Archive for the ‘Cover articles’ Category

OBC issue 3 online now, featuring: cylindrical peptides, tubulin inhibitors, aliphatic C–H functionalization & much more

On the front cover (right) of this week’s issue is a paper on cylindrical peptide assemblies from Andrew D. Abell and colleagues from The University of Adelaide. Abell et al. present a new template-based approach to peptide based nanotubes using a ‘smart’ scaffold designed to be constrained into a β-strand geometry.

New cylindrical peptide assemblies defined by extended parallel β-sheets
Ashok D. Pehere, ChRistopher J. Sumby and Andrew D. Abell
DOI: 10.1039/C2OB26637G

Featuring on the inside cover (left) is a paper from Mouad Alami, Abdallah Hamze and co-workers reporting the synthesis and antiproliferative activity of tri- and tetrasubstituted 1,1-diarylolefins related to isocombretastatin A-4.

Synthesis, biological evaluation, and structure–activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors
Abdallah Hamze and Mouad Alami et al.
DOI: 10.1039/C2OB26253C

Both cover articles are free to access for 6 weeks.

Also in this issue and free to access:

HOT – Sulfoxide-TFAA and nucleophile combination as new reagent for aliphatic C–H functionalization at indole 2α-position

HOT – Integrin and matrix metalloprotease dual-targeting with an MMP substrate–RGD conjugate

HOT – Organocatalytic conjugate addition promoted by multi-hydrogen-bond cooperation: access to chiral 2-amino-3-nitrile-chromenes

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Organic & Biomolecular Chemistry issue 2, 2013 featuring: asymmetric phase-transfer catalysis & ion channel inhibitors

Welcome to the second issue of Organic & Biomolecular Chemistry of 2013. In this issue we have: 3 perspectives, 4 communications and 15 articles.

Featuring on the front cover this week is the paper of Keiji Maruoka et al. who report the catalytic asymmetric synthesis of a wide variety of cyclic amino acid derivatives using chiral phase transfer catalysts.

Stereoselective synthesis of cyclic amino acids via asymmetric phase-transfer catalytic alkylation
Taichi Kano, Takeshi Kumano, Ryu Sakamoto and Keiji Maruoka
DOI: 10.1039/C2OB26778K

Taking us under the sea on the inside cover is the work of Tushar Kanti Chakraborty et al. who have developed a convergent method, involving Julia–Kocienski olefination, Urpi acetal aldol and Shiina macrolactonization as the key steps, for the total synthesis of the potent ion channel inhibitor (29S,37S)-isomer of malevamide E.

Total synthesis of (29S,37S)-isomer of malevamide E, a potent ion-channel inhibitor
Praveen Kumar Gajula, Shrikant Sharma, Ravi Sankar Ampapathi and Tushar Kanti Chakraborty
DOI: 10.1039/C2OB26533H

Both of these articles will be free to access for 6 weeks. Read all this in issue 2 of OBC today.

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OBC Issue 1, 2013 – featuring DNA–peptide energetic studies & prodigiosenes to treat leukemia

Welcome to issue 1, 2013, of Organic & Biomolecular Chemistry. The entire issue is free for you to access so get busy downloading!

Front cover: This very elegant cover highlights the work of Leung Sheh and co-workers. The study of Sheh et al. further explores the allosteric features of DNA–peptide molecular recognition with regard to interaction networks, choosing designed peptides that exhibit significant cooperativity in binding to DNA.

Energetic studies on DNA–peptide interaction in relation to the enthalpy–entropy compensation paradox
Robin C. K. Yang, Jonathan T. B. Huang, Shih-Chuan Chien, Roy Huang, Kee-Ching G. Jeng, Yen-Chung Chen, Mokai Liao, Jia-Rong Wu, Wei-Kang Hung, Chia-Chun Hung, Yu-Ling Chen, Michael J. Waring and Leung Sheh

Inside cover: Featuring on this cover is the work of Alison Thompson and co-workers who have structurally modified the C-ring of a series of prodigiosenes to produce a series of analogues that show promising activity against leukemia cell lines.

Investigations regarding the utility of prodigiosenes to treat leukemia
Deborah A. Smithen, A. Michael Forrester, Dale P. Corkery, Graham Dellaire, Julie Colpitts, Sherri A. McFarland, Jason N. Berman and Alison Thompson


Both of these papers have been highlighted by the reviewers as being HOT.

Also in this issue:

HOTPd-catalyzed Suzuki coupling reaction of chloroalkylidene-β-lactones with LB-Phos as the ligand
Pengbin Li, Bo Lü, Chunling Fu and Shengming Ma

HOT An efficient organocatalytic enantioselective synthesis of spironitrocyclopropanes
Utpal Das, Yi-Ling Tsai and Wenwei Lin

HOT Synthesis of a four-component [3]catenane using three distinct noncovalent interactions
Miguel Á. Alemán García and Nick Bampos

Find all this great FREE content and more in issue 1

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OBC Issue 48 online now; it’s the last one of 2012!

Issue 48 of OBC is now online; the last issue of 2012!

Front cover:
Anyone for a game of dominos? In this paper Alessandro Volonterio and colleagues report a one-pot, three-component sequential procedure for the synthesis of diversely 1,3,5- and 1,3,5,5-substituted hydantoins. Volonterio et al. believe that this methodology is especially convenient for the synthesis of spiro-hydantoins, which are particularly interesting bioactive compounds in medicinal chemistry.

Regioselective multicomponent sequential synthesis of hydantoins
Francesca Olimpieri, Maria Cristina Bellucci, Tommaso Marcelli and Alessandro Volonterio
DOI: 10.1039/C2OB26498F

Inside cover:
This colourful cover highlights the work of Atul Goel & Gerhard Bringmann et al., who report a short and efficient synthesis of racemic cis-pterocarpans and highlight a new protocol for the resolution of the enantiomers on a chiral phase through analytical and preparative HPLC.

Synthesis, optical resolution, absolute configuration, and osteogenic activity of cis-pterocarpans
Atul Goel, Amit Kumar, Yasmin Hemberger, Ashutosh Raghuvanshi, Ram Jeet, Govind Tiwari, Michael Knauer, Jyoti Kureel, Anuj K. Singh, Abnish Gautam, Ritu Trivedi, Divya Singh and Gerhard Bringmann
DOI: 10.1039/C2OB25722J

Download both cover articles for free for 6 weeks!

Also in this issue:

HOT article – 1,5-(H, RO, RS) shift/6π-electrocyclic ring closure tandem processes on N-[(α-heterosubstituted)-2-tolyl]ketenimines: a case study of relative migratory aptitudes and activating effects

Get all of this and more today! Go to the issue now…..

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OBC issue 47 – genomics driven discoveries and click reactions in preotein chemistry

Welcome to issue 47 of Organic & Biomolecular Chemistry. So what have we got in store for you this week?

On the front cover:
In this paper by Martin F. Kreutzer and Markus Nett from the Leibniz Institute for Natural Product Research and Infection Biology, report the bioinformatic analysis of an orphan nonribosomal peptide synthetase gene cluster in the rhizobium Cupriavidus taiwanensis. This genome mining strategy led to the isolation of the associated metabolite; a previously unrecognised lipopeptide siderophore.

Genomics-driven discovery of taiwachelin, a lipopeptide siderophore from Cupriavidus taiwanensis
Martin F. Kreutzer and Markus Nett
DOI: 10.1039/C2OB26296G

On the inside cover:
This attractive image highlights the perspective of Jose M. Palomo who describes the current application of click reactions in protein chemistry, the creation of new semisynthetic enzymes by site-specific modifications and the recent design and creation of enzymes with synthetic click activities.

Click reactions in protein chemistry: from the preparation of semisynthetic enzymes to new click enzymes
Jose M. Palomo
DOI: 10.1039/C2OB26409A


Also in this issue is this HOT Communication:

Benzimidazolium-based synthetic chloride and calcium transporters in bacterial membranes
Claude-Rosny Elie, Audrey Hébert, Mathieu Charbonneau, Adam Haiun and Andreea R. Schmitzer

Read the issue today! The cover articles are free to access for 6 weeks and the HOT article is free for 4 weeks.

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Organic & Biomolecular Chemistry issue 46: achiral supramolecular stacks & heteroaromatic α-hydroxy esters

Guess what…. yes you got it, it’s Organic & Biomolecular Chemistry time! This week’s issue has 1 Perspective, 5 Communications and 17 Papers for your reading pleasure.

Front cover:

Put your hands together for this very nice image highlighting the work of David B. Amabilino and colleagues. Amabilino et al. use the induction of chirality in achiral aggregates of an oligo(p-phenylenevinylene) to detect the enantiomeric excess in acids used in the resolution of chiral compounds. These achiral supramolecular stacks can detect the enantiomeric excess of substoichiometric amounts different organic acids.

Sensitive detection of enantiomeric excess in different acids through chiral induction in an oligo(p-phenylenevinylene) aggregate
François Riobé, Albertus P. H. J. Schenning and David B. Amabilino
DOI: 10.1039/C2OB26411K

Inside cover:

This image of seaside chemistry is courtesy of Ming-Hua Xu and co-workers at Shanghai Institute of Materia Medica. Xu et al. present their work on developing a highly efficient and enantioselective route to quaternary carbon-containing heteroaromatic α-hydroxy esters. Xu et al. employ the catalytic asymmetric 1,2-addition of arylboronic acids to obtain these heteroaryl α-ketoesters.

Rhodium-catalyzed enantioselective 1,2-addition of arylboronic acids to heteroaryl α-ketoesters for synthesis of heteroaromatic α-hydroxy esters
Hui Wang, Ting-Shun Zhu and Ming-Hua Xu
DOI: 10.1039/C2OB26316E

Hot articles in this issue:

Reduction of metal ions by boranephosphonate DNA
Subhadeep Roy, Magdalena Olesiak, Petra Padar, Heather McCuen and Marvin H. Caruthers

The bacterial second messenger c-di-GMP: probing interactions with protein and RNA binding partners using cyclic dinucleotide analogs
Carly A. Shanahan and Scott A. Strobel

As always the articles featured on the covers are free to access for 6 weeks, and the HOT articles are free for 4!

For all this and much, much more take a look at the issue online today!

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Organic & Biomolecular Chemistry issue 45: poisonous frogs, spirocyclic alkaloids & cycloadditions

Issue 45 of Organic & Biomolecular Chemistry is now online, so hop to it and take a cheeky peek….

Featuring in the issue this week:

Leaping on to the front cover is this image (right) from Andrew B. Holmes, Annabella F. Newton and colleagues. The cover highlights the work of Holmes et al. exploring the synthesis of the histrionicotoxin family, which includes some interesting investigations into the intriguing observed regioselectivity of the dipolar cycloaddition during the key cascade hydroxylamine-alkyne cyclisation/nitrone cycloaddition to form the azaspirocyclic core.

Intramolecular nitrone dipolar cycloadditions: control of regioselectivity and synthesis of naturally-occurring spirocyclic alkaloids
Alastair J. Hodges, Joseph P. Adams, Andrew D. Bond, Andrew B. Holmes, Neil J. Press, Stephen D. Roughley, John H. Ryan, Simon Saubern, Catherine J. Smith,  Michael D. Turnbull and Annabella F. Newton
DOI: 10.1039/C2OB26333E

The inside cover of this week’s issue (left) features the work of Feng Shi and co-workers from Henan University. Shi et al. re-examine the use of the Kobayashi benzyne precursor in the [3 + 2] cycloaddition of arynes with 3-oxidopyridinium species, for the first time in 16 years, expanding investigations further than ever before.

Aryne cycloaddition with 3-oxidopyridinium species
Hailong Ren, Chunrui Wu, Xiuxiu Ding, Xiaoge Chen and Feng Shi
DOI: 10.1039/C2OB26519B

Both of these papers have been highlighted as being HOT chemistry by the reviewers, and they are both FREE to access for the next 6 weeks, so enjoy!

Also in this issue: 6 Communications and a further 14 papers full of great content.

Read the complete issue now…

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Organic & Biomolecular Chemistry issue 44 online now

Welcome to issue 44 of OBC…..

Featuring on the front cover is a paper from Günter Haufe and colleagues, described by the reviewers as being an important contribution to the field of organofluorine chemistry. Haufe et al. present results of the reactions of β-alkoxyvinyl polyfluoroalkyl ketones with ethyl isocyanoacetate and potassium tert-butoxide, which are strongly dependent on the structure of the starting enones, and the application of this reaction to the synthesis of new fluorinated pyrroles.

Reactions of β-alkoxyvinyl polyfluoroalkyl ketones with ethyl isocyanoacetate and its use for the synthesis of new polyfluoroalkyl pyrroles and pyrrolidines
Ivan S. Kondratov, Violetta G. Dolovanyuk, Nataliya A. Tolmachova, Igor I. Gerus, Klaus Bergander, Roland Fröhlich and Günter Haufe
DOI: 10.1039/C2OB26176F

This bright image on the inside cover is courtesy of Kristin Bowman-James and co-workers at the University of Kansas. Bowman-James et al. summarise results from previous studies on the stability and reactivity of the sulfur mustard and its surrogates toward hydrolysis and nucleophilic attack, and add results of their own on the reactivity of this class of molecules with simple nucleophiles in non-polar solvents, assessing their behaviour in the absence of competing solvation effects.

Sulfur, oxygen, and nitrogen mustards: stability and reactivity
Qi-Qiang Wang, Rowshan Ara Begum, Victor W. Day and Kristin Bowman-James
DOI: 10.1039/C2OB26482J

Read the entire issue on our webpage, and don’t forget that the articles featuring on the covers are free for you to download for the next 6 weeks.

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Issue 43 of OBC online now!

Issue 43 of Organic & Biomolecular Chemistry has arrived, and featuring in this week’s issue:

On the front cover:

A HOT Communication from Xiangbao Meng, Zhongjun Li and colleagues from Peking University presenting a convenient, metal-free method for the intramolecular oxidative aminofluorination of unactivated terminal alkenes. This new transformation represents an efficient method for the preparation of fluorine containing cyclic amines.

Metal-free intramolecular aminofluorination of alkenes mediated by PhI(OPiv)2/hydrogen fluoride–pyridine system
Qing Wang, Wenhe Zhong, Xiong Wei, Maoheng Ning, Xiangbao Meng and Zhongjun Li
DOI: 10.1039/C2OB26664D

On the inside cover:

A Communication from Jacek Jemielity and co-workers, University of Warsaw, which is part of OBC’s Nucleic acids: new life, new materials web collection. Jemielity et al. have developed a chemoenzymatic method for obtaining RNAs that are specifically labelled with biotin at the 5′ m7G cap moiety.

Synthesis of biotin labelled cap analogue – incorporable into mRNA transcripts and promoting cap-dependent translation

Jacek Jemielity, Maciej Lukaszewicz, Joanna Kowalska, Jakub Czarnecki, Joanna Zuberek and Edward Darzynkiewicz
DOI: 10.1039/C2OB26060C

Also in this issue – 5 additional HOT articles:

Concise and efficient syntheses of preQ1 base, Q base, and (ent)-Q base
Hans-Dieter Gerber and Gerhard Klebe

Inter- and intramolecular reactions of 1-deoxy-1-thio-1,6-anhydrosugars with α-diazoesters: synthesis of the tagetitoxin core by photochemical ylide rearrangement
Anne J. Price Mortimer, Julien R. H. Plet, Oluwafunsho A. Obasanjo, Nikolas Kaltsoyannis and Michael J. Porter

Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility
Mark von Itzstein et al.

Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines

Mamta Kaura, Pawan Kumar and Patrick J. Hrdlicka

A cucurbit[8]uril sponge
Vijayakumar Ramalingam, Sharon K. Kwee, Lisa M. Ryno and Adam R. Urbach

Read the issue today! The articles on the covers are free to access for 6 weeks, and the HOT articles are free to access for 4 weeks!

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Taking a look at this week’s issue of Organic & Biomolecular Chemistry

Organic & Biomolecular Chemistry issue 42

On the front cover:

We have this HOT article from Marcos N. Eberlin and colleagues studying corrole isomers using traveling wave ion mobility mass spectrometry and collision induced dissociation experiments. The isomers had subtle structural changes, promoted by exchange of nitrogen and carbon atoms in the corrole ring, and significant differences in the shapes and charge distributions of the protonated molecules were found to lead to contrasting gas phase mobilities.

Corrole isomers: intrinsic gas-phase shapes via traveling wave ion mobility mass spectrometry and dissociation chemistries via tandem mass spectrometry
Maíra Fasciotti, Alexandre F. Gomes, Fabio C. Gozzo, Bernardo A. Iglesias, Gilberto F. de Sá, Romeu J. Daroda, Motoki Toganoh, Hiroyuki Furuta, Koiti Araki and Marcos N. Eberlin
DOI: 10.1039/C2OB26209F

On the inside cover:

A Perspective by Xuefeng Jiang, Jason S. Chen and colleagues, on the thermodynamic driving force of many synthetic transformations – gas extrusion. The review focuses on gas expulsion in key reactions within natural products total syntheses, selected from the past two decades. Included are transformations that generate sulfur dioxide, carbon dioxide, carbonyl sulfide, or nitrogen through polar, radical, pericyclic, photochemical, or organometallic mechanisms.

Gas extrusion in natural products total synthesis
Xuefeng Jiang, Lei Shi, Hui Liu, Akbar H. Khan and Jason S. Chen
DOI: 10.1039/C2OB26152A

There is also:

Another HOT article on the efficient synthesis of N-(buta-2,3-dienyl) amides from terminal N-propargyl amides and their synthetic potential towards oxazoline derivatives by Shengming Ma et al., 1 Communication and 16 more Papers… read them all in OBC issue 42 – it’s online now.

And don’t forget, the cover articles will be free to access for the next 6 weeks!

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