A method for preparing block copolypeptides with side-chain groups capable of orthogonal functionalisation via “click” chemistry has been developed by polymer chemists at Louisiana State University, USA. All the block copoly(α-peptide)s adopt α-helical conformations both in solid state and in solution. The team say that this methodology provides a convenient and modular approach towards helical block copoly(α-peptides) with diverse structures by side-chain conjugation, allowing control over polymer bioactivity, solubility and self-assembly properties.
Read the full paper: Haoyu Tang and Donghui Zhang, Polym. Chem., 2011, 2, 1542-1551