There has recently been a lot of effort devoted to developing scaffolds that can mimic naturally occurring microenvironments to promote tissue regeneration. These scaffolds need to provide not only a three-dimensional (3D) structural support but also nanotextured surfaces which comprise of a fibrous network for cell adhesion and signaling.
In this review article Shang-Tian Yang and colleagues from The Ohio State University, USA , look at the influence of 3D microstructures and nanotopographies on cellular functions – cell adhesion, proliferation, morphogenesis and differentiation. The authors then discuss the recent developments in fabrication methods to produce 3D fibrous scaffolds and examples of their applications.
Three-dimensional fibrous scaffolds with microstructures and nanotextures for tissue engineering, Robin Ng, Ru Zang, Kevin K. Yang, Ning Liu and Shang-Tian Yang, RSC Adv., 2012, DOI: 10.1039/C2RA21085A
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