Archive for the ‘Hot article’ Category

Polymer Chemistry Paper of the Week: Aqueous RAFT/MADIX polymerization of N-vinyl pyrrolidone at ambient temperature

Poly(N-vinyl pyrrolidone) has been an important ingredient for medicine, pharmacy and cosmetics due to its excellent wetting and film forming properties. N-vinyl pyrrolidone (NVP) can be readily polymerized by free radical polymerization; however, it has been a challenge to polymerize this monomer by controlled radical polymerization techniques.

Destarac and his co-workers have demonstrated controlled RAFT/MADIX polymerization of NVP in water and at room temperature. Moreover, they have presented the preparation of poly(acrylamide)-b-(N-vinyl pyrrolidone) for the first time.

Aqueous RAFT/MADIX polymerisation of N-vinyl pyrrolidone at ambient temperature by Aymeric Guinaudeau, Stéphane Mazières, D. James Wilson and Mathias Destarac Polym. Chem. 2011, 3, 81-84.

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Introducing Polymer Chemistry Paper of the Week!!!

Dear Polymer Chemistry Blog Readers,

In 2011, we have published short interviews with 48 Polymer Chemistry Authors and these have attracted great attention in the Polymer Chemistry community. We will keep posting short interviews with our authors this year as well.

We are happy to announce that we will start highlighting 4 papers from every issue as Paper of the Week in the Polymer Chemistry blog. From time to time we will be discussing these papers with their authors or other leading scientists in that field. These papers will also be posted on Twitter and Facebook. Please feel free to send us your feedback or questions on these papers. We hope you will enjoy reading our blog posts in 2012!

Best wishes,
PC Blog Writers

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Hot Article: Multi-block copolymer stars via an iterative radical polymerization technique. No purification required!

Graphical abstract: Synthesis of multi-block copolymer stars using a simple iterative Cu(0)-mediated radical polymerization techniqueA simple and efficient route to well-defined multi-block star copolymers has been developed by scientists at the University of New South Wales, Australia.

Based on copper(0)-mediated living radical polymerization, the method involves a core first approach using a multi-functional initiator in connection with iterative copper(0)-mediated radical polymerization steps. No purification is required between the successive chain extension steps as complete monomer conversion is reached before the addition of each consecutive monomer type.

Synthesis of multi-block copolymer stars using a simple iterative Cu(0)-mediated radical polymerization technique: Cyrille Boyer, Aurelia Derveaux, Per B. Zetterlund and Michael R. Whittaker, Polym. Chem., 2012, 3, 117-123

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Hot Paper: Versatile synthesis of temperature-sensitive polypeptides by click grafting of oligo(ethylene glycol)

Graphical abstract: Versatile synthesis of temperature-sensitive polypeptides by click grafting of oligo(ethylene glycol)A series of thermoresponsive polymers suitable for releasing drugs from polymer nanoparticles have been created by a team at Changchun Institute of Applied Chemistry, China.

The team synthesised a series of thermoresponsive oligo(ethylene glycol)-grafted polypeptides that can self-assemble into amphiphilic nanoparticles in aqueous solution. These polymers show sharp temperature-dependent phase transitions and the lower critical solution temperature can be adjusted from 22.3 to 74.1 °C by varying the molecular weight, the length of the OEG side chain, the polymer concentration and salt concentration. The polymer nanoparticles are not toxic and the team demonstrated their drug release profiles using doxorubicin as a model drug.

Versatile synthesis of temperature-sensitive polypeptides by click grafting of oligo(ethylene glycol): Yilong Cheng, Chaoliang He, Chunsheng Xiao, Jianxun Ding, Xiuli Zhuang and Xuesi Chen, Polym. Chem., 2011, 2, 2627-2634

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Hot Paper: Anionic polymeric ionic liquids with high charge delocalization

Graphical abstract: Design and synthesis of new anionic “polymeric ionic liquids” with high charge delocalizationA new family of polymeric ionic liquids could find use as materials for electrochemical devices.

The team led by A. S. Shaplov synthesised three ionic monomers with highly delocalized anions and mobile aprotic cations. These monomers were designed to mimic the structure of three highly conductive anions. A radical polymerization procedure was then used to form the polymeric ionic liquids. Interested to know more? Read the full article for free. 

Design and synthesis of new anionic “polymeric ionic liquids” with high charge delocalization: A. S. Shaplov, P. S. Vlasov, M. Armand, E. I. Lozinskaya, D. O. Ponkratov, I. A. Malyshkina, F. Vidal, O. V. Okatova, G. M. Pavlov, C. Wandrey, I. A. Godovikov and Y. S. Vygodskii, Polym. Chem., 2011, 2, 2609-2618

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Hot Paper: The formation of core cross-linked star polymer and nanogel assemblies facilitated by the formation of dynamic covalent imine bonds

Chemoresponsive polymer structures containing dynamic covalent imine bonds have been created using RAFT polymerisation. The team from Newcastle University, UK, fabricated core-cross-linked star polymers using diblock copolymers containing ‘inert’ and ‘reactive’ blocks. The also team made nanogels using methacrylate copolymers that cross-link by forming kinetically stable imine bonds in organic solvents.

Graphical abstract: The formation of core cross-linked star polymer and nanogel assemblies facilitated by the formation of dynamic covalent imine bonds

Read the full article for free:
Alexander W. Jackson, Christopher Stakes and David A. Fulton, Polym. Chem., 2011, 2, 2500-2511

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Hot Paper: Facile routes to star polymers via an organocatalytic approach

Organocatalyzed ring opening polymerization using multifunctional dendritic and polysaccharide initiators offers a simple method for creating uniform biodegradable or biocompatible star polymers.

Developed by James Hedrick and co-workers in the USA and Singapore, the method can generate homo and block star polymers with a specified average molecular weight and narrow polydispersity. The team say that the method’s ability to create of uniform materials could be useful for developing designer delivery systems.

Daniel J. Coady, Amanda C. Engler, Yi Yan Yang and James L. Hedrick, Polym. Chem., 2011, 2, 2619-2626

Graphical abstract: Facile routes to star polymers via an organocatalytic approach

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Hot Paper: Detection of explosives with fluorescent carbazole dendrimers

Graphical abstract: Fluorescent carbazole dendrimers for the detection of explosivesDendrimers capable of detecting TNT have been developed by scientists in Australia. 

The performance of three generations of fluorescent carbazole dendrimers in solution and in thin films were tested to identify differences in the binding to explosives. This technology could help create portable sensors for detecting nitroaromatic explosives.

Read the full article for free (free registration required): Guoqiang Tang, Simon S. Y. Chen, Paul E. Shaw, Katalin Hegedus, Xin Wang, Paul L. Burn and Paul Meredith, Polym. Chem., 2011, 2, 2360-2368

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Hot Review: Catalytic chain transfer and its derived macromonomers

In this Hot Review Johan P. A. Heuts and Niels M. B. Smeets give an overview of cobalt-catalyzed chain transfer in free-radical polymerization and the chemistry and applications of its derived macromonomers.

Graphical abstract: Catalytic chain transfer and its derived macromonomers

Johan P. A. Heuts and Niels M. B. Smeets, Polym. Chem., 2011, DOI: 10.1039/C1PY00224D, Advance Article

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Improving blood clearance times by copolymerization

Improving the blood clearance time of 125I labeled Dex-g-PMAGGCONHTyr by copolymerization: Pharmacokinetics studies shows that modifying a tyrosine conjugate with a 125I labelled graft copolymer increased the blood clearance time. The Chinese scientists behind the research claim that the modified dextran graft copolymer is potentially an excellent radiotherapy carrier.

Graphical abstract: Improving the blood clearance time of 125I labeled Dex-g-PMAGGCONHTyr by copolymerization 

Why not read the full article available for free (free registration required): Deqian Wang, Ruigang Liu, Ning Che, Qinmei Li, Zhuang Li, Ye Tian, Honglang Kang, Bing Jia and Yong Huang, Polym. Chem., 2011, 2, 1872-1878

To keep up-to-date with all the latest research, sign up for the journal’s e-alerts or RSS feeds or follow Polymer Chemistry on Twitter or Facebook.

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