Thiol-yne chemistry is an efficient mechanism to synthesize A2B star polymers. In the latest Polymer Chemistry Hot Article, Daniel Savin and co-workers at University of Southern Mississippi, USA, report the synthesis and solution characterization of polypeptide-based stars that serve as lipid mimetic molecules.
Using the thiol–yne convergent synthesis, the team envision a modular approach to functionalize proteins or oligopeptides with lipophilic chains that can imbed seamlessly into a cell membrane.
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