Hot Article: Thiol–yne ‘click’ chemistry as a route to functional lipid mimetics

Thiol-yne chemistry is an efficient mechanism to synthesize A2B star polymers. In the latest Polymer Chemistry Hot Article, Daniel Savin and co-workers at University of Southern Mississippi, USA, report the synthesis and solution characterization of polypeptide-based stars that serve as lipid mimetic molecules.

Graphical abstract: Thiol–yne ‘click’ chemistry as a route to functional lipid mimetics

Using the thiol–yne convergent synthesis, the team envision a modular approach to functionalize proteins or oligopeptides with lipophilic chains that can imbed seamlessly into a cell membrane.

Fancy knowing more? Why not read the full article for free here:

Sandeep S. Naik, Justin W. Chan, Christopher Comer, Charles E. Hoyle and Daniel A. Savin, Polym. Chem., 2011, DOI: 10.1039/C0PY00231C

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