Archive for the ‘Article collections’ Category

Unexpected divergent reactivity in Pt-catalyzed cyclizations of 1,5-bisallenes

As a result of their unique physical and chemical properties, allenes have become key building blocks in modern organic synthesis. The discovery and development of their varied reactivity have been extensively reported on in recent years, however, application to more challenging bisallene systems has been comparatively limited.

In her group’s recent OBC publication, Prof. María Paz Muñoz of the University of East Anglia sought to fill this gap in the bisallene literature. The study discusses the development of an unprecedented Pt-catalyzed cyclization of 1,5-bisallenes in the presence of oxygen nucleophiles to selectively access 6- and 7-membered rings.

After initial screening, it was observed that selectivity was highly sensitive to the reaction conditions and could, therefore, be tuned to yield the desired molecular scaffold. Interestingly, in the presence of nucleophilic alcohols, vinyltetrahydropyridines are formed preferentially while the formation of di- and tetrahydroazepines are favoured when water is used.

Exhaustive mechanistic studies provided insight into this divergent reactivity. It was determined that different mechanisms operate depending on the nucleophile and electronic nature of the bisallene (as a result of its nitrogen tether). It is proposed that, in the presence of nucleophilic alcohols, 6-membered vinyltetrahydropyridines are preferentially formed as a result of a platinum hydride active catalyst—which are known to form from platinum complexes and alcohols. Tetrahydroazepines, on the other hand, are favoured when water is used as the nucleophile, proceeding first through a nucleophilic attack followed by carbocylization to form the 7-membered ring.

Understanding this complex mechanistic behaviour provides important insight into bisallene reactivity and will no doubt enhance the scope of this work’s application in organic and medicinal chemistry.

This communication is part of the OBC themed collection, Mechanistic Aspects of Organic Synthesis. You can read the rest of the collection here.

 

To find out more see:

Nucleophile dependent formation of 6- and 7-membered N-heterocycles by platinum-catalysed cyclisation of 1,5-bisallenes
María Teresa Quirós,César Hurtado-Rodrigo and María Paz Muñoz
DOI:10.1039/C7OB01469D


Victoria Corless is currently completing her Ph.D. in organic chemistry with Prof. Andrei Yudin at the University of Toronto. Her research is centred on the synthesis of kinetically amphoteric building blocks which offer a versatile platform for the development of chemoselective transformations with particular emphasis on creating novel biologically active molecules.

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Self-assembly of bioactive peptides, peptide conjugates, and peptide mimetic materials

Molecular self-assembly has become one of the most prominent fields of nanotechnology in recent years. Inspired by nature, many scientists around the world are attempting to utilize it as a tool to design novel nanostructures with desired biomedical properties.

To achieve this goal, it is necessary to understand how self-assembly works and how molecular forces and other conditions drive this self-assembly and define the structure of a specific supramolecular complex.

In a recent Organic & Biomolecular Chemistry publication, Professor Charlotte J. C. Edwards-Gayle and Professor Ian W. Hamley from the University of Reading, UK, have reviewed some of the most prominent self-assembled peptide amphiphiles and their potential applications. These include tissue scaffolds, antimicrobial peptides and drug transporters.

One of the distinct features of self-assembling amphiphiles, which makes them attractive candidates for many applications, is their diversity to form various structures such as micelles, vesicles, nanotubes, fibrils and sheets (Fig.1). The self-assembly of PAs can also be tuned by several factors including amino acid sequence, peptide length, temperature, pH, and concentration.

 

These features make them perfect, novel tools to create biomaterials which can be responsive to different environmental cues. However, the review points out that the key question of whether there is a relationship between bioactivity and self-assembly of peptide amphiphiles has still remained unanswered, despite the advancement in the field.

Extending the success in designing various structures, together with distinct applications, have made peptide amphiphile self-assembly a vibrant field in which researchers will continue to develop functional constructs with novel applications.

To find out more please see:

Self-assembly of bioactive peptides, peptide conjugates, and peptide mimetic materials
Charlotte J. C. Edwards-Gayle and Ian W. Hamley
DOI: 10.1039/C7OB01092C


Zahra Bahrami Dizicheh is a PhD candidate in molecular biology with Dr. Giovanna Ghirlanda at Arizona State University. She does research on photo-electrochemical hydrogen production with designing and developing interconnection between conductive materials and redox proteins to develop dye-sensitized photo-electrochemical cells.

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Celebrating Ian Paterson’s 60th Birthday

In May 2014, Ian Paterson celebrates his sixtieth birthday. Eighty students have completed PhDs under his guidance. To mark this milestone, the RSC are collating the papers he has published in RSC journals and making them available to everybody. Ian was born in Dundee, and studied at St Andrew’s University. Two papers were published in the Journal of the Chemical Society as a result of his undergraduate research. He then moved to the University of Cambridge to work with Ian Fleming and to contribute further to RSC publications. A postdoctoral fellowship at Columbia University followed, working with Gilbert Stork, who had published fewer papers with the RSC than Ian. Ian then returned to the UK, first to UCL and then to Cambridge, where he has been for the last three decades.He has developed new methods for stereoselective transformations, particularly the boron-mediated aldol reaction, and used these in the syntheses of larger and larger molecules with increasing stereochemical complexity. The first report of his approach to discodermolide appeared in Chem Comm (1993) and, in due course, the synthesis was scaled up so that it could be used for clinical development. Studies on spongistatin, spirastrellolide, dictyostatin and other complex natural products have all been reported in RSC journals, as well as investigations of hybrids and semi-synthetic analogues. Ian has been elected to fellowships both of the Royal Society and the Royal Society of Edinburgh, and has won many RSC prizes including the Meldola Prize (1983), Hickinbottom Fellowship (1989), Bader Award (1996), Synthetic Organic Chemistry Award (2001), and the Tilden Prize (2009).Professor Jonathan Goodman
University of Cambridge, UK

All articles are free to access until 13th June 2014

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim and Philip Maltas
Org. Biomol. Chem., 2012,10, 5873-5886, DOI: 10.1039/C2OB25101A 

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Fragment coupling studies and completion of the synthesis

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim, Philip Maltas, Olivier Loiseleur, Julien Genovino and Christian Moessner  
Org. Biomol. Chem., 2012,10, 5861-5872, DOI: 10.1039/C2OB25100K

The stereocontrolled total synthesis of spirastrellolide A methyl ester. Expedient construction of the key fragments

Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues
A. Jonathan Singh, Mina Razzak, Paul Teesdale-Spittle, Thomas N. Gaitanos, Anja Wilmes, Ian Paterson, Jonathan M. Goodman, John H. Miller and Peter T. Northcote  
Org. Biomol. Chem., 2011,9, 4456-4466, DOI: 10.1039/C0OB01127D 

Structure–activity studies of the pelorusides: new congeners and semi-synthetic analogues

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin
Ian Paterson, Guy J. Naylor, Takeshi Fujita, Esther Guzmán and Amy E. Wright  
Chem. Commun., 2010,46, 261-263, DOI: 10.1039/B921237J

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

Synthesis and stereochemical determination of the spirastrellolides
Ian Paterson and Stephen M. Dalby  
Nat. Prod. Rep., 2009,26, 865-873, DOI: 10.1039/B906991G

Synthesis and stereochemical determination of the spirastrellolides

Total synthesis of (-)-spirangien A and its methylester
Ian Paterson, Alison D. Findlay and Christian Noti  
Chem. Commun., 2008, 6408-6410, DOI: 10.1039/B816229H

Total synthesis of the marine macrolide (+)-neopeltolide
Ian Paterson and Natalie A. Miller
Chem. Commun., 2008, 4708-4710, DOI: 10.1039/B812914B

Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide
Ian Paterson, Guy J. Naylor and Amy E. Wright
Chem. Commun., 2008, 4628-4630, DOI: 10.1039/B811575C

Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin
Gordon J. Florence, Nicola M. Gardner and Ian Paterson  
Nat. Prod. Rep., 2008,25, 342-375, DOI: 10.1039/B705661N

Synthesis of two diastereomeric C1–C22 fragments of spirastrellolide A
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Julien Genovino, Jong Ho Lim and Christian Moessner  
Chem. Commun., 2007, 1852-1854, DOI: 10.1039/B700827A

Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid
Ian Paterson and Nicola M. Gardner
Chem. Commun., 2007, 49-51, DOI: 10.1039/B615122A

Synthesis of the DEF-bis-spiroacetal of spirastrellolide A exploiting a double asymmetric dihydroxylation/spiroacetalisation strategy
Ian Paterson, Edward A. Anderson, Stephen M. Dalby, Jong Ho Lim, Philip Maltas and Christian Moessner
Chem. Commun., 2006, 4186-4188, DOI: 10.1039/B612697A

Towards the combinatorial synthesis of spongistatin fragment libraries by using asymmetric aldol reactions on solid support
Ian Paterson, Dirk Gottschling and Dirk Menche  
Chem. Commun., 2005, 3568-3570, DOI: 10.1039/B505746A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the CD-spiroacetal segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, Karl R. Gibson and Debra J. Wallace  
Org. Biomol. Chem., 2005,3, 2410-2419, DOI: 10.1039/B504148A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the AB-spiroacetal segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, Renata M. Oballa, Debra J. Wallace and Roger D. Norcross  
Org. Biomol. Chem., 2005,3, 2399-2409, DOI: 10.1039/B504146E

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: fragment couplings, completion of the synthesis, analogue generation and biological evaluation
Ian Paterson, David Y.-K. Chen, Mark J. Coster, José L. Aceña, Jordi Bach and Debra J. Wallace
Org. Biomol. Chem., 2005,3, 2431-2440, DOI: 10.1039/B504151A

The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: the southern hemisphere EF segment
Ian Paterson, Mark J. Coster, David Y.-K. Chen, José L. Aceña, Jordi Bach, Linda E. Keown and Thomas Trieselmann  
Org. Biomol. Chem., 2005,3, 2420-2430, DOI: 10.1039/B504149J

Phorboxazole B synthetic studies: construction of C(1–32) and C(33–46) subtargets
Ian Paterson, Alan Steven and Chris A. Luckhurst  
Org. Biomol. Chem., 2004,2, 3026-3038, DOI: 10.1039/B407240E

Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.
Ian Paterson, Robert Britton, Oscar Delgado and Amy E. Wright  
Chem. Commun., 2004, 632-633, DOI: 10.1039/B316390C

Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation
Ian Paterson, Jose L. Aceña, Jordi Bach, David Y.-K. Chen and Mark J. Coster  
Chem. Commun., 2003, 462-463, DOI: 10.1039/B212651F

Laboratory emulation of polyketide biosynthesis: an iterative, aldol-based, synthetic entry to polyketide libraries using (R)- and (S )-1-(benzyloxy)-2-methylpentan-3-one, and conformational aspects of extended polypropionates
Ian Paterson and Jeremy P. Scott  
J. Chem. Soc., Perkin Trans. 1, 1999, 1003-1014, DOI: 10.1039/A809818B

Recent developments in asymmetric aldol methodology
Alison S. Franklin and Ian Paterson  
Contemp. Org. Synth., 1994,1, 317-338, DOI: 10.1039/CO9940100317

Studies towards the total synthesis of the marine-derived immunosuppressant discodermolide; asymmetric synthesis of a C1–C8d-lactone subunit
Ian Paterson and Stephen P. Wren  
J. Chem. Soc., Chem. Commun., 1993, 1790-1792, DOI: 10.1039/C39930001790

The formation of allyl sulphides by phenylthio-migration: control by silicon
Ian Fleming, Ian Paterson and Andrew Pearce
J. Chem. Soc., Perkin Trans. 1, 1981, 256-262, DOI: 10.1039/P19810000256

Free radical addition to olefins. Part 23. Kinetics of the addition of chloroiodomethane to ethylene and vinyl fluoride
Ian Paterson, John M. Tedder and John C. Walton  
J. Chem. Soc., Perkin Trans. 2, 1978, 884-887, DOI: 10.1039/P29780000884

Homosolvolysis
Hamish Low, Ian Paterson, John M. Tedder and John Walton  
J. Chem. Soc., Chem. Commun., 1977, 171-172, DOI: 10.1039/C39770000171

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Chemistry in Water

We are delighted to share with you a series of collections of recent books, themed issues and articles on the topic of water. These four collections – one per month – demonstrate different aspects of water: its chemistry, its wide use in reactions and as a solvent, its relationship with energy and sustainability, as well as with human health and the environment.

Image (c) Shutterstock

Here, in our second collection, we have assembled some of the ground-breaking research and transformative reviews related to the chemistry in water – highlighting the importance and versatility of water as a medium in chemistry – from across our journals.

Professor Rafael Luque, winner of the RSC 2013 Environment, Sustainability and Energy Division Early Career Award, welcomes this timely and topical collection. “For a more sustainable future, we need to develop benign chemical protocols,” he notes. “Conducting chemical processes in water is a significant step towards this goal. This high profile collection includes articles from leading scientists in the field with varying topics – from materials synthesis to organocatalysis, synthetic organic chemistry and heterogeneous catalysis – that we hope can provide a starting point for young researchers, as well as key references to stimulate further research in the field.”

“This year, as the IPCC prepares to release the final contributions to their Fifth Assessment Report on climate change, it is timely to consider the role of chemistry in addressing global challenges, such as food, water, raw materials and energy,” remarks Professor Lesley Yellowlees, President of the Royal Society of Chemistry. “This collection from our journals shares the latest research from scientists around the world, aiming to tackle these challenges. Featuring original research and commentary by leaders in the field, we hope that you will find this high-quality collection engaging, inspirational and informative.”

You can read all of these articles for free until 21 April 2014! We truly hope you enjoy this collection.

We have already published an article collection on the chemistry of water.  In the next couple of months, we will be publishing collections on water in energy, health and the environment.

Did you know that the RSC has put together a webpage on Water, which brings together information on activities for scientists, policymakers, educators and young people? Take a look today…


Reviews and Perspectives

In water, on water, and by water: mimicking nature’s aldolases with organocatalysis and water
Nobuyuki Mase and Carlos F. Barbas, III
Org. Biomol. Chem., 2010,8, 4043-4050GA?id=C3CS60025D
DOI: 10.1039/C004970K, Perspective

Benign by design: catalyst-free in-water, on-water green chemical methodologies in organic synthesis
Manoj B. Gawande, Vasco D. B. Bonifácio, Rafael Luque, Paula S. Branco and Rajender S. Varma
Chem. Soc. Rev., 2013,42, 5522-5551
DOI: 10.1039/C3CS60025D, Review Article

Olefin metathesis in aqueous media
Jasmine Tomasek and Jürgen Schatz
Green. Chem., 2013,15, 2317-2338
DOI: 10.1039/C3GC41042K, Critical Review

Green chemistry oriented organic synthesis in water
Marc-Olivier Simon and Chao-Jun Li
Chem. Soc. Rev., 2012,41, 1415-1427
DOI: 10.1039/C1CS15222J, Tutorial Review
From themed collection Green Chemistry

sp2 C–H bond activation in water and catalytic cross-coupling reactions
Bin Li and Pierre H. Dixneuf
Chem. Soc. Rev., 2013,42, 5744-5767 GA?id=C0SM01072C
DOI: 10.1039/C3CS60020C, Review Article

Stimulus responsive core-shell nanoparticles: synthesis and applications of polymer based aqueous systems
Olivier J. Cayre, Nelly Chagneux and Simon Biggs
Soft Matter, 2011,7, 2211-2234
DOI: 10.1039/C0SM01072C, Review Article

Alkynes as an eco-compatible “on-call” functionality orthogonal to biological conditions in water
Nick Uhlig and Chao-Jun Li
Chem. Sci., 2011,2, 1241-1249
DOI: 10.1039/C1SC00164G, Minireview GA?id=C1SC00164G

Anion binding in water at lanthanide centres: from structure and selectivity to signalling and sensing
Stephen J. Butler and David Parker
Chem. Soc. Rev., 2013,42, 1652-1666
DOI: 10.1039/C2CS35144G, Tutorial Review
From themed collection Alfred Werner Nobel Prize 100 year celebration

Prebiotic chemistry in eutectic solutions at the water–ice matrix
César Menor-Salván and Margarita R. Marín-Yaseli
Chem. Soc. Rev., 2012,41, 5404-5415
DOI: 10.1039/C2CS35060B, Tutorial Review
From themed collection Prebiotic Chemistry


Original research articles

An in-water, on-water domino process for synthesis
Philip Norcott, Calan Spielman and Christopher S. P. McErlean
Green. Chem., 2012,14, 605-609
DOI: 10.1039/C2GC16259H, Communication

Highly efficient iron(0) nanoparticle-catalyzed hydrogenation in water in flow
Reuben Hudson, Go Hamasaka, Takao Osako, Yoichi M. A. Yamada, Chao-Jun Li, Yasuhiro Uozumi and Audrey Moores
Green. Chem., 2013,15, 2141-2148
DOI: 10.1039/C3GC40789F, Paper

Water as an additive to enhance the ring opening of naphthalene
Qian Wang, Honglei Fan, Suxiang Wu, Zhaofu Zhang, Peng Zhang and Buxing Han
Green. Chem., 2012,14, 1152-1158 GA?id=C1OB05735A
DOI: 10.1039/C2GC16554F, Paper

Click chemistry from organic halides, diazonium salts and anilines in water catalysed by copper nanoparticles on activated carbon
Francisco Alonso, Yanina Moglie, Gabriel Radivoy and Miguel Yus
Org. Biomol. Chem., 2011,9, 6385-6395
DOI: 10.1039/C1OB05735A, Paper

An organocatalytic highly efficient approach to the direct synthesis of substituted carbazoles in water
Pradeep Kumar Jaiswal, Soumen Biswas, Shivendra Singh and Sampak Samanta
Org. Biomol. Chem., 2013,11, 8410-8418
DOI: 10.1039/C3OB42034E, Paper

GA?id=C1GC15726D

Near-critical water, a cleaner solvent for the synthesis of a metal–organic framework
Ilich A. Ibarra, Peter A. Bayliss, Eduardo Pérez, Sihai Yang, Alexander J. Blake, Harriott Nowell, David R. Allan, Martyn Poliakoff and Martin Schröder Green Chem., 2012,14, 117-122
DOI: 10.1039/C1GC15726D, Paper

Stille couplings in water at room temperature
Guo-ping Lu, Chun Cai and Bruce H. Lipshutz
Green Chem., 2013,15, 105-109
DOI: 10.1039/C2GC36042J, Paper

DNA-based asymmetric organometallic catalysis in water
Jens Oelerich and Gerard Roelfes
Chem. Sci., 2013,4, 2013-2017
DOI: 10.1039/C3SC00100H, Edge Article

Pyridinium-based tripodal chemosensor in visual sensing of AMP in water by indicator displacement assay (IDA)
Kumaresh Ghosh, Sk Sarfaraj Ali, Avik Ranjan Sarkar, Asmita Samadder, Anisur Rahman Khuda-Bukhsh, Ioannis D. Petsalakis and Giannoula Theodorakopoulos
Org. Biomol. Chem. , 2013, 11, 5666-5672
DOI: 10.1039/C3OB40833G, Paper

GA?id=C2GC16240G

Design, synthesis, and solution behaviour of small polyamines as switchable water additives
Sean M. Mercer, Tobias Robert, Daniel V. Dixon, Chien-Shun Chen, Zahra Ghoshouni, Jitendra R. Harjani, Soran Jahangiri, Gilles H. Peslherbe and Philip G. Jessop
Green Chem. , 2012,14, 832-839
DOI: 10.1039/C2GC16240G, Paper

In situ generation of bioreducible and acid labile nanogels/microgels simply via adding water into the polymerization system
Zhong-Kai Wang, Long-Hai Wang, Jiao-Tong Sun, Li-Fen Han and Chun-Yan Hong
Polym. Chem., 2013, 4, 1694-1699
DOI: 10.1039/C2PY21058D, Paper

Template-directed synthesis of multi-component organic cages in water
Artur R. Stefankiewicz, Mark R. Sambrook and Jeremy K. M. Sanders
Chem. Sci., 2012,3, 2326-2329
DOI: 10.1039/C2SC20347B, Edge Article

Tuning the catalytic activity of L-proline functionalized hydrophobic nanogel particles in water
Annhelen Lu, Dafni Moatsou, Deborah A. Longbottom and Rachel K. O’Reilly
Chem. Sci., 2013,4, 965-969
DOI: 10.1039/C2SC21300A, Edge Article

GA?id=C3SC51547H

Gold nanoparticles stabilized by an amphiphilic pillar[5]arene: preparation, self-assembly into composite microtubes in water and application in green catalysis
Yong Yao, Min Xue, Zibin Zhang, Mingming Zhang, Yong Wang and Feihe Huang
Chem. Sci., 2013,4, 3667-3672
DOI: 10.1039/C3SC51547H, Edge Article

Water-controlled synthesis and single-crystal structural transformations of a cyanide-bridged W(IV)–Ni(II) molecular wheel complex and 3D networks
Dao-Peng Zhang, Li-Fang Zhang, Guo-Ling Li and Zhong-Hai Ni
Chem. Comm., 2013,49, 9582-9584
DOI: 10.1039/C3CC46063K, Communication

Oxidation of water by a nonhaem diiron(IV) complex via proton-coupled electron transfer
Dong Wang and Lawrence Que
Chem. Comm., 2013,49, 10682-10684
DOI: 10.1039/C3CC46391E, Communication
From themed collection Biological oxidation reactions: mechanisms and design of new catalysts

Enantioselective Friedel–Crafts reactions in water catalyzed by a human telomeric G-quadruplex DNA metalloenzyme
Changhao Wang, Yinghao Li, Guoqing Jia, Yan Liu, Shengmei Lu and Can Li
Chem. Comm., 2012,48, 6232-6234
DOI: 10.1039/C2CC31320K, Communication

Enhanced imine synthesis in water: from surfactant-mediated catalysis to host–guest mechanisms
Kamel Meguellati, Ali Fallah-Araghi, Jean-Christophe Baret, Abdeslam El Harrak, Thomas Mangeat, Carlos M. Marques, Andrew D. Griffiths and Sylvain Ladame
Chem. Comm., 2013,49, 11332-11334
DOI: 10.1039/C3CC46461J, Communication
Open Access

A method for increasing permeability in O2/N2 separation with mixed-matrix membranes made of water-stable MIL-101 and polysulfone
Harold B. Tanh Jeazet, Claudia Staudt and Christoph Janiak
Chem. Comm., 2012,48, 2140-2142
DOI: 10.1039/C2CC16628C, Communication

Cu(OTf)2-catalysed Ritter reaction: efficient synthesis of amides from nitriles and halohydrocarbons in water
Gui-Rong Qu, Yan-Wei Song, Hong-Ying Niu, Hai-Ming Guo and John S. Fossey
RSC Adv., 2012,2, 6161-6163
DOI: 10.1039/C2RA20941A, Communication

GA?id=C3RA40833G

Recyclable NaHSO4 catalyzed alkylation of tert-enamides with indoles or amines in water: facile construction of pharmaceutically analogous bis-alkaloid scaffolds
Xue-Qiang Chu, Shun-Yi Wang and Shun-Jun Ji
RSC Adv., 2013,3, 8380-8387
DOI: 10.1039/C3RA40833G, Paper

Efficient microwave-assisted preparation of squaric acid monoamides in water
Carlos López, Manuel Vega, Elena Sanna, Carmen Rotger and Antoni Costa
RSC Adv., 2013,3, 7249-7253
DOI: 10.1039/C3RA41369A, Communication

CuI/TBAB as a novel efficient catalytic system for Heck reaction in water
Yufang Wang, Qichao Yang, Li Yang, Jianxin Shi and Mingjie Zhang
RSC Adv., 2013,3, 21251-21255
DOI: 10.1039/C3RA44819C, Communication

Highly efficient visible-light-induced photocatalytic hydrogenation of nitrobenzene to aniline in water
Weiming Wu, Rui Lin, Lijuan Shen, Ruowen Liang, Rusheng Yuan and Ling Wu
RSC Adv., 2013,3, 10894-10899
DOI: 10.1039/C3RA40935J, Paper

Ruthenium catalysed one-pot synthesis of S-allyl and cinnamyl dithiocarbamates using allyl and cinnamyl acetates in water
Sabir Ahammed, Amit Saha and Brindaban C. Ranu
RSC Adv., 2012,3, 6329-6335
DOI: 10.1039/C2RA20856C, Paper

GA?id=C3SC52357H

Water-soluble multi-cage super tetrahedral uranyl peroxide phosphate clusters
Jie Qiu, Jie Ling, Laurent Jouffret, Rebecca Thomas, Jennifer E. S. Szymanowski and Peter C. Burns
Chem. Sci., 2014,5, 303-310
DOI: 10.1039/C3SC52357H, Edge Article

Mechanistic changes observed in heavy water for nitrate reduction reaction on palladium-modified Pt(hkl) electrodes
J. Souza-Garcia, E. A. Ticianelli, V. Climent and J. M. Feliu
Chem. Sci., 2012,3, 3063-3070
DOI: 10.1039/C2SC20490H, Edge Article

Active and reusable Pd(II) organometallic catalyst covalently bonded to mesoporous silica nanospheres for water-medium organic reactions
Wenhan He, Fang Zhang and Hexing Li
Chem. Sci., 2011,2, 961-966
DOI: 10.1039/C0SC00652A, Edge Article

Selective electrocatalytic reduction of carbon dioxide to formate by a water-soluble iridium pincer catalyst
Peng Kang, Thomas J. Meyer and Maurice Brookhart
Chem. Sci., 2013,4, 3497-3502
DOI: 10.1039/C3SC51339D, Edge Article

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C-H activation: an article collection

One of the simplest and most utilised chemical reactions is the burning of hydrocarbons and while combustion is an excellent way to exploit the energy content of this naturally occurring resource, there is a lot more we can do with the ‘inert’ C-H bond.

C-H activation allows us to convert cheaper hydrocarbon starting materials into more valuable and versatile products; leading to the development of a wide range of reagents and catalysts that activate C-H bonds. To keep you up to date with the latest developments in the field we have created this article collection, where all articles are free to download until 15th December.

Click here for the full list of free articles

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Biocatalysis: an article collection

Beers, wines and cheeses are enjoyed around the world today and have been for millennia. In fact the practices of brewing and cheese-making pre-date recorded history so it is difficult to accurately determine when we first started using naturally occurring enzymes and microorganisms to create valuable (and in this case, tastier!) products.

Biocatalysts are of course used in far more diverse applications than the creation of food-stuffs, including in many organic syntheses and in the generation of fine chemicals. Due to their natural design, they can offer superior selectivity for particular products and have a far lower environmental impact than many traditional catalysts. Our knowledge and understanding of biocatalysts has increased dramatically in the last few decades, which has allowed us to develop biologically modified and biomimetic catalysts for a range of applications.

To keep you up to date with the latest advances in this rapidly expanding field we have collected together these high impact articles and made them free to access until the 31st October!

Click here for the full list of free articles

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Physical organic chemistry: An article collection

Physical organic chemistry, the study of the underlying principles and rationale of organic reactions which looks at the interrelationships between the structure and reactivity of organic molecules, now encompasses a wider range of contexts than ever before.

Making use of tools such as chemical kinetics, quantum chemistry, thermochemistry, chemical equilibrium and computational chemistry, to name but a few, researchers are investigating topics such as:

•    Supramolecular interactions, aggregation and reactivity
•    The computation of transition states and mechanisms
•    Molecular recognition, reactions and catalysis in biology
•    Materials where molecular structure controls function
•    Structure activity correlations
•    Mechanisms in synthesis and catalysis

To highlight some of the cutting edge research that ChemComm, Chemical Science and Organic & Biomolecular Chemistry receive we have collected a selection of articles for you to enjoy. These will be free to access until 25th September!

Click here for the full list of free articles

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Organometallics in catalysis: an article collection

Perhaps the most well-known applications of organometallics in catalysis are the Ziegler–Natta catalysts which are used to generate polymers, the catalysts are made up of mixtures of transition metal halides and organo-aluminium complexes. Karl Ziegler and Giulio Natta were awarded the 1963 Nobel Prize in Chemistry for their discovery and development of the catalysts, which today are the most commonly used for the manufacture of polythene.

The esteemed history of organometallics are not to be under-estimated and include Grignard’s reagents, the Heck reaction, Schrock catalysts, Grubbs’ catalysts and the Suzuki Coupling to name just a few. Organometallic compounds have revolutionised science and industry and to keep you up to date with the latest break-through research being made across all areas of organometallics in catalysis, we have made this cross-journal article collection free until the 26th September.

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Outstanding organocatalysis: An article collection

Catalysts are key to some of the most important reactions on the planet; a world without the Haber process or catalysts to crack crude oil is difficult to imagine. Not to mention the enzymatic reactions that are crucial to all life on earth.

Organocatalysts are an important class of catalyst and consist of carbon-based molecules often functionalised with oxygen, sulfur, nitrogen or phosphorus. They have shown promise in a range of reactions including hydrogenation, Diels-Alder, Michael and Mannich reactions, and are of particular interest in asymmetric reactions.

To help keep you up-to-date with the latest in cutting-edge organocatalytic research we have made the following articles free to access until the 9th July. After reading all these there will be little you won’t know about the exciting world of organocatalysis!

Click here for the full list of free articles

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