Hot Article: Multi-functionalization of helical block copoly(alpha-peptide)s by orthogonal chemistry

A method for preparing block copolypeptides with side-chain groups capable of orthogonal functionalisation via “click” chemistry has been developed by polymer chemists at Louisiana State University, USA. All the block copoly(α-peptide)s adopt α-helical conformations both in solid state and in solution. The team say that this methodology provides a convenient and modular approach towards helical block copoly(α-peptides) with diverse structures by side-chain conjugation, allowing control over polymer bioactivity, solubility and self-assembly properties.

Graphical abstract: Multi-functionalization of helical block copoly(α-peptide)s by orthogonal chemistry

Read the full paper: Haoyu Tang and Donghui Zhang, Polym. Chem., 2011, 2, 1542-1551

 

To keep up-to-date with all the latest research, sign up for the journal’s e-alerts or RSS feeds or follow Polymer Chemistry on Twitter or Facebook.

Digg This
Reddit This
Stumble Now!
Share on Facebook
Bookmark this on Delicious
Share on LinkedIn
Bookmark this on Technorati
Post on Twitter
Google Buzz (aka. Google Reader)

Leave a Reply

*