chemistry (ENQA) was held from September 16th – 19th in Caldas Novas/GO together with the 7th Ibero-American Congress of Analytical Chemistry (CIAQA). The event received 1218 registrations from 25 Brazilian states and the Federal District with 1112 works presented in poster form.

The event was attended by speakers and participants from different countries such as Argentina, Portugal, Canada and the United States and had three thematic sessions. One of was titled  a “Meet the Editor Session” and was sponsored by the Royal Society of Chemistry. This had the participation of the following editors: Dr. Carlos D. Garcia (associate editor, RSC Advances), Dr. Susan M. Lunte (former editor in chief, Analytical Methods) and Dr. Jailson Bittencourt de Andrade (associate editor, Analytical Methods). The present public had the opportunity to discuss general and ethical aspects about “What to publish”, “Where to publish” and “How to publish with quality”.

The following were awarded for their work:

RSC Advances Award

Title: Amperometric detection of citrus tristeza virus using a disposable microfluidic device
Winner: Tayane A. Freitas (Federal University of São Carlos
Full list of authors: Tayane A. Freitas, Camila A. Proença, Thaísa A. Baldo, Elsa M. Materón, Ademar Wong, Rodrigo F. Magnani and Ronaldo C. Faria

Analyst/Analytical Methods Award

Title: Analytical method for the determination and chemical analysis of selenium speciation in milk and infant formula: analysis by isotope dilution and hyphenated techniques
Winner: Bernardo F. Braz (Federal University of Rio de Janeiro)
Full list of authors: Bernardo F. Braz, Vânia O. Trinta, Hélio F. da Rocha, Patrícia de C. Padilha, Cláudia Saunders Maria L. Fernández-Sánchez, Alfredo Sanz-Medel and Ricardo E. Santelli

There were also four symposiums were held at the event, covering “Innovation and Entrepreneurship”, “Passive Sampling in Environmental Chemistry”, “Advances in Spectrometric Analysis” and “Recent Advances in Analytical Instrumentation” and “Development of Chemical Sensors”. All the symposiums had the participation of renowned researchers in the area and had crowded rooms. The Symposium “Advances in Spectrometric Analysis” was dedicated to the memory of Professor Bernhard Welz.

Further information about the meeting can be found on the ENQA webpage.

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2017 Outstanding Reviewers

We are delighted to highlight the Outstanding Reviewers for RSC Advances in 2017, as selected by the editorial team, for their significant contribution to the journal. The reviewers have been chosen based on the quantity, quality and timeliness of the reports completed over the last 12 months.

A big thank you to those individuals listed here as well as to all of the reviewers that have supported the journal. Each Outstanding Reviewer will receive a certificate to give recognition for their significant contribution.

Professor Katsuhiko, Ariga National Institute for Materials Science, ORCID: 0000-0002-2445-2955
Dr Anzar Khan, Korea University, ORCID: 0000-0001-5129-756X
Dr Tapas Purkait, Johns Hopkins University, ORCID: 0000-0001-8948-6526
Dr Lichan Chen, Huaqiao University, ORCID: 0000-0002-0838-776X
Dr Kun Liu, eLab Solutions
Dr Ying Huang, Northwestern Polytechnical University, ORCID: 0000-0002-4364-9323
Dr Lei Yu Yangzhou, University, ORCID: 0000-0001-5659-7289
Dr Murat Yavuz Dicle, University, ORCID: 0000-0003-3452-8551
Dr Kaustabh Maiti, Central Electrochemical Research Institute
Dr Fan Dong, Chongqing Technology and Business University, ORCID: 0000-0003-2890-9964
Dr Serap Evran, Ege University, ORCID: 0000-0001-6676-4888
Dr Nirmal Goswami, University of South Australia, ORCID: 0000-0002-8950-6459
Dr Xinguo Zhang, Sun Yat-Sen University, ORCID: 0000-0002-8950-0831
Dr Hyo Jin Seo, Pukyong National University, ORCID: 0000-0002-0490-8484
Dr Dattatray Late, National Chemical Laboratory
Miss Xi Chen, National University of Singapore, ORCID: 0000-0002-8096-1455
Dr Zhaoyin Wen, Shanghai Institute of Ceramics, ORCID: 0000-0003-1698-7420
Dr Soumik Siddhanta, Johns Hopkins University, ORCID: 0000-0002-1383-6224
Dr Jiaxing Li, Institute of Plasma Physics, ORCID: 0000-0002-7683-2482
Dr Peng Liu, Oak Ridge National Laboratory
Dr Lihua Gan, Tongji University
Dr Miao Shi, University of Rochester, ORCID: 0000-0002-9719-6825
Dr Neal Chung Tai-Shung, National University of Singapore, ORCID: 0000-0002-4569-7169
Dr Xiangyang Shi, Donghua University, ORCID: 0000-0001-6785-6645
Dr Wei Li, Capital Normal University, ORCID: 0000-0001-7669-1125
Dr Bin Ding, Donghua University
Dr Changqiong Zhu, CoolComposites
Dr Dan Xiao, Sichuan University, ORCID: 0000-0001-5295-0540
Professor Sarbani Pal, MNR Degree & PG College, ORCID: 0000-0003-1730-0782
Dr Shiwei Qu, The Scripps Research Institute, ORCID: 0000-0002-9358-066X
Professor Priyadarsi De, Indian Institute of Science Education and Research, ORCID: 0000-0001-5486-3395
Miss Mehmet Yola, Sinop University
Dr Xinle Li, E O Lawrence Berkeley National Laboratory, ORCID: 0000-0001-5747-4029
Dr Kevin Wu, National Taiwan University, ORCID: 0000-0003-0590-1396
Dr Jiaguang Zhang, University of Lincoln, ORCID: 0000-0001-7238-4021
Dr Tongchuan Gao, University of Pittsburgh, ORCID: 0000-0003-4800-3641
Dr Jian Li, Northwest Normal University, ORCID: 0000-0001-5104-1564

Thank you to the RSC Advances board and our community for their continued support of the journal, as authors, reviewers and readers.

The RSC Advances Associate Editors work hand in hand with a dedicated reviewer panel made up of specially selected expert reviewers from across all fields of the chemical sciences (http://www.rsc.org/journals-books-databases/about-journals/rsc-advances/reviewer-panel/). If you would be interested in joining this reviewer panel, please contact us at advances@rsc.org with a resumé to receive further information.

Follow us on Twitter to keep informed!

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RSC Advances Reviewer Panel: 2017 Outstanding Reviewers

We are delighted to highlight the Outstanding Reviewers for RSC Advances in 2017, as selected by the editorial team, for their significant contribution to the journal. The reviewers have been chosen from the reviewer panel based on the quantity, quality and timeliness of the reports completed over the last 12 months.

A big thank you to those individuals listed here as well as to all of the reviewers on the RSC Advances reviewer panel that have supported the journal.

Each Outstanding Reviewer will receive a certificate to give recognition for their significant contribution.

Mr Rok Borstnar, Laboratory for genotoxicity
Dr Nghia Truong, Phuoc Monash University, ORCID: 0000-0001-9900-2644
Dr Wujun Fu, Oak Ridge National Laboratory
Dr S. Girish Kumar, CMR University, ORCID: 0000-0001-9132-1202
Dr Nicholas Geitner, Duke University, ORCID: 0000-0003-4313-372X
Dr Emanuele Curotto, University of Arcadia, ORCID: 0000-0001-9119-3263
Dr Yoong Ahm Kim, Chonnam National University, ORCID: 0000-0003-4074-7515
Dr Paul Trippier, Texas Tech University
Dr Michele Ceotto, Universita’ degli Studi di Milano, ORCID: 0000-0002-8270-3409
Dr Chunping Yang, Hunan University, ORCID: 0000-0003-3987-2722
Dr Wei Li, Utah State University, ORCID: 0000-0003-2802-7443
Dr Mark Waterland, Massey University, ORCID: 0000-0002-8493-9407
Dr Leo Small, Sandia National Laboratories, ORCID: 0000-0003-0404-6287
Dr Marija Gizdavic-Nikolaidis, The University of Auckland, ORCID: 0000-0002-8076-8508
Dr Xin Liu, State Key Laboratory of Fine Chemicals, ORCID: 0000-0002-4422-4108
Dr Zhijie Ma, University of Colorado Boulder, ORCID: 0000-0002-0734-1903
Dr Juliano Bonacin, University of Campinas, ORCID: 0000-0001-9399-1031
Dr Daniela Giacomazza, Istituto di Biofisica, ORCID: 0000-0002-6667-0205
Dr Ekkehard Lindner, Universitat Tubingen
Professor Zhenghua Tang, South China University of Technology, ORCID: 0000-0003-0718-3164
Dr Weixia Zhang, Harvard University, ORCID: 0000-0002-5835-2020
Dr Sreekuttan Unni, Central Electrochemical Research Institute, ORCID: 0000-0002-0403-9186
Professor Christian Robl, Friedrich-Schiller-Universität Jena
Professor Stanislaw Slomkowski, Center of Molecular and Macromolecular Studies, ORCID: 0000-0003-1543-535X
Dr Rui Oliveira, Universidade do Minho, ORCID: 0000-0002-3989-8925
Dr Wan Basirun, University of Malaya, ORCID: 0000-0001-8050-6113
Dr Yang Zhang, Arizona State University
Dr Maria Timofeeva, Novosibirsk State Technichal University
Dr Luis Simon, University of Salamanca, ORCID: 0000-0002-3781-0803
Dr Tsinghai Wang, National Tsing Hua University, ORCID: 0000-0003-4629-2005
Dr Thomas Mayer-Gall, Deutsches Textilforschungszentrum Nord-West, ORCID: 0000-0002-2822-6461
Dr Guowei Zhou Qilu, University of Technology
Dr Xiehong Cao, Nanyang Technological University, ORCID: 0000-0002-3004-7518
Dr Quanjun Xiang, University of Electronic Science and Technology of China, ORCID: 0000-0002-4486-7429
Dr Miklós Kubinyi, Budapest University of Technology and Economics, ORCID: 0000-0002-6343-0820
Dr Hu Li, Guizhou University, ORCID: 0000-0003-3604-9271
Dr Xuefeng Guo, Nanjing University, ORCID: 0000-0002-5492-5899
Dr Ahmad Zoolfakar, Universiti Teknologi MARA
Dr Bogdan-Marian Tofanica, Technical University of Iasi, ORCID: 0000-0002-4975-4650
Dr Zhiwei Xu, Tianjin Polytechnic University, ORCID: 0000-0003-1308-8884
Dr Tamás Vidóczy, Institute of Structuraél Chemistry
Dr Marinos Pitsikalis, University of Athens, ORCID: 0000-0002-7836-4862
Dr Haibo Shu, China Jiliang University, ORCID: 0000-0003-1728-2190
Dr Lin Zhang, Auburn University
Dr Ignacio Alfonso, Instituto de Química Avanzada de Cataluña, ORCID: 0000-0003-0678-0362
Dr Igor Komarov, Taras Shevchenko National University of Kyiv, ORCID: 0000-0002-7908-9145
Dr Xiao-Yu Hu, Nanjing University, ORCID: 0000-0002-9634-315X
Dr Zhe Wang, National Institutes of Health
Dr Muhammad Hossain, Yeungnam University, ORCID: 0000-0002-3428-8271
Dr Vaibhav Mehta, Marwadi University, ORCID: 0000-0003-4426-3374

Thank you to the RSC Advances board and our community for their continued support of the journal, as authors, reviewers and readers.

If you would like to become a reviewer for our journal, just email us with details of your research interests and an up-to-date CV or résumé.  You can find more details in our author and reviewer resource centre

Follow us on Twitter to keep informed!

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Read our most downloaded RSC Advances articles of 2017

We are delighted to present a collection which showcases some of the most accessed RSC Advances articles published in 2017. This provides an easy way to access the most important papers published in RSC Advances in this year in your area of research.

RSC Advances is the largest open access chemistry journal, bringing you the latest research from right across the chemical sciences. For enhanced browsing and discoverability, topic-modelling technology automatically categorises articles into one or more of the 12 main subject categories and over 100 further subcategories.

The articles in the collection highlight the most exciting and important research published across analytical chemistry, biological chemistry, catalysis, chemical biology and medicinal chemistry, energy, environmental chemistry, inorganic chemistry, materials chemistry, nanoscience, organic chemistry and physical chemistry.

Follow the link to find our most downloaded articles in your research area.

We hope you enjoy reading these articles!

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RSC Advances celebrates Open Access week 2017!

As we prepare to celebrate the 8th International Open Access week from 23-29 October 2017, it is an opportunity to highlight the benefits of Open Access and what it means for the RSC Advances research community…

We have published over 5600 open access articles so far in 2017, all of which are freely available to read on our website!

Open access refers to the free and permanent unrestricted online access to scholarly research and aims to maximise the visibility of research.

RSC Advances provides a high quality, open access option that helps get our authors’ work the attention that it deserves. Community-led, with an international team of associate editors, a dedicated reviewer panel and features such as article-based publishing, RSC Advances has been gold open access since January 2017, with one of the lowest article processing charges in the industry.

We deliberately push the boundaries with RSC Advances, always looking for new and unique ways to make the scientific developments we publish accessible to the widest possible audience.

See below for a sample of some of these articles that can be read for free, starting with our 5000th published article this year!

Fabrication of nanoporous copper with tunable ligaments and promising sonocatalytic performance by dealloying Cu–Y metallic glasses

Ning Wang, Ye Pan, Shikai Wu, Enming Zhang and Weiji Dai

RSC Adv., 2017,7, 43255-43265

DOI: 10.1039/C7RA08390D

High-quality CsPbBr3 perovskite nanocrystals for quantum dot light-emitting diodes

Xiafang Du, Guan Wu, Jian Cheng, Hui Dang, Kangzhe Ma, Ya-Wen Zhang, Peng-Feng Tan and Su Chen

RSC Adv., 2017,7, 10391-10396

DOI: 10.1039/C6RA27665b

Auxetic mechanical metamaterials

H. M. A. Kolken and A. A. Zadpoor

RSC Adv., 2017,7, 5111-5129

DOI: 10.1039/C7RA27333e

Enhanced seed germination and plant growth by atmospheric pressure cold air plasma: combined effect of seed and water treatment

L. Sivachandiran and A. Khacef

RSC Adv., 2017,7, 1822-1832

DOI: 10.1039/C6RA24762H

 

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Overwhelmed to death: an anti-cancer gene therapy approach paired with an immune-activating distress signal

Frontline therapies for treating colorectal cancer have shortcomings. These include their inability to impede local tumor recurrence and metastatic spread to distant sites such as the abdomen.  

Researchers have now utilized a gene therapy approach that simultaneously compromises cancer cell survival while activating immune system cells with cancer-killing abilities.

Gene therapy – an advanced technique developed to insert or inject therapeutic genes into human cells – has shown some success in treating the disease. In a previous study, Xiao and co-investigators at State Key Laboratory of Biotherapy, and the Department of Thoracic Oncology Cancer Center, West China Hospital, Sichuan University, had used a gene therapy approach to induce cancer cell death. Their study found that Vesicular Stomatitis Virus Matrix Protein (VSVMP), when inserted into a cancer cell,  compromises the cellular skeletal framework, which is made up of structural proteins. Cell death ensued as a consequence.

In the current study, the research team further armed with VSVMP gene delivery vessel with Interleukin-12 (IL-12) – a protein known to recruit and switch on the cancer-killing functions of immune cells.

The novel drug particles are based on Heparin-polyethyleneimine (HPEI) nanoparticles. To overcome the high toxicity and non-biocompatible nature of PEI, the team used a method to covalently conjugate this substance with heparin.

Their results, based on lab-grown cancer cells and animal studies, suggest that this novel complexed drug molecule (particle size: 53nm) increases tumor cell death, reduces division frequency, and stimulates the recruitment and activation of two types of cancer-killing cells: T cells and NK cells.

Specifically, the drug inhibited the growth of C-26 colon cancer cells. Animal studies showed that the drug reduced tumor weight. Metastatic spread of tumor cells to the abdomen was also reduced. The team proposes that the drug-derived IL-12 induces a secondary cascade of chemical mediators, which in turn recruit and activate cancer-killing immune cells. Their data supports this proposal. Interestingly, their study also found that the complexed drug molecule did not show adverse side effects within the major organs.

Read the full article here:

Nanoparticles co-delivering pVSVMP and pIL12 for synergistic gene therapy of colon cancer

Yuanyuan Xiao, Yuping Yang, Yujiao Wu, Chunmei Wang, Hao Cheng, Wei Zhao, Yang Li, Beibei Liu, Jianlin Long, Wenhao Guo, Guangping Gaoa and Maling Gou

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Killing cancer cells with a DNA-based molecular bridge

Monoclonal antibodies (mAbs) are antibodies made by clones of immune cells derived from a common parent cell. These synthesized molecules have achieved widespread clinical utility in the treatment of cancer owing to their high degree of specificity to proteins present on the surface of cancer cells, lower toxicity compared to other classes of targeted therapies, and improved treatment outcomes among patients with advanced stage cancer.

Non-Hodgkin Lymphoma (NHL) is a type of cancer where a subtype of immune cells called B-cells exhibit unrestrained cell division. The abnormal B-cell, now called a malignant B-cell, produces more abnormal cells like it. CD20 is a protein present on the surface of malignant B-cells. Rituximab (RTX) is used to treat patients with NHL because it can bind CD20 and consequently trigger cell death.

To address the growing need for CD20 targeted therapeutics, Cong and colleagues at the Department of Laboratory Diagnosis/Thoracic Surgery, Changhai Hospital Affiliated to The Second Military Medical University, Shanghai, China, developed molecules called aptamers that can bind to CD20 with greater specificity and strength compared to RTX.

Graphical Abstract

Graphical Abstract

Aptamers are molecules made up of  single stranded DNA that form complex 3D structures and can bind to target proteins, analogous to mAbs. The team used a method called cell-SELEX to retrieve an enriched pool of highly specific CD20-binding aptamers starting with their initial aptamer library. The aptamers used in the study were obtained after 15 rounds of selective refinement.

 

The study finds that Anti-CD20 DNA Aptamer (ACDA) can bind surface CD20 in NHL cells with greater strength compared to RTX. In the past, experiments have shown that cross-linking surface CD20 with mAbs (i.e. extracellular cross-linking) is a potent method of inducing cell death. A major limitation is that extracellular cross-linking cannot be realized in vivo. Cong et al. develop a method to link two ACDA molecules with polyethyleneimine (PEI) linker’, forming a molecular bridge  – the P-ACDA – capable of spanning the distance between and cross-linking two CD20 molecules. The study finds that P-ACDA led to substantially more cell death compared to ACDA.

Aptamers as a novel class of targeted therapies are expected to outperform mAbs because they do not evoke the body’s endogenous immune response (i.e. less immunogenic) and therefore in good compliance with current FDA recommendations. They are also easier to store since they are stable across a broad temperature range ,less expensive to manufacture, show consistency between production batches and can bind to both protein as well as non-protein targets. For these reasons, the clinical relevance of aptamers in treating HNL and potentially other cancers must be watched closely in the years to come.

Read the full article here:

Cong Wu, Wei Wan, Ji Zhua, Hai Jina, Tiejun Zhao and Huafei Li

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